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Search Results: 1 - 10 of 718410 matches for " Elena María Martín López "
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Behavior of Arsenic and Fluoride Concentration in Guadiana Valley Aquifer of Durango, Mexico  [PDF]
María Adriana Martínez-Prado, María Elena Pérez-López, Ignacio Villanueva-Fierro, Cecilia Corazón González-Nevarez
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.412A2003

Fluorine (F) and arsenic (As) are inorganic elements present in the subsurface depending on the geology of the region. These compounds are found in high concentrations in the underground strata of Guadiana Valley of Durango affecting water quality for human consumption (NOM-127-SSA-1994). In the present research the main objective was to assess the behavior in time and space of fluoride (F-) and arsenic concentration, from 1996 to date, in the groundwater of the city of Durango and some wells of the rural area as a reference. The highest concentration of arsenic was found in a rural well, Colonia Hidalgo (0.149 mg/L or ppm), 6 times the maximum permissible limit (MPL); within the city well 54 located in the western sector had the highest value (0.076 ppm), 3 times the MPL, 67% of the wells in the city and 60% of the Guadiana Valley had levels that exceeded the MPL (0.025 ppm), the concentration in the city ranged from 0.009 to 0.149 ppm and from 0.08 to 0.15 ppm for the rural zone. With respect to F-, the highest value was also found in the Colonia Hidalgo well (17.8 mg/L), 12 times the MPL; within the city the highest value was recorded in well 16 in the eastern sector with 7.6 ppm (5 times the MPL) 97% of the wells in the city and 100% of the wells in the Guadiana Valley rural area had concentrations greater than MPL (1.5 ppm), the concentration in the city ranged from 1.1 to 7.6 ppm, while in the Guadiana Valley from 1.7 to 17.8 ppm. Statistical analysis showed no significant difference for fluoride concentration over time (1996-2013); whereas the concentration of arsenic decreased, probably due to the degree of precision required for such small concentrations in groundwater and different analysts ran the samples.

Concentration of Fluoride and Arsenic in Bottled Drinking Water in Durango City, Mexico  [PDF]
María Adriana Martínez-Prado, María Elena Pérez-López, María Guadalupe Vicencio-de la Rosa, Cecilia Corazón González-Nevarez
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.412A2002

Arsenic and fluoride are elements known to cause human health problems and it has been documented that both elements are found in high concentrations in the Guadiana Valley aquifer, in the state of Durango, Mexico. Since underground water is the source for potable water bottling companies commercialized in Durango City; such high concentrations reduced the quality of bottled water for human consumption according to NOM-041-SSA1-1993. Legislation establishes a maximum permissible limit (MPL) of 0.7 mg/L for fluoride and 0.025 mg/L for arsenic. In this research the main objective was to evaluate the quality of bottled water expended in Durango City with respect to the well from which water is extracted. Findings showed that the highest fluoride concentration was 5.86 mg/L (8.4 times MPL), with 100% of sampled brands exceeding the MPL (range: 1.09 to 5.86 mg/L). On the other hand, for arsenic, the highest concentration was 0.076 mg/L (threefold), with 38% exceeding the MPL (range: 0.001 to 0.076 ppm). Statistical analysis showed significant differences only for fluoride, according to Fisher LSD (Least Significant Difference) test, with an F value of 14.5 at a p value of 0.0005. According to the comparison between the quantified concentrations in bottled water and groundwater, it was found that groundwater was subjected to treatment; however, although a significant decrease in fluoride and arsenic concentration was observed, the removal processes used were not efficient to meet set standards.

La Consolidación de Estados Contables en el Sector Público Empresarial. Aplicación al Grupo de Empresas de la Junta de Andalucía
Antonio Manuel López Hernández,Isabel Román Martínez,María Gloria López Gordo,María Elena Gómez Miranda
Revista de Contabilidad : Spanish Accounting Review , 2003,
Abstract: The decentralisation of services brings about the fragmentation of accounting information about public sector economic activity. There is a need, therefore, to establish consolidated balance sheets, since they provide more relevant information than that obtained by merely aggregating the data contained in individual financial statements. At the local level, many studies have been written about the problem of consolidation, however, much less attention has been paid to the autonomous level. Given the experience gained after consolidating the statements of the Junta de Andalusia, this paper deals with two main issues. First, it examines the problems this process poses in the scope of public firms in the autonomous regions. Second, it explains the peculiarities that arose for the specific case of the corporate public sector of the Junta de Andalucía (Andalusian regional government).
Basic and instrumented life support intervention protocol in an adult patient in accordance to new ERC 2005 recommendations
Guillermo Arturo Ca?adas de la Fuente,Ana Belén López Bueno,Carolina Fernández Lao,Elena María Martín López
NURE Investigación , 2009,
Abstract: In this study we make a brief account of the last valid recommendations related to basic life support in 2005. They are the result of the study and the analysis by International Liaison Committee On Resuscitation (ILCOR) and the American Hearth Association (AHA).Like the European Resuscitation Council (ERC) did before, they adopted new rules published on international framework with his inherent changes. On the whole, they has not developed so much, nearly all of them were aimed to improve the efficiency on several skill that take part of the process. In this way, some changes has been justified as a result of obtained data on the study and previous normative test, therefore their modification had scientific evidence.Both, adopted modifications and protocol, are described in order to exemplify all health personnel and other professionals. Like a common aim these changes try to unify criteria to make a universal protocol, independent from professional category and people who applies basic or instrumented CPR.So, new guides try to simplify different techniques and to improve those improvable aspects, at the same time that support better multidisciplinary teams integration in a new algorithm just as we describe on the study.
CD209 in inflammatory bowel disease: a case-control study in the Spanish population
Concepción Nú?ez, Javier Oliver, Juan Mendoza, María Gómez-García, Carlos Taxonera, Luis M Gómez, Miguel A López-Nevot, Emilio G de la Concha, Elena Urcelay, Alfonso Martínez, Javier Martín
BMC Medical Genetics , 2007, DOI: 10.1186/1471-2350-8-75
Abstract: We performed a case-control study with 515 CD patients, 497 UC patients and 731 healthy controls, all of them white Spaniards. Samples were typed for the CD209 single nucleotide polymorphism (SNP) rs4804803 by TaqMan technology. Frequency comparisons were performed using χ2 tests.No association between CD209 and UC or CD was observed initially. However, stratification of UC patients by HLA-DR3 status, a strong protective allele, showed that carriage of the CD209_G allele could increase susceptibility in the subgroup of HLA-DR3-positive individuals (p = 0.03 OR = 1.77 95% CI 1.04–3.02, vs. controls).A functional variant in the CD209 gene, rs4804803, does not seem to be influencing Crohn's disease susceptibility. However, it could be involved in the etiology or pathology of Ulcerative Colitis in HLA-DR3-positive individuals but further studies are necessary.Inflammatory bowel diseases comprise two distinct entities, Crohn's disease (CD) and Ulcerative Colitis (UC). Both forms are characterized by a chronic inflammation of the intestine, but several clinical and immunological profiles differ between them. IBD is a multifactorial disease: environmental factors seem to be involved in disease onset in genetically susceptible individuals. Common susceptibility genetic components exist for both diseases as evidenced apparently by the higher risk of developing UC in relatives of patients with CD or vice versa, but also specific genes seem to play an important role in the development or course of each disease. For CD, CARD15 mutations are the main susceptibility factors described in Caucasian populations [1]. On the other hand, HLA genes show stronger effects on UC in our population, specifically HLA-DR3 seems to have a protective role in the development of this disease [2]. However, a complex genetic contribution exists in both diseases and new etiological genes remain to be discovered.DC-SIGN (dendritic cell-specific ICAM3-grabbing non-integrin), also named CD209, is a type
Comparative study of breast cancer in Mexican and Mexican-American women  [PDF]
María Elena Martínez, Luis Enrique Gutiérrez-Millan, Melissa Bondy, Adrian Daneri-Navarro, María Mercedes Meza-Montenegro, Ivan Anduro-Corona, Ma Isabel Aramburo-Rubio, Luz María Adriana Balderas-Pe?a, José Adelfo Barragan-Ruiz, Abenaa Brewster, Graciela Caire-Juvera, Juan Manuel Castro-Cervantes, Mario Alberto Chávez Zamudio, Giovanna Cruz, Alicia Del Toro-Arreola, Mary E. Edgerton, María Rosa Flores-Marquez, Ramon Antonio Franco-Topete, Helga Garcia, Susan Andrea Gutierrez-Rubio, Karin Hahn, Luz Margarita Jimenez-Perez, Ian K. Komenaka, Zoila Arelí López Bujanda, Dihui Lu, Gilberto Morgan-Villela, James L. Murray, Jesse N. Nodora, Antonio Oceguera-Villanueva, Miguel Angel Ortiz Martínez, Laura Pérez Michel, Antonio Quintero-Ramos, Aysegul Sahin, Jeong Yun Shim, Maureen Stewart, Gonzalo Vazquez-Camacho, Betsy Wertheim, Rachel Zenuk, Patricia Thompson
Health (Health) , 2010, DOI: 10.4236/health.2010.29153
Abstract: Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.
The Diamine Oxidase Gene Is Associated with Hypersensitivity Response to Non-Steroidal Anti-Inflammatory Drugs
José A. G. Agúndez, Pedro Ayuso, José A. Cornejo-García, Miguel Blanca, María J. Torres, Inmaculada Do?a, María Salas, Natalia Blanca-López, Gabriela Canto, Carmen Rondon, Paloma Campo, José J. Laguna, Javier Fernández, Carmen Martínez, Elena García-Martín
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047571
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in hypersensitivity drug reactions. Histamine is released in the allergic response to NSAIDs and is responsible for some of the clinical symptoms. The aim of this study is to analyze clinical association of functional polymorphisms in the genes coding for enzymes involved in histamine homeostasis with hypersensitivity response to NSAIDs. We studied a cohort of 442 unrelated Caucasian patients with hypersensitivity to NSAIDs. Patients who experienced three or more episodes with two or more different NSAIDs were included. If this requirement was not met diagnosis was established by challenge. A total of 414 healthy unrelated controls ethnically matched with patients and from the same geographic area were recruited. Analyses of the SNPs rs17740607, rs2073440, rs1801105, rs2052129, rs10156191, rs1049742 and rs1049793 in the HDC, HNMT and DAO genes were carried out by means of TaqMan assays. The detrimental DAO 16 Met allele (rs10156191), which causes decreased metabolic capacity, is overrepresented among patients with crossed-hypersensitivity to NSAIDs with an OR = 1.7 (95% CI = 1.3–2.1; Pc = 0.0003) with a gene-dose effect (P = 0.0001). The association was replicated in two populations from different geographic areas (Pc = 0.008 and Pc = 0.004, respectively). Conclusions and implications The DAO polymorphism rs10156191 which causes impaired metabolism of circulating histamine is associated with the clinical response in crossed-hypersensitivity to NSAIDs and could be used as a biomarker of response.
Sludge Density Prediction in a Wastewater Chemical Coagulation Process  [PDF]
Margarita Teutli-León, María Elena Pérez-López
Journal of Water Resource and Protection (JWARP) , 2013, DOI: 10.4236/jwarp.2013.57A001

This paper reports an approach to estimate the sludge density in a physicochemical treatment of municipal wastewater, experiments considered 4 coagulants (aluminum sulfate SAl, iron sulfate SFe, aluminum polychloride PAX, iron polychloride PIX), and 2 flocculant products (cationic CP and anionic AP polymers). Experimental approach is based on running a set of jar tests at different coagulant concentrations. After the stirring and resting times took place, pH and conductivity were registered finding that SAl and SFe either with or without polymers are the coagulants producing the higher pH drop. Conductivity measures also establish two kind of data since higher conductivity (about 2000 \"\") was observed for SAl, and PIX, PIX + CP, PIX + AP; otherwise a conductivity about 1300 \"\" was observed for SAl + PC, SFe and PAX alone and with CP or AP. Settleable solids (SST) determined with an Imhoff cone were similar for sulfates and polychlorides, but dry sludge (DS) clearly set up two groups the one with higher sludge content corresponds to sulfates group. The quotient of DS divided by the SST provided an estimation of the apparent sludge density, in this way it was observed that higher densities were obtained for sludge from sulfates at lower coagulant concentrations; also sludge from SFe was heavier than the one from SAl. Otherwise, polychlorides produced a lighter sludge in respect to the one obtained with sulfates, and between them the PIX coagulant provided a heavier sludge than the PAX coagulan

Manifestaciones cutáneas de la giardiasis, sobredimensión de un problema de salud
Almannoni,Saleh Ali; Martín Pupo,Deisy; Rodríguez,María Elena; Cordoví Prado,Raúl; Domenech Ca?ete,Ingrid; Rubio Ramos,María del Carmen; Iglesias Hernández,Tania; Manzur Katrib,Julián; González-Carbajal Pascual,Miguel; Gómez Gómez,Juana; Serrano López,Teresa; Fonte Galindo,Luis;
Revista Cubana de Medicina Tropical , 2008,
Abstract: objective: to make a clinical and parasitological characterization of a group of patients, who had been or would be treated in the healthcare facilities of the city of havana, due to their cutaneous manifestations attributed to giardiasis. methods: after the consent of their primary care physicians, 114 subjects, who had been or would be treated because of their giardiasis-attributed skin lesions, were referred to "pedro kourí" institute of tropical medicine. on their arrival, the research team physicians characterized each patient according to their clinical manifestations. they were asked to collect their feces for serial sampling, which were subjected to chropological tests through direct simple smears and ritchie′s concentration procedures. in those cases where microscopic observation of samples did not allow confirming giardia lamblia infection, biliary drainage was performed to look for giardias in the corresponding duodenal fluid. the patients whose feces or duodenal fluid showed g.lamblia were instructed to follow an anti-giardiasis treatment and the necessary hygienic-sanitary measures to prevent re-infection. three months after concluding the parasiticidal treatment, the above-mentioned tests were repeated. results: it was proved that the cutaneous manifestations of giardiasis in the city of havana are an overdimensioned health problem. it was also confirmed that urticaria is the most frequent giardiasis-associated dermatological manifestation. conclusions: once the overdimension of giardiasis as a cause of skin lesions is proven, it is necessary to explore the knowledge, perceptions and practice of physicians in charge of diagnosis, treatment and control of this disease.
CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility
Fiona Blanco-Kelly,Fuencisla Matesanz,Antonio Alcina,María Teruel,Lina M. Díaz-Gallo,María Gómez-García,Miguel A. López-Nevot,Luis Rodrigo,Antonio Nieto,Carlos Carde?a,Guillermo Alcain,Manuel Díaz-Rubio,Emilio G. de la Concha,Oscar Fernandez,Rafael Arroyo,Javier Martín,Elena Urcelay
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011520
Abstract: A functional polymorphism located at ?1 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation. It has been consistently associated with Graves' disease risk in populations of different ethnicity and genetic proxies of this variant evaluated in genome-wide association studies have shown evidence of an effect in rheumatoid arthritis and multiple sclerosis (MS) susceptibility. However, the protective allele associated with Graves' disease or rheumatoid arthritis has shown a risk role in MS, an effect that we aimed to replicate in the present work. We hypothesized that this functional polymorphism might also show an association with other complex autoimmune condition such as inflammatory bowel disease, given the CD40 overexpression previously observed in Crohn's disease (CD) lesions.
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