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Search Results: 1 - 10 of 335092 matches for " Enrique Arús Soler "
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Historia natural de la infección por el virus de la hepatitis C
Arús Soler,Enrique;
Revista Cubana de Medicina , 2006,
Abstract: the acute stage of infection goes by inadvertently in most of the patients. the disease has a marked trend of evolution towards chronicity and it evolves very slowly. the chronic persistence of the virus ranges from 54 to 86 % of the cases. the evolution towards liver cirrhosis fluctuates between 2.6 and 42 % of the cases, depending on the study method used to evaluate the natural history. the youngest patients at the moment of infection and the females had the lowest progression rates. the coinfection with hivand hbv favor a rapid progression. some associated diseases as the non-alcoholic steatohepatitis, type ii diabetes mellitus, obesity, and the increase of the iron deposit in the liver have also been related to a rapid progression. alcoholism plays an important role on accelerating the course of the disease to liver cirrhosis and to hepatocellular carcinoma. the transfusion-acquired infection has been considered as a fibrosis-accelerating factor.
Historia natural de la infección por el virus de la hepatitis C Natural history of HCV infection
Enrique Arús Soler
Revista Cubana de Medicina , 2006,
Abstract: La fase aguda de la infección transcurre de forma desapercibida en la mayoría de los enfermos. La enfermedad tiene marcada tendencia de evolución a la cronicidad y evoluciona muy lentamente. La persistencia crónica del virus oscila entre un 54 y 86 % de los casos. La evolución a la cirrosis hepática oscila entre 2,6 y 42 % de los casos, en dependencia del método de estudio que se haya utilizado para evaluar la historia natural. Los pacientes con edades más jóvenes al momento de la infección y del sexo femenino tienen las tasas más bajas de progresión. La coinfección con los virus de la inmunodeficiencia humana y de la hepatitis B favorece una rápida progresión. Algunas enfermedades asociadas como son la esteatohepatitis no alcohólica, la diabetes mellitus tipo II, la obesidad, el aumento del depósito de hierro en el hígado, también se han asociado a una rápida progresión. El alcoholismo desempe a un papel importante en acelerar el curso de la enfermedad tanto a la cirrosis hepática como al carcinoma hepatocelular . La vía transfusional de adquisición de la infección se ha se alado como factor que acelera la fibrosis. The acute stage of infection goes by inadvertently in most of the patients. The disease has a marked trend of evolution towards chronicity and it evolves very slowly. The chronic persistence of the virus ranges from 54 to 86 % of the cases. The evolution towards liver cirrhosis fluctuates between 2.6 and 42 % of the cases, depending on the study method used to evaluate the natural history. The youngest patients at the moment of infection and the females had the lowest progression rates. The coinfection with HIVand HBV favor a rapid progression. Some associated diseases as the non-alcoholic steatohepatitis, type II diabetes mellitus, obesity, and the increase of the iron deposit in the liver have also been related to a rapid progression. Alcoholism plays an important role on accelerating the course of the disease to liver cirrhosis and to hepatocellular carcinoma. The transfusion-acquired infection has been considered as a fibrosis-accelerating factor.
Evolución histórica de las terapias antivirales en hepatitis crónica C
Sánchez Rodríguez,Yoan Antonio; Arús Soler,Enrique;
Revista Cubana de Medicina , 2010,
Abstract: a bibliographic review on the more significant features of historical course experienced by the antiviral therapies used in treatment of chronic hepatitis c virus was carried out due to the increasing incidence and prevalence of this disease with infection estimates about 3% of the world population. a updating was carried out on this subject matter from its origins with special emphasis on future perspectives of this therapeutics, nowadays under consideration by the international scientific community. for the carrying out of present work 69 bibliographic references were reviewed including the meta-analyses available in medline from 1998 up to present time, as well as the publications of researches results performed in our country on this subject.
Evolución histórica de las terapias antivirales en hepatitis crónica C Historical course of antiviral therapies in chronic hepatitis C
Yoan Antonio Sánchez Rodríguez,Enrique Arús Soler
Revista Cubana de Medicina , 2010,
Abstract: Dada la creciente incidencia y prevalencia de la infección crónica por el Virus de la hepatitis cónica C, con estimados de infección de alrededor del 3 % de la población mundial, se realizó una revisión bibliográfica sobre los aspectos más relevantes de la evolución histórica que han experimentado las terapias antivirales utilizadas en el tratamiento de esta enfermedad. Se realizó una puesta al día sobre esta temática desde sus orígenes, con especial énfasis en las perspectivas futuras de esta terapéutica, actualmente en estudio por parte de la comunidad científica internacional. Para la realización de esta obra fueron consultadas 69 citas bibliográficas que incluyen metanálisis disponibles en MEDLINE desde 1998 hasta la actualidad, así como las publicaciones de los resultados de las investigaciones realizadas en nuestro país sobre este tema. A bibliographic review on the more significant features of historical course experienced by the antiviral therapies used in treatment of Chronic Hepatitis C virus was carried out due to the increasing incidence and prevalence of this disease with infection estimates about 3% of the world population. A updating was carried out on this subject matter from its origins with special emphasis on future perspectives of this therapeutics, nowadays under consideration by the international scientific community. For the carrying out of present work 69 bibliographic references were reviewed including the meta-analyses available in MEDLINE from 1998 up to present time, as well as the publications of researches results performed in our country on this subject.
Hepatitis autoinmune
Infante Velázquez,Mirtha; Arús Soler,Enrique;
Revista Cubana de Medicina , 2000,
Abstract: this necroinflammatory liver disease of unknown origin was reported for the first time in 1950. it was mainly described in young women. this nosological entity has had several denominations through history. at present, it is known as autoimmune hepatitis. it appears in individuals with certain genetic predisposition when they are exposed to some environmental agent that has not been identified yet, giving rise to an autoimmune mechanism directed to the liver, where a necroinflammatoy process takes place leading to fibrosis and, finally, to cirrhosis. there are 3 types of autoimmune hepatitis: type1 is characterized by the presence of antinuclear antibodies, smooth antimuscle and antiactin; type 2, by the existance of anti- liver/kidney chromosome antibodies; and type 3, by the appearance of antibodies against the soluble antigen. the diagnosis is based on the histological study of the liver and on the presence of the above mentioned antibodies. monoclonal hypergammaglobulinemia is a laboratory alteration that characterizes the disease. other lab findings were the elevation of aminotranferases, alkaline phosphatase and bilirubin. the response to the treatment with glucocorticoids is common in this affection. azathioprine associated with corticosteroids is used in the maintenance therapy in order to prescribe low doses and to avoid their side effects. azathioprine may be also used alone as a maintenance therapy.
Hepatitis autoinmune
Mirtha Infante Velázquez,Enrique Arús Soler
Revista Cubana de Medicina , 2000,
Abstract: Se reportó, por primera vez, esta enfermedad necroinflamatoria del hígado de causa desconocida en el a o 1950. Se describió principalmente en mujeres jóvenes. Se han conocido a través de la historia, varias denominaciones para esta entidad nosológica. En la actualidad, se conoce con el nombre de hepatitis autoinmune. Se desarrolla en individuos con cierta predisposición genética cuando se exponen a algún agente ambiental que aún no ha sido identificado, a partir de lo cual se desencadena un mecanismo autoinmune dirigido contra el hígado, donde tiene lugar un proceso necroinflamatorio que conduce a la fibrosis y finalmente, a la cirrosis. Se reconocen 3 tipos de hepatitis autoinmune; el tipo I se caracteriza por la presencia de anticuerpos antinucleares, antimúsculo liso y antiactina; en el tipo II están presentes anticuerpos antimicrosomas contra hígado y ri ón y el tipo III se caracteriza por la existencia de anticuerpos contra el antígeno soluble. El diagnóstico se basa en el estudio histológico del hígado y la presencia de los autoanticuerpos antes se alados. La hipergammaglobulinemia monoclonal es una alteración de laboratorio que caracteriza la enfermedad. Otros hallazgos de laboratorio son la elevación de las aminotransferasas, la fosfatasa alcalina y la bilirrubina. Es característica de esta afección la respuesta al tratamiento con glucocorticoides. La azathioprina asociada a los corticosteroides se utiliza en los tratamientos de mantenimiento con el fin de prescribir dosis bajas de éstos y evitar sus efectos secundarios. También la azathioprina puede usarse sola como terapia de sostén. This necroinflammatory liver disease of unknown origin was reported for the first time in 1950. It was mainly described in young women. This nosological entity has had several denominations through history. At present, it is known as autoimmune hepatitis. It appears in individuals with certain genetic predisposition when they are exposed to some environmental agent that has not been identified yet, giving rise to an autoimmune mechanism directed to the liver, where a necroinflammatoy process takes place leading to fibrosis and, finally, to cirrhosis. There are 3 types of autoimmune hepatitis: type1 is characterized by the presence of antinuclear antibodies, smooth antimuscle and antiactin; type 2, by the existance of anti- liver/kidney chromosome antibodies; and type 3, by the appearance of antibodies against the soluble antigen. The diagnosis is based on the histological study of the liver and on the presence of the above mentioned antibodies. Monoclonal hypergam
Influencia de factores epidemiológicos en la progresión de la fibrosis en la hepatitis crónica C
Vilar Gómez,Eduardo; Grá Oramas,Bienvenido; Llanio Navarro,Raimundo; Arús Soler,Enrique;
Revista Cubana de Medicina , 2003,
Abstract: approximately 80 % of hepatitis c evolves to chronicity. the epidemiological and viral factors as well as those of the guest take part in the progression of the disease. the behavior of the epidemiological variables associated with chronic hepatitis c was described and the possible association of these ones with the intensity of fibrosis was identified. 80 patients with hepatitis c were studied and the intensity of fibrosis was determined by the metavir scoring system. they were grouped into absence or little fibrosis (f0-f1) and marked fibrosis (f2-f4) seeking for the possible statistical association with the epidemiological factors. a significant association was found among the infection's oldness estimate, the way it was acquired, the patient's age on catching it and the intensity of fibrosis. the progression of hepatits c may be determined by some epidemiological factors influencing decisively the natural history of the disease.
Bases fisiopatológicas de la insuficiencia hepática aguda
Vilar Gómez,Eduardo; Grá Oramas,Bienvenido; Llanio Navarro,Raimundo; Arús Soler,Enrique;
Revista Cubana de Medicina , 2004,
Abstract: a review was made to explain how the diverse cellular processes occurring in the severely damaged liver tissue and in the mesenteric circulation influence on the different systemic alterations appearing in acute liver failure, and the close relation existing among them. the acute liver failure is a clinical syndrome resulting from a mass liver necrosis generating progressive dysfunction of the organ with the presence of deep alterations in its detoxicating, metabolic, sinthesizing and excreting functions.the hypothesis of critical mass, as well as that on endotoxins-cytokines and vasoactive substances explain somehow the different molecular changes supporting the physiopathological bases of this complex entity.
Hallazgos clínicos, bioquímicos y morfológicos en 103 pacientes con anticuerpos contra el virus de la hepatitis C
Infante Velázquez,Mirtha; Arús Soler,Enrique; Fernández Naranjo,Anayda; Grá Oramas,Bienvenido;
Revista Cubana de Medicina , 1998,
Abstract: 103 patients carriers of hepatitis c virus antibodies detected by the cuban diagnostic system (anti hcv, cigb, havana) were studied. active chronic hepatitis (23.2 %) was the predominant histological lesion, although there were 2 cases with acute severe hepatitis due to a combined infection with a and b viruses. a few symptoms were observed in most of the patients, who were blood donors and blood transfusion receptors (44.5 %). the latter were associated with the most severe hapatic lesions. it is stressed the presence of heal thy carriers of the virus.
Tratamiento de la hepatitis viral aguda c con interferón alfa 2b recombinante: Ensayo clínico
Enrique Arús Soler,Luis Rivera Reimón,Mirtha Infante Velázquez,Marlen Pérez Lorenzo
Revista Cubana de Medicina , 2000,
Abstract: Se llevó a cabo un ensayo clínico con el objetivo de evaluar la eficacia y la seguridad del interferón en un grupo de 13 pacientes con hepatitis aguda por virus C. Se realizó el diagnóstico siguiendo criterios bioquímicos (alaninoaminotransferasa 2 veces por encima del valor normal), serológicos (presencia de anticuerpos contra el virus de la hepatitis C) e histológicos. Se indicó tratamiento con interferón alfa 2b recombinante 3 000 000 UI por vía intramuscular 3 veces por semana por 13 sem. Se comprobó que el 53,8 % de los pacientes concluyeron el período de tratamiento con la alaninoaminotransferasa normal y que, al final del seguimiento, el 30,7 % tuvo una respuesta bioquímica mantenida; 4 enfermos (36,3 %) de los 11 que concluyeron el período de seguimiento tuvieron una histología normal en la biopsia hepática evolutiva y de ellos, 2 tuvieron una respuesta bioquímica mantenida, lo cual hace plantear la posibilidad que estuvieran curados. El interferón fue bien tolerado, sólo el 38,5 % de los enfermos presentó manifestaciones secundarias de toxicidad. Predominó la cefalea, la fiebre, las mialgias y las artralgias. Se concluyó que debe utilizarse el interferón en pacientes con hepatitis aguda C, en protocolos de extensión, que permitirán en un futuro la generalización de este tratamiento. A clinical trial was carried out aimed at evaluating the efficacy and safety of interferon in a group of 13 patients with acute hepatitis C. The diagnosis was made according to biochemical criteria (alanine aminotransferase 2 ti-mes the normal value), serological criteria (presence of anti-hepatitis C virus antibodies) and histological criteria. Treatment with recombinant interferon alfa 2b 3 000 000 IU/ml inj. was indicated 3 times a week during 13 weeks. It was proved that 53.8 % finished the period of treatment with normal alanine aminotransferase and that at the end of the follow-up 30.7 % had a mantained biochemical response. 4 patients (36.3 %) of the 11 that concluded the follow-up had a normal histology in the evolutive hepatic biopsy and of them 2 had a mantained biochemical response, which made us think they were cured. Interferon was well tolerated and only 38.5 % of the patients showed secondary manifestations of toxicity. It was observed a predominance of cephalalgia, fever, myalgias and arthralgias. It was concluded that interferon should be used in patients with acute hepatitis C in extension protocols that will allow the generalization of this treatment in the future.
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