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Search Results: 1 - 10 of 18824 matches for " Elisabeth Le Bihan-Duval "
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Identification of differentially expressed genes in chickens differing in muscle glycogen content and meat quality
Vonick Sibut, Christelle Hennequet-Antier, Elisabeth Le Bihan-Duval, Sylvain Marthey, Michel J Duclos, Cécile Berri
BMC Genomics , 2011, DOI: 10.1186/1471-2164-12-112
Abstract: Among the genes found to be expressed in chicken P. major muscle, 197 and 254 transcripts appeared to be differentially expressed on microarrays for the F vs. L and the G+ vs. G- comparisons, respectively. Some involved particularly in lipid and carbohydrate metabolism were selected for further validation studies by real-time RT-PCR. We confirmed that, as in mammals, the down-regulation of CEBPB and RGS2 coincides with a decrease in peripheral adiposity in the chicken, but these genes are also suggested to affect muscle glycogen turnover through their role in the cAMP-dependent signalling pathway. Several other genes were suggested to have roles in the regulation of glycogen storage in chicken muscle. PDK4 may act as a glycogen sensor in muscle, UGDH may compete for glycogen synthesis by using UDP-glucose for glucoronidation, and PRKAB1, PRKAG2, and PHKD may impact on glycogen turnover in muscle, through AMP-activated signalling pathways.This study is the first stage in the understanding of molecular mechanisms underlying variations in poultry meat quality. Large scale analyses are now required to validate the role of the genes identified and ultimately to find molecular markers that can be used for selection or to optimize rearing practices.With changes similar to those that occurred in the pig industry, the poultry market is now characterized by increasing diversity of processed products [1]. As a consequence, poultry companies are now involved in food technology and product development, and improvement of meat processing ability has become a prevalent concern. As in pigs, post-mortem pH is a key factor controlling chicken meat quality [2]. Variations in ultimate meat pH (pHu) are responsible for variations in several breast meat properties, including water-holding capacity, colour and firmness [2,3]. Low ultimate pH results in "acid meat", with a pale aspect and reduced water-holding capacity [4], while high ultimate pH leads to DFD (dark, firm, dry) meat, dark i
Chicken meat quality: genetic variability and relationship with growth and muscle characteristics
Elisabeth Le Bihan-Duval, Martine Debut, Cécile M Berri, Nadine Sellier, Véronique Santé-Lhoutellier, Yves Jégo, Catherine Beaumont
BMC Genetics , 2008, DOI: 10.1186/1471-2156-9-53
Abstract: Significant levels of heritability (averaging 0.3) were obtained for breast meat quality traits such as pH at 15 min post-slaughter, ultimate pH (pHu), color assessed by lightness L*, redness a* and yellowness b*, drip loss, thawing-cooking loss and shear-force. The rate of decrease in pH early post-mortem and the final pH of the meat were shown to be key factors of chicken meat quality. In particular, a decrease in the final pH led to paler, more exudative and tougher breast meat. The level of glycogen stored in breast muscle estimated by the Glycolytic Potential (GP) at slaughter time was shown to be highly heritable (h2 0.43). There was a very strong negative genetic correlation (rg) with ultimate meat pH (rg -0.97), suggesting a common genetic control for GP and pHu. While breast muscle weight was genetically positively correlated with fiber size (rg 0.76), it was negatively correlated with the level of glycogen stored in the muscle (rg -0.58), and as a consequence it was positively correlated with the final pH of the meat (rg 0.84).This genetic study confirmed that selection should be useful to improve meat characteristics of meat-type chickens without impairing profitability because no genetic conflict was detected between meat quality and meat quantity. Moreover, the results suggested relevant selection criteria such as ultimate pH, which is strongly related to color, water-holding capacity and texture of the meat in this heavy chicken line.As in other animal species, the technological quality of poultry meat is now of major importance, since poultry meat is nowadays usually consumed as cuts or as processed products rather than as whole carcasses. As already reported for pigs [1], technological quality refers to several meat properties, including water-holding capacity (i.e. drip loss during storage), intensity and homogeneity of color, firmness, shelf-life and processing yields. Meat quality is closely related to the decrease in muscle pH post-mortem. Rapid
Improving the efficiency of feed utilization in poultry by selection. 2. Genetic parameters of excretion traits and correlations with anatomy of the gastro-intestinal tract and digestive efficiency
Hugues de Verdal, Agnès Narcy, Denis Bastianelli, Hervé Chapuis, Nathalie Même, Séverine Urvoix, Elisabeth Le Bihan-Duval, Sandrine Mignon-Grasteau
BMC Genetics , 2011, DOI: 10.1186/1471-2156-12-71
Abstract: The genetic parameters of several excretion traits were estimated on 630 chickens originating from 2 chicken lines divergently selected on apparent metabolisable energy corrected for zero nitrogen (AMEn) at constant body weight. The quantity of excreta relative to feed consumption (CDUDM), the nitrogen and phosphorus excreted, the nitrogen to phosphorus ratio and the water content of excreta were measured, and the consequences of such selection on performance and gastro-intestinal tract (GIT) characteristics estimated. The genetic correlations between excretion, GIT and performance traits were established.Heritability estimates were high for CDUDM and the nitrogen excretion rate (0.30 and 0.29, respectively). The other excretion measurements showed low to moderate heritability estimates, ranging from 0.10 for excreta water content to 0.22 for the phosphorus excretion rate. Except for the excreta water content, the CDUDM was highly correlated with the excretion traits, ranging from -0.64 to -1.00. The genetic correlations between AMEn or CDUDM and the GIT characteristics were very similar and showed that a decrease in chicken excretion involves an increase in weight of the upper part of the GIT, and a decrease in the weight of the small intestine.In order to limit the environmental impact of chicken production, AMEn and CDUDM seem to be more suitable criteria to include in selection schemes than feed efficiency traits.Animal excreta provide valuable organic fertilizers. However, in regions where they are used in excess, they can be associated with environmental pollution [1], such as nitrate contamination, soil acidification and water eutrophication. This is often the case for poultry production in Europe, due to the high concentration of poultry farms in several regions such as Brittany in France. For example, French poultry meat production was estimated to be 2.0 106t in 2005 and the quantity of faeces generated has been estimated at 3.0 106t for manure and 6.0 106
Improving the efficiency of feed utilization in poultry by selection. 1. Genetic parameters of anatomy of the gastro-intestinal tract and digestive efficiency
Hugues de Verdal, Agnès Narcy, Denis Bastianelli, Hervé Chapuis, Nathalie Même, Séverine Urvoix, Elisabeth Le Bihan-Duval, Sandrine Mignon-Grasteau
BMC Genetics , 2011, DOI: 10.1186/1471-2156-12-59
Abstract: Genetic parameters were estimated for 630 broiler chickens of the eighth generation of a divergent selection experiment on AMEn. Birds were reared until 23 d of age and fed a wheat-based diet. The traits measured were body weight (BW), feed conversion ratio (FCR), AMEn, weights of crop, liver, gizzard and proventriculus, and weight, length and density of the duodenum, jejunum and ileum.The heritability estimates of BW, FCR and AMEn were moderate. The heritability estimates were higher for the GIT characteristics except for the weights of the proventriculus and liver. Gizzard weight was negatively correlated with density (weight to length ratio) of duodenum, jejunum and ileum. Proventriculus and gizzard weights were more strongly correlated with AMEn than with FCR, which was not the case for intestine weight and density.GIT traits were largely dependent on genetics and that selecting on AMEn or FCR would modify them. Phenotypic observations carried out in the divergent lines selected on AMEn were consistent with estimated genetic correlations between AMEn and GIT traits.Improving feed efficiency is a major factor in reducing the costs of poultry production and the environmental impact of chicken production. Many genetic studies have shown that feed efficiency could be improved by selecting on growth, FCR (feed conversion ratio) or feed intake, which are heritable [1]. Mignon-Grasteau et al. [2] recently showed that the ability of the animal to digest its feed could also be used as a selection criterion. Following this study, two lines (D+ and D-) were divergently selected on digestive efficiency assessed by the AMEn (Apparent Metabolisable Energy corrected for zero nitrogen retention) of a wheat-based diet, measured at 3 weeks of age. After 7 generations of selection, D+ and D- lines differed by about 30 to 40% on the selection criterion, but presented similar body weights [3]. Mignon-Grasteau et al. [2] and Rougière et al. [4] also showed that levels of starch, prot
Evidence of Phenotypic and Genetic Relationships between Sociality, Emotional Reactivity and Production Traits in Japanese Quail
Julien Recoquillay, Christine Leterrier, Ludovic Calandreau, Aline Bertin, Frédérique Pitel, David Gourichon, Alain Vignal, Catherine Beaumont, Elisabeth Le Bihan-Duval, Cécile Arnould
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082157
Abstract: The social behavior of animals, which is partially controlled by genetics, is one of the factors involved in their adaptation to large breeding groups. To understand better the relationships between different social behaviors, fear behaviors and production traits, we analyzed the phenotypic and genetic correlations of these traits in Japanese quail by a second generation crossing of two lines divergently selected for their social reinstatement behavior. Analyses of results for 900 individuals showed that the phenotypic correlations between behavioral traits were low with the exception of significant correlations between sexual behavior and aggressive pecks both at phenotypic (0.51) and genetic (0.90) levels. Significant positive genetic correlations were observed between emotional reactivity toward a novel object and sexual (0.89) or aggressive (0.63) behaviors. The other genetic correlations were observed mainly between behavioral and production traits. Thus, the level of emotional reactivity, estimated by the duration of tonic immobility, was positively correlated with weight at 17 and 65 days of age (0.76 and 0.79, respectively) and with delayed egg laying onset (0.74). In contrast, a higher level of social reinstatement behavior was associated with an earlier egg laying onset (-0.71). In addition, a strong sexual motivation was correlated with an earlier laying onset (-0.68) and a higher number of eggs laid (0.82). A low level of emotional reactivity toward a novel object and also a higher aggressive behavior were genetically correlated with a higher number of eggs laid (0.61 and 0.58, respectively). These results bring new insights into the complex determinism of social and emotional reactivity behaviors in birds and their relationships with production traits. Furthermore, they highlight the need to combine animal welfare and production traits in selection programs by taking into account traits of sociability and emotional reactivity.
Fatness QTL on chicken chromosome 5 and interaction with sex
Behnam Abasht, Frédérique Pitel, Sandrine Lagarrigue, Elisabeth Le Bihan-Duval, Pascale Le Roy, Olivier Demeure, Florence Vignoles, Jean Simon, Larry Cogburn, Sammy Aggrey, Alain Vignal, Madeleine Douaire
Genetics Selection Evolution , 2006, DOI: 10.1186/1297-9686-38-3-297
Abstract: (To access the full article, please see PDF)
Detection of a Cis eQTL Controlling BMCO1 Gene Expression Leads to the Identification of a QTG for Chicken Breast Meat Color
Elisabeth Le Bihan-Duval,Javad Nadaf,Cécile Berri,Frédérique Pitel,Beno?t Graulet,Estelle Godet,Sophie Y. Leroux,Olivier Demeure,Sandrine Lagarrigue,Cécile Duby,Larry A. Cogburn,Catherine M. Beaumont,Michel J. Duclos
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014825
Abstract: Classical quantitative trait loci (QTL) analysis and gene expression QTL (eQTL) were combined to identify the causal gene (or QTG) underlying a highly significant QTL controlling the variation of breast meat color in a F2 cross between divergent high-growth (HG) and low-growth (LG) chicken lines. Within this meat quality QTL, BCMO1 (Accession number GenBank: AJ271386), encoding the β-carotene 15, 15′-monooxygenase, a key enzyme in the conversion of β-carotene into colorless retinal, was a good functional candidate. Analysis of the abundance of BCMO1 mRNA in breast muscle of the HG x LG F2 population allowed for the identification of a strong cis eQTL. Moreover, reevaluation of the color QTL taking BCMO1 mRNA levels as a covariate indicated that BCMO1 mRNA levels entirely explained the variations in meat color. Two fully-linked single nucleotide polymorphisms (SNP) located within the proximal promoter of BCMO1 gene were identified. Haplotype substitution resulted in a marked difference in BCMO1 promoter activity in vitro. The association study in the F2 population revealed a three-fold difference in BCMO1 expression leading to a difference of 1 standard deviation in yellow color between the homozygous birds at this haplotype. This difference in meat yellow color was fully consistent with the difference in carotenoid content (i.e. lutein and zeaxanthin) evidenced between the two alternative haplotypes. A significant association between the haplotype, the level of BCMO1 expression and the yellow color of the meat was also recovered in an unrelated commercial broiler population. The mutation could be of economic importance for poultry production by making possible a gene-assisted selection for color, a determining aspect of meat quality. Moreover, this natural genetic diversity constitutes a new model for the study of β-carotene metabolism which may act upon diverse biological processes as precursor of the vitamin A.
Identification of QTL controlling meat quality traits in an F2 cross between two chicken lines selected for either low or high growth rate
Javad Nadaf, Hélène Gilbert, Frédérique Pitel, Cécile M Berri, Katia Feve, Catherine Beaumont, Michel J Duclos, Alain Vignal, Tom E Porter, Jean Simon, Samuel E Aggrey, Larry A Cogburn, Elisabeth Le Bihan-Duval
BMC Genomics , 2007, DOI: 10.1186/1471-2164-8-155
Abstract: The HG and LG birds exhibit large differences in body weight and abdominal fat content. Several meat quality traits [pH at 15 min post-slaughter (pH15) and ultimate pH (pHu), breast color-redness (BCo-R) and breast color-yellowness (BCo-Y)] were lower in HG chickens. In contrast, meat color-lightness (BCo-L) was higher in HG chickens, whereas meat drip loss (DL) was similar in both lines. HG birds were more active on the shackle line. Association analyses were performed using maximum-likelihood interval mapping in QTLMAP. Five genome-wide significant QTLs were revealed: two for pH15 on GGA1 and GGA2, one for DL on GGA1, one for BCo-R and one for BCo-Y both on GGA11. In addition, four suggestive QTLs were identified by QTLMAP for BCo-Y, pHu, pH15 and DL on GGA1, GGA4, GGA12 and GGA14, respectively. The QTL effects, averaged on heterozygous families, ranged from 12 to 31% of the phenotypic variance. Further analyses with QTLExpress confirmed the two genome-wide QTLs for meat color on GGA11, failed to identify the genome-wide QTL for pH15 on GGA2, and revealed only suggestive QTLs for pH15 and DL on GGA1. However, QTLExpress qualified the QTL for pHu on GGA4 as genome-wide.The present study identified genome-wide significant QTLs for all meat technological traits presently assessed in these chickens, except for meat lightness. This study highlights the effects of divergent selection for growth rate on some behavioral traits, muscle biochemistry and ultimately meat quality traits. Several QTL regions were identified that are worthy of further characterization. Some QTLs may in fact co-localize, suggesting pleiotropic effects for some chromosomal regions.Meat-type chickens have been intensively selected for a long time mainly on growth rate, which has reduced the age at market weight (i.e. ~2 kg live body weight). Selection efforts have improved body composition (i.e. increasing breast yield and lowering carcass fatness). However, these improvements have also led to indi
Genetic parameters of the twisted legs syndrome in broiler chickens
E Le Bihan-Duval, C Beaumont, JJ Colleau
Genetics Selection Evolution , 1996, DOI: 10.1186/1297-9686-28-2-177
Abstract:
Predicting observed and latent responses to BLUP selection involving logistic variates
Jean-Jacques Colleau, Elizabeth Le Bihan-Duval
Genetics Selection Evolution , 2000, DOI: 10.1186/1297-9686-32-3-265
Abstract: (To access the full article, please see PDF)
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