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Search Results: 1 - 10 of 211 matches for " Ekambaram Rajasekaran "
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CARBANA: Carbon analysis program for protein sequences
Ekambaram Rajasekaran,Marimuthu Vijayasarathy
Bioinformation , 2011,
Abstract: There are lots of works gone into proteins to understand the nature of proteins. Hydrophobic interaction is the dominant force that drives the proteins to carry out the biochemical reactions in all living system. Carbon is the only element that contributes towards this hydrophobic interaction. Studies find that globular proteins prefer to have 31.45% of carbon for its stability. Taking this as standard, a carbon analysis program has been developed to study the carbon distribution profile of protein sequences. This carbon analysis program has been made available online. This can be accessed at www.rajasekaran.net.in/tools/carbana.html. This new program is hoped to help in identification and development of active sites, study of protein stability, evolutionary understating of proteins, gene identification, ligand binding site identification, and to solve the long-standing problem of protein-protein and protein-DNA interactions.
BIOFFORC: Tool development for biological file format conversion
Chinnaiah Swaminathan Vinobha,Maruthamuthu Rajadurai,Ekambaram Rajasekaran
Bioinformation , 2008,
Abstract: The use of bioinformatics tools require different sequence formats at various instances. Every tool uses specific set of formats for processing. Sequence in one format is often required in another format. Thus, there is a need for sequence format conversion. A number of such tools are available in the public domain. Here, we describe BIOFFORC as a file format converter. The tool is developed with a graphical user interface in PERL.
Allotment of carbon is responsible for disorders in proteins
Ekambaram Rajasekaran,Kannaiyan Akila,Marimuthu Vijayasarathy
Bioinformation , 2011,
Abstract: Sequence stretches in proteins that do not fold into a form are referred as disordered regions. Databases like Disport describe disordered regions in proteins and web servers like PrDOS and DisEMBL, facilitate the prediction of disordered regions. These studies are often based on residue level features. Here, we describe proteins with disordered regions using carbon content and distributions. The distribution pattern for proteins with disordered regions is different from those that do not show disordered regions.
Role of thymine in protein coding frames of mRNA sequences
Perumal Anandagopu,Sivakumar Suhanya,Veerasamy Jayaraj,Ekambaram Rajasekaran
Bioinformation , 2008,
Abstract: Distribution of thymine in protein coding mRNA sequences has been studied here. Our study suggest that thymine in protein coding sequences are not randomly distributed but with probability. Frame1 prefers to have definite amount of thymine. It is observed that the thymine content of frame 4 is also involved in protein coding. Frame 3 prefers to have least amount of thymine. However, frame 2 and frame 6 shows a variable degree of thymine content. The mRNA sequences of heterosexual animals, particularly, the human show a different distribution profile (less thymine in frame 1) compared to that of yeast and plants.
Evaluation of the Structural disorder of the protein FMR1 with Carbon Composition
Baby Jerald A.,T. R. Gopalakrishnan Nair,Ekambaram Rajasekaran
Quantitative Biology , 2012,
Abstract: Ever since the disorder of proteins is the main cause for many diseases. As compared with other disorders, the major reason that causes disease is of structural inability of many proteins. The potentially imminent availability of recent datasets helps one to discover the protein disorders, however in majority of cases, the stability of proteins depend on the carbon content. Addressing this distinct feature, it is possible to hit upon the carbon distribution along the sequence and can easily recognize the stable nature of protein. There are certain reported mental disorders which fall in to this category. Regardless, such kind of disorder prone protein FMR1p (Fragile X mental retardation 1 protein) is identified as the main cause for the disease Fragile X syndrome. This paper deals with the identification of defects in the FMR1 protein sequence considering the carbon contents along the sequence. This attempt is to evaluate the stability of proteins, accordingly the protein disorders in order to improvise the certain Biological functions of proteins to prevent disease. The transition of the disorder to order protein involves careful considerations and can be achieved by detecting the unstable region that lacks hydrophobicity. This work focuses the low carbon content in the FMR1 protein so as to attain the stable status in future to reduce the morbidity rate caused by Fragile X syndrome for the society.
A Parameter Estimation Model of G-CSF: Mathematical Model of Cyclical Neutropenia  [PDF]
S. Balamuralitharan, S. Rajasekaran
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.21002
Abstract: We investigate the FFT (Fast Fourier Transform) model and G-CSF (granulocyte colony-stimulating factor) treatment of CN (Cyclical Neutropenia). We collect grey collies and normal dog’s data from CN and analyze the G-CSF treatment. The model develops the dynamics of circulating blood cells before and after the G-CSF treatment. This is quite natural and useful for the collection of laboratory data for investigation. The proposed interventions are practical. This reduces the quantity of G-CSF required for potential maintenance. This model gives us good result in treatment. The changes would be practical and reduce the risk side as well as the cost of treatment in G-CSF.
Matrix Metalloproteinase MMP-9 Promotes K/BxN Serum Induced Arthritis in Mice  [PDF]
Narendiran Rajasekaran, Harald Illges
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2014, DOI: 10.4236/ojra.2014.41003
Abstract: Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that are over-expressed in joints of rheumatoid arthritis (RA) patients. However, the contribution of specific MMPs for the development of arthritic joints is unknown. This study is aimed at studying the role of matrix metalloproteinase-9 (MMP-9) in mice, using the K/BxN serum-transfer model of RA. Arthritis was induced in Balb/c mice by injecting K/BxN serum. Development of arthritis was followed in these mice by measuring ankle thickness and clinical index score. MMP-9 expression in the joints of mice killed at various time points during the disease progression was determined by gelatin zymography using ankle lysates. We found that MMP-9 expression increased with the severity of arthritis. Importantly MMP-9 deficient mice injected with K/BxN serum showed a milder form of arthritis in comparison to the control C57BL/6 mice injected with K/BxN serum. We therefore conclude that MMP-9 promotes arthritis in mice.
Fuzzy Based Intelligent Monitoring of Critical Lines in the Restructured Power Market  [PDF]
S. Rajasekaran, S. Sathiyamoorthy
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.79191
Abstract: Restructured electric market environment allows the power wheeling transactions between the power producers and customers to meet the growing load demand. This will lead to the possible of congestion in the transmission lines. The possible contingencies of power components further worsen the scenario. This paper describes the methodology for the identification of critical transmission line by computing the real power and reactive power performance indices. It also demonstrates the importance of fuzzy logic technique used to rank the transmission lines according to the severity and demonstrated on IEEE-30 bus system.
Economically Precise Water Resource Management for Domestic Usage in India  [PDF]
P. Babu, C. Rajasekaran
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.710240
Abstract: In the present years water resource that can be utilized for domestic usage is getting reduced dramatically. In order to have sufficient water for the utilization of future generation, it is our duty to conserve and utilize the available water in a very efficient way. This paper is aimed to help the people to conserve water; it is done with the help of an embedded system that is reconfigurable depending on the number of persons in the family. The system consists of three modules. Each has a different purpose, one module senses the water level present in the tank and intimates the user regarding when the water is needed to be restored. The second module deals with the division of water based on the type of application for which is intended. The third module deals with intimating the municipality regarding the availability of water. All the three modules combine to work in conserving the water; as a result, we can consume nearly 30% per year per head. So this would result in a large amount of conservation of water. Thus the saved water can be reused for several applications.
Improved PLL Tuning of Shunt Active Power Filter for Grid Connected Photo Voltaic Energy System  [PDF]
Rajmohan Rajalakshmi, Vairamani Rajasekaran
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.710261
Abstract: This research work brings out the unique predictive current control method for attaining an efficient grid connected Photo Voltaic (PV) system by Shunt Active Power Filter (SAPF) as grid connected converter. The major objective of the research work is to address the presence of Direct Current (DC) component, frequency improvement, quicker theta response, voltage magnitude estimation in the input signal of the Phase Locked Loop (PLL) which is challenging. This work focuses on tuning the PLL block (Kp,?Ki,?Kv?and Ko)?through Artificial Bee Colony (ABC) optimization algorithm. The proposed ABC based modified three-phase PLL method is based on adding a new loop inside the PLL structure. In power converters, ABC algorithm is used to select the optimal switching states. The voltage vector which minimizes a cost optimization function is selected. Simulation is carried out for both balanced and unbalanced system and the results validate that the performance of the proposed approach is better in terms of harmonic compensation as per the IEEE standards within ±5%, power factor improvement of the system, quicker theta tracking and suppression of frequency jump with the interconnection of PV system.
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