oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2018 ( 1 )

2017 ( 1 )

2016 ( 10 )

2015 ( 35 )

Custom range...

Search Results: 1 - 10 of 2533 matches for " Elaine Hatanaka "
All listed articles are free for downloading (OA Articles)
Page 1 /2533
Display every page Item
La Inactividad Física en Etapas Tempranas del Desarrollo Disminuye la Expresión de Akt en el Músculo Sóleo de Ratas Akt Expression is Diminished by Physical Inactivity in Early Stages of Development in Soleus Muscle of Rats
José L Márquez,Sandro M Hirabara,Jarlei Fiamoncini,Elaine Hatanaka
International Journal of Morphology , 2011,
Abstract: El Síndrome Metabólico corresponde a una serie de trastornos relacionados con obesidad e inactividad física. Poco se conoce respecto de la falta de ejercicio, en estadios tempranos del desarrollo, en la susceptibilidad a un fenotipo insulinoresistente inducido por una dieta alta en grasas. Akt juega un rol clave en la síntesis de proteínas y el transporte de glucosa en el músculo esquelético y ha mostrado ser regulada por la actividad muscular. El objetivo del presente estudio fue determinar el efecto de la inactividad física temprana sobre el crecimiento muscular y la susceptibilidad de adquirir un fenotipo diabético y evaluar su relación con la expresión de Akt. Cuarenta ratas Wistar fueron distribuidas en 2 grupos (Grupos Control, Std) y Restricción de movimiento (RM). Entre los días postnatal 23 y 70 los animales del grupo RM fueron alojados en peque as jaulas que no permitían una actividad motora relevante. A partir del día postnatal 71 y hasta el día 102, 10 ratas de cada grupo fueron alimentadas con una Dieta Alta en Grasas (RM-DAG y Std-DAG). No se observaron diferencias en el peso corporal total pero DAG generó un significativo incremento en la grasa epididimal. RM generó una disminución significativa en el peso de los músculos sóleo. La captación de glucosa estimulada por insulina fue menor en el grupo RM-DAG. Los niveles de proteína Akt fueron menores en los grupos RM. El análisis de PCR a tiempo real mostró que la restricción de movimiento disminuyó los niveles de ARNm de AKT1 en el músculo sóleo, independiente de la dieta administrada. Estos hallazgos sugieren que la inactividad física temprana limita el crecimiento muscular y contribuye en la instauración un fenotipo insulino resistente, lo cual puede ser en parte explicado por una desregulación en la expresión de Akt. Metabolic Syndrome is a group of conditions related to obesity and physical inactivity. Little is known about the role of physical inactivity, in early stages of development, in the susceptibility to insulin resistant phenotype induced by high fat diet. Akt plays a key role in protein synthesis and glucose transport in skeletal muscle and has been regulated by muscle activity. The objective of present study was to determine the effect of early physical inactivity on muscle growth and susceptibility to acquire a diabetic phenotype and to assess its relationship with Akt expression. Forty Wistar male rats were distributed in two groups (standard group, Std) and movement restriction (RM). Between days 23 and 70 after birth, RM group was kept in small cages that did not allow th
mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes
Fernanda Pereira Ribeiro,Cristiane Jaciara Furlaneto,Elaine Hatanaka,Wesley Bueno Ribeiro,Glaucia Mendes Souza,Marco A. Cassatella,Ana Campa
Mediators of Inflammation , 2003, DOI: 10.1080/0962935031000134897
Abstract: The acute phase response is a systemic reaction to inflammatory processes characterized by multiple physiological adaptations, including the hepatic synthesis of acute-phase proteins. In humans, serum amyloid A (SAA) is one of the most prominent of these proteins. Despite the huge increase of serum levels of SAA in inflammation, its biological role remains to be elucidated, even though SAA is undoubtedly active in neutrophils. In a previous study, we reported that SAA induces the release of tumor necrosis factor-α, interleukin (IL)-1β and IL-8 from human blood neutrophils. Here, we extend our earlier study, focusing on the effect of SAA on neutrophil IL-8 transcription and on the signaling pathways involved. We demonstrate herein that SAA, in relatively low concentrations (0.4-100 μg/ml) compared with those found in plasma in inflammatory conditions, induces a dose-dependent release of IL-8 from neutrophils. The p38 mitogen-activated protein kinase inhibitor SB 203580 inhibits the IL-8 mRNA expression and the release of protein from neutrophils. The release of IL-8 from SAA-stimulated neutrophils is strongly suppressed by the addition of N-acetyl-l-cysteine, α-mercaptoethanol, glutathione, and dexamethasone. SAA also induces IL-8 expression and release from monocytes. In conclusion, SAA appears to be an important mediator of the inflammatory process, possibly contributing to the pool of IL-8 produced in chronic diseases, which may play a role in degenerative diseases.
Cytokines and Oxidative Stress Status Following a Handball Game in Elite Male Players
Douglas Popp Marin,Rita de Cassia Macedo dos Santos,Anaysa Paola Bolin,Beatriz Alves Guerra,Elaine Hatanaka,Rosemari Otton
Oxidative Medicine and Cellular Longevity , 2011, DOI: 10.1155/2011/804873
Abstract: Background. Handball is considered an intermittent sport that places an important stress on a player's aerobic and anaerobic metabolism. However, the oxidative stress responses following a handball game remain unknown. We investigated the responses of plasma and erythrocyte antioxidant system and oxidative stress biomarkers following a single handball game. Methods. Fourteen male elite Brazilian handball athletes were recruited in the present study. Blood samples were taken before, immediately, and 24 hours after the game. Results. After the game and during 24 hours of recovery, the concentration of all oxidative stress indices changed significantly in a way indicating increased oxidative stress in the blood (thiol groups and reduced glutathione decreased, whereas TBARS and plasma antioxidant capacity was increased) as well as in erythrocyte (increased levels of TBARS and protein carbonyls). Erythrocyte antioxidant enzyme activities were also significantly changed by handball. Muscle damage indices (creatine kinase and lactate dehydrogenase) increased significantly after exercise. In addition, IL-6 increased after the game, whereas TNF-α decreased during recovery. Conclusion. This study demonstrates that a single handball game in elite athletes induces a marked state of oxidative stress evidenced by the oxidative modification in plasma and erythrocyte macromolecules, as well as by changes in the enzymatic and nonenzymatic antioxidant system.
A proteomic analysis of the functional effects of fatty acids in NIH 3T3 fibroblasts
Juliana Magdalon, Elaine Hatanaka, Talita Romanatto, Hosana G Rodrigues, Wilson MT Kuwabara, Caitriona Scaife, Philip Newsholme, Rui Curi
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-218
Abstract: Found in the majority of tissues of the body, fibroblasts are responsible for the synthesis and secretion of most extracellular matrix (ECM) components, such as proteoglycans, collagens, laminin and fibronectin, which bind to proteins expressed on cell surfaces thus modulating physiologic responses. Fibroblasts can also secrete proteinases, including matrix metalloproteinases and plasminogen, hence playing an important role in ECM degradation and tissue remodeling [1-3].The dysregulation of fibroblast biology is associated with several diseases and pathological states, including deficient wound healing [4-6], pulmonary diseases [7,8], cardiovascular diseases [9,10] and cancer [11]. Therefore, the discovery of new therapies modulating fibroblast biology could be a powerful target to develop treatment against such diseases. Oleic (18:1n-9), linoleic (18:2n-6) and palmitic (16:0) acids are the most abundant fatty acids in the western diets [12]. The latter is a saturated fatty acid found in palm oil, butter, milk, cheese and meats, whereas oleic acid is a monounsaturated fatty acid found in olive oil, meat, eggs and milk and linoleic acid is a polyunsaturated fatty acid found in soybean, sunflower, safflower and corn oils. The effects of prostaglandin derived from n-3 and n-6 fatty acids on specific protein expression (e.g. COX-2 and IL-6) in NIH 3T3 fibroblasts [13] and some aspects of the impact of fatty acids on process involving fibroblast function [14-16] have been reported. However, no systematic study has assessed the pleiotropic effects of fatty acids on fibroblast protein expression. Therefore, the aim of this study was to assess the effects of oleic (OLA), linoleic (LNA) or palmitic acids (PAM) on protein expression of NIH 3T3 fibroblasts, as determined by 2D-DIGE, i.e., separation of proteins by isoelectric focusing in the first dimension followed by SDS-PAGE in the second. This approach has been successful in elucidating the actions of palmitic acid on prot
Cytokines and Oxidative Stress Status Following a Handball Game in Elite Male Players
Douglas Popp Marin,Rita de Cassia Macedo dos Santos,Anaysa Paola Bolin,Beatriz Alves Guerra,Elaine Hatanaka,Rosemari Otton
Oxidative Medicine and Cellular Longevity , 2011, DOI: 10.1155/2011/804873
Abstract: Background. Handball is considered an intermittent sport that places an important stress on a player's aerobic and anaerobic metabolism. However, the oxidative stress responses following a handball game remain unknown. We investigated the responses of plasma and erythrocyte antioxidant system and oxidative stress biomarkers following a single handball game. Methods. Fourteen male elite Brazilian handball athletes were recruited in the present study. Blood samples were taken before, immediately, and 24 hours after the game. Results. After the game and during 24 hours of recovery, the concentration of all oxidative stress indices changed significantly in a way indicating increased oxidative stress in the blood (thiol groups and reduced glutathione decreased, whereas TBARS and plasma antioxidant capacity was increased) as well as in erythrocyte (increased levels of TBARS and protein carbonyls). Erythrocyte antioxidant enzyme activities were also significantly changed by handball. Muscle damage indices (creatine kinase and lactate dehydrogenase) increased significantly after exercise. In addition, IL-6 increased after the game, whereas TNF-α decreased during recovery. Conclusion. This study demonstrates that a single handball game in elite athletes induces a marked state of oxidative stress evidenced by the oxidative modification in plasma and erythrocyte macromolecules, as well as by changes in the enzymatic and nonenzymatic antioxidant system. 1. Introduction Sport training involves repeated bouts of exercise and high volume of physically demanding practice sessions and competitive games, which may lead to decline on performance, oxidative stress, and inflammation [1, 2]. In fact, an exercise stimulus has been well recognized to induce the production of reactive oxygen and nitrogen species (RONS) [2, 3]. In spite of RONS having an essential role as signalling molecules in several cellular pathways, the imbalance in the pro- and antioxidant status can lead to detrimental effect on cellular loss of redox homeostasis and oxidative damage in lipids, proteins, and DNA [3]. In addition, an excessive amount of RONS plays a detrimental role in exercise performance through shifting contractile function or muscle acute fatigue [4]. Regular exercise training has been associated with upregulation of the antioxidant system capacity to cope with the increase of RONS production. For this reason, pro-oxidant response of elite athletes to an acute exercise stimulus can be usually blunted [3]. Most of the studies regarding exercise-induced oxidative stress were carried out
Thermal Phase Transition in the SO(5) x U(1) Gauge-Higgs Unification with 126GeV Higgs
Hatanaka, Hisaki
High Energy Physics - Phenomenology , 2013,
Abstract: We study the phase structure of the gauge theories in the space-time with one compact dimension, where the gauge symmetry can be broken by the Hosotani mechanism. As the extra dimension, we consider the SO(5) x U(1) gauge-Higgs unification in the Randall-Sundrum space-time which reproduce the 126 GeV Higgs mass. It is found that the thermal phase transition of the electroweak symmetry is almost second order and the critical temperature is around 160 GeV for z_L < 10^7 and n_F=3.
Vino y turismo del municipio de Cangas del Narcea (Asturias, Espa a)
Hatanaka, Masanori
PASOS : Revista de Turismo y Patrimonio Cultural , 2008,
Abstract: The objective of this work is to reconstruct the process of decline and the present hope of the wine sector of the municipality of Cangas del Narcea in the southwest of Asturias region in Spain, with attention to its relation with tourism. The stagnation of its wine sector commenced from a mid twentieth centuries by the several technical, economic and social problems. Some local actors with preoccupations react against the decay since 1990s. The attempt of recovery at wine works is parallel with several tourist initiatives. They are a wine museum, visit to wine caves, and some events related with the wine culture. These initiatives are also interesting to combine with other projects like the tourism and cultural interchange.
Matter Representations and Gauge Symmetry Breaking via Compactified Space
Hisaki Hatanaka
Physics , 1999, DOI: 10.1143/PTP.102.407
Abstract: We study dynamical gauge symmetry breaking via compactified space in the framework of SU(N) gauge theory in M^{d-1}\times S^1 (d=4,5,6) space-time. In particular, we study in detail the gauge symmetry breaking in SU(2) and SU(3) gauge theories when the models contain both fundamental and adjoint matter. As a result, we find that any pattern of gauge symmetry breaking can be realized by selecting an appropriate set of numbers (Nf,Nad) in these cases. This is achieved without tuning boundary conditions of the matter fields. As a by-product, in some cases we obtain an effective potential which has no curvature at the minimum, thus leading to massless Higgs scalars, irrespective of the size of the compactified space.
Uniqueness of the direct decomposition of toric manifolds
Miho Hatanaka
Mathematics , 2013,
Abstract: In this paper, we study the uniqueness of the direct decomposition of a toric manifold. We first observe that the direct decomposition of a toric manifold as \emph{algebraic varieties} is unique up to order of the factors. An algebraically indecomposable toric manifold happens to decompose as smooth manifold and no criterion is known for two toric manifolds to be diffeomorphic, so the unique decomposition problem for toric manifolds as \emph{smooth manifolds} is highly nontrivial and nothing seems known for the problem so far. We prove that this problem is affirmative if the complex dimension of each factor in the decomposition is less than or equal to two. A similar argument shows that the direct decomposition of a smooth manifold into copies of $\mathbb{C}P^1$ and simply connected closed smooth 4-manifolds with smooth actions of $(S^1)^2$ is unique up to order of the factors.
Persistence of Inflammatory Response to Intense Exercise in Diabetic Rats
José Ricardo Bortolon,Antonio José de Almeida Silva Junior,Gilson Masahiro Murata,Philip Newsholme,Rui Curi,Tania Cristina Pithon-Curi,Elaine Hatanaka
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/213986
Abstract: In this study we evaluated the onset and resolution of inflammation in control and streptozotocin-induced diabetic rats subjected to a single session of intense exercise. The following measurements were carried out prior to, immediately after, and 2 and 24 hours after exercise: plasma levels of proinflammatory cytokines (TNF-, IL-1, IL-6, CINC-2/, MIP-3, and IL-6), immunoglobulins (IgA and IgM), acute phase proteins (CRP and C3), and creatine kinase (CK) activity. We also examined the occurrence of macrophage death by measurements of macrophages necrosis (loss of membrane integrity) and DNA fragmentation. An increase was observed in the concentration of IL-1 (3.3-fold) and TNF- (2.0-fold) and in the proportion of necrotic macrophages (4.5-fold) in diabetic rats 24 hours after exercise, while the control group showed basal measurements. Twenty-four hours after the exercise, serum CK activity was elevated in diabetic rats but not in control animals. We concluded that lesion and inflammations resulting from intense exercise were greater and lasted longer in diabetic animals than in nondiabetic control rats.
Page 1 /2533
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.