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Search Results: 1 - 10 of 671441 matches for " Elaine M. L. R. Andrade "
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Effect of an Educational Intervention by Attendance and at Distance on Nurses’ Knowledge about Pressure Ulcer  [PDF]
Elaine M. L. R. Andrade, Patrícia A. L. Cavalcanti, Ana Karoline C. Monteiro, Ana Karine C. Monteiro, Maria Helena B. A. Luz, José M. M. Neto, Isabel A. C. Mendes
Creative Education (CE) , 2014, DOI: 10.4236/ce.2014.518185
Abstract: The effect of an educational intervention by attendance and at distance on the knowledge of nurses about pressure ulcer (PU) was verified. An experimental research with a post-test control group was undertaken. A randomized sample of 43 nurses in a Control Group (CG) (N = 20) was submitted to an educational intervention by attendance and an Experimental Group (EG) (N = 23) was submitted to an intervention at distance. Data were collected between January and April 2012 in three phases, which were: location, invitation, registration and adaptation of the nurses to Moodle, educative intervention and post-test. The mean number of correct answers on the posttest among the nurses who participated in the intervention by attendance was 34.0 (sd = 3.3), against 36.2 (sd = 2.7) for the nurses in the distance education intervention. This difference in means was statistically significant (p = 0.019). The research evidenced that continuing education in nursing through distance education (DE) can be effective due to its practicality and interactivity and because it allows nurses in clinical practice to decide on the best time and place to access the content and improve their knowledge about PU.
Canine distemper virus induces apoptosis in cervical tumor derived cell lines
Helen L Del Puerto, Almir S Martins, Amy Milsted, Elaine M Souza-Fagundes, Gissandra F Braz, Barbara Hissa, Luciana O Andrade, Fabiana Alves, Daniela S Raj?o, R?mulo C Leite, Anilton C Vasconcelos
Virology Journal , 2011, DOI: 10.1186/1743-422x-8-334
Abstract: Apoptosis is a regulated form of cell death which occurs during physiological conditions. It plays a critical role in the homeostasis of multicelular organisms, and constitutes a common pathway for cell replacement, tissue remodeling, damaged cell removal and elimination of cancer cells [1]. It is a complex process which involves the participation of caspases, activation of proapoptotic genes, and inhibition of antiapoptotic proteins. Cells undergoing apoptosis present typical morphological characteristics, including membrane blebbing, chromatin condensation, cell shrinkage and apoptotic body formation [2].Apoptosis is triggered by sequential activation of caspases, a group of cysteine proteases, and proceeds primarily through two pathways. The extrinsic pathway involves activation of caspase-8 and is initiated by ligand interaction with death receptors, while the intrinsic pathway is activated by an imbalance between proapoptotic and antiapoptotic proteins from Bcl-2 family in mitochondria and cytosol, resulting in release of cytochrome c from mitochondria, which in turn activates caspase-9 [3]. Both caspase-8 and caspase-9 activate caspase-3, which along with other effectors caspases cleave critical cellular proteins, resulting in apoptosis [3].Many viral proteins can influence the cellular pathways that control cell proliferation and apoptosis. Some viral proteins trigger apoptotic cell death, and this may be important in host defense and viral spread. In other cases, viral proteins inhibit apoptosis [4].HeLa cells, derived from a cervical tumor, encode apoptosis inhibitor proteins E6 and E7, oncoproteins expressed by high-risk human papillomavirus (HPV), among them the HPV18 type [5,6]. HPV E6 protein target p53, a tumor suppressor protein that regulates the cell cycle. The E6 protein binding to p53 causes p53 inactivation by its degradation, turning off its function [6,7]. On the other hand, the HPV E7 protein acts by binding to members of the Rb (retinoblastom
2-Mercaptobenzoxazole pentacyanoferrate(II/III) complexes: UV-Visible, M?ssbauer, electron paramagnetic resonance, electrochemistry and molecular modeling
Luiz, Juciane B;Andrade, Fabiano M. de;Sá, Eduardo L. de;Friedermann, Geraldo R;Mangrich, Antonio S;Barclay, J. Elaine;Evans, David J;Hasegawa, Tai;Nunes, Fábio S;
Journal of the Brazilian Chemical Society , 2004, DOI: 10.1590/S0103-50532004000100003
Abstract: 2-mercaptobenzoxazole pentacyanoferrate(ii/iii) complexes, [feii/iii(cn)5(bzoxs)]3-/2- , were prepared in meoh/h2o 75:25% solutions and characterized by spectroscopic uv-vis, m?ssbauer, electron paramagnetic resonance (epr) and electrochemical-cyclic voltammetry- techniques. uv-vis and epr spectra along with the electrochemical behavior suggested the coordination of the multi-functional n,s,o- donor ligand, bzoxs, to iron(iii) through the sulfur atom. the crystal field parameters, dql and dt, calculated for the iron(ii) complex, in addition to the reversible redox process feiii-bzoxs + e- ? feii-bzoxs also pointed to coordination via the sulfur atom. the results were compared with the chemical properties of pentacyanoferrate complexes containing other monodentate n-, s- and o-donor ligands. ab initio calculations revealed the composition of the frontier orbitals of bzoxs and are in agreement with the mode of coordination proposed from the experimental data.
New Formulation for Semi-Empirical Correlations for Penetration Jets  [PDF]
R. R. Pacheco, L. O. Freire, M. S. Rocha, N. L. Scuro, M. O. Menezes, D. A. Andrade
World Journal of Nuclear Science and Technology (WJNST) , 2019, DOI: 10.4236/wjnst.2019.92007
Abstract: Correlations for the extension of a water vapor jet injected in a liquid pool were historically proposed considering the mass flux (kg/m2/s) as a constant. The results were satisfactory, however adjusting the values by linear regression. Although, it presents the following drawbacks: 1) the formulation is only valid for the specific range of data for what it was created; 2) it does not allow the analytical evaluation of the heat transfer coefficient from the extension equation. This paper proposes a new formulation for the calculation of the mass flux, in such a way to remove both of these drawbacks.
A telomerase em células-tronco hematopoéticas
Perini, Silvana;Silla, Lúcia M. R.;Andrade, Fabiana M.;
Revista Brasileira de Hematologia e Hemoterapia , 2008, DOI: 10.1590/S1516-84842008000100012
Abstract: hematopoietic stem cell proliferation leads to telomere length decreases at each cellular division. some authors disagree about the telomere influence on the reduction of the proliferative potential and capacity of self renewal. here we review telomerase function in the biology of the hematopoietic system, in normal or differentiation and its influence on the ageing of hematopoietic stem cells. the constant cellular renewal required to maintain the hematopoietic system, provides embryonic stem cells, as well as malignant cells, an increased proliferative capacity. this is marked by the detection of telomerase enzyme activity and possible telomere maintenance. clinical trials will be required to clarify telomerase activity in hematopoietic stem cells, its possible use as a diagnostic marker and its use for prognostic purposes.
What stresses men? predictors of perceived stress in a population-based multi-ethnic cross sectional cohort
Timothy R Rebbeck, Anita L Weber, Elaine Spangler, Charnita M Zeigler-Johnson
BMC Public Health , 2013, DOI: 10.1186/1471-2458-13-113
Abstract: We used a population-based survey of 6,773 White, 1,681 Black, and 617 Hispanic men in Southeastern Pennsylvania to evaluate the relationship of self-reported PS and financial security, health status, social factors, and health behaviors. Interactions across levels of age and ethnicity were tested using logistic regression models adjusted for overall health status, education, and household poverty.High PS decreased significantly with age (p<0.0001) and varied by ethnicity (p=0.0001). Exposure to health-related and economic factors were more consistently associated with elevated PS in all ethnicities and ages, while social factors and health behaviors were less strongly or not at all associated with PS in most groups. Significant differences in the relationship of high PS by age and ethnicity were observed among men who are medically uninsured (p=0.0002), reported missing a meal due to cost (p<0.0001), or had spent a night in the hospital (p=0.020). In contrast, not filling a prescription due to cost and diagnosed with a mental health condition were associated with high PS but did not differ by age and ethnicity subgroup.These data suggest that some, but not all, factors associated with high PS differ by age and/or ethnicity. Research, clinical, or public health initiatives that involve social stressors should consider differences by age and ethnicity.
Genomic profiling of tumor initiating prostatospheres
Maria Duhagon, Elaine M Hurt, Jose R Sotelo-Silveira, Xiaohu Zhang, William L Farrar
BMC Genomics , 2010, DOI: 10.1186/1471-2164-11-324
Abstract: Traditional stem cell medium (SCM) supplemented with Knockout?SR (KO) allows the propagation of monoclonal PSs from cell lines and primary cells. PSs display gene expression and tumorigenicity hallmarks of TICs. Gene expression analysis defined a gene signature composed of 66 genes that characterize LNCaP and patient PSs. This set includes novel prostate TIC growth factors (NRP1, GDF1, JAG1), proteins implicated in cell adhesion and cytoskeletal maintenance, transcriptional regulators (MYCBP, MYBL1, ID1, ID3, FOS, ELF3, ELF4, KLF2, KLF5) and factors involved in protein biosynthesis and metabolism. Meta-analysis in Oncomine reveals that some of these genes correlate with prostate cancer status and/or progression. Reporter genes and inhibitors indicate that the Notch pathway contributes to prostatosphere growth.We have developed a model for the culture of PSs, and provide a genomic profile that support CSCs identity. This signature identifies novel markers and pathways that are predicted to correlate with prostate cancer evolution.There is overwhelming evidence supporting the concept that only a specific group of cells, among the cellular heterogeneity of a tumor, possesses self-renewal and multilineage differentiation potential and is, therefore, responsible for tumor development[1]. These cells, so called "tumor initiating cells" (TICs) or "cancer stem cells" (CSCs), have been documented in most circulating and solid tumors as well as in numerous established cancer cell lines[2]. The expression of adult stem cell surface markers (e.g. CD133, CD44, ESA) as well as the expression of specific embryonic stem cell genes (e.g. OCT3/4, NANOG, SOX2) is one of the hallmarks of the TIC [2]. TICs also display increased potential for anchorage-independent growth, capacity to form spheroids in vitro, and propensity to undergo epithelial-mesenchymal transition. Nevertheless, in the current paradigm, the gold standard property of a TIC is its ability to initiate and generate a tum
Control of gag-pol gene expression in the Candida albicans retrotransposon Tca2
Elaine M Forbes, Sian R Nieduszynska, Fiona K Brunton, Joanne Gibson, L Anne Glover, Ian Stansfield
BMC Molecular Biology , 2007, DOI: 10.1186/1471-2199-8-94
Abstract: The hypothesis was tested that in Tca2, gag stop codon flanking sequences direct translational readthrough and synthesis of a gag-pol fusion protein. Sequence from the Tca2 gag-UGA-pol junction (300 nt) was inserted between fused lacZ and luciferase (luc) genes in a Saccharomyces cerevisiae dual reporter construct. Although downstream of UGA, luc was expressed, but its expression was unaffected by inserting additional stop codons at the 3' end of lacZ. Luc expression was instead being driven by a previously unknown minor promoter activity within the gag-pol junction region. Evidence together indicated that junction sequence alone cannot direct UGA readthrough. Using reporter genes in C. albicans, the activities of this gag-pol junction promoter and the Tca2 long terminal repeat (LTR) promoter were compared. Of the two promoters, only the LTR promoter was induced by heat-shock, which also triggers retrotransposition. Tca2 pol protein, epitope-tagged in C. albicans to allow detection, was also heat-shock induced, indicating that pol proteins were expressed from a gag-UGA-pol RNA.This is the first demonstration that the LTR promoter directs Tca2 pol protein expression, and that pol proteins are translated from a gag-pol RNA, which thus requires a mechanism for stop codon bypass. However, in contrast to most other retroelement and viral readthrough signals, immediate gag UGA-flanking sequences were insufficient to direct stop readthrough in S. cerevisiae, indicating non-canonical mechanisms direct gag UGA bypass in Tca2.Retrotransposons are mobile genetic elements that replicate via an RNA intermediate. Their replication cycles and genome organisation are similar in many respects to those of retroviruses, and retrotransposons form a cytoplasmic virus-like particle during replication. Both groups of retroelements have a genome comprising gag and pol coding sequences. Gag proteins make up the capsid of the viral particle while pol encodes a polyprotein usually made up of
Nanosized and reusable SiO2/ZrO2 catalyst for highly efficient biodiesel production by soybean transesterification
Faria, Elaine A.;Marques, Jéssica S.;Dias, Ingrid M.;Andrade, R?mulo D. A.;Suarez, Paulo A. Z.;Prado, Alexandre G. S.;
Journal of the Brazilian Chemical Society , 2009, DOI: 10.1590/S0103-50532009000900023
Abstract: nanosized sio2/zro2 catalyst with high surface area (131.50 ± 14 m2 g-1) was prepared by the sol-gel method. the material presented highly homogeneous particles with an average diameter of 250 nm according to sem images. it was applied in the transesterification of soybean oil for biodiesel production. the biodiesel conversion reached a yield of 96.2 ± 1.4 % after 3 h of transesterification reaction catalised by sio2/zro2 (sizr). the catalyst was recovered and reused six times, maintaining a catalytic efficiency of about 84.1 %.
Photocatalytic Degradation of Ibuprofen Using TiO2 and Ecotoxicological Assessment of Degradation Intermediates against Daphnia similis  [PDF]
Farley S. Braz, Milady R. A. Silva, Flávio S. Silva, Sandro J. Andrade, Ana L. Fonseca, Márcia M. Kondo
Journal of Environmental Protection (JEP) , 2014, DOI: 10.4236/jep.2014.57063
Abstract:

Several pharmaceutical compounds have been detected in natural aqueous systems and ibuprofen (IBF), one of the most consumed medicament, has been detected in many countries. The degradation efficiency of IBF under TiO2/UV radiation was evaluated. Optimum degradation results were observed using 20 mg·L-1 of TiO2, pH 7.8 and 5 mg·L-1 of IBF. Under these experimental conditions total IBF removal was achieved in less than 60 min of irradiation. Although total IBF concentration was observed, the total mineralization of the compound was not achieved. The by-products generated during TiO2/UV reaction showed to be more toxic against Daphnia similis than the initial IBF present in aqueous solution.

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