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Search Results: 1 - 10 of 144417 matches for " Ensani F "
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Pathologic study of thyroid nodules in children and young adult population up to 20 years, in cancer institute-Emam Khomeini Medical Complex during the years 1973 to 1997
Ensani F,Mozaffari K
Tehran University Medical Journal , 2001,
Abstract: Nodules in the thyroid have always commanded a great deal of attention because of the fear of their being cancerous. The estimated incidence of thyroid nodules in children and young adults is about 0.22 to 1.8 percent. According to different epidemiological data, about 10 to 35 percent of thyroid cancers occur in the first two decades. The present study based on microscopic review of tissue slides obtained from thyroid nodules in cancer institute during 24 years focusing on malignant lesions in the mentioned age group revealed the following results: The average age of patients was 16.5. The female to male ratio is about 3.3/1 (76.7 percent female and 23.3 percent male). About 84 percent of thyroid nodules were benign with the following incidence of different morphologic features: nodular goiter 78.6 percent, follicular adenoma 1.96 percent, 16 percent of thyroid nodules were malignant with the following incidence of different morphologic variants: papillary CA 91.3 percent, follicular CA 3.5 percent and medullary CA 5.2 percent. Papillary carcinoma as the predominant from of thyroid cancer was accompanied by unilateral cervical lymph node metastasis in 53.8 percent of cases and distant metastasis (to lung) just in one case. According to major variation of papillary carcinoma, we found the classic type in 33 cases, the follicular variant in 18 cases and micro carcinoma in one case. Based on the above results once again we reach this belief that every thyroid nodule especially in children and young adults demands careful appraisal.
Nasopharyngeal carcinoma: The role of immunohistochemistry and electron microscopy in differentiation between undifferentiated carcinoma and malignant lymphoma: Report of 10 cases and review of literature
Ensani F,Karimi Sh
Acta Medica Iranica , 2000,
Abstract: Undifferentiated nasopharyngeal corcinoma is frequently misdiagnosed as large cell malignant lymphoma. The aim of this study is to evaluate the diagnostic role of immunohistochemistry and electron microscopy in this tumor. 81 cases of nasopharyngeal carcinoma were studied. Patients ranged from 9-90 years in age (mean: 48.5 years). The age incidence curve was bimodal with two peaks in 2-3 and 5-6 upper cervical mass was the first manifestation of the tumor in the majority (87.6%) of cases. Microscopically most o tumors were undifferentiated nasopharyngeal carcinoma, Who type III. Differentiation between undifferentiated nasopharygeal carcinoma and malignant lymphoma, large cases cell type was not possible in 12. Ten of these cases were chosen for immunohistochemical and electron microscopy studies.In our cases cytoplasmic reactivity for cytokeratin and/or epithelial membrane antigen was persent. These tumors possessed desmosomes and tonofilaments in eletron microscopy.While in malignant lymphoma (three cases) tumor cells had leukocytic common antigen remaining. They were discohesive and had irregular nuclei. In the cases, the studies were inconclusive
Comparison of endometrial biopsy by PIPELLE with diagnostic curretage in patients with abnormal utrine bleeding, Imam Khomeini Hospital
Ghaemmaghami F,Ensani F,Bigdely H
Tehran University Medical Journal , 1999,
Abstract: It this prospective cross sectional study out-patient endometrial biopsy by PIPELLE was compared with diagnostic curretage (D&C) in patients suffering of Abnormal Uterine bleeding (AUB). Diagnostic accuracy, sufficient tissue sampling, intensity of pain and effective factors in biopsy results were the evaluated parameters in this study. In 70 patients with complaint of AUB (20 of them were post-menoupsal age admitted in hospital for D&C) endometrial biopsy was conducted by PIPELLE before operation and the results were compared. 96% of total patients (67) and 91% of patients with post menopause age had tolerance of undergoing out-patient PIPELLE biopsy of endometrium. 79% of these individuals complained of mild pain and 21% of moderate pain. Endometrium biopsy by PIPELLE in 77% of patients had similar accurate diagnostic results as compared to D&C. PIPELLE in 34% of patients (24) could not be conducted with the same accuracy of D&C patients, although in 14 (20%) of them, notissue samples could be collected by D&C. In none of these methods endometrial hyperplasia or endometrial cancer were detected. This study showed that in 77% of the total patients, the extra cost and general anesthetical risk of D&C could have been eliminated, by utilization of out-patient biopsy with PIPELLE
What is Your Diagnosis?
A. Khodayari Namin,Sanam Mirbeigi,F. Ensani
Iranian Journal of Radiology , 2012,
Abstract:
"EVALUATION OF THE EFFECTS OF BIOLOGICAL PROGNOSTIC AND PREDICTIVE FACTORS ON SURVIVAL OF BREAST CANCER PATIENTS "
F. Ensani,N. Hajsadeghi,F. Amoozegar-Hashemi P. Haddad
Acta Medica Iranica , 2007,
Abstract: The molecular basis of metastatic potential of human breast carcinoma cells can be useful information to determine the practical implications in the diagnosis, determining prognosis and treatment of breast cancer. The aim of this study was to identify predictors of aggressive biological behavior and metastatic potential in breast carcinoma among a number of intrinsic biomarkers of tumor cells. We used routine formalin fixed, paraffin embedded tumor samples; sections were stained immunohistochemically to determine the expression of estrogen receptor (ER), progesterone receptor (PR), HER2/neu, Ki67, p53 and cathepsin D in 66 breast carcinoma patients. The result of the quantitative immunohistochemical assays were correlated with clinical and histological data such as patient age, tumor size, axillary lymph node status, tumor grade, the therapeutic regimens and survival rates. Univariate analysis revealed a statistically significant relation between tumor size and overexpression of p53, and between tumor grade and PR status, p53 status and Ki67. In multivariate analysis the independent factors predicting for tumor grade were Ki67 and PR status. Among patients with ER expression, negative p53 or Ki67 status, tumors with lower grades and negative axillary lymph nodes (or < 4 involved lymph nodes), there was a higher survival rate (either disease free or overall); however, relationship was not statistically significant, most probably due to the low number of studied patients. In conclusion, Ki67 was an independent factor to predict tumor grade in our study; the use of this proliferation activity marker in routine approach to patients with breast cancer is recommended, at least to evaluate the accuracy of tumor grading by mitotic count.
Immunohistochemical expression of progesterone receptors in adenoid cystic carcinoma and pleomorphic adenoma of salivary glands
Eslami M,Eshghyar N,Ensani F,Seifi S
Journal of Dental Medicine , 2006,
Abstract: Background and Aim: The hormone receptor status in breast cancer has been pivotal in determining the likelihood of response to hormonal manipulation. Tumors which are both estrogen and progesterone receptor positive are much more likely to respond to anti-hormone therapy than negative tumors. There is well-established similarity between breast tissue and salivary glands. The aim of this study was to evaluate the progesterone receptor expression in pleomorphic adenoma and adenoid cystic carcinoma of salivary glands. Materials and Methods: In this descriptive study, immunohistochemical staining with progesterone antibody was performed on 14 pleomorphic adenoma (PA) and 15 adenoid cystic carcinoma (ACC) paraffin blocks. The percentage of positive cells was determined using an eye piece graticule. Immunoreactivity was categorized as either positive (reactivity more than 5%) or negative (reactivity less than 5%). In addition the existence of progesterone receptor in tumor cells, stromal cells (fibroblasts), inflammatory cells and salivary glands around tumors was evaluated. Data were analyzed with T and Mann Whitney U tests with p<0.05 as the limit of significance. Results: Immunohistochemical staining for progesterone receptor was negative in 15 ACC and 13 PA. Only one case of PA showed immunoreactivity for progesterone receptor. Also, 12 normal salivary glands around tumor were positive. Inflammatory cells, endothelial cells and fibroblasts did not show immunoreactivity in most cases. Conclusion: The results indicate the lack of progesterone receptor expression in ACC and PA of salivary glands.
Histologic Findings Of Uterine Cervix Among Women With Cytologic Diagnosis Of ASCUS (Atypical Squamous Cells Of Undetermined Significance)
Ghaem Maghami F,Ensani F,Behtash N,Hosseini Nejad S E
Tehran University Medical Journal , 2004,
Abstract: Background: The aim of this investigation is to evaluate the histologic results of biopsy in women with atypical squamous cells of undetermined significance (ASCUS) cytologic diagnosis. Materials and Methods: We reviewed a series of cases with ASCUS pap smears from March 1999 to Feb 2002 in Imam Khomeini Hospital (n= 104), Who had cervical biopsy indirected colposcopy (103) and in Onec endocervical biopsy obtained without colposcopy. In 60 patients before colposcopy and biopsy repeat pap smear was tabled. Results: Biopsy revealed 28.8% SIL (14 LSIL and 16 HSIL), 1 invasive carcinoma and 1 endometrial carcinoma. Pap smear repeated for 60 women before colposcopy examination, which 7 (11.7%) of them were normal. ASCUS persisted in 45 cases (75%) and 8 cases (13.3%) turned out to be SIL (6 LSIL, 2 HSIL) of 7 normal repeat smear, 2 marked as LSIL by biopsy. In colposcopic examination 22 of 103 (21.4%) had normal view which one of them was LSIL histologically. Conclusion: Based on these findings, it seems immediate colposcopy and directed biopsy are appropriate procedures for management of ASCUS and to detect underlying SIL.
DIAGNOSTIC RELEVANCE OF AgNOR IN OVARIAN SEROUS BORDERLINE TUMORS
Ali Zare Mehrjardi,Fereshteh Ensani
Acta Medica Iranica , 1995,
Abstract: Nucleolar organizer regions are loops a/nuclear DNA related to ribosomal DNA, and their number in cells is believed to indicate cellular proliferative activity. Using_a silver staining methodto visualize thesestructures inparaffin embeddedtissue sections, an attempt was made to determine ifthese AgNOR counts could be used as a diagnostic toolfor serous borderline tumors of the ovary. Ten cases in each group a/benign, borderlineand malignantserous ovarian tumorswereselectedand themean numberofAgNORwas determined in all cases. A progressive increase in mean AgNORvalues was naedfrom the benign l oup towards the borderlinegroup and further to the carcinomagrOUPi the differences between the means in. each gr~Uwere statistically significant However, there was a high ee of overlap between the values ofthe borderline and . ant groups. Theseresults indicatethat AgNORcountsmaynot"nbe very useful as a diagnostic tool in an individual case.
Evaluating the Relationship between the Banking System Stability and the Internal Capital Adequacy Assessment Process: Evidence from the Egyptian Banking Sector  [PDF]
Karim F. F. Mohamed
Journal of Financial Risk Management (JFRM) , 2018, DOI: 10.4236/jfrm.2018.74020
Abstract: In the repercussions of the latest financial crisis that have occurred on the years 2008-2009, to fortify the stability of the banking systems, policy makers, and the Basel Committee on Banking Supervision—BCBS, together with national regulators have built up a few safety measures, and structures to guarantee that banks establishments keep up adequate capital levels through using risk management tools, in specific the Internal Capital Adequacy Assessment Processes (ICAAP). They all have called for thorough evaluations and assessments for the structure and components of risk management frameworks, tools, and practices whether by banks, regulators, analysts and risk management experts consistently, to ascertain the adequacy of the banking systems, policies, arrangements and techniques for overseeing risks, and guaranteeing the sufficiency of holding appropriate capital levels for confronting normal, as well as adverse and unexpected situations or emergencies. The main objectives of this research study are to shed the light on the ICAAP as one of the main keys of risk management programs, a process by which banks can use to ensure that they operate with an appropriate level of capital, forward looking processes for capital planning covering a broad range of risks across banks, activities beyond simple capital management, and bring together risk and capital management activities in a form that can be used to support business decisions. The research study shall evaluate the significant relationship between the Banking System Stability (dependent variable) and the Internal Capital Adequacy Assessment Process (ICAAP—independent variable) with evidence from the Egyptian Banking Sector.
Creation and Analysis of Earth’s Surface Roughness Maps from Airborne LiDAR Measurements in Downtown Urban Landscape  [PDF]
Fahmy F. F. Asal
Journal of Geographic Information System (JGIS) , 2019, DOI: 10.4236/jgis.2019.112015
Abstract: The Earth’s surface roughness constitutes an important parameter in terrain analysis for studying different environmental and engineering problems. Authors gave different definitions and measures for the earth’s surface roughness that usually depend on exploitation of digital elevation data for its reliable determination. This research aimed at exploring the different approaches for defining and extraction of the Earth’s surface roughness from Airborne LiDAR Measurements. It also aimed at evaluating the effects of the window size of the standard deviation filter on the created roughness maps in downtown landscapes using three known approaches namely; standard deviation filtering of the Digital Elevation Model (DEM), standard deviation filtering of the slope gradient model and standard deviation filtering of the profile curvature model. In this context, different roughness maps have been created from Airborne LiDAR measurements of the City of Toronto, Canada using the three filtering approaches with varying window sizes. Visual analysis has shown color tones of small roughness values with smooth textures dominate the roughness maps from small window sizes of the standard deviation filter, however, increasing the window sizes has produced wider variations of the color tones and rougher texture roughness maps. The standard deviations and ranges of the roughness maps from LiDAR DEM have increased due to increasing the filter window size while the skewness and kurtosis have decreased due to increasing the window size, indicating that the roughness maps from larger window sizes are statistically more symmetrical and more consistent. Thus, kurtosis has decreased by 53% and 82% due to increasing the window size to 7 × 7 and 15 × 15 respectively. The standard deviations of the roughness maps from the slope gradient model have increased due to increasing the window size till 15 × 15 while they have decreased with more increases. However, skewness has decreased due to increasing the window size till 15 × 15 and the kurtosis has decreased with higher rate till window size of 11 × 11. In the roughness maps from the profile curvature model, the ranges and skewness have decreased by 93.6% and 82.6% respectively due to increasing the window size to 15 × 15 while, kurtosis has decreased by 58.6%, 76.3% and 93.76% due to increases in the filter window size to 5 × 5, 7 × 7 and 15 × 15 respectively.
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