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Search Results: 1 - 10 of 1164 matches for " Elvira Henze "
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Impairment and Differential Expression of PR3 and MPO on Peripheral Myelomonocytic Cells with Endothelial Properties in Granulomatosis with Polyangiitis
Susann Patschan,Daniel Patschan,Elvira Henze,Sabine Blaschke,Johannes T. Wessels,Gerhard Anton Müller
International Journal of Nephrology , 2012, DOI: 10.1155/2012/715049
Abstract: Background. Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune-mediated diseases characterized by vasculitic inflammation of respiratory tract and kidneys. Clinical observations indicated a strong association between disease activity and serum levels of certain types of autoantibodies (antineutrophil cytoplasm antibodies with cytoplasmic [cANCA in GPA] or perinuclear [pAN CA in MPA] immunofluorescence). Pathologically, both diseases are characterized by severe microvascular endothelial cell damage. Early endothelial outgrowth cells (eEOCs) have been shown to be critically involved in neovascularization under both physiological and pathological condition. Objectives. The principal aims of our study were (i) to analyze the regenerative activity of the eEOC system and (ii) to determine mPR3 and MPO expression in myelo monocytic cells with endothelial characteristics in GPA and MPA patients. Methods. In 27 GPA and 10 MPA patients, regenerative activity blood-derived eEOCs were analyzed using a culture-forming assay. Flk-1+, CD133+/Flk-1+, mPR3+, and Flk-1+/mPR3+ myelomonocytic cells were quantified by FACS analysis. Serum levels of Angiopoietin-1 and TNF- were measured by ELISA. Results. We found reduced eEOC regeneration, accompanied by lower serum levels of Angiopoietin-1 in GPA patients as compared to healthy controls. In addition, the total numbers of Flk-1+ myelomonocytic cells in the peripheral circulation were decreased. Membrane PR3 expression was significantly higher in total as well as in Flk-1+ myelomonocytic cells. Expression of MPO was not different between the groups. Conclusions. These data suggest impairment of the eEOC system and a possible role for PR3 in this process in patients suffering from GPA. 1. Introduction Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune diseases characterized by systemic necrotizing vasculitis mainly affecting the respiratory tract and the kidneys [1]. Histopathological analysis reveals severe structural alterations of microvascular endothelial cells, leading to impaired microcirculation in skin, joints, respiratory tract, and kidneys, respectively. Endothelial damage has been suggested to result from interactions between primed neutrophils and ANCA with the endothelium followed by endothelial detachment from the basement membrane [2]. A number of different studies showed increased levels of both, circulating mature endothelial cells and endothelial microparticles in GPA and MPA [3, 4]. Thus, patients with GPA and MPA suffer from
Endothelial progenitor cells (EPC) in sepsis with acute renal dysfunction (ARD)
Susann A Patschan, Daniel Patschan, Johanna Temme, Peter Korsten, Johannes T Wessels, Michael Koziolek, Elvira Henze, Gerhard A Müller
Critical Care , 2011, DOI: 10.1186/cc10100
Abstract: Patients with newly diagnosed sepsis were recruited from the ICU in a nonrandomized prospective manner. Blood samples were obtained within the first 12 hours after the diagnosis of sepsis. For quantifying endothelial progenitor cells (EPCs), CD133+/Flk-1+ cells were enumerated by cytometric analysis. Analysis of EPC proliferation was performed by a colony-forming units (CFU) assay. Blood concentrations of proangiogenic mediators were measured by ELISA. Acute renal dysfunction was diagnosed according to the Acute Kidney Injury Network (AKIN) criteria. Depending on the overall mean creatinine concentration during the stay at the ICU, patients were either assigned to a 'normal creatinine group' or to a 'high creatinine group'. Survival rates, frequency of dialysis, the simplified acute physiology score (SAPS) II scores, and different laboratory parameters were collected/used for further clinical characterizationCirculating EPCs were significantly higher in all sepsis patients included in the study as opposed to healthy controls. Patients within the 'high creatinine group' showed an even more pronounced EPC increase. In contrast, EPC proliferation was severely affected in sepsis. Neither total circulating EPCs nor EPC proliferation differed between patients requiring dialysis and patients without renal replacement therapy. Cell numbers and cell proliferation also did not differ between surviving patients and patients with sepsis-related death. Serum levels of vascular endothelial growth factor (VEGF), stromal derived factor-1 (SDF-1), and Angiopoietin-2 were higher in sepsis than in healthy controls. Sepsis patients within the 'high creatinine group' showed significantly higher mean serum levels of uric acid.Sepsis significantly affects the endothelial progenitor cell system, as reflected by increased EPC numbers, increased concentrations of proangiogenic mediators, and reduced proliferative capacity of the cells. This occurs independently from the frequency of dialysis
Personalized E-Learning in the Semantic Web
Nicola Henze
International Journal of Emerging Technologies in Learning (iJET) , 2006,
Abstract: This paper describes our idea for realizing personalized e-Learning in the Semantic Web. We have developed a framework for designing, implementing and maintaining Personal Learning Object Readers, which enable the learners to study Learning Objects in an embedding, personalized context. We describe the architecture of our Personal Reader framework, and discuss the possible authoring processes for creating Personal Learning Object Readers.
On counterexamples to a conjecture of Wills and Ehrhart polynomials whose roots have equal real parts
Matthias Henze
Mathematics , 2013,
Abstract: As a discrete analog to Minkowski's theorem on convex bodies, Wills conjectured that the Ehrhart coefficients of a centrally symmetric lattice polytope with exactly one interior lattice point are maximized by those of the cube of side length two. We discuss several counterexamples to this conjecture and, on the positive side, we identify a family of lattice polytopes that fulfill the claimed inequalities. This family is related to the recently introduced class of $l$-reflexive polytopes.
A Blichfeldt-type inequality for centrally symmetric convex bodies
Matthias Henze
Mathematics , 2012, DOI: 10.1007/s00605-012-0461-2
Abstract: In this note, we derive an asymptotically sharp upper bound on the number of lattice points in terms of the volume of centrally symmetric convex bodies. Our main tool is a generalization of a result of Davenport that bounds the number of lattice points in terms of volumes of suitable projections.
Bottleneck Partial-Matching Voronoi Diagrams and Applications
Matthias Henze,Rafel Jaume
Computer Science , 2014,
Abstract: Given two point sets in the plane, we study the minimization of the bottleneck distance between a point set B and an equally-sized subset of a point set A under translations. We relate this problem to a Voronoi-type diagram and derive polynomial bounds for its complexity that are optimal in the size of A. We devise efficient algorithms for the construction of such a diagram and its lexicographic variant, which generalize to higher dimensions. We use the diagram to find an optimal bottleneck matching under translations, to compute a connecting path of minimum bottleneck cost between two positions of B, and to determine the maximum bottleneck cost in a convex polygon.
Development and Application of an Inter-Organizational PPP Knowledge Transfer Effectiveness Model for Knowledge Sourced in Public Sector Organizations  [PDF]
Geoffrey Aerts, Elvira Haezendonck
American Journal of Industrial and Business Management (AJIBM) , 2017, DOI: 10.4236/ajibm.2017.75050
Abstract: The research aim is to develop and apply the conceptual inter-organizational knowledge transfer effectiveness (IOKTE) model to the inter-organizational transfer of Public-Private Partnership (PPP) related knowledge between public sector organizations in Flanders. The model assumes a relationship between an individual’s ability to make PPP-related decisions and the extent to which knowledge is sought after, applied and shared in an inter-organisational manner within the public sector. The inter-organizational transfer of knowledge studied in this article is specific to PPP in Flanders and studied for public sector actors active at diverse policy levels. The aim is to uncover the extent to which the current system of inter-organizational knowledge transfer fits the user’s satisfaction, expressed as the extent to which the use of the system improves the perceived decision-making on PPPs. The results indicate that searching for, sharing and using PPP-related knowledge sourced in public sector organizations improve the perceived decision-making ability. The research establishes that the current public sector PPP knowledge transfer system is perceived as being effective, yet for the assessment of its efficiency, insufficient data is found. Issues that stand to be improved are the fragmentation of the knowledge assets and the access across policy levels.
Biological denitrification of fertiliser wastewater at high chloride concentration
Ahmed S Ucisik, Mogens Henze
Water SA , 2004,
Abstract: Wastewater from the fertiliser industry is characterised by high chloride concentration, normally varying between 60 and 76 g/ . Experiments with biological denitrification were performed in laboratory-scale \'fill and draw\' reactors with synthetic fertiliser wastewater, with chloride concentrations up to 96.7 g Cl/ at 37oC; the pH was controlled in the range 6.8 to 7.2. Potassium acetate was added as carbon source for the suspended cultures. The results of the experiments showed that biological denitrification was feasible at the extreme environmental conditions prevailing in undiluted fertiliser wastewater. However, the extreme conditions affected the denitrification rates. The volumetric rates were reduced by a factor of ten between chloride levels of 4.8 to 96.7 g/ . The results from the performed tests can also be applied to other wastewaters with similar characteristics as that of the fertiliser industry, i.e. with high salinity. As an example, the pharmaceutical and aquacultural industries can be mentioned. WaterSA Vol.30 (2) 2004: 191-195
Foreign Direct Investment and growth in Central, Eastern and Southern Europe
Sapienza, Elvira;
Investigación económica , 2010,
Abstract: this paper examines the role of foreign direct investment (fdi) in promoting growth in 25 central, eastern and southern european countries (cese) using a dynamic panel approach that includes lags of involved variables to mitigate the problem of serial correlation. it adopts also a ‘general-to-specific’ approach to deal with the problem of the omitted variable and uses different estimation methods to control for heterogeneity. the main finding is that fdi has a positive and significant impact on economic growth coupled with an open economic environment.
La orientación intercultural: problemas y perspectivas
Orientaci?3n y sociedad , 2002,
Abstract: this work tries to assess the contributions made to educational counseling in recent years by theoretical and applied research and practical actions in the area of cross-cultural counseling. so, it offers a synthesis of the main contributions made from the theoretical and practical viewpoints within this specific scientific field.
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