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Search Results: 1 - 10 of 135918 matches for " Eva V. Nagy "
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Reliability Modelling of Combined Heat and Power Generating Power Plant Units
Andras Istvan Fazekas,Eva V. Nagy
International Journal of Electrical and Power Engineering , 2012, DOI: 10.3923/ijepe.2010.160.163
Abstract: This study briefly sets out a 3 and more state reliability description of combined heat and power generating units (of extraction condensing and back-pressure steam turbine power plant units). The new procedure improves the accuracy of system-level reliability (Loss of Load Probability (LOLP)) calculations for power generation systems by giving a more differentiated (and thus more accurate) description of the available capacity from extraction condensing and back-pressure turbine power plants. Applying the 3 or more state reliability model for power plant units with extraction condensing and back pressure turbine and the deduction of the reliability calculation s input data form the novelty of the newly developed calculation method.
Treatment of Esthesioneuroblastoma and Nonsmall Cell Lung Cancer with Phenylbutyrate  [PDF]
Stanislaw R. Burzynski, Eva Nagy-Kubove
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.24071
Abstract: Esthesioneuroblastoma is a malignant tumor, arising in the upper nasal cavity, that could spread to the frontal lobe of the brain as well as metastasize to the lymph nodes. Due to the low incidence of this tumor, FDA-approved treatment modalities do not exist and clinical trials have not been performed. We present an interesting case of a 66-year-old female, diagnosed with Kadish stage B esthesioneuroblastoma and stage IIA nonsmall cell carcinoma of the lung, who benefited from our treatment. Both malignancies were diagnosed in 2002 at which time the patient consented to undergo left upper lobectomy for her lung cancer, but she refused the craniofacial resection and radiation therapy recommended for treatment of her esthesioneuroblastoma. From 2003 to 2004 she received treatment at the Burzynski Clinic with oral sodium phenylbutyrate (0.2 g/kg/day). She tolerated the treatment very well without significant adverse events. Gradual reduction in her tumor size was confirmed by repeat MRIs. From treatment start in March 2003 to December 2003 her tumor decreased by 40%. Subsequent MRI from March 2004 revealed increased tumor size, which, however, was still a 13% reduction from the baseline MRI. What is important to mention is that in addition to shrinkage of the esthesioneuroblastoma, the patient obtained the clinical benefit of 3.5-years longer survival than was predicted for her lung cancer—whereas the median survival for a patient with stage IIA adenocarcinoma of the left upper lobe of the lung is approximately two years, our patient survived more than five and a half years. The effect of phenylbutyrate (PB) and its metabolite phenylacetate on neuroblastoma and lung cancer is documented by numerous preclinical studies and is also evident in this case. It is proposed that the activity of these two compounds is mediated through increased expression of the p21 tumor suppressor gene. p21 is a strong inhibitor of cyclin-D and cyclin-dependent kinase 4, which contribute to undifferentiated phenotype in neuroblastoma and are instrumental in cell cycle progression from G1 to S phase. It is hoped that future research and combination of PB with other chemotherapeutic and targeted agents will provide better control of esthesioneuroblastoma and lung cancer.
Successful Treatment of Recurrent Triple-Negative Breast Cancer with Combination of Targeted Therapies  [PDF]
Stanislaw R. Burzynski, Alejandro Marquis, Eva Nagy-Kubove, Tomasz Janicki
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.23050
Abstract: We present an interesting case of a 56-year-old female diagnosed with invasive high-grade triple-negative breast cancer, who developed diffuse liver metastases following lumpectomy and combination chemotherapy with docetaxel, doxorubicin and cyclophosphamide, re-excision and radiation therapy. Restaging CT and PET scans revealed massive involvement of the liver. She was treated with a combination of gene targeted and cytotoxic chemotherapy including capecitabine, erlotinib, bevacizumab and phenylbutyrate. She tested weakly positive for HER-2 despite prior negative FISH, which prompted us to add trastuzumab to her regimen. Baseline CT revealed five liver tumors—the sum of the products of the two largest perpendicular diameters was 110 cm2. Follow-up CT after three months of treatment revealed 62% decrease in total tumor load. More than 50% decrease in tumor size persisted on two follow-up CT scans, confirming partial response. She developed progressive disease after 15 months of treatment. A group of 16 women, including this patient, diagnosed with triple negative breast cancer with distant metastases were treated by our team with a combination of gene targeted therapy and chemotherapy. Six percent of patients obtained partial response, 25% minor response, 31% stable disease, and 38% progressive disease. The median duration of treatment in patients who relapsed after the second-, third- and fourth- to seventh-lines of chemotherapy was 59 weeks, 22 weeks and 17 weeks, respectively. Comparison of results obtained with cytotoxic chemotherapy revealed that MDT in the second- and third-lines was only nine and four weeks, respectively. In conclusion, this case report indicates that it is possible to obtain durable objective response of recurrent TNBC with a combination of gene targeted agents.
Minimal quasivarieties of semilattices over commutative groups
Ildikó V. Nagy
Mathematics , 2012,
Abstract: We continue some recent investigations of W. Dziobiak, J. Jezek, and M. Maroti. Let G=(G,\cdot) be a commutative group. A semilattice over G is a semilattice enriched with G as a set of unary operations acting as semilattice automorphisms. We prove that the minimal quasivarieties of semilattices over a finite abelian group G are in one-to-one correspondence with the subgroups of G. If G is not finite, then we reduce the description of minimal quasivarieties to that of those minimal quasivarieties in which not every algebra has a zero element.
A simple combinatorial proof of Shapiro's Catalan convolution
Gábor V. Nagy
Mathematics , 2012, DOI: 10.1016/j.aam.2012.07.002
Abstract: Shapiro proved an elegant convolution formula involving Catalan numbers of even index. This paper gives a simple combinatorial proof of his formula. In addition, we show that it is equivalent with the alternating convolution formula of central binomial coefficients.
Lucr?ri ?tiin?ifice : Management Agricol , 2008,
Abstract: The instruments and mechanisms of intervention and financial support applied in Romania in various transition steps had an administrative effect, without a strategy established in concordance with some documented analyses, fact that did not determine the concretization of the financial effort in an adequate evolution of the agriculture and rural area on the whole. Public funds for agricultural support, after the adherence to the EU, prove to be insufficient, so that the designing of our own system of agriculture financing, with the help of the bank credit, becomes a must.
Lucr?ri ?tiin?ifice : Management Agricol , 2008,
Abstract: The public funds provided by the EU budget (8022.3 million euro) destined for the financing of the rural development measures comprised within the National Program for Rural Development, for 2007-2013, represent an important sum, of more than 8 milliard euro. The analysis on the destinations of this sums per measures rearranged into fields of activity leads to the conclusion that the agricultural financial support represent only 14.7%, non-agricultural activities 19.9% and infrastructure development 20.2%, requiring a remarkable financial effort, but insufficient, to relaunch the rural economy.
Lucr?ri ?tiin?ifice : Management Agricol , 2008,
Abstract: Rural development policy seeks to establish a coherent and sustainable framework for the future of Europe's rural areas. In September 2005, the Council of Ministers adopted a Rural Development regulation for the period 2007-2013. Rural Development will be implemented through one fund, one management and control system and one type of programming. The aims of the policy have been simplified and clarified around three clearly defined economic, environmental and territorial objectives: improving the competitiveness of agriculture and forestry; improving the environment and the countryside; improving the quality of life in rural areas and encouraging diversification of economic activity.
Lucr?ri ?tiin?ifice : Management Agricol , 2008,
Abstract: Agricultural labour is a relevant factor to consider in the assessment of rural development policies, and especially complex due to the increasing relevance of mixed on-farm and off-farm work in Europe. Within the EU, there is a marked difference in farm structures between Northern/Western and Southern/Eastern regions, with the average size of holdings much smaller in the latter (with the exception of remaining collective farming in some new member states such as Slovakia and Czech Republic and Eastern Germany). In the latter states, the percentage of population that works in part-time in agriculture is much bigger (more than 80%) compared to the countries from North-West Europe, and the occupation of the available time represents a must for the development of agricultural exploitations; this process requires, beside the reduction of the population employed in agriculture by attracting it to other sectors, the development of pluriactivity and the part-time employment of exploitations’ members in other non-agricultural activities.
Quantum Tic-Tac-Toe: A Genuine Probabilistic Approach  [PDF]
Marius Nagy, Naya Nagy
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.331243
Abstract: We propose a quantum version of Tic-Tac-Toe which accurately reflects the inherent probabilistic nature of the measurement principle in quantum mechanics. We then formulate a quantum strategy which allows a quantum player to consistently win over a classical player, with a certain probability. This result can be seen as another proof of the superior computational power of a quantum system with respect to a classical one. Our investigation also reveals that the non-determinism and complexity introduced by the principles of quantum mechanics into even the most simple games make brute-force strategies considerably more difficult to implement. Consequently, games in which machines have gained the upper hand over humans may be made fair again by upgrading them to a quantum level.
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