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Search Results: 1 - 10 of 49147 matches for " Ernesto Antonio Figueiró-Filho "
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Efeito das Drogas Anti-Retrovirais sobre as Taxas de Fertilidade de Ratas Wistar
Figueiró Filho Ernesto Antonio
Revista Brasileira de Ginecologia e Obstetrícia , 2002,
Abstract:
The diagnostic accuracy of the usage of the Fetal Medicine Foundation’s (FMF) on-line risk calculator with first-trimester ultrasound for screening for preeclampsia in high-risk pregnant Brazilian population  [PDF]
Ernesto Antonio Figueiró-Filho, Maithe Vendas Galhardo, Bruno Areco de Souza
Open Journal of Obstetrics and Gynecology (OJOG) , 2012, DOI: 10.4236/ojog.2012.23063
Abstract: To evaluate the sensitivity and specificity of the usage of the FMF On-Line Risk Calculator with first-trimester ultrasound, in screening assessment for preeclampsia (PE), without serum markers. To define the best risk cut-off values for early, intermediate and late preeclampsia. Diagnostic accuracy study of pregnant women who had first-trimester ultrasounds between 11 and 13 weeks. The index test was the first-trimester ultrasound scan plus the FMF On-Line Risk Calculator to assess the risk for PE. The reference standard was the confirmation of actual development of early, intermediate or late PE. For calculations of sensitivity and specificity to determine the best cut-off values for early, intermediate and late PE, all the information was processed into ROC curves. The assessment of preeclampsia risk in the first trimester using an ultrasound plus the FMF On-Line Risk Calculator demonstrated a significant (p < 0.05) area under the ROC curve for early, intermediate and late preeclampsia. The best risk cut-off values were defined as 2.1% for early, 2.5% for intermediate and 3.5% for late preeclampsia. The first trimester US plus the FMF On-Line Risk Calculator tool was useful and applicable when assessing the risk for preeclampsia in a specific pregnant Brazilian population.
Semi-Quantitative Histological Analysis of the Effect of Intense Pulsed Light (IPL) and Carbon Dioxide (CO2) Intradermic Injection on Fibroblast and Collagen Proliferation in the Skin of Wistar Rats  [PDF]
Tamara Lemos Maia-Figueiró, Alexandre Nakao Odashiro, Giovanna Padoa de Menezes, Lilian Rezende Coelho, Ili Breda, Bruno Areco de Souza, Ernesto Antonio Figueiró-Filho
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2012, DOI: 10.4236/jcdsa.2012.23032
Abstract: Background: In recent years, so-called “non-ablative rejuvenation” has been carried out with the use of lasers or intense pulsed light (IPL) to stimulate collagen production by dermal fibroblasts. Intradermal infusion of CO2 stimulates fibroblasts and the synthesis of collagen and elastin, contributing to the retraction of the skin and tissue rejuvenation. Objectives: To evaluate the effects of IPL and the intradermal infusion of CO2 on fibroblast proliferation and collagen in the skin of female rats. Methods: Sixteen adult female Wistar rats were divided into two groups of eight animals. Group 1 underwent IPL and group 2 underwent intradermal CO2 infusion. There was a total of 8 weeks of treatment. We conducted a punch in each animal before any procedure (T0), another punch in the middle of treatment at 4 weeks post-procedure (T1) and a punch at the end of treatment at 8 weeks post-procedure (T2). The cells involved in inflammation, fibrosis and vascularization of the injured tissue by histopathology were analyzed. Results: There was statistically significant fibroblast proliferation and collagen proliferation noted when analyzing all 16 animals together and also when considering the two study groups separately. In both groups, the greatest proliferation of fibroblasts coincided with periods of increased collagen production. Conclusion: Both IPL and intradermal CO2 infusion stimulated fibroblast and collagen proliferation in the skin of the rats studied.
Associa??o entre abortamentos recorrentes, perdas fetais, pré-eclampsia grave e trombofilias hereditárias e anticorpos antifosfolípides em mulheres do Brasil Central
Figueiró-Filho, Ernesto Antonio;Oliveira, Vanessa Marcon de;
Revista Brasileira de Ginecologia e Obstetrícia , 2007, DOI: 10.1590/S0100-72032007001100003
Abstract: purpose: to verify the association of abortion, recurrent fetal loss, miscarriage and severe pre-eclampsia with the presence of hereditary thrombophilias and antiphospholipid antibodies in pregnant women. methods: observational and transverse study of 48 pregnant women with past medical record of miscarriage, repeated abortion and fetal loss story (ab group) and severe pre-eclampsia (pe group), attended to in the high risk pregnancy ambulatory of the faculdade de medicina (famed) from the universidade federal de mato grosso do sul (ufms) from november 2006 to july 2007. the pregnant women of both groups were screened for the presence of antiphospholipid antibodies (anticardiolipin igg and igm, lupic anticoagulant and anti-b2-glycoprotein i) and hereditary thrombophilias (protein c and s deficiency, antithrombin deficiency, hyperhomocysteinemia and factor v leiden mutation). the laboratorial screening was performed during the pregnancy. the parametric data (maternal age and parity) were analyzed with student?s t test. the non-parametric data (presence/absence of hereditary thrombophilias and antiphospholipid antibodies, presence/absence of pre-eclampsia, fetal loss, miscarriage and repeated abortion) were analyzed with fisher?s exact test in contingency tables. it was considered significant the association with p value <0.05. results: out of the 48 pregnant women, 31 (65%) were included in ab group and 17 (35%) in pe group. there was no significant difference between maternal age and parity within the groups. there was significant statistical association between recurrent fetal loss, recurrent abortions and previous miscarriages and maternal hereditary thrombophilias (p<0.05). there was no statistical association between the ab group and the presence of antiphospholipid antibodies. neither there were associations of the pe group with maternal hereditary thrombophilias and the presence of antiphospholipid antibodies. conclusions: the data obtained suggest routine labo
Efeito diabetogênico das drogas anti-retrovirais em ratas Wistar prenhes
Figueiró-Filho, Ernesto Antonio;Duarte, Geraldo;El Beitune, Patrícia;Quintana, Silvana Maria;Marcolin, Alessandra Cristina;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000100005
Abstract: purpose: to experimentally evaluate the diabetogenic effects of antiretroviral drugs on pregnant wistar rats and the perinatal effects on the offspring. methods: adult female pregnant wistar rats weighing 200-230 g were used. the antiretroviral drugs zidovudine (zdv), lamivudine (3tc) and nelfinavir (nfv) were used alone and in association at daily doses of ten times the dose normally used in pregnant women, proportionally to the animal's body weight. seven groups were studied, including the control. the experiment started on day 0 of pregnancy and the pregnant animals were sacrificed on day 21. the fetuses were counted and weighed. blood determinations of glucose, insulin, glucagon and lactate were performed on day 21. the retroperitoneal adipose tissue was weighed. data were analyzed statistically by student's t-test. results: the groups treated with 3tc, zdv + 3tc and zdv + 3tc + nfv showed decreasing values of maternal daily body weight gain, retroperitoneal adipose tissue weight and weight of fetuses (control group: 6.2 g; 3tc group variation: 4.1-5.6 g). the serum lactate levels were also decreased when compared to the control in these groups (control group: 5.8 mmol/ml; 3tc group variations: 3.2-3.7 mmol/ml). all antiretroviral-treated groups showed a decreasing number of fetuses when compared to the control (control group: 14.7; drug group variation: 11.1-12.7). all treated groups also showed decreasing serum values of insulin (control group: 6.2 μiu/ml; drug group variation: 2.1 to 2.7 μiu/ml) and increasing serum levels of glucagon when compared to the control (control group: 88.2 pg/ml; drug group variation: 99.7 to 120.7 pg/ml). there was no statistical significance of glucose levels when comparing treated groups to the control. conclusions: the antiretroviral drugs interfered in carbohydrate metabolism of pregnant rats and reduced the number of fetuses. 3tc caused less maternal body weight gain, decreased fetus weight and lactate and insulin levels and
Marcadores séricos de trombofilias hereditárias e anticorpos antifosfolípides em gestantes com antecedentes de pré-eclampsia grave
Figueiró-Filho, Ernesto Antonio;Oliveira, Vanessa Marcon de;Coelho, Lílian Rezende;Breda, Ili;
Revista Brasileira de Ginecologia e Obstetrícia , 2012, DOI: 10.1590/S0100-72032012000100008
Abstract: purpose: to determine the frequency and the association of serum markers for inherited and acquired thrombophilias in pregnant women with a history of severe pre-eclampsia in previous pregnancies. methods: case-control study consisting of 81 pregnant women with a history of severe pre-eclampsia in previous pregnancies (study group) and 32 women with no history of severe pre-eclampsia in previous pregnancies (control group). the presence of inherited thrombophilia and antiphospholipid antibodies was screened in both groups. we used the chi-square test with yates correction to assess associations and calculate the relative risks. results: the presence of thrombophilia was detected in 60.0% of patients with a previous history of pre-eclampsia and in 6.0% of the control patients. a significant association was found between pre-eclampsia in a previous pregnancy and the presence of markers for hereditary thrombophilia/antiphospholipid antibodies (p<0.05). the relative risk to develop pre-eclampsia was found to be 1.57 (1.34
Efeito diabetogênico das drogas anti-retrovirais em ratas Wistar prenhes
Figueiró-Filho Ernesto Antonio,Duarte Geraldo,El Beitune Patrícia,Quintana Silvana Maria
Revista Brasileira de Ginecologia e Obstetrícia , 2004,
Abstract: OBJETIVO: estudar a a o diabetogênica de drogas anti-retrovirais em ratas prenhes e o prognóstico perinatal das crias. MéTODOS: estudo com ratas fêmeas prenhes adultas da ra a Wistar, pesando entre 200-230 g. Foram testadas a azidotimidina (AZT), lamivudina (3TC) e nelfinavir (NFV), cujas dosagens foram padronizadas em 10 vezes a dose utilizada em gestantes, proporcionalmente ao peso dos animais. Foram avaliados sete grupos, incluindo o controle, contendo 10 ratas por grupo. O início do experimento foi o dia zero da prenhez e as cesarianas realizadas no 21o dia, após decapita o, sendo os fetos contados e pesados. Procedeu-se a dosagens de glicemia, insulina, glucagon e lactato no 21o dia. Avaliou-se também o peso do tecido adiposo retroperitoneal. Os dados foram analisados utilizando-se o teste t de Student para a análise estatística. RESULTADOS: os grupos tratados com 3TC, AZT + 3TC e AZT + 3TC + NFV demonstraram altera es com a redu o das médias de ganho de peso materno diário, do peso da gordura retroperitoneal e peso das crias (grupo controle: 6,2 g; grupos contendo 3TC: 4,1 a 5,6 g), bem como dos valores de lactato (grupo controle: 5,8 mmol/mL; grupos contendo 3TC: 3,2 a 3,7 mmol/mL), quando comparados ao controle. Todos os grupos tratados com drogas anti-retrovirais apresentaram redu o significativa do número de fetos por ninhada (grupo controle: 14,7; grupos medicamentos: 11,1 a 12,7) e dos valores séricos de insulinemia (grupo controle: 6,2 μUI/mL; grupos medicamentos: 2,1 a 2,7 μUI/mL) e eleva o da glucagonemia (grupo controle: 88,2 pg/mL; grupos medicamentos: 99,7 a 120,7 pg/mL). N o houve diferen as estatisticamente significantes entre o grupo controle e tratados nos valores de glicemia. CONCLUS ES: o uso de anti-retrovirais em ratas prenhes causa interferência no metabolismo glicídico dos animais durante o período de prenhez, provocando significativa redu o do número das crias. Observou-se que o uso do 3TC resultou em menor ganho de peso materno e das crias, redu o de insulina e lactato e eleva o do glucagon.
Intolerancia glicêmica e o prognóstico perinatal em gestantes utilizando anti-retrovirais
Duarte Geraldo,El Beitune Patrícia,Figueiró-Filho Ernesto Antonio,Quintana Silvana Maria
Revista Brasileira de Ginecologia e Obstetrícia , 2004,
Abstract:
Controle de polidramnio recorrente em gestante portadora do HIV-1: relato de caso
Duarte Geraldo,Figueiró-Filho Ernesto Antonio,El Beitune Patrícia,Quintana Silvana Maria
Revista Brasileira de Ginecologia e Obstetrícia , 2004,
Abstract: A redu o da transmiss o vertical (TV) do vírus da imunodeficiência humana tipo 1 (HIV-1) utilizando a profilaxia com a zidovudina (AZT) representa significativo avan o na assistência pré-natal e obstétrica destas pacientes. Condutas obstétricas invasivas s o contra-indicadas em gestantes portadoras do HIV-1, em face do risco de aumento da taxa de TV deste vírus. Os autores relatam um caso de polidramnio recorrente em gestante portadora do HIV-1, que exigiu drenagem por amniocentese. Foram realizadas quatro pun es ao longo da gesta o, na 23a, 26a, 27a e 29a semanas, todas guiadas por ultra-sonografia, drenando, respectivamente, 1.800, 1.450, 1.700 e 1.960 mL de líquido amniótico claro em cada pun o. Com 30 semanas e 5 dias de gesta o a paciente apresentou trabalho de parto pré-termo, evoluindo para parto vaginal de recém-nato (RN) pesando 1.690 g e medindo 43 cm. O RN evoluiu com diagnóstico de nefropatia perdedora de sódio, tendo três aferi es de rea o em cadeia de polimerase para HIV-1 negativas. Os autores ilustram uma op o no manejo de situa es que envolvam gestantes portadoras do HIV-1 que necessitem de procedimentos obstétricos invasivos, utilizando AZT endovenoso (2 mg/kg) previamente ao procedimento, medida que apresentou excelente resultado no caso descrito, evitando a infec o perinatal pelo HIV-1.
O uso de anti-retrovirais em gestantes modifica o perfil lipídico?
El Beitune, Patrícia;Duarte, Geraldo;Santos, José Ernesto dos;Quintana, Silvana Maria;Figueiró-Filho, Ernesto Antonio;Marcolin, Alessandra Cristina;
Revista Brasileira de Ginecologia e Obstetrícia , 2003, DOI: 10.1590/S0100-72032003000800008
Abstract: purpose: to investigate the effect of antiretroviral drugs on the lipid metabolism in hiv-infected pregnant women. methods: a prospective study was conducted on 57 pregnant women. the women were divided into three groups: zdv group, consisting of 20 hiv-infected women taking zdv; tt group, consisting of 25 hiv-1-infected women on triple antiretroviral treatment (zdv + 3tc + nfv), and control group, consisting of 12 pregnant women considered to be normal from a clinical and laboratory viewpoint. demographic and anthropometric data were homogeneous. patients with a personal and family history of hyperlipidemia were excluded. blood samples were obtained for the determination of fasting lipids (total cholesterol, ldl and hdl, and triglycerides) at four periods during pregnancy (1st = 14-20 weeks; 2nd = 21-26 weeks; 3rd = 27-32 weeks and 4th = 33-38 weeks). data were analyzed statistically using the nonparametric c2, friedman and kruskal-wallis tests . results: the use of antiretroviral drugs during pregnancy induced no difference in total or hdl cholesterol but caused an increase from 76.5 and 84 mg/dl to 96 and 105 mg/dl in the concentration of the ldl fraction along gestation in zdv and tt groups, respectively (p<0.01). a positive significant association was observed between triglycerides and viral burden in the zdv group (r: 0.534; p=0.015). conclusion: antiretroviral agents during pregnancy increase serum ldl-colesterol levels. the risk of pregnancy regarding potentiation of long-term antiretroviral effects on lipid metabolism, remains to be established.
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