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Search Results: 1 - 10 of 495549 matches for " Enilze Maria S. F. Ribeiro "
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Genome of Herbaspirillum seropedicae Strain SmR1, a Specialized Diazotrophic Endophyte of Tropical Grasses
Fábio O. Pedrosa ,Rose Adele Monteiro,Roseli Wassem,Leonardo M. Cruz,Ricardo A. Ayub,Nelson B. Colauto,Maria Aparecida Fernandez,Maria Helena P. Fungaro,Edmundo C. Grisard,Mariangela Hungria,Humberto M. F. Madeira,Rubens O. Nodari,Clarice A. Osaku,Maria Luiza Petzl-Erler,Hernán Terenzi,Luiz G. E. Vieira,Maria Berenice R. Steffens,Vinicius A. Weiss,Luiz F. P. Pereira,Marina I. M. Almeida,Lysangela R. Alves,Anelis Marin,Luiza Maria Araujo,Eduardo Balsanelli,Valter A. Baura,Leda S. Chubatsu,Helisson Faoro,Augusto Favetti,Geraldo Friedermann,Chirlei Glienke,Susan Karp,Vanessa Kava-Cordeiro,Roberto T. Raittz,Humberto J. O. Ramos,Enilze Maria S. F. Ribeiro,Liu Un Rigo,Saul N. Rocha,Stefan Schwab,Anilda G. Silva,Eliel M. Souza,Michelle Z. Tadra-Sfeir,Rodrigo A. Torres,Audrei N. G. Dabul,Maria Albertina M. Soares,Luciano S. Gasques,Ciela C. T. Gimenes,Juliana S. Valle,Ricardo R. Ciferri,Luiz C. Correa,Norma K. Murace,Jo?o A. Pamphile,Eliana Valéria Patussi,Alberto J. Prioli,Sonia Maria A. Prioli,Carmem Lúcia M. S. C. Rocha,Olívia Márcia N. Arantes,Márcia Cristina Furlaneto,Leandro P. Godoy,Carlos E. C. Oliveira,Daniele Satori,Laurival A. Vilas-Boas,Maria Angélica E. Watanabe,Bibiana Paula Dambros,Miguel P. Guerra,Sandra Marisa Mathioni,Karine Louise Santos,Mario Steindel,Javier Vernal,Fernando G. Barcellos,Rubens J. Campo,Ligia Maria O. Chueire,Marisa Fabiana Nicolás,Lilian Pereira-Ferrari,José L. da Concei??o Silva,Nereida M. R. Gioppo,Vladimir P. Margarido
PLOS Genetics , 2011, DOI: 10.1371/journal.pgen.1002064
Abstract: The molecular mechanisms of plant recognition, colonization, and nutrient exchange between diazotrophic endophytes and plants are scarcely known. Herbaspirillum seropedicae is an endophytic bacterium capable of colonizing intercellular spaces of grasses such as rice and sugar cane. The genome of H. seropedicae strain SmR1 was sequenced and annotated by The Paraná State Genome Programme—GENOPAR. The genome is composed of a circular chromosome of 5,513,887 bp and contains a total of 4,804 genes. The genome sequence revealed that H. seropedicae is a highly versatile microorganism with capacity to metabolize a wide range of carbon and nitrogen sources and with possession of four distinct terminal oxidases. The genome contains a multitude of protein secretion systems, including type I, type II, type III, type V, and type VI secretion systems, and type IV pili, suggesting a high potential to interact with host plants. H. seropedicae is able to synthesize indole acetic acid as reflected by the four IAA biosynthetic pathways present. A gene coding for ACC deaminase, which may be involved in modulating the associated plant ethylene-signaling pathway, is also present. Genes for hemagglutinins/hemolysins/adhesins were found and may play a role in plant cell surface adhesion. These features may endow H. seropedicae with the ability to establish an endophytic life-style in a large number of plant species.
Epigenetic Changes of CXCR4 and Its Ligand CXCL12 as Prognostic Factors for Sporadic Breast Cancer
Edneia A. S. Ramos, Mariana Grochoski, Karin Braun-Prado, Gerusa G. Seniski, Iglenir J. Cavalli, Enilze M. S. F. Ribeiro, Anamaria A. Camargo, Fabrício F. Costa, Giseli Klassen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0029461
Abstract: Chemokines and their receptors are involved in the development and cancer progression. The chemokine CXCL12 interacts with its receptor, CXCR4, to promote cellular adhesion, survival, proliferation and migration. The CXCR4 gene is upregulated in several types of cancers, including skin, lung, pancreas, brain and breast tumors. In pancreatic cancer and melanoma, CXCR4 expression is regulated by DNA methylation within its promoter region. In this study we examined the role of cytosine methylation in the regulation of CXCR4 expression in breast cancer cell lines and also correlated the methylation pattern with the clinicopathological aspects of sixty-nine primary breast tumors from a cohort of Brazilian women. RT-PCR showed that the PMC-42, MCF7 and MDA-MB-436 breast tumor cell lines expressed high levels of CXCR4. Conversely, the MDA-MB-435 cell line only expressed CXCR4 after treatment with 5-Aza-CdR, which suggests that CXCR4 expression is regulated by DNA methylation. To confirm this hypothesis, a 184 bp fragment of the CXCR4 gene promoter region was cloned after sodium bisulfite DNA treatment. Sequencing data showed that cell lines that expressed CXCR4 had only 15% of methylated CpG dinucleotides, while the cell line that not have CXCR4 expression, had a high density of methylation (91%). Loss of DNA methylation in the CXCR4 promoter was detected in 67% of the breast cancer analyzed. The absence of CXCR4 methylation was associated with the tumor stage, size, histological grade, lymph node status, ESR1 methylation and CXCL12 methylation, metastasis and patient death. Kaplan-Meier curves demonstrated that patients with an unmethylated CXCR4 promoter had a poorer overall survival and disease-free survival. Furthermore, patients with both CXCL12 methylation and unmethylated CXCR4 had a shorter overall survival and disease-free survival. These findings suggest that the DNA methylation status of both CXCR4 and CXCL12 genes could be used as a biomarker for prognosis in breast cancer.
Cytogenetic study of Brazilian patients with myelodysplastic syndrome (MDS)
Borgonovo, Tamara;Ribeiro, Enilze M.S.F.;Cornélio, Déborah Afonso;Schmid-Braz, Ana Teresa;Jamur, Valderez Ravaglio;Wuicik, Lismeri;Veiga, Loraine Beatriz Acosta;Ehmke, Néria A. Maia;Pasquini, Ricardo;Cavalli, Iglenir Jo?o;
Genetics and Molecular Biology , 2005, DOI: 10.1590/S1415-47572005000500002
Abstract: bone marrow cytogenetic studies were performed on 93 patients with primary myelodysplastic syndrome (mds) diagnosed at the clinical hospital of the federal university of paraná, brazil. chromosomal alterations were observed in 69% of the patients. monosomy of chromosome 7, deletions of 7q, 5q, 12p and 20q, rearrangements of 11q23 and trisomies of chromosomes 8 and 21 were the most frequent abnormalities observed. among adult patients the most frequent aberrations were rearrangements of 11q23 and 12p deletions. in the pediatric group, 5q deletions and monosomy of chromosome 7 were the most common alterations.
Síndrome de Wolfram: da defini??o às bases moleculares
Ribeiro, Maria Regina F.;Crispim, Felipe;Vendramini, Márcio F.;Moisés, Regina S.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2006, DOI: 10.1590/S0004-27302006000500003
Abstract: wolfram syndrome (ws) is an autosomal recessive progressive neurodegenerative disorder characterized by diabetes mellitus and optic atrophy. diabetes insipidus and sensorineural deafness are also noted frequently, explaining the acronym didmoad (diabetes insipidus, diabetes mellitus, optic atrophy and deafness) by which the syndrome is also referred. additional manifestations such as atonic bladder, ataxia, nystagmus and predisposition for psychiatric illness may be present. the wolfram syndrome gene, wfs1, was mapped to chromosome 4p16.1 by positional cloning. it encodes an 890-amino-acid polypeptide named wolframin. although the wolframin function is still not completely known, its localization to the endoplasmic reticulum suggests it can play a role in calcium homeostasis, membrane trafficking and protein processing. knowing the cellular function of wolframin is necessary for understanding the pathophysiology of wolfram syndrome. this knowledge may lead to development of therapies to prevent or reduce the outcomes of ws.
Gordura visceral e síndrome metabólica: mais que uma simples associa??o
Ribeiro Filho, Fernando F.;Mariosa, Lydia S.;Ferreira, Sandra R. G.;Zanella, Maria Teresa;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2006, DOI: 10.1590/S0004-27302006000200009
Abstract: metabolic syndrome (ms) is seen nowadays as a worldwide epidemic event associated with high cardiovascular morbi-mortality and high socioeconomic cost. the ponderal gain is an independent predictor for the development of ms, although not all obese individuals present it. on the other hand, some populations with low obesity prevalence present high prevalence of ms and cardiovascular mortality. the distribution of corporal fat is relevant and visceral fat (vf), specifically, seems to be the link between adipose tissue and insulin resistance (ir), a mean feature of ms. adipose tissue is now considered a complex organ with multiple functions. vf presents metabolic properties, which are different from the gluteo-femoral subcutaneous fat and related to ir. several studies show the narrow relationship of abdominal adiposity with the glucose tolerance, hyperinsulinemia, hypertriglyceridemia and arterial hypertension. more than a simple association, recently it is thought that the vf plays a central part in the physiopathology of ms. consequently, the quantification of vf plays an important role to identify individuals with larger risk for development of ms, who should be chosen for early interventions in the attempt of reducing the impact of metabolic abnormalities on cardiovascular mortality. this article discusses particularities of the central distribution of fat in ms context, possible physiopathogenic mechanisms related to the vf and available methods for the evaluation of abdominal adiposity.
Serological and genetic diversity amongst Salmonella strains isolated in a salami processing line
Ribeiro, Vinicius B.;Andrigheto, Cristiano;Bersot, Luciano S.;Barcellos, Vinicius;Reis, Eliana F.;Destro, Maria T.;
Brazilian Journal of Microbiology , 2007, DOI: 10.1590/S1517-83822007000100036
Abstract: salmonella is one of the most important agents of foodborne disease in brazil and in other countries, with meat and meat products being identified as important vehicles of salmonelosis. a total of 54 salmonella strains isolated from a commercial salami processing line were first serotyped and then their antibiotic resistance and macro restriction profiles were determined. 11.1% of the strains showed resistance to 3 or more antibiotics with profile ampcstxte being the most frequent. pfge generated 9 and 12 profiles with enzymes xbai and spei, respectively. it was observed that different serotypes of salmonella could be found in the different steps of the processing line. the genetic profile of the strains had low relationship indicating the genetic diversity of the tested strains.
Non-pharmacological treatment of hypertension in primary health care: A comparative clinical trial of two education strategies in health and nutrition
Amanda G Ribeiro, S?nia MR Ribeiro, Cristina MGC Dias, Andréia Q Ribeiro, Fátima AF Castro, Maria M Suárez-Varela, Rosangela MM Cotta
BMC Public Health , 2011, DOI: 10.1186/1471-2458-11-637
Abstract: This study is a randomized controlled trial of a sample composed of 28 women with hypertension enrolled in the Primary Health Care Unit located in the urban area of southeastern Brazil. The participants were already undergoing treatment for hypertension but devoid of nutritional care; and were divided into two groups, each composed of 14 individuals, who received interventions that consisted of two different strategies of nutritional guidance: monthly health education workshops alone (Group 1) and combined with family orientation through home visits (Group 2). Adherence to nutritional guidelines was evaluated by dietary, anthropometric, clinical and serum biochemical parameters, measured before and after the interventions. Knowledge on control and risk of hypertension was also investigated. The study lasted five months.Mean age was 55.6 (± 2.8) and 50.7 (± 6.5) in the groups 1 and 2, respectively. The home orientation strategy promoted greater adherence to dietary changes, leading to a statistically significant improvement in the clinical, anthropometric, biochemical and dietary parameters. The group 2 reduced the consumption of risk foods (p = 0.01), oil (p = 0.002) and sugar (p = 0.02), and decreased body mass index (-0.7 kg/m2; p = 0.01); waist circumference (-4.2 cm; p = 0.001), systolic blood pressure (-13 mm HG; p = 0.004) and glycemia (-18.9 mg/dl; p = 0. 01). In group 1 only waist circumference (-2 cm; p = 0.01) changed significantly.Nutritional orientations at the household level were more effective with regard to the adherence of individuals to non-pharmacological treatment of hypertension, regarding the reduction of clinical and behavioral risk parameters.Cardiovascular disease accounts for one third of deaths worldwide. In the Americas, the World Health Organization reports about 140 million people suffer from hypertension (1). Hypertension is one of the most important risk factors of cardiovascular and kidney disease and is a serious public health probl
Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants
Maciel, Marcos Euzébio;Oliveira, Fausto Koga;Propst, Gustavo Bonfim;Bicalho, Maria da Gra?a;Cavalli, Iglenir Jo?o;Ribeiro, Enilze Maria de Souza Fonseca;
Genetics and Molecular Biology , 2009, DOI: 10.1590/S1415-47572009005000087
Abstract: individual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene frequencies in mixed populations makes interpretation of the results difficult. we sought to estimate population parameters for the cytochrome p450 and glutathione s-transferase gene families, thus contributing to studies using these genes as markers. we describe the frequencies of six genes (cyp1a1, cyp2d6, cyp2e1, gstm1, gstt1, and gstp1) and estimate population parameters in 115 euro-descendants and 196 afro-descendants from curitiba, south of brazil. pcr-based methods were used for genotyping, and statistical analysis were performed by amova with arlequin software. the mutant allele frequencies in the afro-descendants and euro-descendants, respectively, were: cyp1a1*2a = 30.1% and 15.2%; cyp2d6*4 = 14.5% and 21.5%; cyp2e1*5b = 7.9% and 5%; gstp1*b = 37.8% and 28.3%. the null genotype frequencies were: gstm1*0 = 36.8% and 46.1%; gstt1*0 = 24.2% and 17.4%.
In vitro establishment and propagation of a Brazilian strain ofAnaplasma marginale with appendage in IDE8 (Ixodes scapularis) cells
Bastos, Camila V.;Passos, Lygia M. F.;Vasconcelos, Maria Mercês C.;Ribeiro, Múcio F. B.;
Brazilian Journal of Microbiology , 2009, DOI: 10.1590/S1517-83822009000200034
Abstract: a brazilian isolate of anaplasma marginale with appendage was successfully established and maintained in vitro in a tick cell line (ide8). infection was confirmed by optical and transmission electron microscopy. in addition, primers msp1anf2 and msp1anr2 amplified products from dna extracted from infected ide8 cells. comparisons with partial sequences of the msp1α gene and the complete genome of a. marginale confirmed that the sequences of amplified fragments were from the a. marginale genome. this is the first establishment of a brazilian a. marginale isolate in tick cells, representing a new system for biological and molecular studies and also a new source of material for diagnosis and development of vaccines.
Exclus?o social do doente mental: discursos e representa??es no contexto da reforma psiquiátrica
Maciel, Silvana Carneiro;Maciel, Carla Maria Carvalho;Barros, Daniela Ribeiro;Sá, Roseane Christhina da Nova;Camino, Le?ncio F.;
Psico-USF , 2008, DOI: 10.1590/S1413-82712008000100014
Abstract: the aim of the present work is to know the representations about the mental disease and the psychiatric reform, according to the opinion of some mental health professionals as well as of some family members of those who suffer from that disease and are kept in mental hospitals. for this purpose, semistructured interviews were made with 25 professionals including psychiatrists, psychologists, head-nurses, nurse technicians, and social workers, and 24 family members of institutional patients in the city of jo?o pessoa-pb. such interviews were analyzed according to the thematic content analysis. the resulting data show that there is still a predominance of pejorative and stereotyped views about the mentally disordered person, who is seen as a senseless or a brainless being and as a child who needs to be taken care of and protected. on the other hand, the mental hospital is seen positively, whereas the psychiatric reform is shown as something negative that will let the mental patient free to cause affliction to his/her family and to the population.
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