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Search Results: 1 - 10 of 144455 matches for " F. Heidecke "
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A Prospective Study Comparing Quality of Life and Cosmetic Results between Single-Port and Conventional Laparoscopic Cholecystectomy  [PDF]
Olaf Teubner, Claus D. Heidecke, Thomas Kohlmann, Kaja Ludwig, Maciej Patrzyk
Surgical Science (SS) , 2016, DOI: 10.4236/ss.2016.72016
Abstract: Background: Multiple studies from the last five years have demonstrated that single-incision laparoscopic surgery cholecystectomy (SILS) is not only feasible but also produces a result comparable with that of conventional laparoscopic cholecystectomy (CLC). Methods and results: In this bicentric study, we used the Short Form (36) (SF-36) and Nottingham Health Profile (NHP) surveys to estimate and compare the post-operative quality of life up to the 28th post-operative day for 66 patients who had undergone either CLC (n = 32) or SILS (n = 34). Additionally, we investigated patient satisfaction with the cosmetic results after one year. The curves summarizing the eight sections in the physical sum scale and in the mental sum scale (SF-36) were the same within the confidence interval with a confidence level of 95%. Thus, post-operative quality of life could be assumed to be equivalent for the two groups. Evaluation of the NHP survey produced similar results. The perceived cosmetic results were significantly better for the SILS group (1.3 on a scale of 1 - 5 with 1 being the best) than for the CLC group (1.9) (p = 0.016). Conclusions: This study did not demonstrate better quality of life for the single-port procedure as it had been expected. Instead, the single-port procedure produced subjectively better cosmetic results.
Die infizierte Problemwunde 2009
Kramer, Axel,Assadian, Ojan,Ekkernkamp, Axel,Heidecke, Claus-Dieter
GMS Krankenhaushygiene Interdisziplin?r , 2009,
Abstract:
In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model
Ivo L Partecke, André Kaeding, Matthias Sendler, Nele Albers, Jens-P Kühn, Sven Speerforck, Sebastian Roese, Florian Seubert, Stephan Diedrich, Sandra Kuehn, Ulrich F Weiss, Julia Mayerle, Markus M Lerch, Stefan Hadlich, Norbert Hosten, Claus-D Heidecke, Ralf Puls, Wolfram von Bernstorff
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-40
Abstract: 6606PDA murine pancreatic cancer cells were orthotopically injected into the pancreatic head. Liver metastases were induced through splenic injection. Animals were analyzed by MRI three and five weeks following injection. Tumours were detected using T2-weighted high resolution sequences. Tumour volumes were determined by callipers and MRI. Liver metastases were analyzed using gadolinium-EOB-DTPA and T1-weighted 3D-Flash sequences. Tumour blood flow was measured using low molecular gadobutrol and high molecular gadolinium-DTPA.MRI handling and applicability was similar to human systems, resolution as low as 0.1 mm. After 5 weeks tumour volumes differed significantly (p < 0.01) when comparing calliper measurments (n = 5, mean 1065 mm3+/-243 mm3) with MRI (mean 918 mm3+/-193 mm3) with MRI being more precise. Histology (n = 5) confirmed MRI tumour measurements (mean size MRI 38.5 mm2+/-22.8 mm2 versus 32.6 mm2+/-22.6 mm2 (histology), p < 0,0004) with differences due to fixation and processing of specimens. After splenic injection all mice developed liver metastases with a mean of 8 metastases and a mean volume of 173.8 mm3+/-56.7 mm3 after 5 weeks. Lymphnodes were also easily identified. Tumour accumulation of gadobutrol was significantly (p < 0.05) higher than gadolinium-DTPA. All imaging experiments could be done repeatedly to comply with the 3R-principle thus reducing the number of experimental animals.This model permits monitoring of tumour growth and metastasis formation in longitudinal non-invasive high-resolution MR studies including using contrast agents comparable to human pancreatic cancer. This multidisciplinary environment enables radiologists, surgeons and physicians to further improve translational research and therapies of pancreatic cancer.Pancreatic cancer is the third most common cause of gastrointestinal malignancies and the fourth leading cause of cancer death in the northern hemisphere. Pancreatic cancer accounts for approximately 33,000 cancer deat
The Wave-Front Correction System for the Sunrise Balloon-Borne Solar Observatory
T. Berkefeld,W. Schmidt,D. Soltau,A. Bell,H. P. Doerr,B. Feger,R. Friedlein,K. Gerber,F. Heidecke,T. Kentischer,O. v. d. Lühe,M. Sigwarth,E. W?lde,P. Barthol,W. Deutsch,A. Gandorfer,D. Germerott,B. Grauf,R. Meller,A. Alvarez-Herrero,M. Kn?lker,V. Martinez Pillet,S. K. Solanki,A. M. Title
Physics , 2010, DOI: 10.1007/s11207-010-9676-3
Abstract: This paper describes the wave-front correction system developed for the Sunrise balloon telescope, and provides information about its in-flight performance. For the correction of low-order aberrations, a Correlating Wave-Front Sensor (CWS) was used. It consisted of a six-element Shack-Hartmann wave-front sensor (WFS), a fast tip-tilt mirror for the compensation of image motion, and an active telescope secondary mirror for focus correction. The CWS delivered a stabilized image with a precision of 0.04 arcsec (rms), whenever the coarse pointing was better than 90 arcsec peak-to-peak. The automatic focus adjustment maintained a focus stability of 0.01 waves in the focal plane of the CWS. During the 5.5 day flight, good image quality and stability was achieved during 33 hours, containing 45 sequences that lasted between 10 and 45 minutes.
A retrospective of the GREGOR solar telescope in scientific literature
C. Denker,O. von der Lühe,A. Feller,K. Arlt,H. Balthasar,S. -M. Bauer,N. Bello González,T. Berkefeld,P. Caligari,M. Collados,A. Fischer,T. Granzer,T. Hahn,C. Halbgewachs,F. Heidecke,A. Hofmann,T. Kentischer,M. Klvaňa,F. Kneer,A. Lagg,H. Nicklas,E. Popow,K. G. Puschmann,J. Rendtel,D. Schmidt,W. Schmidt,M. Sobotka,S. K. Solanki,D. Soltau,J. Staude,K. G. Strassmeier,R. Volkmer,T. Waldmann,E. Wiehr,A. D. Wittmann,M. Woche
Physics , 2012, DOI: 10.1002/asna.201211728
Abstract: In this review, we look back upon the literature, which had the GREGOR solar telescope project as its subject including science cases, telescope subsystems, and post-focus instruments. The articles date back to the year 2000, when the initial concepts for a new solar telescope on Tenerife were first presented at scientific meetings. This comprehensive bibliography contains literature until the year 2012, i.e., the final stages of commissioning and science verification. Taking stock of the various publications in peer-reviewed journals and conference proceedings also provides the "historical" context for the reference articles in this special issue of Astronomische Nachrichten/Astronomical Notes.
Risk/benefit evaluation of the use of triclosan in surgical suturing materials
Kramer, Axel,Assadian, Ojan,Guggenbichler, Josef Peter,Heidecke, Claus-Dieter
GMS Krankenhaushygiene Interdisziplin?r , 2006,
Abstract: Based on the current literature, a risk/benefit analysis of the antimicrobial impregnation of surgical sutures with triclosan is performed, focussing on efficacy and indication, risk of resistance development, toxicological characteristics, and environmental tolerance. From a toxicological point of view, there are no restrictions for triclosan-impregnated suturing materials. Environmental tolerance is also acceptable for this application area, because the amounts of triclosan involved pose no problems in terms of degradability. The use of surgical suturing material coated with triclosan is seen especially in contaminated wounds or where the risk of infection is high. In order to meet this requirement, the antimicrobial properties of triclosan are particularly emphasized.Both in vitro and in vivo, triclosan is highly effective against Staphylococcus spp., including MRSA, the pathogens most frequently involved in postoperative wound infections. Triclosan is not effective against Pseudomonas aeruginosa, Serratia marcescens and Alcaligenes spp., due to their intrinsic resistance against this agent.As long as the inducible resistance in vitro against triclosan is not clinically relevant, it does not speak against triclosan use in suturing material, especially because pure triclosan is applied only to a specific, limited area for a short time. However, because triclosan can induce in vitro the development of cross-resistances to antibiotics, the implementation of this agent must be exclusively limited to medically founded indications.
Are laptop ventilation-blowers a potential source of nosocomial infections for patients?
Siegmund, Katja,Hübner, Nils,Heidecke, Claus-Dieter,Brandenburg, Ronny
GMS Krankenhaushygiene Interdisziplin?r , 2010,
Abstract: Inadequately performed hand hygiene and non-disinfected surfaces are two reasons why the keys and mouse-buttons of laptops could be sources of microbial contamination resulting consequently in indirect transmission of potential pathogens and nosocomial infections. Until now the question has not been addressed whether the ventilation-blowers in laptops are actually responsible for the spreading of nosocomial pathogens. Therefore, an investigational experimental model was developed which was capable of differentiating between the microorganisms originating from the external surfaces of the laptop, and from those being blown out via the ventilation-blower duct. Culture samples were taken at the site of the external exhaust vent and temperature controls were collected through the use of a thermo-camera at the site of the blower exhaust vent as well as from surfaces which were directly exposed to the cooling ventilation air projected by the laptop. Control of 20 laptops yielded no evidence of microbial emission originating from the internal compartment following switching-on of the ventilation blower. Cultures obtained at the site of the blower exhaust vent also showed no evidence of nosocomial potential. High internal temperatures on the inner surfaces of the laptops (up to 73°C) as well as those documented at the site of the blower exhaust vent (up to 56°C) might be responsible for these findings.
Simultaneous occurrence of a hepatocellular carcinoma and a hepatic non-Hodgkin’s lymphoma infiltration
Sabine Heidecke, Dirk L Stippel, Arnulf H Hoelscher, Inga Wedemeyer, Hans-Peter Dienes, Uta Drebber
World Journal of Hepatology , 2010,
Abstract: To investigate the simultaneous occurrence of hepatocellular carcinoma and non-Hodgkin’s lymphoma, we report the case of a 70 year old patient with a primary diagnosis of non-Hodgkin’s lymphoma in 2002. In a routine follow up investigation of his chronic lymphocytic leukemia a newly detected mass in the Couinaud's segments 2 and 3 was found. No hepatitis C virus or hepatitis B virus infection or cirrhosis was evident. After laparoscopic segmentectomy the histological examination revealed a hepatocellular carcinoma. While the relation between liver parenchyma damages and hepatocellular carcinoma or non-Hodgkin’s lymphoma is well known, only a few publications have focused on the coexistence of hepatocellular carcinoma and non-Hodgkin’s lymphoma. With this case we demonstrate the coexistence of these diseases without having a predamaged liver parenchyma.
Experimental Sepsis Impairs Humoral Memory in Mice
Christian P?tschke, Wolfram Kessler, Stefan Maier, Claus-Dieter Heidecke, Barbara M. Br?ker
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081752
Abstract: Patients with sepsis are often immune suppressed, and experimental mouse models of sepsis also display this feature. However, acute sepsis in mice is also characterized by a generalized B cell activation and plasma cell differentiation, resulting in a marked increase in serum antibody concentration. Its effects on humoral memory are not clearly defined. We measured the effects of experimental sepsis on long-term immunological memory for a defined antigen: we induced colon ascendens stent peritonitis (CASP) 8 weeks after 2 rounds of immunization with ovalbumin. Four weeks later, the antigen-specific bone marrow plasma cell count had doubled in immunized non-septic animals, but remained unchanged in immunized septic animals. Sepsis also caused a decrease in antigen-specific serum antibody concentration. We conclude that sepsis weakens humoral memory by impeding the antigen-specific plasma cell pool’s development, which is not complete 8 weeks after secondary immunization.
The Filter Imager SuFI and the Image Stabilization and Light Distribution System ISLiD of the Sunrise Balloon-Borne Observatory: Instrument Description
A. Gandorfer,B. Grauf,P. Barthol,T. L. Riethmueller,S. K. Solanki,B. Chares,W. Deutsch,S. Ebert,A. Feller,D. Germerott,K. Heerlein,J. Heinrichs,D. Hirche,J. Hirzberger,M. Kolleck,R. Meller,R. Mueller,R. Schaefer,G. Tomasch,M. Knoelker,V. Martinez Pillet,J. A. Bonet,W. Schmidt,T. Berkefeld,B. Feger,F. Heidecke,D. Soltau,A. Tischenberg,A. Fischer,A. Title,H. Anwand,E. Schmidt
Physics , 2010, DOI: 10.1007/s11207-010-9636-y
Abstract: We describe the design of the Sunrise Filter Imager (SuFI) and the Image Stabilization and Light Distribution (ISLiD) unit onboard the Sunrise balloon borne solar observatory. This contribution provides the necessary information which is relevant to understand the instruments working principles, the relevant technical data, and the necessary information about calibration issues directly related to the science data.
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