oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 11 )

2019 ( 607 )

2018 ( 729 )

2017 ( 742 )

Custom range...

Search Results: 1 - 10 of 486719 matches for " Evelyn C. S. Marin "
All listed articles are free for downloading (OA Articles)
Page 1 /486719
Display every page Item
Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation
Terezila M. Coimbra,Heloísa D. C. Francescato,Ana Paula C. Balbi,Evelyn C. S. Marin,Roberto S. Costa
International Journal of Nephrology , 2012, DOI: 10.1155/2012/919128
Abstract: Exposure to an adverse environment in utero appears to programme physiology and metabolism permanently, with long-term consequences for health of the fetus or offspring. It was observed that the offspring from dams submitted to high-sodium intake during pregnancy present disturbances in renal development and in blood pressure. These alterations were associated with lower plasma levels of angiotensin II (AII) and changes in renal AII receptor I (AT1) and mitogen-activated protein kinase (MAPK) expressions during post natal kidney development. Clinical and experimental evidence show that the renin-angiotensin system (RAS) participates in renal development. Many effects of AII are mediated through MAPK pathways. Extracellular signal-regulated protein kinases (ERKs) play a pivotal role in cellular proliferation and differentiation. In conclusion, high-sodium intake during pregnancy and lactation can provoke disturbances in renal development in offspring leading to functional and structural alterations that persist in adult life. These changes can be related at least in part with the decrease in RAS activity considering that this system has an important role in renal development. 1. Introduction The risk of hypertension, renal, and cardiovascular disease are in part determined before birth by intrauterine factors. Exposure to an adverse environment in utero appears to programme physiology and metabolism permanently, with long-term consequences for health of the fetus or offspring [1, 2]. The nephrogenesis in rats begins on embryonic day 12 and is completed at between 10 and 15 days after birth [3, 4]. Clinical and experimental evidence show that the renin-angiotensinn system (RAS) participates in renal development [5–11]. In the rat kidney, angiotensinogen expression is higher during the late gestation and newborn period whilst renin mRNA is detected from embryonic day 17 and is higher on embryonic day 20 and in newborns compared to adults [7, 8]. Renal AII content is several fold higher in newborn rats and mice than in their adult counterparts. The AII receptors are also expressed to a greater degree in newborn rats [9]. The mRNA for the type 1 AII receptor (AT1) has been detected in the renal glomeruli of newborn rats during cellular proliferation and differentiation [10]. Increase in fibronectin, -SM-actin ( -smooth muscle actin), PCNA (proliferating cell nuclear antigen) and p-ERK (extracellular signal-regulated protein kinase) expressions were observed in the renal cortex of 1- and 7-day-old rats, followed by a decrease during renal development [12].
A finite element method for exterior interface problems
R. C. Maccamy,S. P. Marin
International Journal of Mathematics and Mathematical Sciences , 1980, DOI: 10.1155/s0161171280000233
Abstract: A procedure is given for the approximate solution of a class of two-dimensional diffraction problems. Here the usual inner boundary conditions are replaced by an inner region together with interface conditions. The interface problem is treated by a variational procedure into which the infinite region behavior is incorporated by the use of a non-local boundary condition over an auxiliary curve. The variational problem is formulated and existence of a solution established. Then a corresponding approximate variational problem is given and optimal convergence results established. Numerical results are presented which confirm the convergence rates.
Clinical, aetiological and evolutive aspects of West syndrome in Yaoundé (Cameroon)  [PDF]
Séraphin Nguefack, Boniface Moifo, Andréas Chiabi, Antoine Ledoux Defo, Evelyn Mah, Florence Fru, Paul Cédric Mbonda, Pierre Fernand Tchokoteu, Elie Mbonda
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.34055
Abstract:

Background: West syndrome (WS) is an epileptic syndrome of the infant occurring between the 3rd and 12th months of life and characterized by the triad: infantile spasms in flexion, extension or mixed; global developmental delay; and hypsarrythmia on the electroencephalogram (EEG). Its incidence varies between 2.9 and 4.5 per 10,000 live births. West syndrome is caused by a brain dysfunction whose origins can be prenatal, neonatal and postnatal. Sometimes the aetiology is genetic or unknown. Purpose: To determine the main clinical, aetiological and major evolutive aspects of West syndrome in child neurology unit in a university-affiliated hospital in Yaoundé. Materials and Methods: It was a retrospective descriptive study conducted from September 2011 to January 2012 inthe child neurology unit of the Yaoundé gynaeco-obstetric and paediatric hospital. The medical records of 68 children followed for West syndrome (WS) in the service during the period from February 2008 to January 2012 (48 months) were used. All infants of 1- to 16-month-old with the diagnosis of WS were included. The diagnosis of WS was based on clinical evidence of spasm in flexion and/or in extension with global development delay, and EEG evidence of hypsarythmia or focal/multifocal epileptic abnormalities when hypsarythmia is absent. For each included infant, relevant medical history and complete physical examination were performed. The following data were collected and reported on a standardized questionnaire: prenatal, perinatal and postnatal past histories, age at onset of spasms, age at diagnosis, semiology of spasms, psychomotor development, the EEG and CT aspects and the evolutive modes of WS under treatment. Psychomotor development was assessed using theDenverdevelopmental screening test (DDST) which assesses the mental age compared to

Effect of cocaine on periadolescent rats with or without early maternal separation
Planeta, C.S.;Marin, M.T.;
Brazilian Journal of Medical and Biological Research , 2002, DOI: 10.1590/S0100-879X2002001100015
Abstract: cocaine-induced behavioral sensitization and weight loss were investigated in periadolescent wistar rats kept with their mothers or subjected to repeated maternal separation. litters allocated to the separation procedure were placed in a temperature-controlled (33oc) chamber for 3 h per day from postnatal day 6 (p6) to p20. non-handled rats were left undisturbed until weaning. treatments were started on p30-31 and the test was performed on p36-37. animals received injections of saline or cocaine (10 mg/kg, sc) twice daily for 5 days. on day 6 all animals received saline. on day 7 animals were challenged with 10 mg/kg cocaine and their locomotion was evaluated in activity cages. a third group received saline throughout the 7-day period. body weights were recorded on p30-31 and p36-37. two-way anova on body weights showed a main effect of treatment group (f(1,35) = 10.446, p = 0.003; n = 10-12). non-handled rats treated with cocaine for 5 days gained significantly less weight, while no significant effect was observed in maternally separated rats. two-way anova revealed a main effect of drug treatment on locomotor activity (f(2,32) = 15.209, p<0.001; n = 6-8), but not on rearing condition (f(1,32)<0.001, p = 0.998). animals pretreated with cocaine showed a clear behavioral sensitization relative to the saline group. no difference in the magnitude of sensitization was found between separated and non-handled animals. only the effect of cocaine on weight gain was significantly affected by repeated episodes of early maternal separation during the pre-weaning period.
Effect of cocaine on periadolescent rats with or without early maternal separation
Planeta C.S.,Marin M.T.
Brazilian Journal of Medical and Biological Research , 2002,
Abstract: Cocaine-induced behavioral sensitization and weight loss were investigated in periadolescent Wistar rats kept with their mothers or subjected to repeated maternal separation. Litters allocated to the separation procedure were placed in a temperature-controlled (33oC) chamber for 3 h per day from postnatal day 6 (P6) to P20. Non-handled rats were left undisturbed until weaning. Treatments were started on P30-31 and the test was performed on P36-37. Animals received injections of saline or cocaine (10 mg/kg, sc) twice daily for 5 days. On day 6 all animals received saline. On day 7 animals were challenged with 10 mg/kg cocaine and their locomotion was evaluated in activity cages. A third group received saline throughout the 7-day period. Body weights were recorded on P30-31 and P36-37. Two-way ANOVA on body weights showed a main effect of treatment group (F(1,35) = 10.446, P = 0.003; N = 10-12). Non-handled rats treated with cocaine for 5 days gained significantly less weight, while no significant effect was observed in maternally separated rats. Two-way ANOVA revealed a main effect of drug treatment on locomotor activity (F(2,32) = 15.209, P<0.001; N = 6-8), but not on rearing condition (F(1,32)<0.001, P = 0.998). Animals pretreated with cocaine showed a clear behavioral sensitization relative to the saline group. No difference in the magnitude of sensitization was found between separated and non-handled animals. Only the effect of cocaine on weight gain was significantly affected by repeated episodes of early maternal separation during the pre-weaning period.
G-equivalence in group algebras and minimal abelian codes
Raul Antonio Ferraz,Marinês Guerreiro,César Polcino Milies
Mathematics , 2012,
Abstract: Let G be a finite abelian group and F a field such that char(F) does not divide |G|. Denote by FG the group algebra of G over F. A (semisimple) abelian code is an ideal of FG. Two codes I and J of FG are G-equivalent if there exists an automorphism of G whose linear extension to FG maps I onto J In this paper we give a necessary and sufficient condition for minimal abelian codes to be G-equivalent and show how to correct some results in the literature.
The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
Angela C. Poole,Ruth E. Thomas,Selina Yu,Evelyn S. Vincow,Leo Pallanck
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0010054
Abstract: Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism. Genetic studies of Drosophila orthologs of PINK1 and parkin indicate that PINK1, a mitochondrially targeted serine/threonine kinase, acts upstream of Parkin, a cytosolic ubiquitin-protein ligase, to promote mitochondrial fragmentation, although the molecular mechanisms by which the PINK1/Parkin pathway promotes mitochondrial fragmentation are unknown. We tested the hypothesis that PINK1 and Parkin promote mitochondrial fragmentation by targeting core components of the mitochondrial morphogenesis machinery for ubiquitination. We report that the steady-state abundance of the mitochondrial fusion-promoting factor Mitofusin (dMfn) is inversely correlated with the activity of PINK1 and Parkin in Drosophila. We further report that dMfn is ubiquitinated in a PINK1- and Parkin-dependent fashion and that dMfn co-immunoprecipitates with Parkin. By contrast, perturbations of PINK1 or Parkin did not influence the steady-state abundance of the mitochondrial fission-promoting factor Drp1 or the mitochondrial fusion-promoting factor Opa1, or the subcellular distribution of Drp1. Our findings suggest that dMfn is a direct substrate of the PINK1/Parkin pathway and that the mitochondrial morphological alterations and tissue degeneration phenotypes that derive from mutations in PINK1 and parkin result at least in part from reduced ubiquitin-mediated turnover of dMfn.
EL MéTODO DE DIFERENCIAS FINITAS EN EVALUACIóN DE OPCIONES REALES
Otero G,Sebastián; Andalaft C,Alejandro; Vásquez S,Evelyn;
Ingeniare. Revista chilena de ingeniería , 2008, DOI: 10.4067/S0718-33052008000100013
Abstract: in the past few years, real options, an extension of financial derivatives, have arisen as an alternative to traditional valuation methods, such as net present value (npv). the key attribute of real options is that they take into consideration the uncertainty and flexibility involved in investment valuation. this article provides an overview of the finite difference method, by presenting an application to the real options valuation. the empirical section of the article, which makes use of the implicit finite difference method (ifd), analyzes the options of waiting, abandoning, contracting, expanding and switching, by valuing all the options involved and their possible combinations. the results are compared with those of the npv method and the binomial tree with a logarithmic transformation (btlt). both methods (ifd and btlt) yield similar results, being both greater than those provided by the npv. this difference comes to no surprise as it represents the value of the flexibility associated to an investment opportunity.
EL MéTODO DE DIFERENCIAS FINITAS EN EVALUACIóN DE OPCIONES REALES THE FINITE DIFFERENCE METHOD IN REAL OPTIONS VALUATION
Sebastián Otero G,Alejandro Andalaft C,Evelyn Vásquez S
Ingeniare : Revista Chilena de Ingeniería , 2008,
Abstract: Una respuesta a las falencias de los métodos tradicionales de evaluación de proyectos de inversión corresponde a la metodología de "Opciones Reales" que proviene del análisis de opciones sobre instrumentos financieros desarrollado en la década de los 70. Esta técnica, aplicada inicialmente a activos no financieros o reales, ha sido aplicada con singular éxito en la evaluación de proyectos de inversión y se presenta como una alternativa a los métodos de evaluación tradicionales, pues incluye tanto los aspectos estratégicos como de la teoría financiera. La variación fundamental que experimenta la evaluación de proyectos de inversión mediante opciones reales con respecto a la realizada mediante los métodos tradicionales es la incorporación de la incertidumbre y la flexibilidad como elementos que agregan valor al proyecto. En el presente este trabajo se realiza un recorrido del estado del arte en lo que respecta a la teoría de opciones reales para la evaluación de proyectos de inversión mediante diferencias finitas. Se describe la importancia de los componentes económicos y estratégicos a la hora de evaluar proyectos de inversión ante escenarios de incertidumbre, analizando las características de esta metodología, destacando sus virtudes y defectos e identificándose su aplicabilidad en la evaluación de proyectos de inversión. Finalmente se realiza una implementación del método de diferencias finitas implícitas (DFI) para la evaluación de un caso real que cuenta con las opciones de esperar, abandonar, contraer, expandir y cambiar a mejor uso alternativo, evaluándose para todas las opciones y combinaciones de opciones posibles. Los resultados fueron comparados con la metodología tradicional (VAN) y el árbol binomial con transformada logarítmica (ABTL). Ambas metodologías (DFI y ABTL) entregan valores equivalentes, siendo ambos superiores a los obtenidos mediante la metodología tradicional (VAN), diferencia que representa su capacidad de incorporar en el análisis el valor de la flexibilidad operativa del proyecto. In the past few years, real options, an extension of financial derivatives, have arisen as an alternative to traditional valuation methods, such as net present value (NPV). The key attribute of real options is that they take into consideration the uncertainty and flexibility involved in investment valuation. This article provides an overview of the finite difference method, by presenting an application to the real options valuation. The empirical section of the article, which makes use of the implicit finite difference method (IFD), analyzes the opti
More productive in vitro culture of Cryptosporidium parvum for better study of the intra- and extracellular phases
Perez Cordón, G;Marin, C;Romero, D;Rosales, C;Sánchez Moreno, M;Rosales, MJ;
Memórias do Instituto Oswaldo Cruz , 2007, DOI: 10.1590/S0074-02762007005000071
Abstract: the great difficulties in treating people and animals suffering from cryptosporidiosis have prompted the development of in vitro experimental models. due to the models of in vitro culture, new extracellular stages of cryptosporidium have been demonstrated. the development of these extracellular phases depends on the technique of in vitro culture and on the species and genotype of cryptosporidium used. here, we undertake the molecular characterization by polymerase chain reaction-restriction fragment lenght polymorphism of different cryptosporidium isolates from calves, concluding that all are c. parvum of cattle genotype, although differing in the nucleotide at positions 472 and 498. using these parasites, modified the in vitro culture technique for hct-8 cells achieving greater multiplication of parasites. the hct-8 cell cultures, for which the culture had not been renewed in seven days, were infected with c. parvum sporozoites in rpmi-1640 medium with 10% ifbs, cacl2 and mgcl2 1 mm at ph 7.2. percentages of cell parasitism were increased with respect to control cultures (71% at 48 h vs 14.5%), even after two weeks (47% vs 1.9%). also, the percentage of extracellular stages augmented (25.3% vs 1.1% at 96 h). this new model of in vitro culture of c. parvum will enable easier study of the developmental phases of c. parvum in performing new chemotherapeutic assays.
Page 1 /486719
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.