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Search Results: 1 - 10 of 406614 matches for " Edward M. Manno "
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Neurohospitalists: Challenges for the Integration of a New Field: A Neurointensivist's Perspective
Edward M. Manno
Frontiers in Neurology , 2010, DOI: 10.3389/fneur.2010.00154
Abstract:
A prospective trial of elective extubation in brain injured patients meeting extubation criteria for ventilatory support: a feasibility study
Edward M Manno, Alejandro A Rabinstein, Eelco FM Wijdicks, Allen W Brown, William D Freeman, Vivien H Lee, Stephen D Weigand, Mark T Keegan, Daniel R Brown, Francis X Whalen, Tuhin K Roy, Rolf D Hubmayr
Critical Care , 2008, DOI: 10.1186/cc7112
Abstract: Sixteen neurologically stable but severely brain injured patients with a Glasgow Coma Score (GCS) of 8 or less were randomised to early or delayed extubation until their neurological examination improved. Eligible patients met standard respiratory criteria for extubation and passed a modified Airway Care Score (ACS) to ensure adequate control of respiratory secretions. The primary outcome measured between groups was the functional status of the patient at hospital discharge as measured by a Modified Rankin Score (MRS) and Functional Independence Measure (FIM). Secondary measurements included the number of nosocomial pneumonias and re-intubations, and intensive care unit (ICU) and hospital length of stay. Standard statistical assessments were employed for analysis.Five female and eleven male patients ranging in age from 30 to 93 years were enrolled. Aetiologies responsible for the neurological injury included six head traumas, three brain tumours, two intracerebral haemorrhages, two subarachnoid haemorrhages and three ischaemic strokes. There were no demographic differences between the groups. There were no unexpected deaths and no significant differences in secondary measures. The difference in means between the MRS and FIM were small (0.25 and 5.62, respectively). These results suggest that between 64 and 110 patients are needed in each treatment arm to detect a treatment effect with 80% power.Recruitment and randomisation of severely brain injured patients appears to be safe and feasible. A large multicentre trial will be needed to determine if stable, severely brain injured patients who meet respiratory and airway control criteria for extubation need to remain intubated.More than 200,000 patients per year require mechanical ventilation primarily for neurological reasons based on rates of endotracheal intubation for patients with ischaemic and haemorrhagic stroke, head trauma and subarachnoid haemorrhage [1-6]. The direct and indirect costs of caring for head trau
Habitat abundances of a cricket-parasitizing wasp Rhopalosoma nearcticum (Hymenoptera: Rhopalosomatidae) in a United States mid-Atlantic park  [PDF]
Edward M. Barrows
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.34046
Abstract: Adults of the nocturnal, cricket-parasitizing wasp Rhopalosoma nearcticum flew in Dyke Marsh Wildlife Preserve (DMWP) from late June through late September, based on a 2-year, Malaise-trap sample of 617 individuals from three habitats. These wasps were significantly more abundant in the floodplain forest compared to the tidal, freshwater marsh and forest-marsh ecotone. Females were more likely to be in the ecotone and marsh than males. The pooled sample from all three habitats was significantly male biased. This study provides baseline information on R. nearcticum that can be used in assessing the health of the DMWP entomofauna in view of global change, accelerating DMWP erosion and marsh loss, invasive species, and other threats to this fragile preserve.
Early events in insulin fibrillization studied by time-lapse atomic force microscopy
A. Podesta',G. Tiana,P. Milani,M. Manno
Quantitative Biology , 2005, DOI: 10.1529/biophysj.105.068833
Abstract: The importance of understanding the mechanism of protein aggregation into insoluble amyloid fibrils relies not only on its medical consequences, but also on its more basic properties of self--organization. The discovery that a large number of uncorrelated proteins can form, under proper conditions, structurally similar fibrils has suggested that the underlying mechanism is a general feature of polypeptide chains. In the present work, we address the early events preceeding amyloid fibril formation in solutions of zinc--free human insulin incubated at low pH and high temperature. Aside from being a easy--to--handle model for protein fibrillation, subcutaneous aggregation of insulin after injection is a nuisance which affects patients with diabetes. Here, we show by time--lapse atomic force microscopy (AFM) that a steady-state distribution of protein oligomers with an exponential tail is reached within few minutes after heating. This metastable phase lasts for few hours until aggregation into fibrils suddenly occurs. A theoretical explanation of the oligomer pre--fibrillar distribution is given in terms of a simple coagulation--evaporation kinetic model, in which concentration plays the role of a critical parameter. Due to high resolution and sensitivity of AFM technique, the observation of a long-lasting latency time should be considered an actual feature of the aggregation process, and not simply ascribed to instrumental inefficency. These experimental facts, along with the kinetic model used, claim for a critical role of thermal concentration fluctuations in the process of fibril nucleation.
On the geometry of Grassmannian equivalent connections
Gianni Manno
Mathematics , 2006,
Abstract: We introduce the equation of n-dimensional totally geodesic submanifolds of a manifold E as a submanifold of the second order jet space of n-dimensional submanifolds of E. Next we study the geometry of n-Grassmannian equivalent connections, that is linear connections without torsion admitting the same equation of n-dimensional totally geodesic submanifolds. We define the n-Grassmannian structure as the equivalence class of such connections, recovering for n=1 the case of theory of projectively equivalent connections. By introducing the equation of parametrized n-dimensional totally geodesic submanifolds as a submanifold of the second order jet space of the trivial bundle on the space of parameters, we discover a relation of covering between the `parametrized' equation and the `unparametrized' one. After having studied symmetries of these equations, we discuss the case in which the space of parameters is equal to R^n.
The Dynamic-to-Static Conversion of Dynamic Fault Trees Using Stochastic Dependency Graphs and Stochastic Activity Networks  [PDF]
Gabriele Manno, Ferdinando Chiacchio, Francesco Pappalardo
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.52023
Abstract:

In this paper a new modeling framework for the dependability analysis of complex systems is presented and related to dynamic fault trees (DFTs). The methodology is based on a modular approach: two separate models are used to handle, the fault logic and the stochastic dependencies of the system. Thus, the fault schema, free of any dependency logic, can be easily evaluated, while the dependency schema allows the modeler to design new kind of non-trivial dependencies not easily caught by the traditional holistic methodologies. Moreover, the use of a dependency schema allows building a pure behavioral model that can be used for various kinds of dependability studies. In the paper is shown how to build and integrate the two modular models and convert them in a Stochastic Activity Network. Furthermore, based on the construction of the schema that embeds the stochastic dependencies, the procedure to convert DFTs into static fault trees is shown, allowing the resolution of DFTs in a very efficient way.

Looking for a Silver Lining: The Possible Positives of Declining Energy Return on Investment (EROI)
Jack P. Manno
Sustainability , 2011, DOI: 10.3390/su3112071
Abstract: Declining energy return on investment (EROI) of a society’s available energy sources can lead to both crisis and opportunity for positive social change. The implications of declining EROI for human wellbeing are complex and open to interpretation. There are many reasons why frugal living and an energy diet could be beneficial. A measure of wellbeing or welfare gained per unit of energy expended (WROEI) is proposed. A threshold is hypothesized for the relation between energy consumption and wellbeing. The paper offers a biophysical-based social science explanation for both the negative and positive possible implications of declining EROI. Two sets of future scenarios based on environmental and economic trends are described. Six types of social change activism are considered essential if the positives of declining EROI are to balance or exceed the negatives.
The geometry of finite order jets of submanifolds and the variational formalism
Gianni Manno,Raffaele Vitolo
Physics , 2003,
Abstract: We study the geometry of jets of submanifolds with special interest in the relationship with the calculus of variations. We give a new proof of the fact that higher order jets of submanifolds are affine bundles; as a by-product we obtain a new expression for the associated vector bundles. We use Green-Vinogradov formula to provide coordinate expressions for all variational forms, i.e., objects in the finite-order variational sequence on jets of submanifolds. Finally, we formulate the variational problem in the framework of jets of submanifolds by an intrinsic geometric language, and connect it with the variational sequence. Detailed comparison with literature is provided throughout the paper.
Geometric aspects of higher order variational principles on submanifolds
Gianni Manno,Raffaele Vitolo
Mathematics , 2006, DOI: 10.1007/s10440-008-9190-x
Abstract: The geometry of jets of submanifolds is studied, with special interest in the relationship with the calculus of variations. A new intrinsic geometric formulation of the variational problem on jets of submanifolds is given. Working examples are provided.
Meta-symplectic geometry of $3^\textrm{rd}$ order Monge-Ampère equations and their characteristics
Gianni Manno,Giovanni Moreno
Mathematics , 2014,
Abstract: This paper is a natural companion of [Alekseevsky et al.: Contact geometry of multidimensional Monge-Amp\`ere equations: characteristics, intermediate integrals and solutions. Ann. Inst. Fourier (Grenoble) (2012)], generalising its perspectives and results to the context of third-order (2D) Monge-Amp\`ere equations. We use the so-called "meta-symplectic structure" associated with the 8D prolongation $M^{(1)}$ of a 5D contact manifold $M$ and the corresponding notion Lagrangian planes. The analogy with standard symplectic structures allows to write down a geometric definition of a third-order Monge-Amp\`ere equation in terms of a (class of) differential two-form on $M^{(1)}$. In particular, the equations corresponding to decomposable forms admit a simple description in terms of Lagrangian planes which are non-transversal to a certain three-dimensional distribution. We show that such a distribution is made from the characteristics of the original equation, and that there can be up to three mutually orthogonal distributions determining the same equation. We conclude the paper with a study of the intermediate integrals of third-order Monge-Amp\`ere equations of Goursat type.
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