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Search Results: 1 - 10 of 26626 matches for " Eun-Joo Lee "
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Analysis of Multiple Myeloma Life Expectancy Using Copula
Seung-Hwan Lee,Philip Deng,Eun-Joo Lee
International Journal of Statistics and Probability , 2013, DOI: 10.5539/ijsp.v2n1p44
Abstract: Multiple myeloma is a blood cancer that develops in the bone marrow. It is assumed that in most cases multiple myeloma develops in association with several medical factors acting together, although the leading cause of the disease has not yet been identified. In this paper, we investigate the relationship between the factors to measure multiple myeloma patients' survival time. For this, we employ a copula that provides a convenient way to construct statistical models for multivariate dependence. Through an approach via copulas, we find the most influential medical factors that affect the survival time. Some goodness-of-fit tests are also performed to check the adequacy of the copula chosen for the best combination of the survival time and the medical factors. Using the Monte Carlo simulation technique with the copula, we re-sample survival times from which the anticipated life span of a patient with the disease is calculated.
Interval Estimation for Extreme Value Parameter with Censored Data
Eun-Joo Lee,Dane Walker,David Elliott,Katlyn Mathy
ISRN Applied Mathematics , 2011, DOI: 10.5402/2011/687343
Gluon Propagation in Curved Space
Su Kyeong Lee,Eun-Joo Kim,Jong Bum Choi
Physics , 2015,
Abstract: In quantum chromodynamics (QCD), the vacuum structures are taken to be formed by nonperturbative interactions between gluons. The contributions of gluonic interactions can be parametrized by gluon condensates and especially the dimension-2 condensate $\langle A_{\mu}^{2} \rangle$ can be used to generalize the $\theta$ vacuum. In the generalized picture, each gauge fixed slice forms a curved surface around a hadron and other strongly interacting objects, and the propagation of a gluon has to be considered on this curved surface. The gluon propagator turns out to be massive due to the curvature of the gauge fixed surface implementing the possibility that the massless gauge bosons might provide the majority of the hadronic mass and even behave as dark matter in cosmological scales.
Life Expectancy Estimate With Bivariate Weibull Distribution Using Archimedean Copula
Eun-Joo Lee, Chang-Hyun Kim & Seung-Hwan Lee
International Journal of Biometric and Bioinformatics , 2011,
Abstract: Archimedean copulas are used to construct bivariate Weibull distributions. Co-movementstructures of variables are analyzed through the copulas, where the tail dependence between thevariables is explored with more flexibility. Based on the distance between the copula distributionand its empirical version, a copula that may best fit data is selected. With extra computing costs,the adequacy of the copula chosen is then assessed. When multiple myeloma data areconsidered, it is found that relationship between survival time of a patient and the hemoglobinlevel is well described by the Clayton copula. The bivariate Weibull distribution constructed by thecopula is used to estimate value at risk from which we investigate the anticipated longest lifeexpectancy of a patient with the disease over the treatment period.
MR thermometry characterization of a hyperthermia ultrasound array designed using the k-space computational method
Osama M Al-Bataineh, Christopher M Collins, Eun-Joo Park, Hotaik Lee, Nadine Smith
BioMedical Engineering OnLine , 2006, DOI: 10.1186/1475-925x-5-56
Abstract: A 3D acoustical prostate model was created using photographic data from the Visible Human Project?. The k-space computational method was used on this coarse grid and inhomogeneous tissue model to simulate the steady state pressure wavefield of the designed phased array using the linear acoustic wave equation. To ensure the uniformity and spread of the pressure in the length of the array, and the focusing capability in the width of the array, the equally-sized elements of the 4 × 20 elements phased array were 1 × 14 mm. A probe was constructed according to the design in simulation using lead zerconate titanate (PZT-8) ceramic and a Delrin? plastic housing. Noninvasive MRI thermometry and a switching feedback controller were used to accomplish ex vivo and in vivo hyperthermia evaluations of the probe.Both exposimetry and k-space simulation results demonstrated acceptable agreement within 9%. With a desired temperature plateau of 43.0°C, ex vivo and in vivo controlled hyperthermia experiments showed that the MRI temperature at the steady state was 42.9 ± 0.38°C and 43.1 ± 0.80°C, respectively, for 20 minutes of heating.Unlike conventional computational methods, the k-space method provides a powerful tool to predict pressure wavefield in large scale, 3D, inhomogeneous and coarse grid tissue models. Noninvasive MRI thermometry supports the efficacy of this probe and the feedback controller in an in vivo hyperthermia treatment of canine prostate.Prostate cancer causes approximately 30,000 deaths among Americans every year with more than 230,000 new patients in 2004 [1]. Most of the patients are elderly and often can not withstand invasive surgical procedures to eradicate the tumor in its early stages [2]. Radiation and hormone therapies are still the treatment of choice for these patients [3]. Thermal treatment has shown to be effective in therapy for different kinds of tumors including prostate cancer [4-8]. Hyperthermia therapy raises the temperature of the tumor and a
Clinicopathologic significance of fascin, extracellular matrix metalloproteinase inducer, and ezrin expressions in colorectal adenocarcinoma
Jung Eun-Joo,Lee Ju-Han,Min Byung-Wook,Kim Young-Sik
Indian Journal of Pathology and Microbiology , 2011,
Abstract: Background: The over expression of fascin, extracellular matrix metalloproteinase inducer (EMMPRIN), and ezrin proteins has been associated with poor prognosis in various carcinomas and sarcomas. However, very few studies have reported the relationship between the expression of fascin, EMMPRIN, and ezrin proteins and the clinico-pathologic parameters of colorectal carcinomas. Aims: The aim was to investigate the relationship between fascin, EMMPRIN, and ezrin proteins in colorectal adenocarcinomas and their correlation with clinico-pathologic parameters. Settings and Design: The expression of fascin, EMMPRIN, and ezrin proteins was studied in 210 colorectal adenocarcinoma patients through immunohistochemical staining. Materials and Methods: Immunohistochemical staining by the avidin-biotin peroxidase method was done. The scoring of each protein expression was done and divided into three groups (negative, low-, and high-expression groups). Statistical Analysis: A chi-square test, and Kendall′s tau-b correlation test were used for comparing. Survival analysis was performed using the Kaplan-Meier method with log-rank tests and the Cox proportional hazard model. Results: The percentages of the high-expression group of fascin, EMMPRIN, and ezrin proteins in colorectal adenocarcinomas were 24%, 73%, and 62%, respectively. Weak positive correlations were observed among these protein expressions. An increased expression of the fascin protein was significantly associated with advanced tumor depth and shorter survival times, and a high expression of fascin protein was an independent prognostic factor in univariate and multivariate survival analyses. EMMPRIN and ezrin protein expressions were not associated with the clinico-pathologic parameters. Conclusions: The high expression of fascin protein may be an unfavorable prognostic marker for individual colorectal cancer patients.
Asymptotically efficient estimation of linear functionals in inverse regression models
Chris A. J. Klaassen,Eun-Joo Lee,Frits H. Ruymgaart
Mathematics , 2002,
Abstract: In this paper we will discuss a procedure to improve the usual estimator of a linear functional of the unknown regression function in inverse nonparametric regression models. In Klaassen, Lee, and Ruymgaart (2001) it has been proved that this traditional estimator is not asymptotically efficient (in the sense of the H\'{a}jek - Le Cam convolution theorem) except, possibly, when the error distribution is normal. Since this estimator, however, is still root-n consistent a procedure in Bickel, Klaassen, Ritov, and Wellner (1993) applies to construct a modification which is asymptotically efficient. A self-contained proof of the asymptotic efficiency is included.
System and rapidity dependence of baryon to meson ratios at RHIC
Eun-Joo Kim
Physics , 2005,
Abstract: The rapidity and centrality dependence of baryon to meson ratios in Au$+$Au, Cu$+$Cu and p$+$p collisions at $\sqrt{s_{NN}}$ = 200 GeV at RHIC is presented. The $\bar{p}/\pi^{-}$ ratios are founded to be independent of collision system at a fixed $$ at mid- and forward rapidities.
Parton energy loss, saturation, and recombination at BRAHMS
Eun-Joo Kim
Physics , 2005,
Abstract: Particle production as observed with the BRAHMS experiment at RHIC is presented. Preliminary baryon/meson ratios and nuclear modification factors at different rapidities will be discussed.
Ascorbic Acid Attenuates Acute Ethanol-Induced Liver Injury in SMP30 Knockout Mice  [PDF]
Eun-Mi Cho, H. M. Arif Ullah, Ahmed K. Elfadl, Myung-Jin Chung, Soong-Koo Kim, Yong Deuk Kim, Eun-Joo Lee, Kyu-Shik Jeong
Food and Nutrition Sciences (FNS) , 2017, DOI: 10.4236/fns.2017.812083
Ascorbic acid (AA) is recognized as a free radical scavenger that protects cells from oxidative stress-induced damage. However, no studies have investigated the role of AA in acute alcoholic liver disease using senescence marker protein-30 (SMP30) knockout (KO) mice. SMP30 is a novel 34-kDa protein involved in AA biosynthesis. The present study aimed to elucidate the physiological functions of AA in acute ethanol-induced liver injury using SMP30 KO mice, which cannot synthesize AA in vivo. After a 4-week experimental period, mice were divided into six groups. The following three groups comprised the ethanol treatment groups: WT-E group (wild-type), KV-E group (AA-supplemented), and KT-E group (AA-deficient). Mice were exposed to an acute dose of ethanol (6 g ethanol/kg) administered by gavage once a day for three days. The other three control groups, namely, WT-C, KV-C, and KT-C control groups, received an equal volume of water via oral administration. Analysis of changes in body weight showed that mice in the KT-E group had significant loss of body weight compared to the control, KV-E, and WT-E groups. Behavioral analysis revealed that alcohol exposure significantly increased alcohol sensitivity in the KT-E group, whereas the WT-E, KV-E, and control groups developed ethanol tolerance. Aspartate transaminase (AST) levels in the KT-E group were significantly higher than those in the control, KV-E, and WT-E groups. The number of large and binucleated hepatocytes was significantly higher in the KT-E group than in the KV-E and WT-E groups. In addition, cytochrome P450 2E1 (CYP2E1) was over expressed in the central vein in the KT-E group when compared to the KV-E and WT-E groups. Our current findings indicate that AA supplementation in SMP30 KO mice can alleviate alcohol-induced liver damage by down regulating CYP2E1 expression. These results suggest that reduced CYP2E1 expression is a novel mechanism responsible for AA-induced reduction of ethanol-mediated oxidative stress.
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