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Search Results: 1 - 10 of 32982 matches for " Elizabeth Ferreira Martinez "
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FGF-2, TGFβ-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study
Miguita, Lucyene;Martinez, Elizabeth Ferreira;Araújo, Ney Soares de;Araújo, Vera Cavalcanti de;
Journal of Applied Oral Science , 2010, DOI: 10.1590/S1678-77572010000100014
Abstract: myoepithelial cells have an important role in salivary gland tumor development, contributing to a low grade of aggressiveness of these tumors. normal myoepithelial cells are known by their suppressor function presenting increased expression of extracellular matrix genes and protease inhibitors. the importance of stromal cells and growth factors during tumor initiation and progression has been highlighted by recent literature. many tumors result from the alteration of paracrine growth factors pathways. growth factors mediate a wide variety of biological processes such as development, tissue repair and tumorigenesis, and also contribute to cellular proliferation and transformation in neoplastic cells. objectives: this study evaluated the expression of fibroblast growth factor-2 (fgf-2), transforming growth factor β-1 (tgfβ-1), platelet-derived growth factor-a (pdgf-a) and their respective receptors (fgfr-1, fgfr-2, tgfβr-ii and pdgfr-α) in myoepithelial cells from pleomorphic adenomas (pa) by in vivo and in vitro experiments. material and methods: serial sections were obtained from paraffin-embedded pa samples obtained from the school's files. myoepithelial cells were obtained from explants of pa tumors provided by surgery from different donors. immunohistochemistry, cell culture and immunofluorescence assays were used to evaluate growth factor expression. results: the present findings demonstrated that myoepithelial cells from pa were mainly positive to fgf-2 and fgfr-1 by immunohistochemistry and immunofluorescence. pdgf-a and pdgfr-α had moderate expression by immunohistochemistry and presented punctated deposits throughout cytoplasm of myoepithelial cells. fgfr-2, tgfβ-1 and tgfβr-ii were negative in all samples. conclusions: these data suggested that fgf-2 compared to the other studied growth factors has an important role in pa benign myoepithelial cells, probably contributing to proliferation of these cells through the fgfr-1.
Dentin matrix protein 1 (DMP1) expression in developing human teeth
Martinez, Elizabeth Ferreira;Silva, Luciana Alves Herdy da;Furuse, Cristiane;Araújo, Ney Soares de;Araújo, Vera Cavalcanti de;
Brazilian Dental Journal , 2009, DOI: 10.1590/S0103-64402009000500002
Abstract: dentin matrix protein 1 (dmp1) is an acidic phosphoprotein that plays an important role in mineralized tissue formation by initiation of nucleation and modulation of mineral phase morphology. the purpose of the present study was to examine the immunoexpression of dmp1 in tooth germs of 7 human fetuses at different gestational ages (14, 16, 19, 20, 21, 23 and 24 weeks) comparing with completed tooth formation erupted teeth. the results showed the presence of dmp1 in the dental lamina, as well as in the cells of the external epithelium, stellate reticulum and stratum intermedium of the enamel organ. however, in the internal dental epithelium, cervical loop region and dental papilla some cells have not labeled for dmp1. in the crown stage, dmp1 was expressed in the ameloblast and odontoblast layer, as well as in the dentinal tubules of coronal dentin near the odontoblast area. erupted teeth with complete tooth formation exhibited immunolabeling for dmp1 only in the dentinal tubules mainly close to the dental pulp. no staining was observed in the enamel, predentin or dental pulp matrix. dmp1 is present in all developing dental structures (dental lamina, enamel organ, dental papilla) presenting few immunoexpression variations, with no staining in mineralized enamel and dentin.
Intraoral Adult Rhabdomyoma: A Case Report
Ana Amelia Souza,Vera Cavalcanti de Araújo,Fabricio Passador Santos,Elizabeth Ferreira Martinez,Jose Ferreira de Menezes Filho,Ney Soares de Araujo,Andresa Borges Soares
Case Reports in Dentistry , 2013, DOI: 10.1155/2013/741548
Abstract: A case of adult rhabdomyoma is reported. The lesion is a rare benign tumor of skeletal muscle origin which occurs predominantly in the head and neck region. In the present case, the clinical diagnosis favored a benign salivary gland tumor. Histologically, the tumor was composed of large round, oval, and polygonal cells of varying size with abundant pale, eosinophilic, fine, granular cytoplasm with peripherally located nuclei. Immunohistochemically, the lesion was positive for muscle-specific actin, smooth muscle actin, desmin, S100 protein, and Masson’s trichrome. Electron microscopic examination confirmed the presence of numerous myofibrils. The lesion was treated by surgical resection. The clinical, histological, immunohistochemical, and ultrastructural features are discussed in this study. 1. Introduction Rhabdomyomas are rare benign tumors derived from striated muscle, and can be classified generally into two types: cardiac type and extracardiac type. Cardiac rhabdomyoma occurs almost exclusively in the pediatric age group and may be associated with tuberous sclerosis, neurofibromatosis, and sebaceous adenomas. Current opinion is that the cardiac type represents a hamartomatous growth [1]. Extracardiac rhabdomyoma can be divided into three groups (adult, fetal, and genital types) with regards to clinical and morphological differences. The adult type is characterized by a slowly growing mass typically seen in the head and neck of elderly patients. In the fetal type, the lesion also typically involves the head and neck region and tends to occur at younger ages. The genital type is almost always found in the vulvovaginal region of middle-aged women [2]. The fetal and vaginal types are morphologically similar [3]. Seventy-seven percent of all extracardiac rhabdomyomas occur in the head and neck and 14% in the genital region [4]. The adult rhabdomyoma is the most common form of extracardiac rhabdomyoma. The tumor arises mainly within the head and neck region where it is believed to originate from the skeletal musculature of the third and fourth branchial arches. It is so called because of the histological resemblance to mature skeletal muscle cells [5]. These tumors are usually solitary; however, several authors have reported cases of adult multifocal extracardiac rhabdomyomas [6, 7]. In this paper we report a rare case of an adult rhabdomyoma originating in the floor of the mouth. 2. Case Report The patient, a 40-year-old white woman, came to dentistry complaining of a painless swelling in the left floor of mouth that had been present for 6 months. The
“Tourism Potentiality” as an Additional Activity for Socio-Economic Development of the Fishing Field in Las Aguamitas, Sinaloa, Mexico  [PDF]
Marcela Rebeca Contreras-Loera, Elizabeth Olmos-Martinez
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.56063

Riparian rural communities are characterized as spaces whose main activity is the exploitation of natural resources of the sea, but the diversification of economic activities is an option to change their current situation. The fishing cooperative plays a critical role in addressing the challenges imposed by the demands of today’s world. It is necessary to implement practices that contribute to economic, social and ecological development of the locality. This paper presents results of research whose objective was to identify the tourism potentiality as a complementary activity to economic and social development of the rural community in Las Aguamitas and the role of the fishing cooperative Barra de La Tonina, in local community development. Data collection was conducted through semi-structured interviews and observation. In addition, a survey to characterize socioe-conomically cooperative members was applied. The findings indicate that Las Aguamitas is a rural community with a wide range of natural and human resources to promote and encourage tourism. Even though the members of the cooperative and the community residents offer travel services, these are informal and without professionalization of the activity. From the above, it is concluded that the rural community has potential for tourism as a complementary activity for socioeconomic development, however it needs to train and professionalize the activity.

Neutrophils in Oral Paracoccidioidomycosis and the Involvement of Nrf2
Vera Cavalcanti Araújo, Ana Paula Dias Demasi, Andresa Borges Soares, Fabrício Passador-Santos, Marcelo Henrique Napimoga, Elizabeth Ferreira Martinez, Nadir Severina Freitas, Ney Soares Araújo
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076976
Abstract: Neutrophils have been implicated in granuloma formation in several infectious diseases, in addition to their main phagocytic and pathogen destruction role. It has been demonstrated that Nrf2 regulates antioxidant protection in neutrophils, attenuating inflammation without compromising the hosts bacterial defense. In this study, we analyzed the presence of neutrophils in Paracoccidioides brasiliensis mycosis (PCM), as well as the immunoexpression of Nrf2. Thirty-nine cases of oral PCM were classified according to quantity of fungi and to the presence of loose or well-organized granulomas and microabscesses. An Nrf2 antibody was used for immunohistochemical analysis. The results showed that neutrophils are present in microabscesses and loose granulomas, but were absent in structured granulomas. A greater quantity of fungi was shown in cases with only loose granulomas when compared to loose and well organized granulomas. Nrf2 was observed in the nuclei of neutrophils of loose granulomas and abscesses, with its expression in loose granulomas maintained despite the additional presence of well organized granulomas in the same specimen. This study suggests that neutrophils participate in P. brasiliensis granuloma formation and that Nrf2 has a possible role in neutrophil survival, via modulation of the inflammatory response.
Escravos na ro?a, anjos na escola
Linhares, Elizabeth Ferreira;
Tempo Social , 2008, DOI: 10.1590/S0103-20702008000100005
Abstract: based on a case study, this article analyses the process of change and construction of different social contexts and the respective meanings of childhood and school to a group of former colonos in rio de janeiro coffee plantations, now living on a rural settlement in the state's mountain region. considering the historical and social development of the colonato system and the progressive deconstruction of its constituent relationships, the conditions experienced by the children of different generations are analysed with special emphasis on the changes of role and meaning of the school to this group and its implications for the children's daily lives and the representations of childhood itself.
Elizabeth Igne Ferreira
Revista Brasileira de Ciências Farmacêuticas , 2004, DOI: 10.1590/s1516-93322004000300001
Elizabeth Igne Ferreira
Revista Brasileira de Ciências Farmacêuticas , 2002, DOI: 10.1590/s1516-93322002000400001
Elizabeth Igne Ferreira
Revista Brasileira de Ciências Farmacêuticas , 2006, DOI: 10.1590/s1516-93322006000400001
Elizabeth Igne Ferreira
Revista Brasileira de Ciências Farmacêuticas , 2005, DOI: 10.1590/s1516-93322005000400001
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