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Surgical treatment of globe subluxation in the active phase of the myogenic type of Graves orbitopathy: case reports
Eing, Felipe;Cruz, Antonio Augusto Velasco e;
Arquivos Brasileiros de Oftalmologia , 2012, DOI: 10.1590/S0004-27492012000200012
Abstract: the purpose of the present article is to present and discuss two cases of globe su-blu-xation in the active phase of myogenic graves' orbitopathy and to evaluate the prevalence of this phenomenon. two patients with the myogenic variant of graves' orbitopathy that had being treated with oral and intravenous steroid pulses developed globe subluxation. both had to have urgent eyelid and orbital decompression. after these observations, we reviewed the medical records of a sample of 284 patients (482 orbits) who had had orbital decompression at our institution from 1992 to 2010, with a search for cases presenting severe proptosis or globe subluxation in the active phase of myogenic graves' orbitopathy. no patient had to have decompression for globe subluxation in the active phase of graves' orbitopathy. the prevalence of this event as an indication for surgery in the myogenic variant of graves' orbitopathy was therefore 0.7% (2/284) or even less. the combination of lowering the upper eyelid and orbital decompression had a dramatic therapeutic effect on these patients des-pite the presence of intense inflammatory signs in the orbits. in conclusion, patients affected with the myogenic variant of graves' orbitopathy may develop globe subluxation. urgent surgical treatments should not be postponed despite the presence of active inflammation.
Overview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods  [PDF]
Bertyl Andri, Amandine Dispas, Roland Djang’eing’a Marini, Philippe Hubert
American Journal of Analytical Chemistry (AJAC) , 2016, DOI: 10.4236/ajac.2016.71008
Abstract: In recent times, the overall interest over Supercritical Fluid Chromatography (SFC) is truly growing within various domains but especially for pharmaceutical analysis. However, in the best of our knowledge modern SFC is not yet applied for drug quality control in the daily routine framework. Among the numerous reported SFC methods, none of them could be found to fully satisfy to all steps of the analytical method lifecycle. Thereby, the present contribution aims to provide an overview of the current and past achievements related to SFC techniques, with a targeted attention to this lifecycle and its successive steps. The included discussions were therefore structured accordingly and emphasizing the analytical method lifecycle in accord with the International Conference on Harmonisation (ICH). Recent and important scientific outputs in the field of analytical SFC, as well as instrumental evolution, qualification strategies, method development methodologies and discussions on the topic of method validation are reviewed.
Efecto de la disciplina deportiva sobre valores hematológicos en hombres deportistas
Arias Mutis Daniel,Cristancho Mejía Edgar,B?eing Dieter
Acta Biológica Colombiana , 2007,
Abstract: Se establecieron los volúmenes sanguíneos y la masa de Hb (método de retoma de CO) y el consumo de oxígeno máximo (VO2max) en 15 individuos sedentarios de Bogotá (UT-Bog), 17 deportistas de diferentes disciplinas residentes en Bogotá (TR-Bog), divididos por deporte (marcha, cinco; patinaje, siete; triatlón, cinco) y cuatro deportistas provenientes de Sao Paulo (Brasil), que permanecieron ocho semanas en Bogotá, Colombia y a los que se les efectuaron dos medidas, a las dos (Brasil 1) y a las siete (Brasil 2) semana. Hubo diferencia significativa en el VO2max entre TR-Bog (65,4 +/- 7,9), Brasil 1 y 2 (56,2 +/- 1,7, y 55,8 +/- 2,8, p<0,1), y UT-Bog (41,7 +/- 5,7 p< 0,01). La [Hb] fue significativamente mayor en Ut-Bog (17,4 +/- 0,84) que en marcha (15,4 +/- 0,67, p<0,05) y Brasil 1 (15,3 +/- 0,53). El Hct presentó el mismo patrón. El Hct y [Hb] mostraron una relación negativa con el volumen plasmático (PV) y el VO2max, pero no con el volumen de eritrocitos (EV) o la masa de HB. El PV fue mayor en TR-Bog (59,3 +/- 5,4) que en UT-Bog (46,7, p< 0,01), y este fue menor que el registrado por Brasil 1 (58,8 +/- 4,2, p< 0,05), sin embargo este no mostró diferencia con Brasil 2. El volumen sanguíneo (BV) mostró un patrón similar. El PV y BV mostraron una relación positiva con el VO2max. Los valores de masa de Hb y EV no mostraron diferencia estadística entre los diferentes grupos ni tampoco relación con el VO2max. Se propone que el aumento del PV y BV se deben al estímulo deportivo; la homogeneidad en los valores de EV y masa de Hb se propone puede encontrarse relacionado a un límite en la respuesta de estos parámetros.
Unsuspected foreign object in the bronchus
Cheng Yu-Jen,Kao Eing-Long
Annals of Saudi Medicine , 2006,
Abstract:
Factors associated with tocolytic hospitalizations in Taiwan: evidence from a population-based and longitudinal study from 1997 to 2004
Ke-Zong Ma, Edward C Norton, Eing-Mei Tsai, Shoou-Yih Lee
BMC Pregnancy and Childbirth , 2009, DOI: 10.1186/1471-2393-9-59
Abstract: Longitudinal data from the 1996 to 2004 National Health Insurance Research Database in Taiwan were used to identify tocolytic hospitalizations. The probit model was used to estimate factors associated with tocolytic hospitalizations.The decline in fertility was significantly associated with the probability of tocolytic hospitalizations. Several physician and institutional factors-including physician's age, hospital ownership, accreditation status, bed size, and teaching status-were also significantly correlated to the dependent variables.The provision of inpatient tocolysis is influenced not only by clinical considerations but also by physician, institutional, and area factors unrelated to clinical need. Fertility declines in Taiwan may have led obstetricians/gynecologists to provide more tocolysis to make up for their lost income. If the explanation is further validated, reimbursement policies may need to be reviewed to correct for overuse of inpatient tocolysis. The correlation could also be explained by the increasing use of artificial reproductive technologies and higher social value of newborns. In addition, the physician and institutional variations observed in the study indicate potential misuse of inpatient tocolysis that warrant further investigation.Antenatal care generally improves maternal and infant health [1]. The most commonly stated reason for antenatal hospitalizations is having symptoms of threatened preterm labor [2-8]. Tocolytic treatment, which uses pharmacologic agents to inhibit uterine contractions and to prevent delivery before the completion of 37 weeks of gestation, is touted to reduce perinatal morbidity and mortality associated with threatened preterm labor [9,10]. However, the use of tocolytic hospitalization in antenatal care is controversial due to the potential adverse health effects and conflicting evidence of effectiveness [8,11-15]. Research indicated that antenatal hospitalizations with a pregnancy-related diagnosis may impose si
Acesso posterior para implante de peso de ouro
Pereira, Filipe José;Eing, Felipe;Marquardt, Francisco Azevedo;Cavalheiro, Rodrigo;Cruz, Antonio Augusto Velasco e;
Arquivos Brasileiros de Oftalmologia , 2008, DOI: 10.1590/S0004-27492008000500017
Abstract: purpose: to demonstrate an innovative technique of gold weight implantation through a posterior approach and evaluate its effectiveness and possible complications. the results will be compared to the other existing technique through anterior approach which has been unchanged for a long time, according to the literature. methods: a prospective study (sequence of cases) was undertaken with patients who presented paralytic lagophthalmos for over 6 months. these patients presented many different etiologies and were assisted at the department of ophthalmology of governador celso ramos hospital-sc from february 2006 to february 2007. the implantation through posterior approach was performed by only 2 surgeons. results: thirteen patients with paralytic lagophthalmos, 9 men and 4 women, with an average age of 53.07 (range from 17 to 73) were submitted to a gold weight implantation through posterior approach. the follow-up period of those patients varied from 2 months to 1 year, with an average of 6.3 months. in 3 of the patients, the implanted weight caused asymmetry to the margin-reflex distance (mrd) on the primary look position with ptosis of 2 mm in 2 patients and 4 mm in 1 patient. conclusions: although such technique has shown a satisfactory result, the authors believe that it is essential to extend the follow-up a little longer, so that the sustainability of its efficacy can be proved.
Health Promoting Lifestyles and Related Factors in Pregnant Women
Yu-Hua Lin,Eing-Mei Tsai,Te-Fu Chan,Fan-Hao Chou
Chang Gung Medical Journal , 2009,
Abstract: Background: The purpose of this study was to explore health promoting lifestyles andrelated factors in pregnant women.Methods: This was a descriptive study using convenience sampling. Altogether, 172pregnant women were recruited from a medical center in southern Taiwan.Personal data was collected, and the instruments used included perceivedhealth status, self-efficacy of health behaviors, perception of family or peers’health-promoting behaviors, and Health Promoting Lifestyle Profile (HPLPΠ).Results: The results showed that the standardized total score of health promotinglifestyles was 66.88 (moderate level). The subscales of the HPLP Π indescending order of standardized scores were as follows: “interpersonal relationships,”“health responsibility,” “psychological wellness,” “nutrition,”“stress management” and “physical activity.” There were significant differencesin the total scores of the HPLP Π among subjects with different educationallevel, socioeconomic status, chronic diseases, exercise habits, lengthof sleep, and perceived health status. Both perception of health-promotingbehaviors among family (or peers) and self-efficacy of health behaviors hadsignificantly positive relationships with health-promoting lifestyles.Perception of the family or peers’ health-promoting behaviors, self-efficacyof health behaviors, perceived health status and chronic diseases were thefour significant predictors of health-promoting lifestyles, accounting for62.4% of the variance.Conclusion: The findings of this study could be used as a reference for prenatal care,nursing education, and maternal / neonatal health policies.
Catheter Fracture and Cardiac Migration - An Unusual Fracture Site of Totally Implantable Venous Devices: Report of Two Cases
Chia-Lo Chang,Hong-Hwa Chen,Shung-Eing Lin
Chang Gung Medical Journal , 2005,
Abstract: Totally implantable venous devices (TIVDs) are used increasingly in patients with cancersand other debilitating diseases requiring long-term chemotherapy, total parental nutrition,and fluid replacement. The TIVDs are surgically inserted and fixed in the soft tissues ofthe chest wall to prevent infection and accidental dislodgment. Acute and chronic complicationsassociated with these catheters include infection, thrombosis, venous perforation,catheter leakage, dislodgment and fall out, subintimal entrapment, and tip migration toneighboring veins after satisfactory initial placement. Catheter fracture and cardiac migrationis a rare complication and most reported cases have developed between the clavicle andthe first rib as a consequence of a pinch-off sign. We present two patients with metastaticcolon cancers with unusual catheter fracture site and migration and discuss the clinicalimplications.
Fighting Poor Quality Medicines: Development, Transfer and Validation of Generic HPLC Methods for Analyzing Two WHO Recommended Antimalarial Tablets  [PDF]
Jérémie Kindenge Mbinze, Achille Yemoa, Pierre Lebrun, Pierre-Yves Sacré, Védaste Habyalimana, Nicodème Kalenda, André Bigot, Eugène Atindehou, Philippe Hubert, Roland Djang’eing’a Marini
American Journal of Analytical Chemistry (AJAC) , 2015, DOI: 10.4236/ajac.2015.62012
Abstract: As serious but neglected public health problems, poor quality medicines, i.e. for antimalarial medicines, urged to be fought. One of the approaches is to consider the analytical chemistry and separative techniques. In this study, a generic liquid chromatographic method was firstly developed for the purpose of screening 8 antimalarial active ingredients, namely amodiaquine (AQ), piperaquine (PPQ), sulfalene (SL), pyrimethamine (PM), lumefantrine (LF), artesunate (AS), artemether (AM) and dihydroartemisinine (DHA) by applying DoE/DS optimization strategy. Since the method was not totally satisfying in terms of peak separation, further experiments were undergone applying the same development strategy while splitting the 8 ingredients into five groups. Excellent prediction was observed prior to correlation between retention times of predicted and observed separation conditions. Then, a successful geometric transfer was realized to reduce the analysis time focusing on the simultaneous quantification of two WHO’s recommended ACTs in anti-malarial fixed-dose combination (AM-LF and AS-AQ) in tablets. The optimal separation was achieved using an isocratic elution of methanol-ammonium formate buffer (pH 2.8; 10 mM) (82.5:17.5, v/v) at 0.6 ml/min through a C18 column (100 mm × 3.5 mm, 3.5 μm) thermostated at 25. After a successful validation stage based on the total error approach, the method was applied to determine the content of AM/LF or AS/AQ in seven brands of antimalarial tablets currently marketed in West, Central and East Africa. Satisfying results were obtained compared to the claimed contents.
Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines  [PDF]
Jérémie Kindenge Mbinze, Jean Nsangu Mpasi, Elza Maghe, Sébastien Kobo, Rodrigue Mwanda, Guy Mulumba, Jacquie Bolavie Bolande, Trésor Menanzambi Bayebila, Maguy Borive Amani, Philippe Hubert, Roland Djang’eing’a Marini
American Journal of Analytical Chemistry (AJAC) , 2015, DOI: 10.4236/ajac.2015.62010
Abstract: In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2 - 10 μg/mL (for quinine sulfate in tablet), 4 - 12 μg/mL (for quinine bichlorhydrate in oral drop-metronidazole benzaote in oral suspension) and 15 - 35 μg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms.
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