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Search Results: 1 - 10 of 120468 matches for " Elizabeth O'Day "
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MicroRNAs and their target gene networks in breast cancer
Elizabeth O'Day, Ashish Lal
Breast Cancer Research , 2010, DOI: 10.1186/bcr2484
Abstract: MicroRNAs (miRNAs) are an evolutionarily conserved class of small, approximately 22-nucleotide non-coding RNAs that decrease gene expression post-transcriptionally in a sequence-specific manner. Most miRNAs are transcribed in the nucleus by RNA polymerase II (although some miRNAs are also transcribed by RNA polymerase III [1]) as long primary transcripts (primiRNAs) that undergo processing by Drosha and DGCR8, resulting in an approximately 70-nucleotide stem-loop RNA (pre-miRNA). Pre-miRNAs are subsequently exported to the cytoplasm via Exportin 5 and cleaved by Dicer, giving rise to approximately 22-nucleotide RNA duplexes. The strand with decreased base-pairing at its 5' end is then selected to function as a mature miRNA, while the other strand (also referred to as the passenger strand) is typically degraded [2,3]. The mature miRNA associates with Argonautes and other proteins to form the RNA-induced silencing complex (miRISC), which then binds to target mRNAs via partial complementarity. Many transcription factors that regulate mRNA transcription also control miRNA biogenesis. Although transcription plays a major role in miRNA biogenesis, additional mechanisms, such as DNA methylation, can also regulate miRNA expression [4]. Mammalian miRNAs predominantly act by binding to the 3' untranslated region (UTR) of cognate mRNAs. However, there is growing evidence that they can also downregulate the expression of some genes by base-pairing to the coding region [5-8] or the 5' UTR of some mRNAs [9].Initially, miRNAs were thought to function mainly by suppressing mRNA translation [10]. However, two recent studies combined proteomics and microarrays to reveal that changes in protein expression mediated by a miRNA are usually associated with altered mRNA expression, suggesting that mRNA degradation may be the major component of mammalian miRNA repression [11,12]. Although most studies suggest that miRNAs negatively regulate gene expression by base-pairing to the 3' UTR, a f
Secretory Protein mRNA Finds Another Way Out
Kira E. O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0050330
Abstract:
Shedding Light on Animal Cryptochromes
Kira E. O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060168
Abstract:
Completing the Candida Loop
Kira O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0050270
Abstract:
Gut Reaction: Pyrosequencing Provides the Poop on Distal Gut Bacteria
Kira O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060295
Abstract:
Conspicuous Chameleons
Kira E. O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060021
Abstract:
An Enzymatic Palimpsest
Kira E. O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060217
Abstract:
Omnidirectional Electric Fish
Kira E. O'Day
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0050314
Abstract:
Completing the Candida Loop
Kira O'Day
PLOS Biology , 2007, DOI: 10.1371/journal.pbio.0050270
Abstract:
Conspicuous Chameleons
Kira E O'Day
PLOS Biology , 2008, DOI: 10.1371/journal.pbio.0060021
Abstract:
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