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Search Results: 1 - 10 of 468754 matches for " Elena A. Sorokina "
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MIP/Aquaporin 0 Represents a Direct Transcriptional Target of PITX3 in the Developing Lens
Elena A. Sorokina, Sanaa Muheisen, Nevin Mlodik, Elena V. Semina
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021122
Abstract: The PITX3 bicoid-type homeodomain transcription factor plays an important role in lens development in vertebrates. PITX3 deficiency results in a spectrum of phenotypes from isolated cataracts to microphthalmia in humans, and lens degeneration in mice and zebrafish. While identification of downstream targets of PITX3 is vital for understanding the mechanisms of normal ocular development and human disease, these targets remain largely unknown. To isolate genes that are directly regulated by PITX3, we performed a search for genomic sequences that contain evolutionarily conserved bicoid/PITX3 binding sites and are located in the proximity of known genes. Two bicoid sites that are conserved from zebrafish to human were identified within the human promoter of the major intrinsic protein of lens fiber, MIP/AQP0. MIP/AQP0 deficiency was previously shown to be associated with lens defects in humans and mice. We demonstrate by both chromatin immunoprecipitation and electrophoretic mobility shift assay that PITX3 binds to MIP/AQP0 promoter region in vivo and is able to interact with both bicoid sites in vitro. In addition, we show that wild-type PITX3 is able to activate the MIP/AQP0 promoter via interaction with the proximal bicoid site in cotransfection experiments and that the introduction of mutations disrupting binding to this site abolishes this activation. Furthermore, mutant forms of PITX3 fail to produce the same levels of transactivation as wild-type when cotransfected with the MIP/AQP0 reporter. Finally, knockdown of pitx3 in zebrafish affects formation of a DNA-protein complex associated with mip1 promoter sequences; and examination of expression in pitx3 morphant and control zebrafish revealed a delay in and reduction of mip1 expression in pitx3-deficient embryos. Therefore, our data suggest that PITX3 is involved in direct regulation of MIP/AQP0 expression and that the alteration of MIP/AQP0 expression is likely to contribute to the lens phenotype in cataract patients with PITX3 mutations.
Methyl (9aR*,10S*,11R*,13aS*,13bS*)-9-oxo-6,7,9,9a,10,11-hexahydro-5H,13bH-11,13a-epoxypyrrolo[2′,1′:3,4][1,4]diazepino[2,1-a]isoindole-10-carboxylate
Flavien A. A. Toze,Inga K. Airiyan,Eugeniya V. Nikitina,Elena A. Sorokina
Acta Crystallographica Section E , 2011, DOI: 10.1107/s1600536811040360
Abstract: The title compound, C17H18N2O4, is the methyl ester of the adduct of intramolecular Diels–Alder reaction between maleic anhydride and 1-(2-furyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepine. The molecule comprises a fused pentacyclic system containing four five-membered rings (viz. pyrrole, 2-pyrrolidinone, tetrahydrofuran and dihydrofuran) and one seven-membered ring (1,4-diazepane). The pyrrole ring is approximately planar (r.m.s. deviation = 0.003 ) while the 2-pyrrolidinone, tetrahydrofuran and dihydrofuran five-membered rings have the usual envelope conformations. The central seven-membered diazepane ring adopts a boat conformation. In the crystal, molecules are bound by weak intermolecular C—H...O hydrogen-bonding interactions into zigzag chains propagating in [010]. In the crystal packing, the chains are stacked along the a axis.
Dimethyl 11,13-dimethyl-16-[1,2-bis(methoxycarbonyl)ethenyl]-12-oxo-16,17-dioxa-18-azahexacyclo[7.5.1.11,4.16,9.110,14.05,15]octadeca-2,7-diene-2,3-dicarboxylate
Atash V. Gurbanov,Eugeniya V. Nikitina,Elena A. Sorokina,Fedor I. Zubkov
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809050600
Abstract: The title compound, C27H29NO11, is a product of the tandem `domino' Diels–Alder reaction. The molecule comprises a fused hexacyclic system containing four five-membered rings (two dihydrofuran and two tetrahydrofuran) in the usual envelope conformations and two six-membered rings (tetrahydropyridinone and piperidine) adopting slightly flattened boat and chair conformations, respectively. The dispositions of the carboxylate substituents relative to each other are determined by both steric reasons and intermolecular C—H...O hydrogen bonding and attractive antiparallel C=O...C=O interactions [C...O = 2.995 (2) ].
Light Curves of Type Ia Supernovae as a Probe for an Explosion Model
Elena Sorokina,Sergey Blinnikov
Physics , 2002, DOI: 10.1007/10828549_37
Abstract: We present theoretical UBVI- and bolometric light curves of SNe Ia for several explosion models, computed with our multi-group radiation hydro code. We employ our new corrected treatment for line opacity in the expanding medium. The results are compared with observed light curves. Our goal is to find the most viable thermonuclear SN model that gives good fits not only to a typical SN Ia light curves, but also to X-ray observations of young SN Ia remnants. It appears that classical 1D SN Ia models, such as deflagration model W7 and delayed detonation one DD4, fit the light curves not so good as a new 3D deflagration model by Reinecke et al. (which is averaged over angles for our LC modelling). This model seems good also in reproducing X-ray observations of Tycho SNR. We believe that the main feature of this model which allows us to get correct radiation during the first month, as well as after a few hundred years, when an SNR forms, is strong mixing that pushes material enriched in iron and nickel to the outermost layers of SN ejecta.
THE ROLE OF DEVELOPMENT INSTITUTES IN THE STATE REGULATION OF AGRICULTURAL PRODUCING Роль институтов развития в государственном регулировании сельскохозяйственного производства
Sorokina I. A.,Sorokina L. V.
Polythematic Online Scientific Journal of Kuban State Agrarian University , 2013,
Abstract: The role of development institutes in the state regulation of agricultural producing and the problems of its realization are considered in the article
Effect of Iron Fe (II) and Fe (III) in a Binary System Evaluated Bioluminescent Method
Elena Sorokina,Tatiana Yudina,Vadim Danilov
European Researcher , 2013,
Abstract: The effect of iron ions Fe2+ and Fe3+ on the bioluminescent recombinant strain of Escherichia coli in a single-component and binary system. Found that for the bacteria E. coli Fe3+ ions are more toxic than Fe2+. Under the combined effect of iron toxicity increases, the percentage of luminescence quenching increases, but the value is much less than the sum of the indicator for the Fe2+ and Fe3+. The biological effect of insertion of iron is not proportional to their content in the mixture.
Hydrogenless Superluminous Supernova PTF12dam in the Model of an Explosion inside an Extended Envelope
Petr Baklanov,Elena Sorokina,Sergei Blinnikov
Physics , 2015, DOI: 10.1134/S1063773715040027
Abstract: A model of a supernova explosion inside a dense extended hydrogenless envelope is proposed to explain the properties of the light curve for one of the superluminous supernovae PTF12dam. It is argued in the literature that the flux of this supernova rises too fast to be explained by the explosion model due to the instability associated with the electron-positron pair production (pair-instability supernova, PISNe), but it is well described by the models with energy input by a magnetar. We show that the PTF12dam-type supernovae can be explained without a magnetar in a model with a radiative shock in a dense circumstellar envelope that does not require an excessively large explosion energy.
Functional analysis of human mutations in homeodomain transcription factor PITX3
Satoru Sakazume, Elena Sorokina, Yoshiki Iwamoto, Elena V Semina
BMC Molecular Biology , 2007, DOI: 10.1186/1471-2199-8-84
Abstract: We studied the PITX3 mutant proteins S13N and G219fs to determine the type and severity of functional defects. Our results demonstrate alterations in DNA-binding profiles and/or transactivation activities and suggest a partial loss-of-function in both mutants with the G219fs form being more severely affected. No anomalies in cellular distribution and no dominant-negative effects were discovered for these mutants. Interestingly, the impairment of the G219fs activity varied between different ocular cell lines.The G219fs mutation was found in multiple families affected with congenital cataracts along with anterior segment malformations in many members. Our data suggest that the presence/severity of anterior segment defects in families affected with G219fs may be determined by secondary factors that are expressed in the developing anterior segment structures and may modify the effect(s) of this mutation. The S13N mutant showed only minor alteration of transactivation ability and DNA binding pattern and may represent a rare polymorphism in the PITX3 gene. A possible contribution of this mutation to human disease needs to be further investigated.Cataracts remain a leading cause of blindness worldwide accounting for 42% of all blindness [1,2]. In one large study, about 30% of all congenital/infantile cataracts was attributed to genetic factors as identified by the presence of multiple affected family members or the association of other dysmorphology suggestive of a genetic syndrome [3]. The etiology of about 87% of unilateral and 50% of bilateral cataracts remains unknown [3], and is likely to have some genetic basis as well. In recent years, multiple genes underlying human congenital cataracts have been identified and opened the way to functional studies and a better understanding of lens development [4].PITX3 is a homeodomain transcription factor found to be responsible for human congenital cataract that can be associated with abnormal development of the anterior segment
Modulational instability in Bose--Einstein condensate in optical superlattice
Ekaterina A. Sorokina,Andrei I. Maimistov
Physics , 2007,
Abstract: We consider the Bose-Einstein condensate trapped in optical lattice, which is formed from two kinds of deep potentials. The tight-binding approximation was used. Steady state distribution of the probability amplitudes and the site population in the one dimensional optical superlattice were found. It was shown that this solution of the equations which describe the dynamics of the Bose-Einstein condensate in superlattice is unstable at the sufficiently high density of the bosons. The expression for increment of the modulational instability was found on base of the linear stability analysis. Numerical simulation demonstrates the evolution of the steady state distributions of bosons into the space array of the solitary peaks before the chaotic regime generation.
Shannon capacity of nonlinear regenerative channels
M. A. Sorokina,S. K. Turitsyn
Mathematics , 2013,
Abstract: We compute Shannon capacity of nonlinear channels with regenerative elements. Conditions are found under which capacity of such nonlinear channels is higher than the Shannon capacity of the classical linear additive white Gaussian noise channel. We develop a general scheme for designing the proposed channels and apply it to the particular nonlinear sine-mapping. The upper bound for regeneration efficiency is found and the asymptotic behavior of the capacity in the saturation regime is derived.
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