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Search Results: 1 - 10 of 861 matches for " Estibaliz Tamayo-Orbegozo "
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Natural killer (NK) cells for cancer immunotherapy: pluripotent stem cells-derived NK cells as an immunotherapeutic perspective
Cristina Eguizabal,Olatz Zenarruzabeitia,Jorge Monge,Miguel A. Vesga,Marta Ri?ón,Estibaliz Tamayo-Orbegozo,Laura Amo,Francisco Borrego
Frontiers in Immunology , 2014, DOI: 10.3389/fimmu.2014.00439
Abstract: Natural killer (NK) cells play an essential role in the fight against tumor development. Over the last years, the progress made in the NK cell biology field and in deciphering how NK cell function is regulated, is driving efforts to utilize NK cell-based immunotherapy as a promising approach for the treatment of malignant diseases. Therapies involving NK cells may be accomplished by activating and expanding endogenous NK cells by means of cytokine treatment or by transferring exogenous cells by adoptive cell therapy and/or by hematopoietic stem cell transplantation (HSCT). NK cells that are suitable for adoptive cell therapy can be derived from different sources, including ex vivo expansion of autologous NK cells, unstimulated or expanded allogeneic NK cells from peripheral blood, derived from CD34+ hematopoietic progenitors from peripheral blood and umbilical cord blood, and NK cell lines. Besides, genetically modified NK cells expressing chimeric antigen receptors (CARs) or cytokines genes may also have a relevant future as therapeutic tools. Recently, it has been described the derivation of large numbers of functional and mature NK cells from pluripotent stem cells (PSCs), both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), which adds another tool to the expanding NK cell-based cancer immunotherapy arsenal.
Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1
Laura Amo,Estibaliz Tamayo-Orbegozo,Cristina Eguizabal,Olatz Zenarruzabeitia,Jorge Monge,Miguel A. Vesga,Francisco Borrego,Susana Larrucea
Frontiers in Oncology , 2014, DOI: 10.3389/fonc.2014.00245
Abstract: Besides their essential role in hemostasis and thrombosis, platelets are involved in the onset of cancer metastasis by interacting with tumor cells. Platelets release secretory factors that promote tumor growth, angiogenesis, and metastasis. Furthermore, the formation of platelet-tumor cell aggregates in the bloodstream provides cancer cells with an immune escape mechanism by protecting circulating malignant cells from immune-mediated lysis by natural killer (NK) cells. Platelet-tumor cell interaction is accomplished by specific adhesion molecules, including integrins, selectins, and their ligands. Podocalyxin-like protein 1 (PCLP1) is a selectin ligand protein which overexpression has been associated with several aggressive cancers. PCLP1 expression enhances cell adherence to platelets in an integrin-dependent process and through the interaction with P-selectin expressed on activated platelets. However, the involvement of PCLP1-induced tumor-platelet interaction in tumor immune evasion still remains unexplored. The identification of selectin ligands involved in the interaction of platelets with tumor cells may provide help for the development of effective therapies to restrain cancer cell dissemination. This article summarizes the current knowledge on molecules that participate in platelet-tumor cell interaction as well as discusses the potential role of PCLP1 as a molecule implicated in tumor immune evasion.
Emaús, a charity organization
Cuadernos de Gestión , 2002,
Abstract: Emaús Bilbao Cooperative Company is a social economy and solidarity organization for socio-labour insertion. It is dedicated to the comprehensive management of solid urban waste. It has its headquarters in Bilbao and carries out its work in Vizcaya.From 1970, the year in which Emaús established itself in Vizcaya, to the present day, the organization has experienced an evolution which has led it to change its management direction. Gone are the days when they were only known as “the rag and bone men of Emaus” with all the connotations that were associated with that name. At present we find a company which has adopted new management formulas without losing the characteristics of its social and solidarity project. This has enabled it to face up to the prevailing conditions in todays economic climate. In this way it has been able to guarantee its survival.The comprehensive management of solid urban waste is made up of four diverse parts: The location of the urban solid waste through the receiving of telephone calls, its collection and selection, and the final elimination of those things that can not be incorporated again into the consumer chain. Through this case, the problems that arise for the organization with reference to the management of Human Resources are analysed. These are related above all to the motivational and decision making aspects due to the diverse characteristics as much in their own workers as in the organization.
Revisión de la metodología empleada y resultados alcanzados en la investigación sobre actuación medioambiental de la empresa y rendimiento económico (1972-2009) || Review of Methodology and Results of Research on Environmental Management of the Firm and Economic Performance (1972-2009)
Vicente Molina, María Azucena,Tamayo Orbegozo, Unai,Izaguirre Olaizola, Julen
Revista de Métodos Cuantitativos para la Economía y la Empresa , 2012,
Abstract: La variable “medio ambiente" ha cobrado una creciente importancia en la gestión empresarial. Durante las dos últimas décadas la investigación empírica sobre la relación existente entre la actuación medioambiental de la empresa y su rendimiento económico ha sido uno de los temas recurrentes. No obstante, se detectan diversas lagunas en este ámbito de estudio, como la falta de conformación de un marco teórico y de una metodología de investigación fiable que permita contrastar y comparar los resultados obtenidos, al objeto de orientar adecuadamente a investigadores o decisores empresariales interesados por la gestión medioambiental. Así, la evidencia empírica sobre dicha relación presenta, a veces, resultados contradictorios. Por ello, el objetivo perseguido en este trabajo es doble. Por una parte, se realiza una profunda revisión de la literatura a fin de identificar y tratar de sistematizar el tipo de estudios realizados, las técnicas de análisis empleadas, los factores clave de dicha relación, las carencias de tales estudios, etc., identificando el signo predominante de la relación objeto de estudio. Por otra, se intenta fomentar la reflexión crítica sobre la investigación realizada y se plantean algunas sugerencias para futuras investigaciones. || The `environment' factor has become increasingly important in business management. The relationship between the environmental behavior of the company and its economic performance has been one of the recurring themes of research, especially in the last two decades. However, many gaps still exist in this field of study, such as the lack of a theoretical framework and a methodology that allow reliable research in order to empirically contrast and compare the results of the different studies. Thus, we found that the empirical evidence on this relationship sometimes presents contradictory results. Therefore, this work has two objectives. On the one hand, we review the existing literature in order to identify and systematize the type of studies, the analysis techniques, the key factors of such relationship, the shortcomings and limitations of these studies, etc. trying to throw some light on the sign of the target relation. On the other hand, we look for fostering critical reflection, and we make some suggestions for future research.
The influence of size factor on the core membership of buying agencies from small retailers
Cuadernos de Gestión , 2001,
Abstract: For several years, small shops in Spain and in other European countries have found themselves facing up to a situation of increasing convergence with the inrush of new commercial ways which are more vertical and horizontally integrated and better prepared to compete in price and variety. Faced with this fact, the trade associations (central offices of purchasing) offer themselves as an alternative designed to reduce distances on these two questions and at the same time providing certain services to help the small trader to manage his business more efficiently and effectively. In this article before you, this recent evolution and the supply trend by the small shops through the trade associations (central offices of purchasing) in Spain are analysed. Then, through an empirical study, it is tried to establish the answers of the small shops to a suggested relationship of points in favour and against which grouping together in a trade association (central office of purchasing) would suppose. With regards to this question, it is analysed in a particular way, to what extent we can relate the size of the commercial company with the degree of agreement with the trade associations (central office of purchasing).
Cuadernos de Gestión , 2003,
Abstract: Kukuxumusu, S.L. is an organization that commercializes draws in different quality supports to be bought, used and enjoyed by people of any age, sex and condition, who expect amusing, original and different messages of a T-shirt, a cup, a key-ring. Kukuxumusu develops its activity in the souvenir and gift’s markets. The article analizes the global market strategy adopted by Kukuxumusu related to its portfolio, distribution channels and communication instruments. Since 1989, the year they sold their first T-shirt in San Fermin feasts, Kukuxumusu has become a firm with a strong corporate culture, which has grown making use of the new technologies. Both the brand management and the differentiation based on intangible attributes, are key factors in Kukuxumusu’s marketing strategy.
La Constitución de 1991 y la política exterior colombiana
Bernardo Vela Orbegozo
Revista Derecho del Estado , 2008,
Abstract: Introducción. i. Una política exterior para un mundo en transformación. ii. El viejo orden y la transformación de las relaciones internacionales. iii. La precariedad de la política exterior colombiana. iv. A manera de conclusión: la política exterior de un Estado legítimo
La integración regional como un factor de desarrollo nacional
Bernardo Vela Orbegozo
Revista Opera , 2003,
Year in review 2011: Critical Care - cardiology
Daniel De Backer, Diego Orbegozo Cortés
Critical Care , 2012, DOI: 10.1186/cc11826
Abstract: We review key research papers in intensive care cardiology published during 2011 in Critical Care. Related studies published in other journals are also discussed, whenever appropriate.Inotropic agents are used to increase oxygen delivery in the perioperative setting but their impact on mortality is not well defined. In a retrospective study including 1,326 cardiac surgery patients, those exposed to inotropes had, as expected, a higher unadjusted mortality rate than those patients not exposed [1]. After adjustment, inotrope exposure was still associated with increased hospital mortality and renal dysfunction. A propensity score-matched analysis yielded similar results. A limitation of this trial is that this type of analysis only takes into account measured variables, but other factors may play a role. Postoperative inotrope exposure may thus be associated with worse outcomes, but this should be tested in interventional trials.Should nonadrenergic inotropic agents be preferred? A meta-analysis evaluated the effects of levosimendan, versus control, in patients after percutaneous or surgical cardiac revascularization [2]. The meta-analysis included 729 patients from 17 studies. Levosimendan increased the cardiac index. Compared with controls, levosimendan treatment was associated with a mortality reduction after coronary revascularization (odds ratio = 0.40, 95% confidence interval (CI) = 0.21 to 0.76) and a reduction in the length of ICU stay. An important limitation of this analysis is that most of the studies included were small sized, and that there was an important heterogeneity in dosing and time of administration of levosimendan as well as in drugs used in the control arms. This potentially beneficial effect of levosimendan should be evaluated in a large-scale randomized trial.Another meta-analysis evaluated the renal effects of carperitide, an atrial natriuretic peptide, and nesiritide, a B-type natriuretic peptide (BNP) [3]. The systematic review included 15 s
Comportamiento de los materiales bajo carga repetida
Tamayo Tamayo Jorge
Ingeniería e Investigación , 1985,
Abstract: Este es un trabajo presentado al V Simposio Colombiano sobre Ingeniería de Pavimentos, realizado en Cúcuta en octubre de 1983.
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