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A rare cutaneous tumor of the axilla: Apocrine adenocarcinoma
Karaca Semsettin,Kulac Mustafa,Sahin Onder,Esme Hidir
Indian Journal of Dermatology , 2007,
Abstract: Sweat gland neoplasms are rare with approximately 200 cases of eccrine sweat gland and less than 50 cases of apocrine gland carcinoma being reported in the worldwide literature. More than half of the reported cases with apocrine adenocarcinoma had lymph node metastases at the time of diagnosis. We report a case of a 56-year-old man, presented with a left axillary slow-growing seven year old painless nodule. Histopathological examination revealed an invasive apocrine adenocarcinoma with lymph node metastases. The patient successfully treated with total excision and radiotherapy. Apocrine adenocarcinoma is a rare malignancy with high metastatic potential that occurs mostly in the axilla. Physicians should be aware of this entity while differentiating cutaneous tumor located on the axillary region.
Effects of Flurbiprofen on CRP, TNF-α, IL-6, and Postoperative Pain of Thoracotomy
Hidir Esme, Recep Kesli, Burhan Apiliogullari, Ferdane Melike Duran, Banu Yoldas
International Journal of Medical Sciences , 2011,
Abstract: Objective: The aims of this study were to evaluate serum levels of acute phase reactants, such as CRP and cytokines (TNF-α and IL-6) in patients who have undergone thoracotomy and to investigate the effects of flurbiprofen on postoperative inflammatory response. Methods: Forty patients undergoing posterolateral thoracotomy were randomly divided into 2 groups of 20 each. Control group received tramadol (4 x 100 mg) intravenously for four days, and flurbiprofen group received both tramadol (4 x 100 mg) and flurbiprofen (2 x 100 mg). Blood samples were collected before surgery and at the 3th and 168th hours after surgical procedure to measure serum CRP, IL-6, and TNF-α. Pain visual analog scales were recorded daily during the first four postoperative days. Spirometric measurement of forced expiratory volume in the first second (FEV 1) was done before and four days after the operation. Results: The serum CRP, IL-6, and TNF-α levels in both groups increased significantly at 3th hour after thoracotomy. Serum TNF-α levels did not differ significantly between the groups at postoperative 4th day. However, IL-6 and CRP were significantly lower in flurbiprofen group than in control group at the same day (p<0.05). Visual analog scale was significantly lower in flurbiprofen group at 6th, 12th, 48th, 72th, and 96th hours postoperatively (p<0.05). The patients receiving flurbiprofen had higher FEV 1 values when compared with control group at postoperative 4th day. Conclusions: Patients undergoing thoracotomy showed reduced postoperative pain, mean additional analgesic consumption, and serum IL-6 and CRP levels, when flurbiprofen was added to systemic analgesic therapy. Analgesia with anti-inflammatory drug may contribute to the attenuation of the postoperative inflammatory response and prevent postoperative pain in patients undergoing thoracotomy.
Mechanisms of action of intravenous immunoglobulins
Umit Hidir ULAS
Journal of Neurological Sciences , 2003,
Abstract: Although the mechanism of immunomodulatory action of intravenous immunoglobulins (IVIg) which are used for about last two decades is complex, many advances have been made in this era. IVIg is a composition of immonuglobulins having many immuno-active molecules that can react with impaired immune system cells in many diseases. It is related with Fc receptor expression and function, complements, cytokines and anti-idiotype antibodies. Their action on cellular development, activation, differentiation and functions of T cells and B cells are established. Ig’s therapeutic effects in immune balance mimic the effects of natural antibodies in healthy individuals.
Les changements sémantiques et les ambigu tés au niveau du discours : l'exemple du fr. on
Winter-Froemel Esme
SHS Web of Conferences , 2012, DOI: 10.1051/shsconf/20120100116
Abstract: Dans cette contribution sera analysé le changement sémantique du pronom impersonnel on qui acquiert une valeur de 1Pl dans le fran ais parlé. Pour expliquer ce changement, nous nous intéresserons à des emplois précoces du pronom dans son sens novateur qui peuvent s'observer dès le XVIe siècle. Grace à des analyses sémantiques et pragmatiques d'extraits de corpus (Frantext), on peut distinguer deux scénarios d'innovations potentiels (réanalyses sémantiques et actes de langage indirects). En même temps, on constate, dans les deux cas, une ambigu té entre le sens ancien (qui est le sens impersonnel, soit générique ou gnomique, soit épisodique ou existentiel) et le sens nouveau (de la 1Pl). Sur la base de cette observation, nous approfondirons ensuite nos réflexions sur le concept des bridging contexts (Evans & Wilkins 2000) et sur le concept de l'ambigu té en proposant une distinction entre les ambigu tés au niveau de la langue et les ambigu tés au niveau du discours, ces dernières se révélant fondamentales pour expliquer le changement sémantique décrit. De même, nous montrerons de quelle manière les deux types d'ambigu té se manifestent et interagissent à différents stades des changements linguistiques. Les réflexions et analyses suggèrent ainsi différentes voies par lesquelles les recherches sur les phénomènes d'ambigu té peuvent présenter des apports prometteurs pour la modélisation des changements linguistiques en général.
The Effect of Parity and Litter Size on Birth Weight and the Effect of Birth Weight Variations on Weaning Weight and Pre-Weaning Survival in Piglet
Filiz Akdag,Serhat Arslan,Hidir Demir
Journal of Animal and Veterinary Advances , 2012,
Abstract: This study investigated the effect of litter size and parity on birth weight, weaning weight and survival at weaning and also, the effect of variations of birth weight on number and weight of piglets weaned and on pre-weaning survival. This experiment was performed on 114 sows and their 851 piglets. All piglets were divided into two groups for litter size, parity and birth weight and the main analyses were based on weight groups. Litter size affected birth weight significantly (p<0.01), but parity did not affect this trait (p>0.05). Furthermore, birth weight was determined to affect weaning weight, the number weaned and survival at weaning (p<0.01). It was demonstrated that each unit increase in litter size reduces birth and weaning weight. It was also shown that birth weight is a determining factor for weaning weight and survival at weaning and that high variations in birth weight cause high variations in survival.
Older Asian Americans and Pacific Islanders with Activities of Daily Living (ADL) Limitations: Immigration and Other Factors Associated with Institutionalization
Esme Fuller-Thomson,Monica Chi
International Journal of Environmental Research and Public Health , 2012, DOI: 10.3390/ijerph9093264
Abstract: This study determined the national prevalence and profile of Asian Americans with Activities of Daily Living (ADL) limitations and identified factors associated with institutionalization. Data were obtained from 2006 American Community Survey, which replaced the long-form of the US Census. The data are nationally representative of both institutionalized and community-dwelling older adults. Respondents were Vietnamese (n = 203), Korean (n = 131), Japanese (n = 193), Filipino (n = 309), Asian Indian (n = 169), Chinese (n = 404), Hawaiian/Pacific Islander (n = 54), and non-Hispanic whites (n = 55,040) aged 55 and over who all had ADL limitations. The prevalence of institutionalized among those with ADL limitations varies substantially from 4.7% of Asian Indians to 18.8% of Korean Americans with ADL limitations. Every AAPI group had a lower prevalence of institutionalization than disabled Non-Hispanic whites older adults (23.8%) ( p < 0.001). After adjustment for socio-demographic characteristics, Asian Indians, Vietnamese, Japanese, Filipino, and Chinese had significantly lower odds of institutionalization than non-Hispanic whites (OR = 0.29, 0.31, 0.58, 0.51, 0.70, respectively). When the sample was restricted to AAPIs, the odds of institutionalization were higher among those who were older, unmarried, cognitively impaired and those who spoke English at home. This variation suggests that aggregating data across the AAPI groups obscures meaningful differences among these subpopulations and substantial inter-group differences may have important implications in the long-term care setting.
Modeling and predicting abrasive wear behaviour of poly oxy methylenes using response surface methodolgy and neural networks
A. Sagbas,F. Kahraman,U. Esme
Metalurgija , 2009,
Abstract: In this study, abrasive wear behaviour of poly oxy methylenes (POM) under various testing conditions was investigated. A central composite design (CCD) was used to describe response and to estimate the parameters in the model. Response surface methodology (RSM) was adopted to obtain an empirical model of wear loss as a function of applied load and sliding distance. Also, a neural network (NN) model was developed for the prediction and testing of the results. Finally, a comparison was made between the results obtained from RSM and NN.
The effect of dry corn gluten feed on chewing activities and rumen parameters in lactating dairy cows
Hakan Biricik,Hidir Gencoglu,Birgul Bozan,B. Haluk Gulmez
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2007.61
Abstract: The objectives of this research were to evaluate the effects of increasing levels of dry corn gluten feed (DCGF) on dry matter intake (DMI), chewing activity, and rumen fermentation when used to replace a portion of corn silage in diets for lactating Holstein cows. Eight lactating Holstein primiparous cows averaging 98±20 d in milk and weighing 515±20 kg were randomly assigned in a 4x4 Latin square design with 4 week periods. Dietary treatments were 1) a control diets (C) of 50% forage (corn silage and wheat straw, 35%, 15% DM basis, respectively), 2) a low DCGF diet (L-DCGF) in which 10% of the same corn silage was replaced by DCGF, 3) a medium DCGF diet (M-DCGF) in which 18% of the same corn silage was replaced by DCGF, and 4) a high DCGF diet (H-DCGF) in which 25% of the same corn silage was replaced by DCGF. The proportion of particles retained on the 19.0 mm screen and physical effectiveness factor of the HDCGF was lower (P<0.05) than in the other groups. Increasing the level of DCGF did not change DMI. Cows fed the C diet spent significantly more time ruminating and chewing per day compared with the MDCGF and H-DCGF diets (483.88, 435.63, 431.25 min/d, P<0.05; and 818.38, 753.00, 745.75 min/d respectively, P<0.05). Cows fed the C diet had ruminal pH values higher than the cows fed the M-DCGF and H-DCGF diets (6.02, 5.95, and 5.91, P<0.05). The total volatile fatty acid and propionate levels of H-DCGF fed cows were higher than the control (P<0.05). The changes in acetate (A) and propionate (P) concentrations resulted in a decrease in A/P ratio, when corn silage was replaced by DCGF, which led to a reduction in the particle size of the diets (P<0.05). It was concluded that when ratio 18 and 25% DCGF were substituted for corn silage, rumination time, chewing activities and ruminal pH are negatively affected. The optimum level for the addition of DCGF was found to be below 18% of the diet for a healthy rumen and a chewing behaviour in dairy cows.
A Case of Asymptomatic Rebound Intracranial Hypertension After Treatment of Spontaneous Intracranial Hypotension by Epidural Blood Patch
Umit Hidir ULAS,Omer KARADAS,Oguzhan OZ,Hakan AKGUN
Journal of Neurological Sciences , 2010,
Abstract: Epidural blood patch (EBP) is the treatment of choice if non-invasive (bed rest, hydration) treatment is ineffective in spontaneous intracranial hypotension (SIH). However, the possibility of a rebound increase of intracranial pressure after EBP with sudden or slow onset is known. A 43-year-old female presented with orthostatic headache and diagnosed as SIH based on clinical, laboratory and imaging criteria. The opening cerebrospinal fluid (CSF) pressure was 60 mm of water. Radionuclide cisternography indicated thoracic CSF leakage. Epidural blood patch injected at thoracic level. In order to evaluate epidural space completely this procedure was made under fluoroscopic guidance. The localization was confirmed by injecting contrast material. Our case was symptom free after EBP treatment but a follow-up CSF opening pressure at the third week after EBP treatment was 250 mm of water that suggested a rebound intracranial hypertension. Cerebrospinal fluid pressure was successfully decreased with acetazolamide without the occurrence of high pressure symptoms. Our case differs from other reports of intracranial hypertension after EBP. In previously reported cases, headache was the clinical manifestation of intracranial hypertension. Our case was symptom free after EBP and intracranial hypertension was observed on a follow-up lumbar puncture (LP) examination, CSF pressure was successfully decreased with acetazolamide without the occurrence of high pressure symptoms. We presented a case of asymptomatic rebound intracranial hypertension after treatment of spontaneous intracranial hypotension that was observed on a follow-up LP examination, up to our knowledge previously unreported in published literature.
Acute Neuro-Behcet's Disease
Oguzhan OZ,Vedat Semai BEK,Mehmet YUCEL,Umit Hidir ULAS
Journal of Neurological Sciences , 2010,
Abstract: Beh et's disease (BD) is a multisystem vasculitis that may affect central nervous system (CNS). Neuromyelitis optica (NMO) is a severe CNS inflammatory demyelinating disorder. Here we describe a patient with myelitis whose clinical course included oral and scrotal ulcerations and an episode of optic neuritis. He applied with suddenly developed mild right hemiparesis. Brain computed tomography and magnetic resonance imaging (MRI) were unremarkable. He developed tetraparesis in clinical foolow up. Cervical and thoracal spinal MRIs disclosed diffuse cord lesions with contrast enhancement. Medical history revealed oral aphtae 1 month ago before admission that lasted in seven days and no other periods of genital ulceration or oral aphtae. To our knowledge rapidly progressive CNS involvement resembling NMO with no clinical findings in previous history has not been described in BD earlier.
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