oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 149 )

2018 ( 296 )

2017 ( 302 )

2016 ( 417 )

Custom range...

Search Results: 1 - 10 of 225032 matches for " Edward C. Lisic "
All listed articles are free for downloading (OA Articles)
Page 1 /225032
Display every page Item
Cu(II) Propionyl-Thiazole Thiosemicarbazone Complexes: Crystal Structure, Inhibition of Human Topoisomerase IIα, and Activity against Breast Cancer Cells  [PDF]
Edward C. Lisic, Victoria G. Rand, Lana Ngo, Patrick Kent, Jeffrey Rice, Deidra Gerlach, Elizabeth T. Papish, Xiaohua Jiang
Open Journal of Medicinal Chemistry (OJMC) , 2018, DOI: 10.4236/ojmc.2018.82004
Abstract: Two new thiosemicarbazone ligands, 2-propionylthiazole ethylthiosemicarbazone (PTZ-ETSC), and 2-propionylthiazole tert-butylthiosemicarbazone (PTZ-tBTSC), along with their two copper(II) complexes, [Cu(PTZ-ETSC)Cl] and [Cu(PTZ-tBTSC)Cl], are reported here for the first time. Once characterized by NMR and MS, these mono-anionic tridentate ligands were reacted with Cu2+ to form the square planar metal complexes [Cu(PTZ-ETSC)Cl] and [Cu(PTZ-tBTSC)Cl]. The x-ray crystal structure of the [Cu(PTZ-tBTSC)Cl] complex shows that the complex adopts a square planar arrangement around the copper(II) ion, but forms a sulfur-bridged dimer in the solid state. Both of the copper complexes displayed strong inhibition of human topoisomerase IIα at activities between 2-4 μM for [Cu(PTZ-ETSC)Cl], and between 8-10 μM for the [Cu(PTZ-tBTSC)Cl] complex. The EC50 values for the MDA-MB-231 breast cancer cell line were 82.6 μM for (PTZ-ETSC), 17.9 μM for [Cu(PTZ- ETSC)Cl], 97.8 μM for (PTZ-tBTSC), and 1.41 μM for [Cu(PTZ-tBTSC)Cl]. The EC50 values for the MCF7 breast cancer cell lines were 9.36 μM for (PTZ-ETSC), 0.13 μM for [Cu(PTZ-ETSC)Cl], 0.333 μM for (PTZ-tBTSC), and 0.093 μM for [Cu(PTZ-tBTSC)Cl].
Cu(II) Benzoylpyridine Thiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells  [PDF]
Jennifer D. Conner, Wathsala Medawala, Madison T. Stephens, William H. Morris, Joseph E. Deweese, Patrick L. Kent, Jeffery J. Rice, Xiaohua Jiang, Edward C. Lisic
Open Journal of Inorganic Chemistry (OJIC) , 2016, DOI: 10.4236/ojic.2016.62010
Abstract: The focus of this research is on the study of a series of copper (II) benzoylpyridine thiosemicarbazone complexes. Of the six benzoylpyridine thiosemicarbazone ligands used in this study, two are reported for the first time; 2-benzoylpyridine tert-butyl thiosemicarbazone (BZP-tBTSC), and 2-benzoylpyridine benzyl thiosemicarbazone (BZP-BzTSC). Once characterized by NMR, melting point, and MS, these mono-anionic tridentate ligands were then reacted with Cu2+ to form the new square planar metal complexes [Cu(BZP-tBTSC)Cl] and [Cu(BZP-BzTSC)Cl]. All of the copper complexes display marked inhibition of human topoisomerase IIα. The [Cu(BZP-tBTSC)Cl] complex shows marked activity against human breast cancer cell lines.
Therapeutic Effects of Curcumin on Alzheimer’s Disease  [PDF]
Edward C. Yao, Lei Xue
Advances in Alzheimer's Disease (AAD) , 2014, DOI: 10.4236/aad.2014.34014
Abstract: As the number of patients with Alzheimer’s disease (AD) continues to rise throughout the twenty- first century, scientists are increasingly looking for remedies, although the cause and pathology of the disease remain uncertain. Among treatments for AD, there is a renewed interest in curcumin as a potential medication. Studies of the substance have found a large amount of consumption associated benefits, including anti-inflammatory and antioxidant effects. Its wide healing properties make it increasingly interesting to scientists, with potential uses in the treatment of cancers, arthritis, various cardiovascular diseases, and neurodegenerative diseases. More recently, curcumin has been shown to have multipotent effects against various symptoms of AD. Among other things, curcumin has been able to ameliorate toxicity of beta-amyloid species, a key part of AD nuerodegeneration, in vivo and in vitro, and has been able to inhibit multiple parts along suspected AD pathology. The goal of this review is to summarize the research done on curcumin with respect to its applicability as a treatment for AD and AD related pathology.
Personality change in older adults with dementia: Occurrence and association with severity of cognitive impairment  [PDF]
Edward Helmes, Maria C. Norton, Truls ?stbye
Advances in Aging Research (AAR) , 2013, DOI: 10.4236/aar.2013.21004
Abstract:

Personality change is among criteria for the diagnosis of dementia. We examine first whether personality changes are related to severity of cognitive impairment in a linear or an inverted-U fashion in 1132 demented older people from the Canadian Study of Health and Aging (CSHA) and 921 unimpaired older people. The proportion with reported change was larger for all measures in the demented group than in the cognitively unimpaired group, and was more consistent with a linear increase in personality change with increasing cognitive impairment than with an inverted-U relationship, as seen in only one variable. In our second (longitudinal) study, we evaluate which aspects of personality change most in dementia; changes in mood and an exaggeration of existing traits were the variables most closely related to the development of dementia.

Viral Evolution in the Genomic Age
Edward C. Holmes
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0050278
Abstract:
Complex life forms may arise from electrical processes
Edward C Elson
Theoretical Biology and Medical Modelling , 2010, DOI: 10.1186/1742-4682-7-26
Abstract: Goldbeter [1] has classified some of the main biological cycles (rhythms) in order of increasing period. Only one, that of the cardiac rhythm, can be regarded as truly governed by a pacemaker in the deterministic sense. The others have large numbers of sub-systems interacting via laws of probability, and although exhibiting "tight" control in some sense, do not possess the high auto-correlation of the cardiac pace-maker, which this paper suggests may be an adaptation of the first pace-maker in evolution, the one facilitating cell specialization (differentiation) as well as proliferation.The proposal of this paper is that the fundamental cycle supplies the coordination and disciplining of the growth process which the myriads of stochastic biochemical cycles cannot. The fundamental cycle can be thought of deterministic and therefore may explain how development occurs, even though biological organisms remain subject to the second law of thermodynamics.In what sense does growth and differentiation of a biological organism violate the second law? This is perhaps intuitively apparent, but one should try to make the concept more concrete. It is known that in an isolated box filled with Avogadro's number of gas molecules at equilibrium, the probability that all of the molecules will go in the same direction simultaneously (will "fall up") is very low, even unlikely to happen during the presumed age of the universe. If one places a permeable membrane across the middle of the box, the probability that all molecules will be found in one compartment of the box at a later time is also very low. Likewise, the probability that a lowly protist, say, a bacterium assembles itself from complete, nutrient medium is similarly low. It is known that, over millennia, such a process has occurred, but this article inquires no further about that process, as it pertains to the origin of life, a large and even now incompletely understood process, beyond the scope chosen by the author. Rather th
TECHNIQUE ESTIMATING SEA SPRAY PRODUCTION RATE FOR GLOBAL CLIMATE MODELS FROM SATELLITE-DERIVED MEASURES OF OCEANIC WHITECAP COVERAGE
Monahan,Edward C.;
Gayana (Concepción) , 2004, DOI: 10.4067/S0717-65382004000300016
Abstract: by combining laboratory-determined values for the number of sea spray droplets, per increment of droplet radius, that are produced during the decay of an oceanic whitecap of initial unit surface area, and values determined from both laboratory experiments and field observations for the e-folding time associated with the decay of individual oceanic whitecaps, with satellite-derived measures of the fraction of the sea surface covered at any instant by spilling wave crests (stage a whitecaps), the number of sea spray droplets, per droplet radius increment, that are produced per unit time, per unit area of the ocean surface, can be estimated. this sea spray aerosol source function can be incorporated in any global climate model where the role of spray droplets in influencing maritime cloudiness, in affecting the over-ocean radiative balance, and in contributing to the sea-air moisture flux, need be explicitly parameterized
Apatia e alheamento político numa sociedade paralisada: os limites da nova democracia chilena
Epstein, Edward C.;
Opini?o Pública , 2001, DOI: 10.1590/S0104-62762001000100002
Abstract: the notion of a "stalemate society" used here to describe contemporary chilean democracy is meant to suggest a particular political system where the likelihood of significant change resulting through elections and bargaining has been reduced to a minimum. given restrictive political provisions imposed by the pinochet military regime upon the new democracy such as the constitutionally-sanctioned appointed institutional senators and the "binomial" election law which dramatically over-represents the largest minority group one can argue that political power was meant to be almost equally divided between those center and center-left forces grouped in the concertación coalition and those opposing them on the political right, in seeming disregard of what the voters wanted. what is raised as the central question for examination in this essay relates to the likely effects such entrenched political immobilism may have had on chileans as they became aware that the political forces representing a popular majority had only a limited ability to achieve the changes sought. the type of effect suggested here focuses on existing political apathy and alienation.
TECHNIQUE ESTIMATING SEA SPRAY PRODUCTION RATE FOR GLOBAL CLIMATE MODELS FROM SATELLITE-DERIVED MEASURES OF OCEANIC WHITECAP COVERAGE
Edward C. Monahan
Gayana (Concepción) , 2004,
Abstract: By combining laboratory-determined values for the number of sea spray droplets, per increment of droplet radius, that are produced during the decay of an oceanic whitecap of initial unit surface area, and values determined from both laboratory experiments and field observations for the e-folding time associated with the decay of individual oceanic whitecaps, with satellite-derived measures of the fraction of the sea surface covered at any instant by spilling wave crests (Stage A whitecaps), the number of sea spray droplets, per droplet radius increment, that are produced per unit time, per unit area of the ocean surface, can be estimated. This sea spray aerosol source function can be incorporated in any global climate model where the role of spray droplets in influencing maritime cloudiness, in affecting the over-ocean radiative balance, and in contributing to the sea-air moisture flux, need be explicitly parameterized
Matawai lineage fission
Edward C. Green
Bijdragen tot de Taal-, Land- en Volkenkunde , 1977,
Abstract:
Page 1 /225032
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.