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Search Results: 1 - 10 of 144769 matches for " F. Lehner "
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Pediatric Kidney Transplantation 2011
N. K. Kanzelmeyer,F. Lehner,L. Pape
Transplantationsmedizin , 2011,
Abstract: As recently as 50 years ago, children suffering from renal insuffiency were dying due to a lack of adequate treatment. Nowadays providing different kinds a dialysis modalities, e. g. peritoneal dialysis and hemodialysis, as well as kidney transplantation have nearly become routine therapeutic options in children. Today, dialysis treatment or kidney transplantation can even be performed in infants.Patient survival of 20 years and near-normal mental and physical development is observed in more than 90% of kidney transplant patients.In comparison to deceased organ donation, living donor organ transplantation leads to better transplant survival. For deceased donation it has been shown that kidneys from deceased children and young adults should be preferably allocated to children because long- and middle term transplant function is significantly better.Long waitlist times for a deceased donor kidney is still a major problem for children throughout the Eurotransplant region. Allocation system for children has been altered in December 2010, however, it remains to be seen whether this alteration will have a positive impact on reducing waitlist times.Development of new immunosuppressive protocols has led to a significant improvement of longterm transplant function and transplant survival. Nevertheless, chronic humoral rejection, treatment of recurrence of underlying condition and performing AB0 incompatible transplantations are major challenges in kidney transplantation.
A numerical examination of an evolving black string horizon
D. Garfinkle,L. Lehner,F. Pretorius
Physics , 2004, DOI: 10.1103/PhysRevD.71.064009
Abstract: We use the numerical solution describing the evolution of a perturbed black string presented in Choptuik et al. (2003) to elucidate the intrinsic behavior of the horizon. It is found that by the end of the simulation, the affine parameter on the horizon has become very large and the expansion and shear of the horizon in turn very small. This suggests the possibility that the horizon might pinch off in infinite affine parameter.
Do unbounded bubbles ultimately become fenced inside a black hole?
F. S. Guzman,L. Lehner,O. Sarbach
Physics , 2007, DOI: 10.1103/PhysRevD.76.066003
Abstract: We examine the dynamical behavior of recently introduced bubbles in asymptotically flat, five-dimensional spacetimes. Using numerical methods, we find that even bubbles that initially start expanding eventually collapse to a Schwarzschild-Tangherlini black hole.
Freeness of Linear and Quadratic Forms in von Neumann Algebras
G. P. Chistyakov,F. G?tze,F. Lehner
Mathematics , 2010, DOI: 10.1016/j.jfa.2011.07.012
Abstract: We characterize semicircular distribution by the freeness of linear and quadratic forms in noncommutative random variables from a tracial $W^*$-probability space with relaxed moment conditions.
Evaluation of process management of postpartum hemorrhage due to uterine atony  [PDF]
Iris Holzer, Rainer Lehner
Open Journal of Obstetrics and Gynecology (OJOG) , 2013, DOI: 10.4236/ojog.2013.37093

Objective: To evaluate the management process and the guidelines for management of postpartum hemorrhage due to uterine atony at the General Hospital Vienna, Medical University Vienna. Material and Methods: A retrospective analysis was carried out on all 24 cases of postpartum hemorrhage due to uterine atony with an estimated blood loss of more than 800 mL, in which standardized guidelines were obtained. We included all women who gave birth at the General Hospital of Vienna, the Medical University Vienna, during the period from January 1st 2003 and December 31st 2009 and who suffered blood loss 800 mL at minimum due to uterine atony. Results: The guidelines were in use for 14% - 71%. The average blood loss of the 24 cases with uterine atony was 1342 mL. Conclusion: The management process of postpartum hemorrhage due to uterine atony deviates from the hospital’s guidelines in many cases.

Implications of Organ Allocation on Waitlist Time for Liver Transplantation in Children and Adolescents – Review on the Past 10 Years in the Eurotransplant Region
E.-D. Pfister,T. Becker,F. Lehner,U. Baumann
Transplantationsmedizin , 2011,
Abstract: Liver transplantation (LTx) has developed into an established therapy also in children and adolescents. In pediatric patients, numbers of transplantations, age distribution of patients as well as underlying diseases for LTx have remained constant since many years and there is also no increase to be expected as to the indications for pediatric LTx. Whereas splitting of livers, an established surgical therapy modality to provide two recipients with a new organ, is not performed in all divisable organs, mortality of children waiting for a liver transplant remains a critical topic. Waitlist time of a maximum of 3 months as required by law is largely exceeded. In the medium term, we cannot abstain from a split liver transplant program in order to provide adequate care for terminally ill pediatric liver patients and to optimally use divisable donor organs. Therefore, models of cooperation between centres with and without split organ programs have to be developed and sufficient time, staff and financial resources have to be dedicated to this project.
A Model of Secondary Hydrocarbon Migration As a Buoyancy-Driven Separate Phase Flow Un modèle de migration secondaire des hydrocarbures considéré comme un écoulement en phases séparées régi par la poussée d'Archimède
Lehner F. K.,Marsal D.,Hermans L.,Van Kuyk A.
Oil & Gas Science and Technology , 2006, DOI: 10.2516/ogst:1988010
Abstract: A mathematical model of secondary migration is described which permits the prediction of hydrocarbon migration and accumulation patterns in a sedimentary basin, if source rock expulsion rates and geometrical and hydraulic properties of major carrier systems are known through geological time. In this model, secondary migration is treated as buoyancy-driven, segregated flow of hydrocarbons in hydrostatic aquifers. Lateral, updip migration is conceived as a Boussinesq-type, free-surface flow, with source and sink terms representing supply from source rocks and leakage through cap rocks and faults. This permits a two-dimensional, map-view mathematical description of a three-dimensional, time-dependent secondary migration system. A nine-point finite difference approximation has been developed to minimize numerical dispersion, and upstream-weighting is used to obtain stable solutions. Example computations for simple, single carrier bed structures are presented. L'article décrit un modèle mathématique de migration secondaire prédisant la migration des hydrocarbures et leur accumulation dans un bassin sédimentaire, lorsque les taux d'expulsion des roches mères et les propriétés géométriques et hydrauliques des principaux systèmes de drainage sont connus à l'échelle du temps géologique. Dans ce modèle, la migration secondaire est traitée comme un écoulement des hydrocarbures en phase séparée, contr lé par la poussée d'Archimède, dans des aquifères hydrostatiques. La migration latérale est considérée comme un écoulement de type Boussinesq, à surface libre, avec des termes sources et puits représentant les apports venant des roches mères et les fuites à travers les couvertures et les failles. Ceci permet une description mathématique bidimensionnelle cartographiable d'un système de migration secondaire tridimensionnel et dépendant du temps. On utilise une approximation type différences finies à neuf points pour minimiser la dispersion numérique et une pondération amont pour obtenir des solutions stables. Des exemples de calcul pour des structures simples avec une seule couche perméable sont présentés.
Komplikationen bei Schrittmacherimplantation - eine Analyse anl sslich eines Fallberichtes
Eber B,Lehner S,Lassnig E,Pichler F
Journal für Kardiologie , 2009,
Optical spectroscopy of the M15 intermediate velocity cloud
J. V. Smoker,F. P. Keenan,N. Lehner,C. Trundle
Physics , 2002, DOI: 10.1046/j.1365-8711.2001.03999.x
Abstract: We present echelle spectrograph observations in NaD, at resolutions of 6.2-8.5 km/s, for 11 stars located in the line-of-sight to the M15 intermediate velocity cloud, which has a radial velocity of 70 km/s. This cloud is a part of IVC Complex gp. The targets range in magnitude from V=13.3-14.8. Seven of the observed stars are in the M15 globular cluster, the remaining four being field stars. Column density ratios of log(N cm^-2)=11.8-12.5 are derived. Combining the current sightlines with previously-existing data, we find the NaD/HI ratio in the IVC varies by upto a factor of 25. One cluster star, M15 ZNG-1, was also observed in Calcium. We find N(CaI)/N(CaII)<0.03 and NaI/CaII=0.25, similar to values seen in the local ISM. Finally, we detect tentative evidence for IV absorption in KI towards 3 cluster stars.
Conflict between Noise and Plasticity in Yeast
Ben Lehner
PLOS Genetics , 2010, DOI: 10.1371/journal.pgen.1001185
Abstract: Gene expression responds to changes in conditions but also stochastically among individuals. In budding yeast, both expression responsiveness across conditions (“plasticity”) and cell-to-cell variation (“noise”) have been quantified for thousands of genes and found to correlate across genes. It has been argued therefore that noise and plasticity may be strongly coupled and mechanistically linked. This is consistent with some theoretical ideas, but a strong coupling between noise and plasticity also has the potential to introduce cost–benefit conflicts during evolution. For example, if high plasticity is beneficial (genes need to respond to the environment), but noise is detrimental (fluctuations are harmful), then strong coupling should be disfavored. Here, evidence is presented that cost–benefit conflicts do occur and that they constrain the evolution of gene expression and promoter usage. In contrast to recent assertions, coupling between noise and plasticity is not a general property, but one associated with particular mechanisms of transcription initiation. Further, promoter architectures associated with coupling are avoided when noise is most likely to be detrimental, and noise and plasticity are largely independent traits for core cellular components. In contrast, when genes are duplicated noise–plasticity coupling increases, consistent with reduced detrimental affects of expression variation. Noise–plasticity coupling is, therefore, an evolvable trait that may constrain the emergence of highly responsive gene expression and be selected against during evolution. Further, the global quantitative data in yeast suggest that one mechanism that relieves the constraints imposed by noise–plasticity coupling is gene duplication, providing an example of how duplication can facilitate escape from adaptive conflicts.
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