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Search Results: 1 - 10 of 331 matches for " Elisabet Ekman "
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Antihypertensive drugs and erectile dysfunction as seen in spontaneous reports, with focus on angiotensin II type 1 receptor blockers
Elisabet Ekman, Staffan H gg, Anders Sundstr m, et al
Drug, Healthcare and Patient Safety , 2010, DOI: http://dx.doi.org/10.2147/DHPS.S8432
Abstract: ntihypertensive drugs and erectile dysfunction as seen in spontaneous reports, with focus on angiotensin II type 1 receptor blockers Original Research (5418) Total Article Views Authors: Elisabet Ekman, Staffan H gg, Anders Sundstr m, et al Published Date March 2010 Volume 2010:2 Pages 21 - 25 DOI: http://dx.doi.org/10.2147/DHPS.S8432 Elisabet Ekman1, Staffan H gg2, Anders Sundstr m3, Viktoria Werkstr m1 1Regional Pharmacovigilance Unit, Clinical Pharmacology, Lund University Hospital, Lund, Sweden; 2Division of Clinical Pharmacology, Link ping University, Link ping, Sweden; 3Centre for Pharmacoepidemiology, Karolinska Institute, Stockholm, Sweden Aim: To describe spontaneously reported cases of erectile dysfunction (ED) in association with angiotensin II type I blockers (ARB) and other antihypertensive drugs. Subjects and methods: All spontaneously reported cases of ED submitted to the Swedish Medical Products Agency (MPA) between 1990 and 2006, where at least one antihypertensive drug was the suspected agent, were scrutinized. Patient demographics, drug treatment and adverse reactions were recorded. Using the Bayesian Confidence Propagation Neural Network (BCPNN) method, the information component (IC) was calculated. Results: Among a total of 225 reports of ED, 59 involved antihypertensive drugs including ARB (9 cases) as suspected agents. A positive IC value was found indicating that ED was reported more often in association with antihypertensive drugs classes, except for angiotensin-converting enzyme inhibitors, compared with all other drugs in the database. Positive dechallenge was reported in 43 cases (72%). Discussion: All classes of major antihypertensive drugs including ARB were implicated as suspected agents in cases of ED. Few risk factors were identified. The relatively high reporting of ED in association with ARB is in contrast with previous studies, suggesting that ARB have neither a positive nor any effect on ED. This discrepancy suggests that further studies are warrnted on this potential adverse reaction to ARB.
Antihypertensive drugs and erectile dysfunction as seen in spontaneous reports, with focus on angiotensin II type 1 receptor blockers
Elisabet Ekman,Staffan Hägg,Anders Sundström,et al
Drug, Healthcare and Patient Safety , 2010,
Abstract: Elisabet Ekman1, Staffan H gg2, Anders Sundstr m3, Viktoria Werkstr m11Regional Pharmacovigilance Unit, Clinical Pharmacology, Lund University Hospital, Lund, Sweden; 2Division of Clinical Pharmacology, Link ping University, Link ping, Sweden; 3Centre for Pharmacoepidemiology, Karolinska Institute, Stockholm, SwedenAim: To describe spontaneously reported cases of erectile dysfunction (ED) in association with angiotensin II type I blockers (ARB) and other antihypertensive drugs.Subjects and methods: All spontaneously reported cases of ED submitted to the Swedish Medical Products Agency (MPA) between 1990 and 2006, where at least one antihypertensive drug was the suspected agent, were scrutinized. Patient demographics, drug treatment and adverse reactions were recorded. Using the Bayesian Confidence Propagation Neural Network (BCPNN) method, the information component (IC) was calculated.Results: Among a total of 225 reports of ED, 59 involved antihypertensive drugs including ARB (9 cases) as suspected agents. A positive IC value was found indicating that ED was reported more often in association with antihypertensive drugs classes, except for angiotensin-converting enzyme inhibitors, compared with all other drugs in the database. Positive dechallenge was reported in 43 cases (72%).Discussion: All classes of major antihypertensive drugs including ARB were implicated as suspected agents in cases of ED. Few risk factors were identified. The relatively high reporting of ED in association with ARB is in contrast with previous studies, suggesting that ARB have neither a positive nor any effect on ED. This discrepancy suggests that further studies are warrnted on this potential adverse reaction to ARB.Keywords: adverse drug reaction, spontaneous reporting, antihypertensive drugs, angiotensin II type 1 receptor blockers, erectile dysfunction
Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis
Jun Wu, Carl Ekman, Andreas J?nsen, Gunnar Sturfelt, Anders A Bengtsson, Anders Gotts?ter, Bengt Lindblad, Elisabet Lindqvist, Tore Saxne, Bj?rn Dahlb?ck
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3316
Abstract: ELISA kits were used to test plasma concentrations in controls and in patients with SLE, RA or CLI.Increased levels of, in particular, sMer and, to some extent, sTyro3, were found in patients with SLE or RA, but not in patients with CLI. Patients with SLE demonstrated the highest sMer levels and there was a strong correlation to higher SLE disease activity score (SLEDAI). In contrast, in patients with RA, the sMer levels did not correlate with the disease activity score (DAS). In SLE, sMer levels were particularly high in those with lupus nephritis, patients who also had decreased C1q levels and increased titers of anti-DNA antibodies. After therapy, the plasma concentrations of sMer decreased in parallel to the decrease in SLEDAI score.The plasma concentrations of sMer and sTyro3 were significantly increased in patients with active SLE and RA, suggesting the TAM receptor shedding was affected by these autoimmune diseases. In particular, sMer was increased in SLE, the plasma levels of sMer reflecting disease activity.Mer is a cell membrane-bound receptor tyrosine kinase (RTK), which together with Axl and Tyro3 constitutes the TAM receptor family [1,2]. The vitamin K-dependent proteins Gas6 (a 'product of growth arrest-specific gene 6') and protein S are important biological ligands for the TAM receptors [3]. Axl is ubiquitously expressed, whereas Tyro3 is predominantly found in the central nervous system and the reproductive system. Mer is named after its expression in monocytes, epithelium and reproductive tissue. Activation of the TAM receptors has been shown to affect a diversity of cellular functions, including survival, proliferation, migration and phagocytosis [4]. Mer is an important mediator of apoptotic cell phagocytosis [5]. It is also important for phagocytosis of photoreceptor outer segments (POS) by retinal pigment epithelial (RPE) cells and genetic defects of the Mer gene Mertk are associated with retinitis pigmentosa, which results in the development
Internet-Based Support and Coaching for Adolescents and Young Adults with Neuropsychiatric Disorders—The Implementation of an Intervention from an Organizational Perspective  [PDF]
Nanna Gillberg, Elisabet Wentz
Health (Health) , 2017, DOI: 10.4236/health.2017.91006
Abstract: There is a documented and often unmet need for interventions aimed at supporting young people with attention-deficit/hyperactivity disorder (ADHD) and/or autism spectrum disorder (ASD) in their transition between adolescence and adulthood. Difficulties with social interaction, initiation difficulties, and impairments in executive function can complicate visits at a clinic, i.e. traditional treatment, for individuals with neuropsychiatric disorders (NPD). A model for internet-based support and coaching aimed at young people with ASD and/or ADHD was developed and tested at three treatment sites in western Sweden. The implementation was analyzed against an inventory according to which implementations are more likely to be successful if an intervention: 1) has advantages compared to other existing methods, 2) matches the individual and organizational values, norms and work practices of its recipients, 3) is perceived as easy to use, and 4) is adaptable to local conditions and the recipients’ needs. Data were collected through group interviews with professionals involved in the implementation of the intervention. The implementation of the intervention showed promising results on measures such as access, delivery/quality of healthcare services, and equality of distribution of healthcare services. The identified impediments to successful implementation related to a wide range of factors and levels, including the design of the intervention, technical issues, attitudes of staff, organizational culture, and organizational structure at the implementation sites in terms of patient stock, work division, and resource allocation. The results are consistent with previous studies that stress the need for multi-component implementation strategies.
FCJ-129 Interaction Designs for Ubicomp Cultures
Ulrik Ekman
Fibreculture Journal , 2011,
Abstract: This is a journal issue invested in remarking more than once upon the undecidability hovering today around our getting into contact with ‘ubiquity’ or ‘pervasiveness’ as a potential to be further actualized in the fields of human-computer interaction (HCI), interaction design, and the cultural life worlds of information societies more generally. Affirming this undecidability is a necessity – since both of these alternatives are currently at stake, and since ‘ubiquity’ and ubicomp remain potentialities of whose actualization we are not yet sure, whether this is matter of an explicit articulation of the principal ideas or of the concrete lines of development and research making of this so many hands-on facts inherent in the interactions in our contemporary life worlds. In other words, the focus and special merit of this issue is not least to enter into the set of questions surrounding the notion of ‘interaction designs for ubicomp cultures’ – as something partaking of that which Michel Foucault would have called ‘a history of the present.’ This introduction gives a comprehensive account of current thinking and practice in this contemporary field of research in order to make a difference that makes a difference while the cultural and technical developments at stake are still undecidable, multiple, and emergent – at a fast pace, too.
La pauvreté dans les villes chinoises : le cas des migrants (Poverty in Chinese Cities: The Case of Migrants)
Alice Ekman
Ceriscope , 2012,
Abstract: Deux catégories de population pauvre existent en Chine : celle des zones rurales, la plus démunie et la plus vaste, et celle des villes, constituée principalement de migrants. Ceux-ci, paysans venus chercher du travail et une opportunité d'améliorer leurs conditions de vie en zone urbaine, représentent aujourd'hui entre un quart et un tiers de la population des grandes villes chinoises et près de 20% de la population totale du pays. Les différences de revenu et de mode de vie existent dans toutes les sociétés urbaines, développées ou en développement. Mais le cas chinois est particulièrement marquant pour deux raisons : l'ampleur du décalage et le nombre de personnes concernées. Les migrants constituent une part significative de la population active et vivent différemment des autres citadins. Avec eux émerge une nouvelle catégorie sociale qui n'existe nulle part ailleurs, résultat d'un exode rural massif dans le pays le plus peuplé du monde.(Two categories of poverty exist in China: that in rural areas, the poorest and largest, and that in cities, composed largely of migrants. The latter, peasants in search of work and an opportunity to improve their living conditions in urban areas, represent between one quarter and one third of the population in the large Chinese cities and close to 20% of the national population. Differences in income and lifestyles exist in all cities, both developed and developing. However, China’s case is noteworthy for two reasons: the magnitude of the differences and the number of people concerned. Migrants make up a significant part of the population yet live differently from other citizens. Consequence of a mass rural exodus in the most populous nation on earth, they constitute a social category that does not exist elsewhere).
Life cycle of Misumenops pallida (Araneae, Thomisidae)
Minervino, Elisabet;
Memórias do Instituto Oswaldo Cruz , 1993, DOI: 10.1590/S0074-02761993000100009
Abstract: postembryonic development of misumenops pallida (keyserling) (araneae, thomisidae), one of the most abundant predator species in soybean fields in buenos aires province (argentina) was studied. the life cycle was observed in the laboratory from egg sacs collected in the field, and from egg sacs spined in the laboratory by gravid females collected in the field. results indicated that instar length and feeding rate increased throughout the life cycle being higher in females than in males. greater mortality was observed to third and fourth instars decreasing thereafter. these results may contribute to deternmine the efficiency of this species as a natural enemy of insect pests of soybean.
Climate and Tickborne Encephalitis
Elisabet Lindgren
Ecology and Society , 1998,
Abstract: Climatic changes are projected to alter the abundance, dynamics, and geographical distribution of many vector-borne diseases in human populations. Tick-borne diseases such as Lyme disease and tick-borne encephalitis (TBE) are a growing concern in northern Europe and the United States. The impact of a future climate change on the transmission of tick-borne diseases is not known. To make such assumptions, more empirical data are needed on the relations between short-term fluctuations in contemporary weather and disease incidence. This paper analyzes relations between daily minimum and maximum temperatures, monthly precipitation, and TBE incidence during a 36-yr period in Stockholm County, a high-endemic region for TBE in Sweden. Multiple regression analyses were performed, with temperature variables expressed as number of days per winter or spring - summer - fall season with temperatures above, below, or in the interval between different temperature limits. The limits used for daily minimum temperatures represent bioclimatic thresholds of importance for pathogen transmission. To adjust for the length of the tick's life cycle, each TBE incidence rate was related to meteorological data over two consecutive years. Results reveal that increased incidence of tick-borne encephalitis is related to a combination of two successive years of more days with temperatures permitting prolonged seasonal tick activity and, hence, pathogen transmission (i.e., daily minimum temperatures above 5oC-10oC), and a mild winter preceding the year before the incidence year (i.e., fewer winter days with minimum temperatures below -7oC). Alternative explanations of the results are discussed. Findings of this study suggest that a climate change may extend the seasonal range and intensify the endemicity of tick-borne diseases, in particular, at northern latitudes.
V lkomna (n stan) allihopa! Mellan kategoriserade olikheter och radikal skillnad
Elisabet Langmann
Utbildning & Demokrati : Tidsskrift f?r Didaktik och Utbildningspolitik , 2010,
Abstract: Welcome (almost) everyone! Between social categories and radicaldifference. This article explores the dilemmas involved in welcoming differences in education without simultaneously fostering structural conditions that reproduce discrimination and intolerance. Taking an excerpt from Fanny Abj rnsson’s doctoral thesis I en klass f r sig (2004) and Jacques Derrida’s deconstructions of the concept of hospitality as points of departure, the article unfolds in three parts. First, I make a distinction between two ways of responding to the otherness of the other: a conditional welcoming of social categories, and an unconditional welcoming of radical difference. These are further explored in part two. In part three I turn to he “double responsiveness” Derrida highlights as inherent in the paradoxes of hospitality, and ask how it is possible to act within this tension in relation to education. I argue that the welcoming of differences in education demands sensitivity to ambiguity and uncertainty, as well as tact and improvisation in concrete pedagogical situations.
Erratum: Early ERP signature of hearing impairment in visual rhyme judgment
Elisabet Classon
Frontiers in Psychology , 2013, DOI: 10.3389/fpsyg.2013.00897
Abstract:
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