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Search Results: 1 - 10 of 191203 matches for " Evin D. Bruschweiler "
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Generation of polycyclic aromatic hydrocarbons (PAHs) during woodworking operations
Evin D. Bruschweiler,Cong Khanh Huynh,Pascal Wild,Philippe Boiteux,Nancy B. Hopf
Frontiers in Oncology , 2012, DOI: 10.3389/fonc.2012.00148
Abstract: Occupational exposures to wood dust have been associated with an elevated risk of sinonasal cancer (SNC). Wood dust is recognized as a human carcinogen but the specific cancer causative agent remains unknown. One possible explanation is a co-exposure to; wood dust and polycyclic aromatic hydrocarbons (PAHs). PAHs could be generated during incomplete combustion of wood due to heat created by use of power tools. To determine if PAHs are generated from wood during common wood working operations, PAH concentrations in wood dust samples collected in an experimental chamber operated under controlled conditions were analyzed. In addition, personal air samples from workers exposed to wood dust (n = 30) were collected. Wood dust was generated using three different power tools: vibrating sander, belt sander, and saw; and six wood materials: fir, Medium Density Fiberboard (MDF), beech, mahogany, oak and wood melamine. Monitoring of wood workers was carried out by means of personal sampler device during wood working operations. We measured 21 PAH concentrations in wood dust samples by capillary gas chromatography-ion trap mass spectrometry (GC-MS). Total PAH concentrations in wood dust varied greatly (0.24–7.95 ppm) with the lowest being in MDF dust and the highest in wood melamine dust. Personal PAH exposures were between 37.5–119.8 ng m?3 during wood working operations. Our results suggest that PAH exposures are present during woodworking operations and hence could play a role in the mechanism of cancer induction related to wood dust exposure.
Middle East Technical University Journal of the Faculty of Architecture , 2010,
Gisements naturels Pléistocenes et Holocènes des cavités des Pyrénées Occidentales Fran aises: Inventaire et datages 14C.
Andre Clot,Jacques Evin
Munibe Antropologia-Arkeologia , 1986,
Abstract: Recientes descubrimientos fortuitos de espeleólogos permiten completar los datos proporcionados por los yacimientos paleontológicos clásicos. Se redacta un primer inventario de las cavidades de los Pirineos Atlánticos y de los Altos Pirineos franceses, donde han caído animales salvajes accidentalmente, sea en simas verticales o sea a lo largo de fuertes pendientes. Se da cuenta de dataciones 14 C sobre algunos de estos restos.
An analysis of silver candlesticks from a casting point of view: originals,copies, forgeries
Jaromir Audy,Emil Evin
China Foundry , 2010,
Abstract: Collecting silver artefacts has traditionally been a very popular hobby. Silver is addictive, therefore the number of potential collectors and investors appears to grow each year. Unfortunately, increases in the interest and buying potentials resulted in a number of forgeries manufactured and introduced to the open antique market. The items such as early silver candlesticks dictate a very high price, for many high quality fakes show very good appearances and matching similarities with originals. Such copies are traditionally manufactured by casting using the original items as patterns. Small details and variances in design features, position and shape of hallmarks, including the final surface quality are usual features to distinguish the fakes from the originals. This paper presents results of a study conducted on several silver candlesticks, including two artefacts bearing features of those produced in the mid 18th century, one original Italian candelabrum from Fascist era, and small candlesticks made in the early 20th century. Also, the paper presents some interesting contemporary coins ?replicas of many those produced in different countries. The coins were offered for sale by unscrupulous dealers via auctions and e-bays. Finally the main results and findings from this study are discussed from a manufacturing point of view, such as fabrication technology, surface quality and hallmarks, which will help the collectors, dealers and investors to detect and avoid forgeries.
Autoimmune inflammatory disorders, systemic corticosteroids and pneumocystis pneumonia: A strategy for prevention
Evin Sowden, Andrew J Carmichael
BMC Infectious Diseases , 2004, DOI: 10.1186/1471-2334-4-42
Abstract: In adults with AID, the risk of PCP is related to treatment with systemic steroid, ill-defined individual variation in steroid sensitivity and CD4+ lymphocyte count. Rather than opting for PCP prophylaxis on the basis of disease or treatment with cyclophosphamide, we argue the case for carrying out CD4+ lymphocyte counts on selected patients as a means of identifying individuals who are most likely to benefit from PCP prophylaxis.Corticosteroids, lymphopenia and a low CD4+ count in particular, have been identified as risk factors for the development of PCP in adults with AID. Trimethoprim-sulfamethoxazole (co-trimoxazole) is an effective prophylactic agent, but indications for its use remain ill-defined. Further prospective trials are required to validate our proposed prevention strategy.Pneumocystis carinii was identified a hundred years ago by Chagas [1] and recognised as a pathogen in marasmic children at the end of World War II [2]. The organism came to the fore again in the early 1980s when apparently healthy homosexual men developed PCP and heralded the acquired immunodeficiency syndrome (AIDS) epidemic [3]. With highly active antiretroviral therapy (HAART) and prophylactic antibiotics, attention has turned to PCP in human immunodeficiency virus (HIV) negative individuals. We recently treated a young woman with steroid-based immunosuppression for dermatomyositis. Four months after diagnosis, she was admitted acutely breathless to the intensive care unit with a presumptive diagnosis of PCP. Although the final diagnosis was rapidly progressive alveolitis related to dematomyositis, it prompted us to consider whether we should use PCP prophylaxis for selected patients receiving systemic steroids for AID. In this article we explore the background of PCP in HIV negative patients, consider the incidence of PCP in AID, discuss predisposing factors and propose a strategy for prevention.Pneumocystis pneumonia is caused in humans by the recently renamed Pneumocystis jiro
An audit of influenza and pneumococcal vaccination in rheumatology outpatients
Evin Sowden, William S Mitchell
BMC Musculoskeletal Disorders , 2007, DOI: 10.1186/1471-2474-8-58
Abstract: We audited a sample of 101 patients attending hospital rheumatology outpatient clinics on any form of disease modifying treatment by clinical questionnaire and medical record perusal. Further data were collected from the local immunisation coordinating agency and analysed by logistic regression modelling.Although there was a high rate of awareness with regard to immunisation, fewer patients on major immunosuppressants were vaccinated than patients with additional clinical risk factors against influenza (53% vs 93%, p < 0.001) or streptococcus pneumoniae (28% vs 64%, p = 0.001). The presence of additional risk factors was confirmed as significant in determining vaccination status by logistic regression for both influenza (OR 10.89, p < 0.001) and streptococcus pneumoniae (OR 4.55, p = 0.002). The diagnosis of rheumatoid arthritis was also found to be a significant factor for pneumococcal vaccination (OR 5.1, p = 0.002). There was a negative trend suggesting that patients on major immunosuppressants are less likely to be immunised against pneumococcal antigen (OR 0.35, p = 0.067).Influenza and pneumococcal immunisation is suboptimal amongst patients on current immunosuppressant treatments attending rheumatology outpatient clinics. Raising awareness amongst patients may not be sufficient to improve vaccination rates and alternative strategies such as obligatory pneumococcal vaccination prior to treatment initiation and primary care provider education need to be explored.Influenza infection is responsible for considerable morbidity and mortality in epidemic years [1], whilst streptococcus pneumoniae infection accounts for 48% of bacteriologically confirmed community acquired pneumonias [2]. A number of groups have been identified as being at high risk for whom vaccination is currently recommended in the United Kingdom (UK), including individuals over 65 years of age or with heart disease, chronic lung disease, diabetes, chronic renal failure, chronic liver failure or hy
Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein
Jiang-Li Tan, Qiao-Xin Li, Giuseppe D. Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061246
Abstract: BACE1 is responsible for β-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the production of amyloid β (Aβ) peptides. Previous reports, by us and others, have indicated that the levels of BACE1 protein and activity are increased in the brain cortex of patients with Alzheimer’s disease (AD). The association between oxidative stress (OS) and AD has prompted investigations that support the potentiation of BACE1 expression and enzymatic activity by OS. Here, we have established conditions to analyse the effects of mild, non-lethal OS on BACE1 in primary neuronal cultures, independently from apoptotic mechanisms that were shown to impair BACE1 turnover. Six-hour treatment of mouse primary cortical cells with 10–40 μM hydrogen peroxide did not significantly compromise cell viability but it did produce mild oxidative stress (mOS), as shown by the increased levels of reactive radical species and activation of p38 stress kinase. The endogenous levels of BACE1 mRNA and protein were not significantly altered in these conditions, whereas a toxic H2O2 concentration (100 μM) caused an increase in BACE1 protein levels. Notably, mOS conditions resulted in increased levels of the BACE1 C-terminal cleavage product of APP, β-CTF. Subcellular fractionation techniques showed that mOS caused a major rearrangement of BACE1 localization from light to denser fractions, resulting in an increased distribution of BACE1 in fractions containing APP and markers for trans-Golgi network and early endosomes. Collectively, these data demonstrate that mOS does not modify BACE1 expression but alters BACE1 subcellular compartmentalization to favour the amyloidogenic processing of APP, and thus offer new insight in the early molecular events of AD pathogenesis.
The Use of Scalp as a Donor Site for Pediatric Burn Patients to Obtain Split Thickness Skin Graft
Fatih Uygur,Rahmi Evin,Fuat Yüksel
Güncel Pediatri , 2009,
Abstract: Aim: To treat the pediatric burn patients, split thickness skin grafting (STSG) is used widespreadly. STSG is frequently taken from the thigh or buttock. Some serious donor site morbidities such as long healing period and permanent scars are seen in these patients. Materials and Method: We retrospectively analyzed 86 pediatric burn patients in wich scalp was used as a donor-site of STSG between January 2002 and November 2008. Results: We determined that the healing time of the scalp is more rapid than conventional STSG donor site. Furthermore, this technique had important advantages such as to minimize postoperative discomforts, to allow repetitive graft harvesting and to camouflage visible scar. Conclusion: In our study, we revealed that scalp donor sites were dependable areas with low morbidity in pediatric burn patients. (Journal of Current Pediatrics 2009; 7: 1-6)
Roles on the Health Care and the Pleasement at Work of the Nurses Working at the Hospitals and the Health Centres in Diyarbakir City
Rojan Arcak,Evin Kas?mo?lu
Dicle Medical Journal , 2006,
Abstract: In April, 2004, a survey has been realized on 320 nurses at the hospitals and the primary health care centres in the centre of Diyarbak r aiming to understand their professional expectations and complaints, their working conditions, their scientifical approach to work and finally, how harmonious they are with the social life and the Union. After all, the datas have been evaluated statistically. The study we have carried out demonstrated that the ratio of those loving their job is 63%. 31% of them mostly complain about the patients and their relatives. This is followed by the problem of shortcoming of Staff with a rate of 26%. Of all 18% are complaint for the length of the working hours.Then, comes 23% emphasizing the excess number of the duties. 45% of the nurses pointed out their membership to a Union and 31% we questioned have determined that they read the publications related to their jobs. Of all samples 30% get preventive measures for the possible infections at work. %20 of all nurses had been exposed to abuse done by patients and patients’relatives during previous year.
Sistemas de análisis acústico y de reconocimiento autom ático en habla espontánea
Gurlekian,Jorge A; Evin,Diego; Torres,Humberto; Renato,Alejandro;
Subjetividad y procesos cognitivos , 2010,
Abstract: in this paper two acoustic speech analysis systems are presented with applications to the description of spontaneous speech segments and a system of automatic spontaneous speech recognition oriented to word detection. the first analysis system presents in detail all segment and supra-segment instinct speech features simultaneously and associated frequency, power and duration. the second automatically displays the physical parameters associated to intonation in a surface that quantifies the vocal field of the speaker and measures the vocal and dynamic range in spoken discourse. a histogram of the fundamental frequency proves useful to compare intonation tendencies from session to session. finally a recognition tool with acoustic models was developed for spanish spoken in argentina. it transcribes the recorded text sounds and enables the application of other tools for natural language processing.
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