oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2018 ( 5 )

2017 ( 1 )

2016 ( 6 )

2015 ( 55 )

Custom range...

Search Results: 1 - 10 of 1643 matches for " Eugenio Martignani "
All listed articles are free for downloading (OA Articles)
Page 1 /1643
Display every page Item
New Risks and the Reframing of Local Welfare as Social Investment: The Case of the FORJAD Program in Switzerland  [PDF]
Luca Martignani
Open Journal of Political Science (OJPS) , 2016, DOI: 10.4236/ojps.2016.61002
Abstract: FORJAD (Formation Professionelle pour le Jeunes Adults en Difficulté) was a program of social policy implemented in Switzerland since 2006. Its specific aim is to sustain the professional training of young unemployed adults (18 - 25) in order to allow them to become autonomous from the social assistance and to (re)entry into the labour market. This paper deals with specific dimensions of this program, with particular reference to its complex and plural governance and to the cultural framework of the Social Investment Welfare State (SIWS). This paradigm tries to connect the logics of activation and training with the necessity to realize a better quality of welfare services and to invest in personal capabilities of welfare recipients. In this framework, FORJAD seems to represent a social innovation realized to contrast at a local level the young unemployment as an example of emergent new social risks.
Met Receptor Acts Uniquely for Survival and Morphogenesis of EGFR-Dependent Normal Mammary Epithelial and Cancer Cells
Paolo Accornero, Silvia Miretti, Francesca Bersani, Elena Quaglino, Eugenio Martignani, Mario Baratta
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0044982
Abstract: Mammary gland development and breast cancer growth require multiple factors both of endocrine and paracrine origin. We analyzed the roles of Epidermal Growth Factor Receptor (EGFR) and Hepatocyte Growth Factor Receptor (Met) in mammary epithelial cells and mammary tumor cells derived from a mutated-ErbB2 transgenic mice. By using highly specific tyrosine kinase inhibitors we found that MCF-10A and NMuMG mammary epithelial cell lines are totally dependent on EGFR activation for their growth and survival. Proliferation and 3D-morphogenesis assays showed that HGF had no role in maintaining mammary cell viability, but was the only cytokine able to rescue EGFR-inhibited mammary cells. Insulin-Like Growth Factor-I (IGF-I), basic-Fibroblast Growth Factor (b-FGF) and Neuregulin, which are well known mammary morphogenic factors, did not rescue proliferation or morphogenesis in these cell lines, following EGFR inhibition. Similarly, ErbB2-driven tumor cells are EGFR-dependent and also display HGF-mediated rescue. Western-blot analysis of the signaling pathways involved in rescue after EGFR inhibition indicated that concomitant ERK1/2 and AKT activation was exclusively driven by Met, but not by IGF-I or b-FGF. These results describe a unique role for EGFR and Met in mammary epithelial cells by showing that similar pathways can be used by tumorigenic cells to sustain growth and resist to EGFR-directed anti-tumorigenic drugs.
Human Milk Protein Production in Xenografts of Genetically Engineered Bovine Mammary Epithelial Stem Cells
Eugenio Martignani,Peter Eirew,Paolo Accornero,Connie J. Eaves,Mario Baratta
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013372
Abstract: In the bovine species milk production is well known to correlate with mammary tissue mass. However, most advances in optimizing milk production relied on improvements of breeding and husbandry practices. A better understanding of the cells that generate bovine mammary tissue could facilitate important advances in milk production and have global economic impact. With this possibility in mind, we show that a mammary stem cell population can be functionally identified and isolated from the bovine mammary gland. We also demonstrate that this stem cell population may be a promising target for manipulating the composition of cow's milk using gene transfer.
The Virtuous Circle of Corporate Social Performance and Corporate Social Disclosure  [PDF]
Francesco Gangi, Eugenio D’Angelo
Modern Economy (ME) , 2016, DOI: 10.4236/me.2016.712129
Abstract: Previous literature in the field of corporate social responsibility investigates whether corporate social performance can be seen as a determinant of corporate social disclosure or, conversely, if corporate social disclosure is a determinant of corporate social performance. The aim of this paper is to join these two streams of research in a unique theoretical model, which can demonstrate that there is a mutual interaction between performance and disclosure. This can result, in the long run, in a virtuous circle where higher social performance generates future higher social disclosure and this determines higher future social performance and so on. An analytical model has been adopted to demonstrate the research hypothesis. Gathering data from the portfolios of the European Socially responsible funds (SRFs) listed on the Morningstar platform in 2010, the study analyzed 160 social reports published by 80 companies during 2008 and 2009. Findings, by demonstrating the non-one-way relationship between social performance and social disclosure, confirm the existence of a mutual influence between the results gained in different CSR areas and the capability to control and communicate such performance. In this way, the paper provides not only theoretical insights, but also practical implications for managers that are required to put in place responsive and effective initiatives towards the increasing pressure exerted by the internal and external environments in which they operate.
The Risks of Inappropriateness in Cardiac Imaging
Eugenio Picano
International Journal of Environmental Research and Public Health , 2009, DOI: 10.3390/ijerph6051649
Abstract: The immense clinical and scientific benefits of cardiovascular imaging are well-established, but are also true that 30 to 50% of all examinations are partially or totally inappropriate. Marketing messages, high patient demand and defensive medicine, lead to the vicious circle of the so-called Ulysses syndrome. Mr. Ulysses, a typical middle-aged “worried-well” asymptomatic subject with an A-type coronary personality, a heavy (opium) smoker, leading a stressful life, would be advised to have a cardiological check-up after 10 years of war. After a long journey across imaging laboratories, he will have stress echo, myocardial perfusion scintigraphy, PET-CT, 64-slice CT, and adenosine-MRI performed, with a cumulative cost of >100 times a simple exercise-electrocardiography test and a cumulative radiation dose of >4,000 chest x-rays, with a cancer risk of 1 in 100. Ulysses is tired of useless examinations, exorbitant costs. unaffordable even by the richest society, and unacceptable risks.
Mammography and beyond: developing technologies for the early detection of breast cancer
Eugenio Paci
Breast Cancer Research , 2002, DOI: 10.1186/bcr429
Abstract: Following a short presentation of the history of mammography, the theory of efficacy evaluation through randomized clinical trials (all referenced) and the more recent evaluations of screening programmes that are ongoing in several countries are critically re-examined. The second chapter discusses new developments in breast imaging and in related technologies; a table presents the current status of imaging technologies for a large number of devices, few of which are currently of interest with regard to early detection. Most of the technologies discussed pertain to clinical diagnosis, and are unlikely to surpass mammography in the field of early detection in the near future.A chapter entitled Technologies in development: genetic and tumor markers reports on the progress that has been made in this important field, but it states that "... the ability to predict who will develop breast cancer is modest at best." We are still in the realm of basic research, and application of these technologies in screening is far from reaching routine daily practice. However, the authors emphasize the opportunity to improve predictive oncology in the early stages of breast cancer. Furthermore, with private companies developing genetic tests, and the fact that "The tests are not subject to FDA [Food and Drug Administration] regulation and thus clinical validity and utility did not have to be documented before entry into the market", there is a need for a new policy and for genetic counselling for women who request testing.The following chapter on the development and regulation of new technologies (which is referred to only within the context of the USA) is original to the best of my knowledge, at least for a European audience. The narrative of the initiatives and collaborations that have been active between government agencies, private industries and associations, and the examples of funding mechanisms for medical technology development confirm the massive investment into breast cancer c
Economic and biological costs of cardiac imaging
Eugenio Picano
Cardiovascular Ultrasound , 2005, DOI: 10.1186/1476-7120-3-13
Abstract: A Renaissance of cardiac imaging occurred in the 1980s [1]. New technologies allowed the non-invasive description of cardiac function, perfusion, and metabolism in a polychrome, three-dimensional, overwhelming fashion. Almost unlimited resources were devoted to patient care in the economic framework of the affluent society. At the beginning of the 1990s, The Renaissance made its transition into the splendid decadence of the Baroque. The increasing technological burden in clinical cardiology paradoxically did not bring a parallel increase in the quality of care but rather an increase in cost. The economic climate had changed; the illusion of unlimited economic resources had come to an end [2]. Keeping in mind that each test represents a cost, often a risk, and always a diagnostic hypothesis, we can agree that every unnecessary and unjustifiable test is one test too many. Small individual costs, risks, and wastes multiplied by billions of examinations per year represent an important population [3], society [4] and environmental [5] burden. Unfortunately, the appropriateness of cardiac imaging is usually extra-ordinarily low and there is little awareness among patients and physicians of the elementary physical basis, differential costs, radiological doses, and long term risks of different imaging modalities [6]. It is also well known that – in the words of Bernard Lown – "technology in medicine is frequently untested scientifically, often applied without data relating to cost benefit, and driven by market forces rather than by patient needs." Bernard Lown, 2004 [7]."Ten years ago, medical imaging wasn't even in the radar screen for most health insurers. In 2004, it' s one of the highest cost items in a health plan's medical budget, and also one of the fastest growing". (Atlantic info service newsletter, 2004) [8]. As an example, in U.S. during the year 2002, 7.8 million cardiac perfusion scans were performed, with a growth of 40% in the last 3 years [9]. Still in U.S.,
Anniversary Editorial: One year of Cardiovascular Ultrasound
Eugenio Picano
Cardiovascular Ultrasound , 2004, DOI: 10.1186/1476-7120-2-3
Abstract: Cardiovascular Ultrasound is an Open Access, peer-reviewed online journal covering clinical, technological, experimental, biological, and molecular aspects of ultrasound applications in cardiovascular physiology and disease.Cardiovascular Ultrasound is aimed at providing a suitable tribune for the most current, clinically and biologically relevant, and high quality research in the field of ultrasound of heart and vessels. The journal publishes peer-reviewed original research, updated reviews, case reports on challenging and/or unusual diagnostic aspects, and expert opinions on new techniques and technologies. Other feature of interest to the cardiologist, the sonographer and allied scientists is the "natural born digital" nature of the journal, with the possibility to publish colour illustrations and video clips with no extra costs. This feature is especially attractive in a field so dynamic (both in a conceptual and in a cinematic sense) as ultrasound. The possibility to go immediately to Pubmed, and the publication of video-clips, will tremendously increase the scientific impact of your material. Cardiovascular Ultrasound might become a good first choice for much of your "hot material", when time is not an independent variable.The cardiovascular ultrasound community needs an Open Access forum in which to publish peer-reviewed articles with speed (in revision and publication), and versatility (in arguments, ranging from biology to engineering to clinical echocardiography). Cardiovascular Ultrasound aims to be that forum.Manuscripts must be submitted to Cardiovascular Ultrasound electronically using the online submission system. Full details of how to submit a manuscript are given in the instructions for authors. Cardiovascular Ultrasound reviews all the material it receives. About 10 % of articles are rejected after review in-house. The usual reasons for rejection at this stage are insufficient originality or serious scientific flaws. We aim to reach a decision on
Zinc and ageing: third Zincage conference
Eugenio Mocchegiani
Immunity & Ageing , 2007, DOI: 10.1186/1742-4933-4-5
Abstract: Zincage [1] is a specific targeted research project (STREP) funded by the European Union in the 6th Framework Program (FP6). It includes epidemiological studies on the influence of diet and lifestyle on healthy ageing, aimed at preventing adult degenerative disease, particularly focusing on cardiovascular diseases and also addressing malnutrition of the elderly. The conference held in Ancona, January 2007, was focussed particularly on the effects of Zn supplementation in the elderly and on the possible influences of dietary, biochemical and genetic factors on the individual response. Zn deficiency, cell-mediated immune dysfunction and increased oxidative stress are common in elderly subjects and it is quite clear that dietary habits including Zn consumption have a great impact on these factors. Zn supplementation in the elderly can improve the immune response and reduce oxidative stress markers, thereby contributing to a reduced incidence of infections. However, individual differences in the response to Zn can lead to contradictory results even with supplementation trials performed in elderly people of the same age-groups. One of the reasons for these individual differences is the different genetic background of the subjects enrolled in the study. In fact, some proteins with documented polymorphic sites are involved in regulating Zn homeostasis. One important class of such proteins are the metallothioneins (MT), which bind Zn with high affinity but, at the same time, release free Zn ions in response to oxidative/nitrosative stress and thereby modulate the expression of Zn-dependent genes and activate antioxidant enzymes. Differences in Zn status have also been observed in individuals carrying different alleles for polymorphisms of pro-inflammatory cytokines (i.e. IL-6 and TNF-alpha). In addition, the individual response can be modulated by dietary habits because Zn absorption and availability is dependent on the intake of other nutrients and trace elements.These asp
Potential emissions of Kyoto and Non-Kyoto climate active compounds in the production of sugarcane ethanol
Sanhueza,Eugenio;
Interciencia , 2009,
Abstract: sugarcane ethanol is the most commercially developed liquid biofuel. the potential emissions of kyoto and non-kyoto protocol climate active compounds in the production of sugarcane ethanol in agricultural lands are evaluated herein. various scenarios are considered, such as low or high n2o emission from n-fertilizers, inclusion or not of pre-harvest burning, uncontrolled or controlled emissions in bagasse based boilers, and 20 or 100 years time horizons in gwps. the co2 emitted in ethanol fuel combustion is recycled during sugarcane "re-growing" and does not count as greenhouse gas. however, even though many uncertainties remain, the available information allows estimating that co2-eq emissions are very large when ethanol production is based on pre-harvest burning and there is non-controlled particle emission in boilers. in these scenarios, compared with the combustion of equivalent amounts of gasoline, higher co2-eq emission would take place. halting sugarcane field burning would not be sufficient to revert the situation, especially in a 20-years time horizon. only when more environmental friendly procedures are applied, a significant saving of co2-eq emissions occurs at 20 and 100-years horizon scenarios. in all scenarios, non-kyoto protocol compounds make an important net contribution. therefore, if a real evaluation of climate active compounds emissions is to be reached, it would be crucial to include these compounds in life cycles studies. to reduce uncertainties, especially of non-kyoto compounds, additional research is needed.
Page 1 /1643
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.