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Search Results: 1 - 10 of 99 matches for " Ercole Brusamolino "
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THE RISK OF THERAPY-RELATED MYELODYSPLASIA/ACUTE MYELOID LEUKEMIA IN HODGKIN LYMPHOMA HAS SUBSTANTIALLY DECREASED IN THE ABVD ERA ABOLISHING MECHLORETHAMINE AND PROCARBAZINE AND LIMITING VOLUMES AND DOSES OF RADIOTHERAPY
Ercole Brusamolino,Manuel Gotti,Valeria Fiaccadori
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Patients with Hodgkin lymphoma treated with DNA-breaking alkylating agents such as mechlorethamine and procarbazine in the MOPP regimen and with topoisomerase II inhibitors, such as etoposide did show a long-term risk of developing therapy-related myelodysplasia and acute myelogenous leukaemia (MDS/AML). With the introduction of the ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) regimen, this risk has substantially been reduced. In this review, different experiences are discussed to determine whether and how modifications of treatment in different cohorts of patients have reduced the overall risk of secondary MDS/AML. These data are drawn from large cohorts of patients treated over time with different therapies with an adequate follow-up.
Da Fiume a Fogna. Il fiume e lo smaltimento dei rifiuti nelle città europee tra tardo medioevo e prima età contemporanea
Ercole Sori
Revista Theomai , 2001,
Abstract: Este ensayo describe, desde una perspectiva eco-histórica, la compleja relación entre las ciudades y sus ríos en la experiencia urbana europea de la época moderna y contemporánea. Explora la red urbana hidráulica, su contaminación y su recarga durante la difícil transición del poblado tradicional de matriz hidraúlica estática a una de tipo dinámico, como resultado de las innovaciones tecnológicas de la revolución industrial. También se exploran las crisis del sistema así como las soluciones adoptadas, teniendo a las ciudades de París y Londres como paradigmas.
An inverse iteration method for obtaining q-eigenpairs of the p-Laplacian in a general bounded domain
Grey Ercole
Mathematics , 2015,
Abstract: Let $\Omega$ be a bounded and smooth domain of $\mathbb{R}^{N}$, $N\geq2$, and consider the eigenvalue problem: $-\Delta_{p}u=\lambda\left\Vert u\right\Vert _{L^{q}(\Omega)}^{p-q}\left\vert u\right\vert ^{q-2}u$ in $\Omega,$ $u=0$ on $\partial\Omega,$ where $p>1$, $1\leq q
Absolute continuity of the best Sobolev constant of a bounded domain
Grey Ercole
Mathematics , 2012, DOI: 10.1016/j.jmaa.2013.03.044
Abstract: Let $\lambda_{q}:=\inf{\Vert\nabla u\Vert_{L^{p}(\Omega)}^{p}/\Vertu\Vert_{L^{q}(\Omega)}^{p}:u\in W_{0}^{1,p}(\Omega)\setminus{0}} $, where $\Omega$ is a bounded and smooth domain of $\mathbb{R}^{N},$ $1
On the resonant Lane-Emden problem for the p-Laplacian
Grey Ercole
Mathematics , 2012, DOI: 10.1142/S0219199713500338
Abstract: We study the positive solutions of the Lane-Emden equation $-\Delta_{p}u=\lambda_{p}|u|^{q-2}u$ in $\Omega$ with homogeneous Dirichlet boundary conditions, where $\Omega\subset\mathbb{R}^{N}$ is a bounded and smooth domain, $N\geq2,$ $\lambda_{p}$ is the first eigenvalue of the $p$-Laplacian operator $\Delta_{p}$ and $q$ is close to $p>1.$ We prove that any family of positive solutions of this problem converges in $C^{1}(\bar{\Omega})$ to the function $\theta_{p}e_{p}$ when $q\rightarrow p,$ where $e_{p}$ is the positive and $L^{\infty}$-normalized first eigenfunction of the $p$-Laplacian and $\theta_{p}:=\exp(|e_{p}|_{L^{p}(\Omega)}^{-p}\int_{\Omega}e_{p}% ^{p}|\ln e_{p}|dx).$ A consequence of this result is that the best constant of the immersion $W_{0}^{1,p}(\Omega)\hookrightarrow L^{q}(\Omega)$ is differentiable at $q=p.$ Previous results on the asymptotic behavior (as $q\rightarrow p$) of the positive solutions of the non-resonant Lane-Emden problem (i.e. with $\lambda_{p}$ replaced by a positive $\lambda\neq\lambda_{p}$) are also generalized to the space $C^{1}% (\bar{\Omega})$ and to arbitrary families of these solutions. Moreover, if $u_{\lambda,q}$ denotes a solution of the non-resonant problem for an arbitrarily fixed $\lambda>0,$ we show how to obtain the first eigenpair of the $p$-Laplacian as the limit in $C^{1}(\bar{\Omega}),$ when $q\rightarrow p$, of a suitable scaling of the pair $(\lambda,u_{\lambda,q}).$ For computational purposes the advantage of this approach is that $\lambda$ does not need to be close to $\lambda_{p}.$ Finally, an explicit estimate involving $L^{\infty}$ and $L^{1}$ norms of $u_{\lambda,q}$ is also deduced using set level techniques.
Catastrophes et disparités de développement dans le Bassin cara be
Robert d’Ercole
Mappemonde , 2003,
Abstract: L’article met en relation le bilan des catastrophes survenues dans le Bassin cara be durant la période 1972-2001 avec le niveau de développement des différents pays de la région. La relation est globalement forte. Certaines distorsions sont néanmoins observables, pour lesquelles des interprétations sont proposées.
FEASIBILITY IN MULTIPLE OBJECTIVES FACTIBILIDAD EN OBJETIVOS MúLTIPLES FACTIBILIDAD EN OBJETIVOS MúLTIPLES
Raúl Alberto Ercole
Revista Universo Contábil , 2007,
Abstract: In general, organizations establish different objectives. Singleness in the organizational goal is not common. The objectives can be, without a doubt, ordered hierarchically, and thus originate a need to find appropriate answers to a planning model that contemplates, justly, variety of objectives to be attempted at somehow, but, repeatedly, the enhancement of one leads to the detriment of another or other ones. In this article, we present a model –among so many feasible to be analyzed - which allows to carry out planning for multiple objectives prioritized by some criterion of the organization, in this specific case, a micro enterprise of manufacturing a new product. It is in that part that the application of quantitative methods of management can constitute a valuable tool for an appropriate planning. Particularly, mathematical programming (linear, non-linear, integral, of goals) is an example of concrete application of a prescriptive model (that tries to optimize the solution) in a case of multiple objectives planning. The last part of the study considers an example of application of the technique described for an enterprise in which one wants to maximize one’s participation in the market and one’s monthly use (objectives in conflict), with an additional series of restrictions and goals, and having as variables of decision on price, investment in marketing, the policy for sales financing and the mixture of raw materials of different qualities. The conclusion emphasizes the importance of quantitative methods for management to reach a solution that contemplates the proposed objectives in the best possible way. Keywords: Feasibility. Objectives. Programming. Enterprise. En general las organizaciones se plantean distintos objetivos. No es común la unicidad en la meta organizacional. Podrán, sin duda, jerarquizarse los objetivos, y de allí la necesidad de encontrar respuestas adecuadas a un modelo de planeamiento que contemple, justamente, variedad de objetivos que de alguna manera se intentan cumplir pero que en reiteradas oportunidades el acrecentamiento de uno lleva consigo el desmedro de otro u otros. El objetivo del presente trabajo es presentar un modelo - entre los tantos que sería factible analizar - que permita efectuar el planeamiento de múltiples objetivos priorizados con algún criterio de la organización, en este caso un micro emprendimiento de fabricación de un nuevo producto. Es en esta parte en donde la aplicación de métodos cuantitativos de gestión puede aportar una valiosa herramienta para una planificación adecuada. Más concretamente, la p
Représentations cartographiques des facteurs de vulnérabilité des populations exposées à une menace volcanique. Application à la région du volcan Cotopaxi (Equateur)
Ercole, Robert D'
Bulletin de l'Institut Francais d'études Andines , 1996,
Abstract: Suivant une définition sociale, la vulnérabilité est la propension plus ou moins prononcée à subir des dommages. L atténuation des risques naturels auxquels les hommes sont confrontés suppose la réduction de la vulnérabilité en matière de vies humaines, de biens et d activités. Il s agit au préalable d identifier les facteurs de vulnérabilité, d en mesurer la portée, et de localiser dans l espace les secteurs les plus sensibles. La cartographie de la vulnérabilité et de ses facteurs est une étape indispensable vers une cartographie globale du risque à laquelle de nombreux chercheurs et décideurs aspirent. à partir de l exemple des régions des provinces du Pichincha et du Cotopaxi exposées aux conséquences de l activité du volcan Cotopaxi, l article propose quelques jalons méthodologiques pour une cartographie de la vulnérabilité des populations menacées. Des typologies spatiales de vulnérabilité sont représentées à partir d une analyse factorielle. La carte intégrée des facteurs de vulnérabilité permet la réalisation de diagnostics locaux, tandis qu une troisième carte fournit des orientations pour des actions de préparation. Une réflexion est également menée sur l intérêt et sur les limites d utilisation de ces cartes. CARTOGRAFíA DE LOS FACTORES DE VULNERABILIDAD DE LAS POBLACIONES EXPUESTAS A UNA AMENAZA VOLCáNICA. APLICACIóN A LA REGIóN DEL VOLCáN COTOPAXI (ECUADOR). Según una definición social, la vulnerabilidad es la propensión más o menos pronunciada a sufrir perjuicios cuando ocurre un fenómeno natural destructor. La mitigación de los riesgos naturales que enfrentan los hombres supone la reducción de la vulnerabilidad de éstos, de sus bienes y actividades económicas. Se trata previamente de identificar los factores de vulnerabilidad, medir sus consecuencias y localizar los sectores más sensibles. La cartografía de la vulnerabilidad y sus factores constituye una etapa indispensable para una cartografía global del riesgo, la cual buscan los científicos y los tomadores de decisiones. Basado sobre el ejemplo de los sectores amenazados por el volcán Cotopaxi en las provincias de Pichincha y Cotopaxi, el artículo presenta algunos métodos de cartografía de la vulnerabilidad poblacional. Apoyándose en un análisis factorial, los tipos espaciales de vulnerabilidad están representados en un primer mapa. El segundo, al integrar los factores de vulnerabilidad permite un diagnóstico sector por sector, mientras el tercer mapa propone algunas recomendaciones en cuanto a la preparación de la población. Se discute también el interés, los límites y el uso de estos
A quasilinear problem in two parameters depending on the gradient
Hamilton Bueno,Grey Ercole
Mathematics , 2010,
Abstract: The existence of positive solutions is considered for the Dirichlet problem \[ \left\{ \begin{array} [c]{rcll}% -\Delta_{p}u & = & \lambda\omega_{1}(x)\left\vert u\right\vert ^{q-2}% u+\beta\omega_{2}(x)\left\vert u\right\vert ^{a-1}u|\nabla u|^{b} & \text{in }\Omega\\ u & = & 0 & \text{on }\partial\Omega, \end{array} \right. \] where $\lambda$ and $\beta$ are positive parameters, $a$ and $b$ are positive constants satisfying $a+b\leq p-1$, $\omega_{1}(x)$ and $\omega_{2}(x)$ are nonnegative weights and $1
Solutions of the Cheeger problem via torsion functions
Hamilton Bueno,Grey Ercole
Mathematics , 2010, DOI: 10.1016/j.jmaa.2011.03.002
Abstract: The Cheeger problem for a bounded domain $\Omega\subset\mathbb{R}^{N}$, $N>1$ consists in minimizing the quotients $|\partial E|/|E|$ among all smooth subdomains $E\subset\Omega$ and the Cheeger constant $h(\Omega)$ is the minimum of these quotients. Let $\phi_{p}\in C^{1,\alpha}(\bar{\Omega})$ be the $p$-torsion function, that is, the solution of torsional creep problem $-\Delta_{p}\phi_{p}=1$ in $\Omega$, $\phi_{p}=0$ on $\partial\Omega$, where $\Delta_{p}u:=\operatorname{div}(|\nabla u|^{p-2}\nabla u)$ is the $p$-Laplacian operator, $p>1$. The paper emphasizes the connection between these problems. We prove that $\lim_{p\rightarrow1^{+}}(\|\phi_{p}\|_{L^{\infty}(\Omega)})^{1-p}=h(\Omega)=\lim_{p\rightarrow1^{+}}(\|\phi_{p}\|_{L^{1}(\Omega)})^{1-p}$. Moreover, we deduce the relation $\lim_{p\to1^{+}}\|\phi_{p}\|_{L^{1}(\Omega)}\geq C_{N}\lim_{p\to1^{+}}\|\phi_{p}\|_{L^{\infty}(\Omega)}$ where $C_{N}$ is a constant depending only of $N$ and $h(\Omega)$, explicitely given in the paper. An eigenfunction $u\in BV(\Omega)\cap L^{\infty}(\Omega)$ of the Dirichlet 1-Laplacian is obtained as the strong $L^{1}$ limit, as $p\rightarrow1^{+}$, of a subsequence of the family $\{\phi_{p}/\|\phi_{p}\|_{L^{1}(\Omega)}\}_{p>1}$. Almost all $t$-level sets $E_{t}$ of $u$ are Cheeger sets and our estimates of $u$ on the Cheeger set $|E_{0}|$ yield $|B_{1}|h(B_{1})^{N}\leq |E_{0}|h(\Omega)^{N},$ where $B_{1}$ is the unit ball in $\mathbb{R}^{N}$. For $\Omega$ convex we obtain $u=|E_{0}|^{-1}\chi_{E_{0}}$.
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