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Search Results: 1 - 10 of 8771 matches for " Enrique Villegas "
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Síndrome X vs síndrome metabolico: Entendiendo sus coincidencias y sus diferencias hacia una "nueva cardiología"
Morales Villegas, Enrique;
Archivos de cardiología de México , 2006,
Abstract: himsworth in 1939 postulated that diabetes mellitus type 2 (dm2) was not only an insulin deficiency state but also a cellular insulin insensitivity disease. thirty years later, defronzo and reaven demonstrated that insulin resistance (ir) preceded and predisposed for dm2 and atherosclerotic-cardiovascular-disease (acvd). reaven was the first to point out the relationship between ir and with hyperglycemia, dyslipidosis, and hypertension as mediators for acvd, creating the concept of syndrome x (sx) in 1988. who and, thereafter, other medical societies and medical groups, mainly atp-iii, in 2002, based on the difficulty of diagnosing ir in a simple, reliable, and inexpensive way, proposed and published the metabolic syndrome (ms) concept, as a group of five variables, i.e., obesity, hyperglycemia, hypertriglyceridemia, low hdl, and hypertension, as an easy clinical approximation to suspect and treat an increased cardiometabolic risk. nowadays, there are deep and extensive controversies on this issue; however, these controversies do not really exist since all discordant points of view are rather quantitative and not qualitative in nature. this article is aimed at differentiating and harmonizing the complementary concepts of sx and ms, at analyzing why ms is a good "clinical window" to lookfor ir and its underlying manifestations, and finally to accept that the ms concept complements, but does not substitute or antagonize, traditional scales used to asses cardiovascular risk, such as the framingham scale.
Statins: Cardiovascular Risk Reduction in Percutaneous Coronary Intervention—Basic and Clinical Evidence of Hyperacute Use of Statins
Enrique C. Morales-Villegas,Germano Di Sciascio,Carlo Briguori
International Journal of Hypertension , 2011, DOI: 10.4061/2011/904742
Abstract: Reduction of LDL-cholesterol concentration in serum, blocking the isoprenylation of GTPases and the activation of myocyte-protective enzyme systems are three mechanisms that currently explain the lipid and non-lipid effects of statins. However, the decrease of LDL-cholesterol, the reduction of inflammation biomarkers and even the atheroregresion, as surrogate effects to the mechanisms of action of statins would be irrelevant if not accompanied by a significant decrease in the incidence of cardiovascular events. Statins like no other pharmacological group have proven to reduce the incidence of cardiovascular events and prolong life in any clinical scenario. This article review the basic and clinical evidence that support a new indication for HMG-CoA reductase inhibitors “pharmacological myocardial preconditioning before anticipated ischemia” or hyperacute use of statins in subjects with any coronary syndrome eligible for elective, semi-urgent or primary percutaneous coronary intervention: ARMYDA-Original, NAPLES I-II, ARMYDA-ACS, ARMYDA-RECAPTURE, Non-STEMI-Korean, Korean-STEMI trials.
Análisis de razones financieras en la empresa lechera intensiva: un estudio de caso en el altiplano mexicano
Enrique Villegas Valladares,José Luis Dávalos Flores
Veterinaria México , 2005,
Abstract: En un ambiente de competitividad intensifi cado por la globalización, los márgenes de utilidad tienden a decrecer. Esta circunstancia hace que el análisis de la información fi nanciera tenga especial importancia para la toma de decisiones estratégicas. El propósito de esta investigación es contribuir a la construcción de nuevas referencias para comparar y evaluar el desempe o de empresas lecheras. Con el fi n de alcanzar este propósito se utilizó el método de estudio de caso, a partir del análisis de ocho a os de información fi nanciera de una empresa lechera localizada en el centro de México, que está integrada vertical y horizontalmente, con un sistema de producción estabulado, mil vacas en línea y autosufi ciencia forrajera de 40%. Se emplearon los estados fi nancieros: Posición fi nanciera y de resultados, y se construyeron 22 razones, agrupadas en cuatro categorías: liquidez, apalancamiento, administración de los activos y rentabilidad. Entre los principales resultados destacan que la empresa cuenta con capacidad de pago a corto y largo plazos, fi nancia su operación principalmente con recursos propios, debido a que fue forzada a reducir su deuda como consecuencia de la crisis económica de México posterior a la devaluación del peso en 1994. Las razones que miden la administración de activos muestran que la empresa fi nancia a sus clientes, pero sus proveedores no lo hacen con ella. Los indicadores de rentabilidad presentan razones bajas con tendencia decreciente, lo cual coincide con la implantación del Tratado de Libre Comercio para América del Norte. Al realizar el trabajo se detectó la necesidad de generar información histórica fi nanciera, que permita hacer comparaciones por sector y tama o para llegar a conclusiones contundentes.
Statins: Cardiovascular Risk Reduction in Percutaneous Coronary Intervention—Basic and Clinical Evidence of Hyperacute Use of Statins
Enrique C. Morales-Villegas,Germano Di Sciascio,Carlo Briguori
International Journal of Hypertension , 2011, DOI: 10.4061/2011/904742
Abstract: Reduction of LDL-cholesterol concentration in serum, blocking the isoprenylation of GTPases and the activation of myocyte-protective enzyme systems are three mechanisms that currently explain the lipid and non-lipid effects of statins. However, the decrease of LDL-cholesterol, the reduction of inflammation biomarkers and even the atheroregresion, as surrogate effects to the mechanisms of action of statins would be irrelevant if not accompanied by a significant decrease in the incidence of cardiovascular events. Statins like no other pharmacological group have proven to reduce the incidence of cardiovascular events and prolong life in any clinical scenario. This article review the basic and clinical evidence that support a new indication for HMG-CoA reductase inhibitors “pharmacological myocardial preconditioning before anticipated ischemia” or hyperacute use of statins in subjects with any coronary syndrome eligible for elective, semi-urgent or primary percutaneous coronary intervention: ARMYDA-Original, NAPLES I-II, ARMYDA-ACS, ARMYDA-RECAPTURE, Non-STEMI-Korean, Korean-STEMI trials. 1. Introduction The inhibitors of Hydroxy Methyl Glutaryl-Coenzyme A Reductase (I-HMG-CoA-R) or statins have become the cornerstone of drug therapy that aimed at reducing cardiovascular risk. Statins are the pharmacological group with the highest reduction power of the serum LDL cholesterol concentration, apart from other lipid and pleiotropic actions. Therefore, their therapeutic efficacy can be explained if we remember that LDL cholesterol modified by oxidation becomes an epitope, which provokes along with other endothelial-vascular lesion factors, a pathological sequence with atherosis, endothelial activation-dysfunction lesion, atherosclerosis, and atherothrombosis. Thus, statins have become the most important pharmacological weapon for cardiovascular risk reduction when associated to atherosclerosis. This paper reviews the most important pharmacological properties of statins, starting with new information on the mechanisms of action and effects that explain the reduction of LDL cholesterol concentration in serum, as well as nonlipid or pleiotropic effects. These basic concepts will be the foundations that will lead us to a better understanding of the impact of statins in new clinical applications, specially focusing on the role they play as reducers of Percutaneous Coronary Intervention (PCI) complications in individuals with stable and unstable coronary syndromes with and without ST segment elevation. 2. Statins: Mechanism of Action The first statin extracted from
Efficiency in vitro culture of Toxoplasma gondii in THP1 and Vero cell lines Eficiencia de cultivo in vitro de Toxoplasma gondii en las líneas celulares THP1 y Vero
Jorge Andrés Cuellar,Alejandro Hernández,Enrique Villegas,Jorge Enrique Gómez
Biomédica , 2012,
Abstract: Introduction. Cell culture is an important method to obtain Toxoplasma gondii for clinical diagnosis or biotechnological purposes. Objective. To determine the percentage of invasion and production of T. gondii in THP1 and Vero cell lines. Materials and methods. We determined the growth conditions for T. gondii in Vero and THP1 cell lines by counting in hemocytometer chamber. We determined the percentage of invasion of T. gondii in THP1 and Vero cells by flow cytometry in different cell/tachyzoite ratios: 1/5, 1/20, 1/50. We also calculated the growth performance index of T. gondii RH strain and CIBM1 isolate in THP1 cells. Results. Vero cells multiplied faster than the THP1 cells, showing an exponential and one sigmoidal growth curve respectively, within a period of 7 days. The CIBM1 isolate infected the THP1 cells in three different parasite concentrations: 1/5, 1/20 and 1/50, with invasion percentages in THP1 cells of 57.1%, 15.5% and 12.2% and for the Vero cells 25.3%, 17.8% and 8.8% respectively. The RH strain of T. gondii had the lowest invasion percentage with 32.6%, 14.8% and 8.1% in THP1 cells and 22.3%, 14.1% and 3.4% in Vero cells. Conclusions. The CIBM1 isolate had a higher yield than the RH strain of T. gondii in THP1 cells. THP1 cells are a good model to study invasion and for the assays of new pharmacological candidates against T. gondii. Introducción. El cultivo in vitro es un método importante para la obtención de Toxoplasma gondii con fines de diagnóstico clínico o biotecnológico. Objetivo. Determinar el porcentaje de invasión y producción de Toxoplasma gondii en las líneas celulares THP1 y Vero. Materiales y métodos. Se determinó la curva de crecimiento para las células Vero y THP1 por conteo en hemocitómetro. Posteriormente, se identificó el porcentaje de invasión de T. gondii en células THP1 y Vero por citometría de flujo, en diferentes proporciones célula / taquizoito de 1/5, 1/20, 1/50. Por otro lado, se calculó el índice de rendimiento de T. gondii cepa RH y del aislamiento CIBM1 en células THP1. Resultados. Las células Vero crecen más rápido que las células THP1 mostrando un crecimiento exponencial en un periodo de 7 días. El aislamiento CIBM1 infecta las células THP1 en tres proporciones diferentes de 1/5,1/20 y 1/50 con porcentajes de invasión de 57,1%, 15,5% y 12,2% y en células Vero de 25,3%, 17,8% y 8,8%. La cepa RH de T. gondii mostró porcentajes de invasión más bajos de 32,6%, 14,8% y 8,1% en células THP1 y de 22,3%, 14,1% y 3,4% en células Vero. Conclusiones. El aislamiento CIBM1 presentó mayor rendimiento con respecto a
Presentación general Comentarios sobre las diferentes secciones
María Cristina Villegas,Enrique Chaux,ángela María Estrada,Lina María Saldarriaga
Revista de Estudios Sociales , 2004,
Abstract:
Inmovilización de una peroxidasa de chayote [Sechium edule (jacq.) SW] y su potencial aplicación en la remoción de sustancias fenólicas en aguas contaminadas
María Lioba Osnelda Villegas Rosas,Gunther Geissler,Anabella Handal Silva,Enrique González Vergara
Revista internacional de contaminación ambiental , 2003,
Abstract: Se presenta la inmovilización de una peroxidasa obtenida a partir de chayote [Sechium edule (Jacq.) Sw] en un soporte funcionalizado adecuadamente y con activación previa, lo que impide que la enzima pierda sus propiedades catalíticas. También se realizaron estudios para demostrar su potencial aplicación en la descontaminación de aguas artificialmente contaminadas con sustancias fenólicas. Los resultados obtenidos muestran que una de las peroxidasas de chayote es inmovilizada con éxito en el soporte orgánico poliestireno-divinilbenceno funcionalizado con triglicina y activado con 1,1 carbonildiimidazol hasta valores alrededor de 100 %, sin perder su actividad de peroxidasa. El tratamiento de aguas artificialmente contaminadas con fenol, 2- metoxifenol ó 3-clorofenol, sujetas a la formación de sus polímeros mediada por peroxidasa en presencia de peróxido de hidrógeno, muestra que los porcentajes de remoción de estos contaminantes se encuentran entre 75 y 100 %, mientras que la eliminación de los polímeros, provenientes de fenol y 2-metoxifenol están entre 65 y el 80 % en el mismo ensayo mediante filtración. Con 3-clorofenol no se observó la formación de los polímeros y por lo tanto su efectividad no pudo ser determinada y requiere de una investigación subsecuente. La peroxidasa de chayote puede tener gran utilidad para la descontaminación de aguas con compuestos fenólicos en su forma inmovilizada como aquí se describe.
Monopolar capacitive coupled Radiofrequency (mcRF) and ultrasound-guided Platelet Rich Plasma (PRP) give similar results in the treatment of enthesopathies: 18-Month follow-up  [PDF]
Joseph Cronkey, Diana Villegas
Health (Health) , 2013, DOI: 10.4236/health.2013.56A2011
Abstract:

Introduction: Emergent technologies, i.e., monopolar capacitive coupled Radiofrequency (mcRF) and Platelet Rich Plasma (PRP) are now available to treat conditions characterized by a failed Wound Healing Response. Both mcRF and PRP positively influence the chemical/cellular inflammatory cascade to promote healing. mcRF application results in temperature elevation at the targeted structure up to 50℃ stimulating heat shock proteins, thus inciting the Wound Healing Response. Ultrasound-guided PRP injections results in an inflammatory/reparative reaction through cytokinin release. Methods: Sixty-eight patients who have failed previous conservative treatment for tendinopathies and chronic ligament conditions of the elbow, hip, knee and ankle/foot, were treated either with mcRF or PRP. Treatments were delivered directly by the investigator, and patients were followed prospectively for an average of 19.7 months (range 15 to 24 months). Results: Average age for the mcRF cohort was 53 years (range 17 to 88). Average age for the PRP group was 58 (range 19 to 90). The male to female ratio for both groups was 1/1. 33 of 42 patients treated with mcRF experienced marked improvement (78%), while in the PRP group 19 of 26 patients experienced marked improvement (73%) as self-assessed by study subjects. Discussion/Conclusion: Results of this study are in agreement with reports on the use of both technologies; however, this is the first time that a side-by-side comparison is established. PRP and mcRF represent a new approach to musculoskeletal pathology; both modalities aim at inducing a biological response and are considered at the frontier of regenerative therapeutics. The high safety profile suggests that these, non-invasive (mcRF) and minimally invasive (PRP), office-based alternatives for the management of musculoskeletal conditions are valuable tools and should be used in accordance with a clear understanding of the underlying pathology.

Hongos micorrízicos arbusculares y la fitorremediación de plomo
ALVARADO, Carlos J.;DASGUPTA-SCHUBERT, Nabanita;AMBRIZ, Enrique;SáNCHEZ-YA?EZ, Juan M.;VILLEGAS, Javier;
Revista internacional de contaminación ambiental , 2011,
Abstract: amongst the heavy metals, lead (pb) is a potential and in many cases an actual contaminant in several areas of the world as it accumulates easily in soil and sediment. its presence in the environment is mainly due to anthropogenic activities. pb is not an essential element for plants, animals and humans. high concentrations of pb in humans causes different symptoms of toxicity such as the lack of growth and an impact on the nervous system, amongst others. phytoremediation is an alternative environmental technology that is low in cost and environmentally sustainable. arbuscular mycorrhizal fungi (amf) offer an attractive system to assist in phytoremediation because the symbiotic interaction increases the root system of plants and thereby the potential of the bioavailability of pb in soil is increased. amf also confer high resistance to drought, salinity and others stresses. when the highest concentration of pb in plants grown in contaminated soil is found in the roots, the fungus-plant interaction is considered as a phytostabilization system. some studies have shown that mycorrhizal plants accumulate high amounts of pb in their above-ground parts. according to these reports the plant-fungus interaction could also be suitable for phytoextraction. the mechanisms involved in the remediation of pb contaminated soils are unknown. therefore in this paper an overview of the use of arbuscular mycorrhizal fungi and the mechanism involved in phytoremediation of soils contaminated by pb is presented.
De la cuestión del ser a la filosofía de la producción: El lugar de la estética en la obra de Enrique Dussel
Villegas,Karla;
Estudios de filosof?-a pr??ctica e historia de las ideas , 2007,
Abstract: we focus on the aesthetics issues occurring in enrique dussel's work, a subject not sufficiently explored by other studies. aesthetics holds a central place in his writings dealing with subjects such as its ontological character, an original proposal regarding design, and the problems related to the philosophy of poiesis. we took three of his key texts: the essay "aesthetics and being" published in 1969; "the question of a general model in a design process", of 1977, and his work "philosophy of production" published in colombia in 1984. each of these writings represents a clue in the development of his thinking.
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