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Search Results: 1 - 10 of 152455 matches for " F. Marie "
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Level crossings and other level functionals of stationary Gaussian processes
Marie F. Kratz
Mathematics , 2006, DOI: 10.1214/154957806000000087
Abstract: This paper presents a synthesis on the mathematical work done on level crossings of stationary Gaussian processes, with some extensions. The main results [(factorial) moments, representation into the Wiener Chaos, asymptotic results, rate of convergence, local time and number of crossings] are described, as well as the different approaches [normal comparison method, Rice method, Stein-Chen method, a general $m$-dependent method] used to obtain them; these methods are also very useful in the general context of Gaussian fields. Finally some extensions [time occupation functionals, number of maxima in an interval, process indexed by a bidimensional set] are proposed, illustrating the generality of the methods. A large inventory of papers and books on the subject ends the survey.
Turen g r til Second Life - Tips til dig, der planl gger et bes g til den virtuelle verden
Inger-Marie F. Christensen
L?ring og Medier , 2009,
Abstract: (Artiklen er uden for review) Form let med denne artikel er at give et overblik over Second Life for at g re det lettere for is r nybegyndere at orientere sig og planl gge mere m lrettede og dermed succesfulde bes g in-world. Artiklen vil derfor ikke g i dybden med de emner, der tages op, men i stedet ganske kort forsyne l seren med en indledende begrebsafklaring, fakta, praktiske oplysninger og links til yderligere information. Sidste del af artiklen indeholder slurls til og beskrivelser af interessant steder i Second Life, som er et bes g v rd. Denne del af artiklen var ikke blevet til uden anbefalinger fra en r kke erfarne og dedikerede Second Life brugere, som velvilligt har delt deres viden og erfaringer med mig og LOMs l sere. Artiklen indeholder bidrag fra: Anders Quitzau og Anja P. Nielsen, IBM Tony Breindal, Det Nationale VidenCenter for e-L ring Marianne Riis, ph.d.-stipendiat fra Aalborg Universitet Inge Knudsen, Horsens Handelsskole Signy óskarsdóttir, Bifr st Universitet p Island.
The Role of Nuclear Bodies in Gene Expression and Disease
Marie Morimoto,Cornelius F. Boerkoel
Biology , 2013, DOI: 10.3390/biology2030976
Abstract: This review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription, modification and assembly of spliceosomal snRNPs, histone gene synthesis and nuclear RNA retention, has significant implications for gene regulation. These functional nuclear domains include the nucleolus, nuclear speckle, nuclear stress body, transcription factory, Cajal body, Gemini of Cajal body, histone locus body and paraspeckle. We herein review the roles of nuclear bodies in regulating gene expression and their relation to human health and disease.
A representation of Gibbs measure for the random energy model
Marie F. Kratz,Pierre Picco
Mathematics , 2004, DOI: 10.1214/105051604000000053
Abstract: In this work we consider a problem related to the equilibrium statistical mechanics of spin glasses, namely the study of the Gibbs measure of the random energy model. For solving this problem, new results of independent interest on sums of spacings for i.i.d. Gaussian random variables are presented. Then we give a precise description of the support of the Gibbs measure below the critical temperature.
An inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode vulva
Marie-Anne Félix
Quantitative Biology , 2005, DOI: 10.1002/bies.20275
Abstract: Signal transduction pathways are largely conserved throughout the animal kingdom. The repertoire of pathways is limited and each pathway is used in different intercellular signaling events during the development of a given animal. For example, Wnt signaling is recruited, sometimes redundantly with other molecular pathways, in four cell specification events during Caenorhabditis elegans vulva development, including the activation of vulval differentiation. Strikingly, a recent study finds that Wnts act to repress vulval differentiation in the nematode Pristionchus pacificus, demonstrating evolutionary flexibility in the use of intercellular signaling pathways.
Evolution of Susceptibility to Ingested Double-Stranded RNAs in Caenorhabditis Nematodes
Isabelle Nuez, Marie-Anne Félix
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029811
Abstract: Background The nematode Caenorhabditis elegans is able to take up external double-stranded RNAs (dsRNAs) and mount an RNA interference response, leading to the inactivation of specific gene expression. The uptake of ingested dsRNAs into intestinal cells has been shown to require the SID-2 transmembrane protein in C. elegans. By contrast, C. briggsae was shown to be naturally insensitive to ingested dsRNAs, yet could be rendered sensitive by transgenesis with the C. elegans sid-2 gene. Here we aimed to elucidate the evolution of the susceptibility to external RNAi in the Caenorhabditis genus. Principal Findings We study the sensitivity of many new species of Caenorhabditis to ingested dsRNAs matching a conserved actin gene sequence from the nematode Oscheius tipulae. We find ample variation in the Caenorhabditis genus in the ability to mount an RNAi response. We map this sensitivity onto a phylogenetic tree, and show that sensitivity or insensitivity have evolved convergently several times. We uncover several evolutionary losses in sensitivity, which may have occurred through distinct mechanisms. We could render C. remanei and C. briggsae sensitive to ingested dsRNAs by transgenesis of the Cel-sid-2 gene. We thus provide tools for RNA interference studies in these species. We also show that transgenesis by injection is possible in many Caenorhabditis species. Conclusions The ability of animals to take up dsRNAs or to respond to them by gene inactivation is under rapid evolution in the Caenorhabditis genus. This study provides a framework and tools to use RNA interference and transgenesis in various Caenorhabditis species for further comparative and evolutionary studies.
Role of Pleiotropy in the Evolution of a Cryptic Developmental Variation in Caenorhabditis elegans
Fabien Duveau,Marie-Anne Félix
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1001230
Abstract: Robust biological systems are expected to accumulate cryptic genetic variation that does not affect the system output in standard conditions yet may play an evolutionary role once phenotypically expressed under a strong perturbation. Genetic variation that is cryptic relative to a robust trait may accumulate neutrally as it does not change the phenotype, yet it could also evolve under selection if it affects traits related to fitness in addition to its cryptic effect. Cryptic variation affecting the vulval intercellular signaling network was previously uncovered among wild isolates of Caenorhabditis elegans. Using a quantitative genetic approach, we identify a non-synonymous polymorphism of the previously uncharacterized nath-10 gene that affects the vulval phenotype when the system is sensitized with different mutations, but not in wild-type strains. nath-10 is an essential protein acetyltransferase gene and the homolog of human NAT10. The nath-10 polymorphism also presents non-cryptic effects on life history traits. The nath-10 allele carried by the N2 reference strain leads to a subtle increase in the egg laying rate and in the total number of sperm, a trait affecting the trade-off between fertility and minimal generation time in hermaphrodite individuals. We show that this allele appeared during early laboratory culture of N2, which allowed us to test whether it may have evolved under selection in this novel environment. The derived allele indeed strongly outcompetes the ancestral allele in laboratory conditions. In conclusion, we identified the molecular nature of a cryptic genetic variation and characterized its evolutionary history. These results show that cryptic genetic variation does not necessarily accumulate neutrally at the whole-organism level, but may evolve through selection for pleiotropic effects that alter fitness. In addition, cultivation in the laboratory has led to adaptive evolution of the reference strain N2 to the laboratory environment, which may modify other phenotypes of interest.
Polymorphisme de la caséine αs2 des Bovinés: caractérisation du variant C du Yak (Bos grunniens)
Marie-Fran?oise Mahé, F Grosclaude
Genetics Selection Evolution , 1982, DOI: 10.1186/1297-9686-14-4-401
Instrumentalizing Cognitive Dissonance Emotions  [PDF]
Marie-Claude Bonniot-Cabanac, Michel Cabanac, José F. Fontanari, Leonid I. Perlovsky
Psychology (PSYCH) , 2012, DOI: 10.4236/psych.2012.312153
Abstract: Many psychologists think that there are few basic emotions, and most emotions are combinations of these few. Here we advance a hypothesis that the number of principally different emotions is near infinite. We consider emotions as mental states with hedonic content, indicating satisfaction and dissatisfaction. Basic emotions correspond to bodily signals, and there are relatively few of them. Our hypothesis is that a large number of emotions are related to the knowledge instinct (KI, or a need for knowledge). KI drives the mind to fit mental representations to cognitive experiences and to resolve mental contradictions. Discomfort due to holding contradictory knowledge elements are known as cognitive dissonances. We emphasize that cognitive dissonances involve specific emotions. The number of cognitive dissonances is combinatorial in terms of elements of knowledge. Correspondingly, the number of these knowledge-related emotions is very large. We report experimental results on measuring these emotions and indicating that emotions of cognitive dissonance exist. We also make a step toward proving that these emotions are different from basic emotions in principle, and outline future research directions toward proving that their number is large.
L ringspotentialet i virtuelle verdener
Rasmus Blok,Inger-Marie F. Christensen
L?ring og Medier , 2009,
Abstract: Om temaet: L ringspotentialet i virtuelle verdener
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