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Search Results: 1 - 10 of 3660 matches for " Elisa Borghi "
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Invasive Mold Infections: Virulence and Pathogenesis of Mucorales
Giulia Morace,Elisa Borghi
International Journal of Microbiology , 2012, DOI: 10.1155/2012/349278
Abstract: Mucorales have been increasingly reported as cause of invasive fungal infections in immunocompromised subjects, particularly in patients with haematological malignancies or uncontrolled diabetes mellitus and in those under deferoxamine treatment or undergoing dialysis. The disease often leads to a fatal outcome, but the pathogenesis of the infection is still poorly understood as well as the role of specific virulence determinants and the interaction with the host immune system. Members of the order Mucorales are responsible of almost all cases of invasive mucormycoses, the majority of the etiological agents belonging to the Mucoraceae family. Mucorales are able to produce various proteins and metabolic products toxic to animals and humans, but the pathogenic role of these potential virulence factors is unknown. The availability of free iron in plasma and tissues is believed to be crucial for the pathogenesis of these mycoses. Vascular invasion and neurotropism are considered common pathogenic features of invasive mucormycoses.
Invasive Mold Infections: Virulence and Pathogenesis of Mucorales
Giulia Morace,Elisa Borghi
International Journal of Microbiology , 2012, DOI: 10.1155/2012/349278
Abstract: Mucorales have been increasingly reported as cause of invasive fungal infections in immunocompromised subjects, particularly in patients with haematological malignancies or uncontrolled diabetes mellitus and in those under deferoxamine treatment or undergoing dialysis. The disease often leads to a fatal outcome, but the pathogenesis of the infection is still poorly understood as well as the role of specific virulence determinants and the interaction with the host immune system. Members of the order Mucorales are responsible of almost all cases of invasive mucormycoses, the majority of the etiological agents belonging to the Mucoraceae family. Mucorales are able to produce various proteins and metabolic products toxic to animals and humans, but the pathogenic role of these potential virulence factors is unknown. The availability of free iron in plasma and tissues is believed to be crucial for the pathogenesis of these mycoses. Vascular invasion and neurotropism are considered common pathogenic features of invasive mucormycoses. 1. Introduction The Mucorales, which is the core group of the traditional Zygomycota [1–3], have been recently reclassified into the subphylum Mucoromycotina of the Glomeromycota phylum of the kingdom Fungi [4]. This new classification does not include Zygomycota, because the authors consider the phylum polyphyletic, indeed the name zygomycosis, which encompassed infections caused by members of Mucorales and Entomophthorales, has become obsolete [4]. The Mucorales are characterized by aseptate (coenocytic) hyaline hyphae, sexual reproduction with the formation of zygospores, and asexual reproduction with nonmotile sporangiospores. They are ubiquitous in nature, being found in food, vegetation, and soil [1–3]. The majority of the invasive diseases are caused by genera of the Mucoraceae family, and the resulted disease is called mucormycosis [1–3, 5–7]. Transmission occurs by inhalation of aerosolized spores, ingestion of contaminated foodstuffs, or through cutaneous exposure, the latter being the most important mode of acquisition of mucormycosis in immunocompetent hosts [6, 8]. Risk factors for invasive diseases include uncontrolled diabetes mellitus, haematological malignancies, bone marrow and solid organ transplantation, deferoxamine therapy, corticosteroid therapy, or other underlying conditions impairing the immune system [9]. Limited activity of some principal classes of antifungal drugs (i.e., echinocandins and azole derivatives) as well as vascular invasion and neurotropic activity could explain the high mortality seen in
CLUSTERS INDUSTRIALES E INNOVACIóN REGIONAL: UNA EVALUACIóN E IMPLICACIONES PARA LA COHESIóN ECONóMICA
ELISA BORGHI,CHIARA F. DEL BO,MASSIMO FLORIO
Revista Galega de Economía , 2010,
Abstract: Este trabajo estudia el papel de los clusters industriales para fomentar la innovación regional y la cohesión económica en Europa. A partir de una visión de conjunto de los clusters industriales en la UE, en la que se destacan las fortalezas y debilidades de las aglomeraciones de empresas, investigamos empíricamente la forma en que los clusters y las características regionalesafectan a la inversión en I+D y al output de innovación y, asimismo, investigamos el papel que desempe an en el impulso de la cohesión económica. Encontramos que la existencia y el tama o de los clusters regionales fomentan de manera significativa la innovación regional en Europa. Sin embargo, tiene importancia la industria en la que se especializan las distintas regiones. En particular, la especialización en clusters de tecnología media-alta y alta parece crear un entorno más favorable para la innovación y la I+D. Por último, la presencia de clusters en una región se asocia positivamente con mayores niveles de empleo.
8-Chloro-Cyclic AMP and Protein Kinase A I-Selective Cyclic AMP Analogs Inhibit Cancer Cell Growth through Different Mechanisms
Simona Lucchi,Davide Calebiro,Tiziana de Filippis,Elisa S. Grassi,Maria Orietta Borghi,Luca Persani
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020785
Abstract: Cyclic AMP (cAMP) inhibits the proliferation of several tumor cells. We previously reported an antiproliferative effect of PKA I-selective cAMP analogs (8-PIP-cAMP and 8-HA-cAMP) on two human cancer cell lines of different origin. 8-Cl-cAMP, another cAMP analog with known antiproliferative properties, has been investigated as a potential anticancer drug. Here, we compared the antiproliferative effect of 8-Cl-cAMP and the PKA I-selective cAMP analogs in three human cancer cell lines (ARO, NPA and WRO). 8-Cl-cAMP and the PKA I-selective cAMP analogs had similarly potent antiproliferative effects on the BRAF-positive ARO and NPA cells, but not on the BRAF-negative WRO cells, in which only 8-Cl-cAMP consistently inhibited cell growth. While treatment with the PKA I-selective cAMP analogs was associated with growth arrest, 8-Cl-cAMP induced apoptosis. To further investigate the actions of 8-Cl-cAMP and the PKA I-selective cAMP analogs, we analyzed their effects on signaling pathways involved in cell proliferation and apoptosis. Interestingly, the PKA I-selective cAMP analogs, but not 8-Cl-cAMP, inhibited ERK phosphorylation, whereas 8-Cl-cAMP alone induced a progressive phosphorylation of the p38 mitogen-activated protein kinase (MAPK), via activation of AMPK by its metabolite 8-Cl-adenosine. Importantly, the pro-apoptotic effect of 8-Cl-cAMP could be largely prevented by pharmacological inhibition of the p38 MAPK. Altogether, these data suggest that 8-Cl-cAMP and the PKA I-selective cAMP analogs, though of comparable antiproliferative potency, act through different mechanisms. PKA I-selective cAMP analogs induce growth arrest in cells carrying the BRAF oncogene, whereas 8-Cl-cAMP induce apoptosis, apparently through activation of the p38 MAPK pathway.
Los primeros 10 a os
Carlos Borghi
Mastozoolog?-a neotropical , 2003,
Abstract:
La PAC del 2003 e gli accordi agricoli in seno al WTO 83
Paolo Borghi
Aestimum , 2008,
Abstract:
Remarks on Andreas Abegg's paper “From the Social Contract to a Social Contract Law”
Maurizio Borghi
Ancilla Iuris , 2008,
Abstract: The fact that a big, tacit social contract crumbles into a multitude of tiny explicit contracts, which govern a load of social duties, relationships and behaviours, is a striking and enigmatic phenomenon. A similar Zergliederung [dissection] undoubtedly occurs in many other areas of the Law, producing the overall effect of a “law-saturated society.” However, the most relevant feature in this process is not the astonishing shift from one legal paradigm to another, but the – mostly unnoticed – emergence of the trait of functionality.
Angela Borghesi, Genealogie. Saggisti e interpreti del Novecento
Daniele Borghi
Enthymema , 2012, DOI: 10.6092/2037-2426/2226
Abstract: Recensiamo Angela Borghesi. Genealogie. Saggisti e interpreti del Novecento. Macerata: Quodlibet. 2012, pp. 257, 22 euro. Raccolta di saggi che propone una riflessione sul mestiere di critico e sull’analisi letteraria attraverso gli esempi di alcuni dei suoi più prestigiosi esponenti.
Giulio Ferroni, Scritture a perdere. Possibilità e responsabilità della critica Giulio Ferroni, Scritture a perdere. Possibilità e responsabilità della critica
Daniele Borghi
Enthymema , 2010, DOI: 10.6092/2037-2426/765
Abstract: The book reviewed in this pages, Giulio Ferroni, Scritture a perdere. La letteratura negli anni zero, Laterza,Bari 2010, deals with the subject which is very important to the author, with a tone freer, nimble and light than an academic essays. In the one hundred pages of his pamphlet, Ferroni thickens theory and criticism and he is back to speak of short stories and novels with an argument often replaced by interviews, friendly commentaries and celebrations of ordinary craze. Il testo qui recensito, Giulio Ferroni, Scritture a perdere. La letteratura negli anni zero, Laterza, Bari, 2010, affronta un argomento che sta fortemente a cuore all’autore, con un tono più libero, agile e leggero, fuori dagli schemi della saggistica accademica. In questo suo pamphlet Ferroni condensa teoria e critica e torna a parlare di racconti e romanzi con un’argomentazione ormai spesso sostituita da interviste,commenti amichevoli, celebrazioni della moda corrente.
Dialogismi. VI conferenza internazionale interdisciplinare. Messina, 8-9 ottobre 2009 Dialogism. VIth International Interdisciplinary Conference - Messina, October 8th-9th 2009
Daniele Borghi
Enthymema , 2009, DOI: 10.6092/2037-2426/423
Abstract:
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