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Search Results: 1 - 10 of 403621 matches for " Emilia M. Carmona-Calero "
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High Blood Pressure Effects on the Brain Barriers and Choroid Plexus Secretion  [PDF]
Ibrahim González-Marrero, Leandro Casta?eyra-Ruiz, Juan M. González-Toledo, Agustín Casta?eyra-Ruiz, Héctor de Paz-Carmona, Lidia Ruiz-Mayor, Agustín Casta?eyra-Perdomo, Emilia M. Carmona-Calero
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.31009
Abstract: High blood pressure produces ventricular dilation, variations in circumventricular organs and changes in the cerebrospinal fluid compositions. On the other hand, chronic hypertension in spontaneously hypertensive rats can cause changes in the integrity of the brain barriers: blood-cerebrospinal fluid barrier and blood brain barrier. The permeability of the brain barriers can be studied by using transthyretin and S-100β. In the present work we study the integrity of the brain barrier and the choroid plexus function variations in arterial hypertension. Control rats and spontaneously hypertensive rats were used and the choroid plexus were processed by immunohistochemistry with anti-transthyretin and anti-vasopressin. Western blot was also performed in cerebrospinal fluid, serum and choroid plexus using anti-S-100β, anti-transthyretin. The accumulation of transthyretin immunoreactive was bigger in spontaneously hypertensive rats with respect to the control. Vasopressin was also higher in spontaneously hypertensive rats with respect to the control. Western blot showed that transthyretin tetramer was higher in the spontaneously hypertensive rats than in the control rats. The expression of transthyretin monomer was lower in hypertensive rats than the control in the cerebrospinal fluid, the transthyretin monomer reaction in the blood was stronger in hypertensive than in control rats. Western blot for the S-100 β showed an increase in blood and cerebrospinal fluid of hypertensive rats. The high blood pressure produces a disruption of the blood brain barrier and blood to cerebrospinal fluid barrier that allows extravasations from the cerebrospinal fluid to the blood and from the blood to the cerebrospinal fluid.
Hypertension effects on p73 expression in the rat circumventricular organs and cerebrospinal fluid  [PDF]
Emilia M. Carmona-Calero, Ibrahim González-Marrero, Manuela Casta?eyra-Martin, Juan M. González-Toledo, Leandro Casta?eyra-Ruiz, Héctor de Paz-Carmona, Agustín Casta?eyra-Ruiz, Lidia Ruiz-Mayor, Agustín Casta?eyra-Perdomo
World Journal of Neuroscience (WJNS) , 2012, DOI: 10.4236/wjns.2012.22010
Abstract: It has been reported that spontaneously hypertensive rats (SHR) show ventricular dilation, changes in CSF proteins and variations in the circumventricular organs (CVO) such as: the subcommissural organ (SCO), the subfornical organ (SFO) and the area postrema (AP) which are located in the walls of the third and fourth ventricles. On the other hand, p73 proteins are present in cells of the central nervous system (CNS) such as circumventricular structures and the neuroepithelium which are altered in ventricular dilation. The purpose of the present work is to study the TAp73 isoform expression in the circumventricular organs (CVO) and their variations in ventricular dilatation and arterial hypertension. Brains and cerebrospinal fluid (CSF) from control Wistar-Kyoto rats (WKY) and SHR were used. The paraffin sections containing the CVO were immunohistochemically proc-essed with anti-TAp73 and by western blot, p73 bands in the CSF and circumventricular organ extract were also identified. The western blot study showed bands marked with p73 in the CSF and CVO, the p73 band expression was bigger in the SHR than in the WKY rats. We also found stronger markings in the SFO, SCO and AP of the hypertensive rats than in the WKY rats. It could be concluded that hypertension in the SHR produces altera-tions in the relationship between the p73 protein, circumventricular structures and CSF.
High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition: A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats
Ibrahim González-Marrero,Leandro Casta?eyra-Ruiz,Juan M. González-Toledo,Agustín Casta?eyra-Ruiz,Hector de Paz-Carmona,Rafael Castro,Juan R. Hernandez-Fernaud,Agustín Casta?eyra-Perdomo,Emilia M. Carmona-Calero
International Journal of Hypertension , 2013, DOI: 10.1155/2013/164653
Abstract: The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β-amyloid metabolism and inflammatory processes. Cerebrospinal fluid (CSF) is a system linked to the brain and its composition can be altered not only by encephalic disorder, but also by systemic diseases such as arterial hypertension, which produces alterations in the choroid plexus and cerebrospinal fluid protein composition. 2D gel electrophoresis in cerebrospinal fluid extracted from the cistern magna before sacrifice of hypertensive and control rats was performed. The results showed different proteomic profiles between SHR and WKY, that α-1-antitrypsin, apolipoprotein A1, albumin, immunoglobulin G, vitamin D binding protein, haptoglobin and α-1-macroglobulin were found to be up-regulated in SHR, and apolipoprotein E, transthyretin, α-2-HS-glycoprotein, transferrin, α-1β-glycoprotein, kininogen and carbonic anhidrase II were down-regulated in SHR. The conclusion made here is that hypertension in SHR produces important variations in cerebrospinal fluid proteins that could be due to a choroid plexus dysfunction and this fact supports the close connection between hypertension and blood to cerebrospinal fluid barrier disruption. 1. Introduction Cerebrospinal fluid is a functional system closely connected to the brain, and changes or variations in the CSF may mean an alteration in the brain expressed by encephalic disorders. However, the composition of CSF may also be altered by systemic diseases, such as arterial hypertension, and cerebral ventricular dilatation, changes in CSF protein, and variations of the choroid plexus and other circumventricular organs (CVO) have been described in spontaneously hypertensive rats (SHR) [1–5]. Therefore, SHR develop hydrocephalus and experimental studies explain that hydrocephalus induces alterations in CSF since there are disturbances, in the hydrocephalic brain, of oxidative metabolism and neurotransmission and perhaps damage to periventricular cells, particularly when intracranial pressure is elevated [6]. The sharp increase in systemic blood pressure only causes an acute increase in CSF pressure in normotensive animals and not in hypertensive patients [6]. The CSF pressure of SHR showed greater protection to the acute effects of phenylephrine than in control Wistar-Kyoto (WKY) rats, but a permeability increase of the blood to cerebrospinal fluid barrier to sucrose in
Luteinizing Hormone-Releasing Hormone Distribution in the Anterior Hypothalamus of the Female Rats
Leandro Casta?eyra-Ruiz,Ibrahim González-Marrero,Agustín Casta?eyra-Ruiz,Juan M. González-Toledo,María Casta?eyra-Ruiz,Héctor de Paz-Carmona,Agustín Casta?eyra-Perdomo,Emilia M. Carmona-Calero
ISRN Anatomy , 2013, DOI: 10.5402/2013/870721
Abstract: Luteinizing hormone-releasing hormone (LHRH) neurons and fibers are located in the anteroventral hypothalamus, specifically in the preoptic medial area and the organum vasculosum of the lamina terminalis. Most luteinizing hormone-releasing hormone neurons project to the median eminence where they are secreted in the pituitary portal system in order to control the release of gonadotropin. The aim of this study is to provide, using immunohistochemistry and female brain rats, a new description of the luteinizing hormone-releasing hormone fibers and neuron localization in the anterior hypothalamus. The greatest amount of the LHRH immunoreactive material was found in the organum vasculosum of the lamina terminalis that is located around the anterior region of the third ventricle. The intensity of the reaction of LHRH immunoreactive material decreases from cephalic to caudal localization; therefore, the greatest immunoreaction is in the organum vasculosum of the lamina terminalis, followed by the dorsomedial preoptic area, the ventromedial preoptic area, and finally the ventrolateral medial preoptic area, and in fibers surrounding the suprachiasmatic nucleus and subependymal layer on the floor of the third ventricle where the least amount immunoreactive material is found. 1. Introduction The luteinizing hormone-releasing hormone (LHRH) is a gonadotropin releasing hormone (GnRH), which acts on the pituitary hormones as a follicle stimulating hormone (FSH) and luteinizing hormone (LH), which act on the gonads, [1]. The GnRH neurons are originated in the nasal epithelium and migrate accompanying the fibers of the vomeronasal and terminal nerves [2, 3] up to the anterobasal part of the brain, where they enter the brain together with nerve terminals and then move caudally to the preoptic hypothalamus, where GnRH neurons are definitively located [2, 4]. These GnRH neurons and fibers are mainly located in the anteroventral third ventricle region, specifically in the preoptic area (PA) and the organum vasculosum of the lamina terminalis (OVLT) [5]. The anterior hypothalamus is the major region of the diencephalon implicated in the development of the olfactory system and the sexual differentiation of the brain. Most of the GnRH neurons axons project to the external zone of the median eminence where is GnRH secreted into the pituitary portal vasculature to control the release of gonadotropin [6–8]. The preoptic area (PA) is part of the anterior hypothalamus and is confined to the anteroventral region of the third ventricle (AV3V); the PA is divided into, the medial
Angiotensin II, Vasopressin, and Collagen-IV Expression in the Subfornical Organ in a Case of Syndrome of Inappropriate ADH
Emilia M. Carmona-Calero,Juan M. González-Toledo,Leandro Casta?eyra-Ruiz,Ibrahim González-Marrero,María Casta?eyra-Ruiz,Héctor de Paz-Carmona,Agustín Casta?eyra-Ruiz,Nélida Rancel-Torres,Agustín Casta?eyra-Perdomo
Advances in Endocrinology , 2014, DOI: 10.1155/2014/179795
Abstract: The syndrome of inappropriate antidiuretic hormone (SIADH) is a disease characterized by hyponatremia and hyperosmolarity of urine where vasopressin and angiotensin II are implicated in the alteration of salt water balance and cardiovascular and blood pressure regulation. The aim of this study is to analyse the expression of substances related with cardiovascular and salt water regulation in the subfornical organ in a case of SIADH. Two brains, one taken from a 66-year-old man with SIADH and the other from a 63-year-old man without SIADH, were used. Immunohistochemical study was performed using anti-angiotensin II, anti-vasopressin, and anti-collagen-VI as primary antibodies. Angiotensin and vasopressin immunoreaction were found in neurons, in perivascular spaces, and in the ependymal layer in the subfornical organ in both cases. However, in the SIADH case, the angiotensin II and collagen-IV expression in the SFO were different suggesting this organ’s possible participation in the physiopathology of SIADH. 1. Introduction Diabetes insipidus (DI), syndrome of inappropriate antidiuretic hormone (SIADH), and syndrome cerebral salt-wasting (CSW) are three pathologies with hyponatremia and hyperosmolarity and differentiation between them is important to prescribe the most appropriate treatments [1, 2]. SIADH is a disease which is characterized by the hyponatremia and hyperosmolarity of urine [3–5]. There are well known causes for this syndrome, such as neoplasmatic processes, disorders of the central nervous system, lung diseases, and the side effects of drugs. A study [6] of a large group of patients has revealed that SIADH occurs in 3% of patients with head and neck cancer, in 0.7% of patients with non-small-cell lung cancer, and in 15% of cases of small-cell lung cancer [6]. The standard therapy for SIADH is to treat the underlying malignant disease. If this is not possible or if the disease has become refractory, other treatment methods are available such as water restriction, demeclocycline therapy, or, in severe cases, infusion of hypertonic saline together with furosemide during treatment [6]. Total body water and tonicity are strictly regulated by the renal action of the antidiuretic hormone (ADH), renin-angiotensin-aldosterone system, and norepinephrine and by the thirst mechanism. Abnormalities in water balance are manifested in SIADH as sodium disturbances-hyponatremia and hypernatremia [6]. On the other hand, the presence of VAS, AGII, and TH and their implication in cardiovascular, salt water balance and blood pressure regulation have long been
Rabi oscillations from ultrasound in spin systems
C. Calero,E. M. Chudnovsky
Physics , 2007,
Abstract: It is shown that ultrasound in the GHz range can generate space-time Rabi oscillations between spin states of molecular magnets. We compute dynamics of the magnetization generated by surface acoustic waves and discuss conditions under which this novel quantum effect can be observed.
A Phytosociological of Plant Communities and Biodiversity in the East-South of Idna Village-Hebron of Palestine  [PDF]
Jehad M. H. Ighbareyeh, Eusebio Cano Carmona
International Journal of Geosciences (IJG) , 2018, DOI: 10.4236/ijg.2018.91003
This paper presents a floristic and vegetation study of the territories of the Idna-Hebron of Palestine, corresponding to one area with three different names as Abu Salman Forest Reserve, Khallet Osman mountains, and Hamra Aslimi. These sites are very important at a local level of the flora with a high endemic rate. The floristic analysis revealed the existence of 48 species, of which 10 (20.83%) are endemic endemic. Seventeen plots of vegetation distributed in one area dominated and have been analyzed in this study. Methodology, the phytosociological approach is based on the Braun-Blanquet method. The results revealed three different kinds of forests, one dominated by the endemic Pino halepensis-Quercetum lookii, which is peculiar to the inframediterranean dry-thermomediterranean environments, with the terra rossa and brown rendzinas territory. The second type of forest is dominated by the Pistacio palaestinae-Ceratonietum silique, which is growing in the dry-subhumid ombrotype and the terra rossa and brown rendzinas territory. The third group of the forest of Khallet Osman and Hamra Aslimi dominated by Quercus lookii-Tamaricetum palestineae. Finally, in this study there are three associations and tow alliances are proposed as new Syntaxa based on statistical and phytosociological analyses in the study area.
Impact of Environment Conditions on Grapevine (Vitis vinifera L.): To Optimal Production and Sustainability, Achieving Food Security and Increasing the Palestinian Economy  [PDF]
Jehad M. H. Ighbareyeh, Eusebio Cano Carmona
Journal of Geoscience and Environment Protection (GEP) , 2018, DOI: 10.4236/gep.2018.62005
Abstract: Grapevine (Vitis vinifera L.) is one of important economic fruit crops found in Hebron of Palestine. Climate is one of the key controlling factors in grape and wine production. Materials & Method: We analyzed grape production in Hebron region, and studied the correlation analyses between productions and climatic, bioclimatic factors. The bioclimate, climatic factors were obtained according to Rivas-Martinez to classification of the earth. However, the independent variables were examined: the bioclimate factors as compensated thermicity index, annual ombrothermic index, water deficit and simple continentality index; and following climate factors: mean monthly temperature, precipitation and soil water reserve. The data used were from one meteorological station of the Palestinian Meteorological Department for the years 1993 to 2009 (16 years), and to the same years of grape production (rain-fed) from the Palestinian Central Bureau of Statistics (PCBS).?Result & Discussion: When we applied a Principal Component Analysis (PCA), and observed that the Hebron type plots are located at the left of axis 1 during 1999-2004 negatively affected by the bioclimate factors as compensated thermicity index, with a large proportion of the variance explained by axes 1 (76.66%), but precipitation was positive influenced on grape yield for the years (2004-2009), with a proportion of the variance explained by axes 2 (23.34%); Hebron type plots are located at the right of axis1during 1993-1999 positive affected by the bioclimate factor as a simple continentality index and annual ombrothermic index, and climate factors as water deficit, soil water reserve and mean monthly temperature, with a large proportion of the variance explained by axes 1 & 2 (100%). Conclusions: Grapes are sensitive climate and the surrounding environment factors, and in order to get a high production and high-quality grapes, mean monthly temperature must be between 15°C - 20°C, and 20°C - 30°C (27
Hacia la europeización de los Parlamentos autonómicos? Reflexiones al hilo del mecanismo de alerta temprana
Ana M. Carmona Contreras
Revista d'Estudis Autonòmics i Federals , 2012,
Abstract: Traditionally, the regional parliaments have been excluded from European decision-making and have occupied an invisible place in that context. The early warning system in monitoring the principle of subsidiariety introduced by the Treaty of Lisbon, allows for the participation of the assembies of regions with legislative competences together with the national parliaments and opens a new mechanism full of Europeanizing. Thus, the Spanish frameworkrelegates the regional parliaments to a purely testimonial or advisory function. So the Spanish law at present is configured as a huge obstacle to the process of Europeanization of autonomous parliaments. Beyond the necessary adjustments (regulatory and systemic) that should be undertaken at both the central and the regional levels, the current Spanish situation reveals interesting lines of action and initiatives that indicate a growing willingness of participation on the part of regional parliaments in monitoringsubsidiarity.
Opiniones y experiencias en el desempe o de la dirección escolar de las mujeres directoras en Andalucía. [Andalusian women principals’ opinions and experiences about their school management performance]
Padilla Carmona, M. Teresa
Revista Electrónica de Investigación y Evaluación Educativa , 2008,
Abstract: This paper aims to identify the opinions and experiences in school management held by women principals in Andalusian early and elementary public schools. Using the survey method, data were collected through a questionnaire from a sample of 206 principals selected through a several-stages procedure. Results show that most women principals were middle-aged, have an extensive professional experience and have no children or other people under their care. They occupied the headship due to altruistic and personal reasons, and they considered the lack of support from Educational Administration as the main problem they have to cope. Also, they conceived their work as a team effort with a facilitator function. Este trabajo persigue identificar las opiniones y experiencias ante la dirección escolar de las directoras de centros públicos de Educación Infantil y Primaria en Andalucía. Se realizó un estudio tipo encuesta con una muestra de 206 directoras seleccionada mediante un muestreo polietápico, utilizando el cuestionario para la recogida de información. Los resultados muestran que las directoras tienen mediana edad, una dilatada experiencia profesional y, en su mayoría, están relativamente libres de cargas familiares. Accedieron al cargo por razones altruistas y personales, y se alan la falta de apoyo de la Administración como su principal problema. Conciben su función como una labor de equipo eminentemente facilitadora.
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