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IVS8 Polyt and M470V Polymorphisms in Healthy Individuals and Cystic fibrosis Patients in Mazandaran Province, Iran
Kholghi Oskooei V,Esmaeeli Douki MR,Tabaripour R,Tavakkoly Bazzaz J
Tehran University Medical Journal , 2012,
Abstract: Background: Cystic fibrosis (CF) is a multiorgan autosomal recessive disorder. As CF is highly heterogeneous in Iran and many mutations have a low frequency, routine molecular diagnostic methods are not very efficient. The use of highly polymorphic intragenic markers not only can facilitate phenotype prediction in prenatal diagnosis by gene tracking, but also can lead to the demonstration of possible associations between haplotypes and specific mutations. We determined IVS8 polyT and M470V polymorphisms in exon 10 of CFTR gene in this case-control study. Methods: Polymorphisms of IVS8 polyT in 53 patients with CF were referred to Amirkola children's Hospital of Babol University of Medical Sciences, 2007 to 2011 and 49 fertile healthy individuals were determined by reverse dot blot method. M470V polymorphism was analyzed by PCR-RFLP. Results: In IVS8 polyT study, T7 was the most frequent allele in healthy individuals than patients with CF (respectively, 82.8% Vs. 77.2%). T9 was more abundant in patients with CF than normal individuals (respectively, 21.7% Vs. 7.4%, P=0.005). T9/T9 genotype was more frequent in patients than healthy individuals (respectively, 15.1% and 2%, P=0.032). Study for M470V polymorphism showed that M/V was the most common genotype in normal individuals and patients with CF (respectively, 49% and 40.4%). M-T9 haplotype was highly associated with the disease in both patients with CF and normal individuals (respectively, 19.1% and 2.4%, (P<0.001 Conclusion: The allelic distribution and heterozygosity results suggest that both M470V and IVS8 polyT can be helpful in the prenatal diagnosis of CF in Northern Iranians with a positive family history of the disease.
The Effect of Performing Preoperative Preparation Program on School Age Childrens Anxiety
Nazanin Vaezzadeh,Zahra Esmaeeli Douki,Abbas Hadipour,Soheil Osia
Iranian Journal of Pediatrics , 2011,
Abstract: Objective: The purpose of this study was to examine effects of performing preoperative preparation program on childrens anxiety.Methods: This study was performed in Amirkola Pediatrics Hospital, Mazandaran. A randomized controlled trail was performed on 122 children (7-12 years of age) admitted for elective surgery during 15 months. The researcher randomly assigned eligible participants in to the experimental and control groups, after pre-test baseline measurement had been taken. Analyzing was performed through independent t-test and χ2 test. P<0.005 was considered statistically significant. The experimental group received therapeutic play and the control group received routine preoperative information preparation.Findings: The mean and standard deviation of the state anxiety scores of children in experimental and control groups before intervention were 35.52±6.99 and 34.98±6.78, after intervention 31.44±5.87 and 38.31±7.44 respectively. The state anxiety score was lower significantly in the experimental group prior to preoperative surgery than in the control group (P=0.000).Conclusion: Performing preoperative program with using therapeutic play intervention is effective for preparing children before surgery and decreases their anxiety.
Poly T polymorphism consideration in normal individuals and cystic fibrosis patients in Mazandaran province, Iran
Haleh Akhavan Niaki,Reza Tabaripour,Mohammad Reza Esmaeeli Douki,Mandana Azizi
Tehran University Medical Journal , 2010,
Abstract: "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Cystic fibrosis is a monogenic recessive disorder founds predominantly in caucasian population causes exocrine glands function defect. This disease arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Because of heterogeneity of the mutations in CFTR gene, phenotypic symptoms in this disease are very variable. In this study we consider poly T polymorphism (T5, T7, T9) in the intron 8 of CFTR gene in normal individuals and cystic fibrosis patients in mazandaran province."n"nMethods: Forty cases of cystic fibrosis patients and 40 normal individuals were screened for poly T polymorphism in intron 8 of CFTR gene using Reverse Dot Blot method."n"nResults: T7 allele is the most prevalent in normal individuals and CF patients and it's abundance is approximately 75%. T9 and T5 represent approximately 20% and 5% of normal or mutant alleles respectively. T7/T7 genotypes in normal individuals and CF patients are the most prevalent with 72.5% and 60% prevalence rate, respectively. T5/T9 and T5/T5 genotypes were not found. 22.5% of normal individuals and 30% of CF patients had heterozygote genotypes."n"nConclusion: The abundance of T5, T7, T9 alleles and the presence of 22.5-30% heterozygote genotypes in normal individuals and CF patients indicates that poly T polymorphism in intron 8 of CFTR gene can be used as a marker for detection of normal and mutant alleles in prenatal diagnosis or can be used in carrier assessment in families with previous history of the disease.
Anesthesiologist`s Attitude Towards Preoperative Patients` Education Needs
Ravanbakhshe Esmaeeli,Ebrahim Nasiri
Research Journal of Biological Sciences , 2012,
Abstract: Lake of information about anaesthesia and fear of post operation consciousness, pain, nausea and vomiting increases patient`s anxiety. There are various reports about patient`s desire for preoperational information in Iran and other countries, but we don`t find any study related to anesthesiologist`s view about patient`s needs before anaesthesia and operation. This descriptive (cross- sectional) study was done in 2005 on 110 anesthesiologists working in hospitals of Mazandaran province. Questionnaire containing 4 questions about demographic and 18 questions related to anaesthesia was prepared. Attitude of the anesthesiologists was studied by dividing in 4 categories based on Likert rating scale as follow: strongly agree, agree, particularly agree, disagree and strongly disagree. The obtained data were shown in table; chi-square test was used for the statistical analysis of the data. Results of this study showed that the most positive attitude of anesthesiologists about patient teaching was related to the proper explanation about duration of N.P.O before operation (97.3%) and 52.7% were against about giving explanation of the during and post operation possible problems. In this regard no significant difference was observed between educational and non educational hospitals (p<0.018). No significant view point difference was observed between anesthesiologists at different level of education (p<0.07). Considering the positive attitude of the anesthesiologists towards education to preoperational patients, it is recommended that such education be implemented and the patients be charged for preoperational consultation. In order to give explanation about anaesthesia at proper time, when needed.
Intraparenchymal hemorrhage after surgical decompression of a Sylvian fissure arachnoid cyst
Esmaeeli Babak,Eftekhar Behzad
Neurology India , 2006,
Abstract:
Anesthesiologist`s Attitude Towards Preoperative Patients` Education Needs
Ravanbakhshe Esmaeeli,Ebrahim Nasiri
Research Journal of Biological Sciences , 2008,
Abstract: Lake of information about anaesthesia and fear of post operation consciousness, pain, nausea and vomiting increases patient`s anxiety. There are various reports about patient`s desire for preoperational information in Iran and other countries, but we don`t find any study related to anesthesiologist`s view about patient`s needs before anaesthesia and operation. This descriptive (cross- sectional) study was done in 2005 on 110 anesthesiologists working in hospitals of Mazandaran province. Questionnaire containing 4 questions about demographic and 18 questions related to anaesthesia was prepared. Attitude of the anesthesiologists was studied by dividing in 4 categories based on Likert rating scale as follow: strongly agree, agree, particularly agree, disagree and strongly disagree. The obtained data were shown in table; chi-square test was used for the statistical analysis of the data. Results of this study showed that the most positive attitude of anesthesiologists about patient teaching was related to the proper explanation about duration of N.P.O before operation (97.3%) and 52.7% were against about giving explanation of the during and post operation possible problems. In this regard no significant difference was observed between educational and non educational hospitals (p<0.018). No significant view point difference was observed between anesthesiologists at different level of education (p<0.07). Considering the positive attitude of the anesthesiologists towards education to preoperational patients, it is recommended that such education be implemented and the patients be charged for preoperational consultation. In order to give explanation about anaesthesia at proper time, when needed.
American Options with Asymmetric Information and Reflected BSDE
Neda Esmaeeli,Peter Imkeller
Quantitative Finance , 2015,
Abstract: We consider an American contingent claim on a financial market where the buyer has additional information. Both agents (seller and buyer) observe the same prices, while the information available to them may differ due to some extra exogenous knowledge the buyer has. The buyer's information flow is modeled by an initial enlargement of the reference filtration. It seems natural to investigate the value of the American contingent claim with asymmetric information. We provide a representation for the cost of the additional information relying on some results on reflected backward stochastic differential equations (RBSDE). This is done by using an interpretation of prices of American contingent claims with extra information for the buyer by solutions of appropriate RBSDE.
To Determine the Challenges in Commercialization of Nanotechnology in Agricultural Sector of Iran
Seyed Jamal Hosseini,Somaeih Esmaeeli
Research Journal of Biological Sciences , 2012, DOI: 10.3923/rjbsci.2010.448.451
Abstract: Faculty members in agricultural colleges and research centers in the Mazandaran Province were surveyed in order to explore their perception about the challenges influencing the commercialization of the data was analyzed by using ordinal factor analysis technique. Based on the perception of the respondents and ordinal factor analysis, factors were categorized into eight challenges namely, infrastructural, production, business, management, economic, technical, social/cultural and research challenges nanotechnology in agricultural sector in Iran. The challenges were then ordered by the magnitude of their impact.
Transient diabetes insipidus as a part clinical presentations of preeclampsia: a case report
Esmaeeli Azad R,Jamal A
Tehran University Medical Journal , 2011,
Abstract: "n 800x600 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Background: Diabetes insipidus is a rare disease which can be considered as a part of broad spectrum of preeclampsia manifestations."n"nCase presentation : A 39-year old primigravid woman, with an unremarkable past medical history, was admitted in the 33rd week of gestation for elevated blood pressure. On admission, her blood pressure was 140/90 mmHg and the only abnormal laboratory findings were trace proteinuria and elevated liver enzymes. During the following days her blood pressure rose to 150/100 mmHg with deterioration of clinical and paraclinical status of the patient characterized by excessive thirst, polydipsia and excretion of large amounts of diluted urine. Having considered the patient's aggravating status, termination of pregnancy was planned. Fortunately, all the clinical and paraclinical presentations, including those related to the probable diabetes insipidus disappeared on the second day of postpartum period. "n"nConclusion: Sign and symptoms of diabetes insipidus should be considered in all cases admitted for preeclampsia.
Classifying Inputs and Outputs with Fuzzy Data
Mehrdad Nabahat,Fardin Esmaeeli Sangari
Journal of Mathematics Research , 2012, DOI: 10.5539/jmr.v4n4p46
Abstract: Data envelopment analysis is a nonparametric technique checking efficiency of DMUs using math programming. In conventional DEA, it has been assumed that the status of each measure is clearly known as either input or output. However in some situations, a performance measure can play input role for some DMUs and output role for others. There are different models for classifying inputs and outputs, but all of these models are with crisp data. In this paper we want to classify inputs and outputs when all of the DMUs have symmetrical triangular fuzzy inputs and outputs and flexible measures. The basic idea is to transform the fuzzy model into a crisp linear programming problem by applying an $alpha$-cut approach.Finally, a numerical example is proposed to display the application of this method.
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