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Search Results: 1 - 10 of 21041 matches for " Eui Tae Kim "
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Stroke Management Awareness and Behavior among Nursing Students in Bangladesh  [PDF]
Shariful Islam, Eui Geum Oh, Tae Wha Lee, Sanghee Kim
Open Journal of Nursing (OJN) , 2017, DOI: 10.4236/ojn.2017.71001
Abstract: Background: Stroke is a significant cause of morbidity and mortality throughout the world. In Bangladesh, stroke accounts for 27% of deaths, making it the third leading cause of death and disability [1]. Nurses have a critical role to play in reducing death and disability among stroke victims, but many nursing students are not being educated to meet the challenges of this complex condition. Objectives: This study examined undergraduate nursing students’ awareness of strokes and their stroke patient management behaviors. Method: This was a descriptive study that surveyed undergraduate nursing students about their awareness of strokes and stroke patient management behaviors. One hundred and forty-four students were recruited from Dhaka University’s and Rajshahi University’s nursing colleges in Bangladesh. The students completed and returned the Awareness of Stroke Risk Factors, Awareness of Stroke Warning Signs, and Behavior of First Responses to Strokes and Behaviors of Special Managements of Stroke questionnaires between December, 2014 and February, 2015. Data were analyzed using descriptive statistics and the Pearson’s Product-Moment Correlation-Coefficient. Results: The results showed that nursing students had a moderate awareness level of stroke risk factors (M = 74.24, SD = 12.30) and a very low awareness of stroke warning signs (M = 55, SD = 10.72). In addition, all of the students had a low to very low level of behaviors of special stroke patient management (M = 62.11, SD = 9.75) and a very low level of behaviors of first responses to strokes (M = 0.24, SD = 0.43). There was a significant positive correlation between nursing students’ awareness of stroke risk factors and stroke warning signs (r = 0.247**, p < 0.001). However, no significant correlation was found between students’ awareness of stroke risk factors with their behaviors of first responses to strokes (r = 0.043, p > 0.05). In addition, their awareness of stroke warning signs was not correlated with their behaviors of special stroke patient management (r = 0.031, p > 0.05). These findings suggested that nursing students need to increase their awareness level to develop stroke management behaviors in order to improve practicum preparedness. Conclusion: Work-based education must be a part of nursing students’ curricula to increase their awareness of strokes and improve their stroke management behaviors to improve practicum preparedness.
Analysis of Human Cytomegalovirus-Encoded SUMO Targets and Temporal Regulation of SUMOylation of the Immediate-Early Proteins IE1 and IE2 during Infection
Eui Tae Kim, Young-Eui Kim, Ye Ji Kim, Myoung Kyu Lee, Gary S. Hayward, Jin-Hyun Ahn
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0103308
Abstract: Post-translational modification of proteins by members of the small ubiquitin-like modifier (SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and also interact with the cellular SUMOylation system. During human cytomegalovirus (HCMV) infection, the immediate-early (IE) proteins IE1 and IE2 are covalently modified by SUMO. IE2 SUMOylation promotes its transactivation activity, whereas the role of IE1 SUMOylation is not clear. We performed in silico, genome-wide analysis to identify possible SUMOylation sites in HCMV-encoded proteins and evaluated their modification using the E. coli SUMOylation system and in vitro assays. We found that only IE1 and IE2 are substantially modified by SUMO in E. coli, although US34A was also identified as a possible SUMO target in vitro. We also found that SUMOylation of IE1 and IE2 is temporally regulated during viral infection. Levels of SUMO-modified form of IE1 were increased during the early phase of infection, but decreased in the late phase when IE2 and its SUMO-modified forms were expressed at high levels. IE2 expression inhibited IE1 SUMOylation in cotransfection assays. As in IE2 SUMOylation, PIAS1, a SUMO E3 ligase, interacted with IE1 and enhanced IE1 SUMOylation. In in vitro assays, an IE2 fragment that lacked covalent and non-covalent SUMO attachment sites, but was sufficient for PIAS1 binding, effectively inhibited PIAS1-mediated SUMOylation of IE1, indicating that IE2 expression negatively regulates IE1 SUMOylation. We also found that the IE2-mediated downregulation of IE1 SUMOylation correlates with the IE1 activity to repress the promoter containing the interferon stimulated response elements. Taken together, our data demonstrate that IE1 and IE2 are the main viral SUMO targets in HCMV infection and that temporal regulation of their SUMOylation may be important in the progression of this infection.
Spatiotemporal Segregation of Neural Response to Auditory Stimulation: An fMRI Study Using Independent Component Analysis and Frequency-Domain Analysis
Natalia Yakunina, Woo Suk Tae, Kang Uk Lee, Sam Soo Kim, Eui-Cheol Nam
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066424
Abstract: Although auditory processing has been widely studied with conventional parametric methods, there have been a limited number of independent component analysis (ICA) applications in this area. The purpose of this study was to examine spatiotemporal behavior of brain networks in response to passive auditory stimulation using ICA. Continuous broadband noise was presented binaurally to 19 subjects with normal hearing. ICA was performed to segregate spatial networks, which were subsequently classified according to their temporal relation to the stimulus using power spectrum analysis. Classification of separated networks resulted in 3 stimulus-activated, 9 stimulus-deactivated, 2 stimulus-neutral (stimulus-dependent but not correlated with the stimulation timing), and 2 stimulus-unrelated (fluctuations that did not follow the stimulus cycles) components. As a result of such classification, spatiotemporal subdivisions were observed in a number of cortical structures, namely auditory, cingulate, and sensorimotor cortices, where parts of the same cortical network responded to the stimulus with different temporal patterns. The majority of the classified networks seemed to comprise subparts of the known resting-state networks (RSNs); however, they displayed different temporal behavior in response to the auditory stimulus, indicating stimulus-dependent temporal segregation of RSNs. Only one of nine deactivated networks coincided with the “classic” default-mode network, suggesting the existence of a stimulus-dependent default-mode network, different from that commonly accepted.
Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants
Eui Tae Kim,Jong-Mo Seo,Se Joon Woo,Jing Ai Zhou,Hum Chung,Sung June Kim
Sensors , 2008, DOI: 10.3390/s8095845
Abstract: Polyimide has been widely applied to neural prosthetic devices, such as the retinal implants, due to its well-known biocompatibility and ability to be micropatterned. However, planar films of polyimide that are typically employed show a limited ability in reducing the distance between electrodes and targeting cell layers, which limits site resolution for effective multi-channel stimulation. In this paper, we report a newly designed device with a pillar structure that more effectively interfaces with the target. Electrode arrays were successfully fabricated and safely implanted inside the rabbit eye in suprachoroidal space. Optical Coherence Tomography (OCT) showed well-preserved pillar structures of the electrode without damage. Bipolar stimulation was applied through paired sites (6:1) and the neural responses were successfully recorded from several regions in the visual cortex. Electrically evoked cortical potential by the pillar electrode array stimulation were compared to visual evoked potential under full-field light stimulation.
Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function
Young-Tae Ro, Bo-Kwang Jang, Chan Shin, Eui U Park, Chul Kim, Sung-Il Yang
Journal of Biomedical Science , 2010, DOI: 10.1186/1423-0127-17-18
Abstract: We performed suppression subtractive hybridization on two previously established PC12 sublines, one of which overexpresses the wild-type (WT) form and the other, the dominant-negative (DN) form of Akt. These sublines respond differently to NGF's neuronal differentiation effect.A variety of genes was identified and could be classified into several functional groups, one of which was developmental processes. Two genes involved in neuronal differentiation and function were found in this group. v-Maf musculoaponeurotic fibrosarcoma oncogene homolog K (MafK) induces the neuronal differentiation of PC12 cells and immature telencephalon neurons, and synaptotagmin I (SytI) is essential for neurotransmitter release. Another gene, syntenin-1 (Syn-1) was also recognized in the same functional group into which MafK and SytI were classified. Syn-1 has been reported to promote the formation of membrane varicosities in neurons. Quantitative reverse transcription polymerase chain reaction analyses show that the transcript levels of these three genes were lower in PC12 (WT-Akt) cells than in parental PC12 and PC12 (DN-Akt) cells. Furthermore, treatment of PC12 (WT-Akt) cells with an Akt inhibitor resulted in the increase of the expression of these genes and the improvement of neurite outgrowth. These results indicate that dominant-negative or pharmacological inhibition of Akt increases the expression of MafK, SytI, and Syn-1 genes. Using lentiviral shRNA to knock down endogenous Syn-1 expression, we demonstrated that Syn-1 promotes an increase in the numbers of neurites and branches.Taken together, these results indicate that Akt negatively regulates the expression of MafK, SytI, and Syn-1 genes that all participate in regulating neuronal integrity in some way or another.Akt (also termed "protein kinase B') mediates a variety of biological responses to insulin, cytokines, and numerous growth factors. As such, Akt has been well recognized as an important regulator for multiple biolog
Violet Light Down-Regulates the Expression of Specific Differentiation Markers through Rhodopsin in Normal Human Epidermal Keratinocytes
Hyoung-June Kim, Eui Dong Son, Ji-Yong Jung, Hyun Choi, Tae Ryong Lee, Dong Wook Shin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073678
Abstract: Several recent reports have demonstrated that photoreceptors are expressed in human skin. The rod and cone photoreceptor-like proteins are expressed in human skin and rhodopsin, long wavelength-opsin, and short wavelength-opsin are also present in cultured murine melanocytes. Furthermore, the photopigment rhodopsin is expressed in human melanocytes and is involved in ultraviolet A phototransduction which induces early melanin synthesis. In this study, we investigated whether rhodopsin is expressed and plays any physiological roles in the normal human epidermal keratinocytes (NHEKs). We found that rhodopsin was expressed and localized on the plasma membrane in NHEKs, and only violet light among several wavelengths within the visible range significantly increased the expression of rhodopsin mRNA. We further found that rhodopsin over-expression decreased the mRNA expression levels of keratinocyte differentiation markers, such as keratin-1 and keratin-10, and violet light also decreased the mRNA expression levels of keratinocyte differentiation markers and these decreased expression levels were recovered by a rhodopsin-directed siRNA. Moreover, we further demonstrated that violet light significantly decreased the phosphorylation levels of cAMP responsive element-binding protein (CREB) and that it more effectively decreased the phosphorylation of CREB when rhodopsin was over-expressed. In addition, we observed that pertussis toxin, a Gαi protein inhibitor, restored the rhodopsin-induced decrease in the differentiation markers in NHEKs. Taken together, these results suggest that rhodopsin down-regulates the expression levels of specific keratinocyte differentiation markers via the Gαi signaling pathway in NHEKs.
Expression of calbindin-D28k and its regulation by estrogen in the human endometrium during the menstrual cycle
Hyun Yang, Tae-Hee Kim, Hae-Hyeog Lee, Kyung-Chul Choi, Yeon-pyo Hong, Peter CK Leung, Eui-Bae Jeung
Reproductive Biology and Endocrinology , 2011, DOI: 10.1186/1477-7827-9-28
Abstract: Intracellular calcium binding proteins (calbindins) are critical for regulating the availability of calcium ions (Ca2+) within cells. There are two types of cytosolic calbindins, calbindin-D9k (CaBP-9k) and calbindin-D28k(CaBP-28k), which are cytosolic proteins differentially regulated by steroid hormones in the uterus [1,2]. In addition to its traditional role in extracellular calcium homeostasis [3], vitamin D influences a broad range of cellular events, ranging from oncogene expression [4] and immunoregulation [5] to cellular differentiation [6,7] and intracellular calcium metabolism [8]. Previous studies have documented that vitamin D deficiency decreases fertility in female rats [9-11], and vitamin D-dependent calcium-binding proteins were discovered in reproductive tissues: CaBP-9k in the uterus of rats [12-14], and the larger CaBP-28k in the uterus of domestic fowl [15,16].The expression of CaBP-9k and CaBP-28k in reproductive tissues is affected by steroid hormones [12,14,15,17]. For example, the expression of CaBP-9k mRNA in the mouse uterus was significantly increased by treatment with P4 and E2 plus P4, but not by E2 alone [18,19]. Conversely, rat uterine CaBP-D9k mRNA was induced only by E2 [20]. In hens, uterine expression of the larger calbindin-D28k increased by the addition of testosterone [15].Embryo implantation is a complex process involving interactions between the blastocyst and the uterus. A successful implantation requires the development of the blastocyst stage, its escape from the zonapellucida, and the establishment of a receptive uterus [21]. The primate endometrium undergoes certain hormone-dependent changes during a particular time window within the preimplantation phase that prepares it to receive the growing blastocyst [22-24]. A complex interaction between effectors, including steroid hormones, growth factors, and cytokines, regulates development of the "receptivity" state of the uterine epithelium [25-28].The action of calcium ions i
Double polarization hysteresis loop induced by the domain pinning by defect dipoles in HoMnO3 epitaxial thin films
Daesu Lee,Heung-Sik Kim,Seung Yup Jang,Kwon Woo Joh,Tae Won Noh,Jaejun Yu,Cheol Eui Lee,Jong-Gul Yoon
Physics , 2009, DOI: 10.1103/PhysRevB.81.012101
Abstract: We report on antiferroelectriclike double polarization hysteresis loops in multiferroic HoMnO3 thin films below the ferroelectric Curie temperature. This intriguing phenomenon is attributed to the domain pinning by defect dipoles which were introduced unintentionally during film growth process. Electron paramagnetic resonance suggests the existence of Fe1+ defects in thin films and first principles calculations reveal that the defect dipoles would be composed of oxygen vacancy and Fe1+ defect. We discuss migration of charged point defects during film growth process and formation of defect dipoles along ferroelectric polarization direction, based on the site preference of point defects. Due to a high-temperature low-symmetry structure of HoMnO3, aging is not required to form the defect dipoles in contrast to other ferroelectrics (e.g., BaTiO3).
Using Process Indicators to Facilitate Data-Driven Decision Making in the Era of Accountability  [PDF]
Kyu Tae Kim
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.36102
Abstract: This paper explores which accountability indicators are likely to reveal the distinct contexts and qualitative characteristics of school that stimulate and improve authentic pedagogy and accountability. In the era of accountability, data-driven decision making is a new research area for authentic pedagogy through monitoring student progress and improving school accountability. It is based on input-and-result oriented indicators such as school demographics, facilities, budget, standardized test scores, dropout rates. But the indicators are unlikely to capture a dynamically interactive qualitative characteristics of school organizations featuring a loosely-coupled system and difficult to be measured or assessed. Thus, process indicators need to be complementary to input-and-outcome data for a valid and graphic description, monitoring and explanation of ‘why’ and ‘how’ the school outcomes occur. The author concluded that the data-driven decision making (DDDM) based on process indicators strengthens reflective professionalism and provides for the educational welfare for the poor and left-behind students.
Significant association of SREBP-2 genetic polymorphisms with avascular necrosis in the Korean population
Tae-Ho Kim, Jeong-In Baek, Jung Hong, Su-Jin Choi, Hye-Jin Lee, Hyun-Ju Cho, Eui Park, Un-Kyung Kim, Shin-Yoon Kim
BMC Medical Genetics , 2008, DOI: 10.1186/1471-2350-9-94
Abstract: Four single nucleotide polymorphisms (SNP) in the SREBP-2 gene, IVS1+8408 T>C (rs2267439), IVS3-342 G>T (rs2269657), IVS11+414 G>A (rs1052717) and IVS12-1667 G>A (rs2267443), were selected from public databases and genotyped in 443 AVN patients and 273 control subjects by using single-based extension (SBE) genotyping.The minor allele (C) frequency of rs2267439 showed a significant protective effect on AVN (P = 0.01, OR; 0.75, 95% CI; 0.604–0.935), and the genotype frequencies of this polymorphism were also different from the controls in all alternative analysis models (P range, 0.009–0.03, OR; 0.647–0.744). In contrast, rs1052717 and rs2267443 polymorphisms were significantly associated with AVN risk. Further analysis based on pathological etiology showed that the genotypes of rs2267439, rs1052717 and rs2267443 were also significantly associated with AVN susceptibility in each subgroup.This study is the first report to evaluate the association between SREBP-2 gene polymorphisms and the susceptibility of AVN in the Korean population.Avascular necrosis (AVN), also known as osteonecrosis of the femoral head (ONFH), is a devastating bone disease that develops symptoms of articular destruction and bone collapse of the femoral head due to a disturbance in the supply of blood [1]. This disease mainly occurs in middle aged men, between 30 and 50 years of age. The pathogenic factor of AVN is not definite, but many previous studies have suggested that long term steroid usage [1-5] and alcohol abuse [6,7] are associated with AVN, and in some case it can also be idiopathic. These factors have a harmful influence on oxygen and nutrient supply to the bone through blood vessels in direct or indirect pathways. Steroid administration and alcohol abuse induce an increase of fatty vesicles in the circulation of the blood, causing fat embolism and increased lipid precipitation in osteocytes within the femoral head. Some previous experiments using animal models verified that alcohol fac
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