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Search Results: 1 - 10 of 211371 matches for " Eduardo Vilar Gómez "
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Modelos pronósticos para la cirrosis hepática
Calzadilla Bertot,Luis; Vilar Gómez,Eduardo; Lincheta Enriquez,Laritza;
Revista Cubana de Medicina , 2011,
Abstract: the prognostic models are a significant pillar in assessment of patients presenting hepatic cirrhosis, mainly at moment to make a decision related to liver transplantation. the two more used models at international level, the child pugh turcotte and the model for end stage liver disease ( meld) have advantages and disadvantages in its approximation to patients. the aim of present paper was to review these prognostic models used in the end-terminal liver disease, as well as to compare the above mentioned models on the base of the design, predictive effectiveness and practical application. we conclude that both models are useful to predict mortality in patients presenting with hepatic cirrhosis and also that more future researches must to be performed to improve its discriminatory power.
Modelos pronósticos para la cirrosis hepática Prognostic models for hepatic cirrhosis
Luis Calzadilla Bertot,Eduardo Vilar Gómez,Laritza Lincheta Enriquez
Revista Cubana de Medicina , 2011,
Abstract: Los modelos pronósticos representan un pilar importante en la evaluación de los pacientes con cirrosis hepática, sobre todo a la hora de tomar decisiones como el trasplante hepático. Los 2 modelos más utilizados al nivel mundial, el Child Pugh Turcotte y el Model for end stage liver disease (MELD), presentan ventajas y desventajas en su aproximación a los pacientes. El objetivo de este trabajo fue revisar estos modelos pronósticos utilizados en la enfermedad hepática terminal, así como comparar el modelo MELD y el Child Pugh Turcotte sobre la base del dise o, eficacia predictiva y aplicación practica. Se concluye que ambos modelos son útiles para predecir la mortalidad en los pacientes con cirrosis hepática y que se deben realizar futuras investigaciones para mejorar su poder discriminativo. The prognostic models are a significant pillar in assessment of patients presenting hepatic cirrhosis, mainly at moment to make a decision related to liver transplantation. The two more used models at international level, the Child Pugh Turcotte and the Model for end stage liver disease ( MELD) have advantages and disadvantages in its approximation to patients. The aim of present paper was to review these prognostic models used in the end-terminal liver disease, as well as to compare the above mentioned models on the base of the design, predictive effectiveness and practical application. We conclude that both models are useful to predict mortality in patients presenting with hepatic cirrhosis and also that more future researches must to be performed to improve its discriminatory power.
Influencia de factores epidemiológicos en la progresión de la fibrosis en la hepatitis crónica C
Vilar Gómez,Eduardo; Grá Oramas,Bienvenido; Llanio Navarro,Raimundo; Arús Soler,Enrique;
Revista Cubana de Medicina , 2003,
Abstract: approximately 80 % of hepatitis c evolves to chronicity. the epidemiological and viral factors as well as those of the guest take part in the progression of the disease. the behavior of the epidemiological variables associated with chronic hepatitis c was described and the possible association of these ones with the intensity of fibrosis was identified. 80 patients with hepatitis c were studied and the intensity of fibrosis was determined by the metavir scoring system. they were grouped into absence or little fibrosis (f0-f1) and marked fibrosis (f2-f4) seeking for the possible statistical association with the epidemiological factors. a significant association was found among the infection's oldness estimate, the way it was acquired, the patient's age on catching it and the intensity of fibrosis. the progression of hepatits c may be determined by some epidemiological factors influencing decisively the natural history of the disease.
Bases fisiopatológicas de la insuficiencia hepática aguda
Vilar Gómez,Eduardo; Grá Oramas,Bienvenido; Llanio Navarro,Raimundo; Arús Soler,Enrique;
Revista Cubana de Medicina , 2004,
Abstract: a review was made to explain how the diverse cellular processes occurring in the severely damaged liver tissue and in the mesenteric circulation influence on the different systemic alterations appearing in acute liver failure, and the close relation existing among them. the acute liver failure is a clinical syndrome resulting from a mass liver necrosis generating progressive dysfunction of the organ with the presence of deep alterations in its detoxicating, metabolic, sinthesizing and excreting functions.the hypothesis of critical mass, as well as that on endotoxins-cytokines and vasoactive substances explain somehow the different molecular changes supporting the physiopathological bases of this complex entity.
Tratamiento prolongado con interferón alfa-2b más lamivudina en pacientes con hepatitis crónica B y antígeno e positivo Prolonged treatment with alpha-2b interferon plus lamivudine in patients with e antigen positive chronic hepatitis B
Eduardo Vilar Gómez,Bienvenido Grá Orama,Enrique Arús Soler,Caridad Ruenes Domech
Revista Cubana de Medicina , 2007,
Abstract: Las tasas de seroconversión del antígeno e alcanzadas con los antivirales actuales no sobrepasan el 35 %. La combinación de inmunomodulador y antiviviral ha sido teóricamente la estrategia más aceptada en los últimos a os; sin embargo, los resultados en la práctica clínica han sido contradictorios. Se realizó el presente trabajo para evaluar la eficacia y seguridad de un esquema de tratamiento prolongado durante 52 sem con interferón alfa-2b más lamivudina en pacientes con hepatitis crónica B y antígeno e positivo. Se estudiaron 46 pacientes asignados aleatoriamente: 23 recibieron 150 mg diarios de lamivudina por 4 sem, lamivudina más interferón alfa-2b (10 MU en días alternos) por 24 sem, seguido de lamivudina en la misma dosis y frecuencia hasta completar las 52 sem. Otros 23 recibieron 150 mg diarios de lamivudina por 4 sem y lamivudina más interferón alfa-2b (5 MU en días alternos) durante 52 sem. Se encontró que las tasas de seroconversión del antígeno fueron similares en ambos grupos. Una proporción significativa de pacientes con tratamiento combinado prolongado logró negativizar el ADN viral (52 % frente al 26 %, p=0,06) y el antígeno de superficie (48 % frente al 26 %, p=0,11), comparado con los controles. La mejoría en el índice de actividad histológica fue observada en el 48 % de los pacientes tratados con tratamiento combinado prolongado frente al 22 % de los controles (p=0,06). Se concluyó que el tratamiento prolongado deerferón y lamivudina durante 52 sem puede brindar beneficios clínicos en las tasas de pérdida sostenida del ADN viral, el antígeno de superficie y en el índice de actividad histológica. The seroconversion rates of e antigen attained with the current antivirals do not exceed 35 %. The combination of immunomodulator and antiviral has been theoretically the most accepted strategy in the last five years; however, the results in clinical practice have been contradictory. This paper is aimed at evaluating the efficacy and security of a treatment scheme prolonged for 52 weeks with alpha-2b interferon plus lamivudine in patients with e antigen positive chronic hepatitis B. 46 patients selected at random were studied: 23 received 150 mg of lamivudine daily during 4 weeks, lamivudine plus alpha-2b (10 MU every other day) for 24 weeks, followed by lamivudine in the same dose and frequency until completing the 52 weeks. Other 23 were administered 150 mg of lamivudine daily for 4 weeks plus alpha 2b interferon (5 MU every other day) during 52 weeks. It was found that the antigen seroconversion rates were similar in both groups. A marked
Influencia de factores epidemiológicos en la progresión de la fibrosis en la hepatitis crónica C
Eduardo Vilar Gómez,Bienvenido Grá Oramas,Raimundo Llanio Navarro,Enrique Arús Soler
Revista Cubana de Medicina , 2003,
Abstract: Aproximadamente 80 % de la hepatitis C evoluciona a la cronicidad. Factores como los epidemiológicos, virales y del huésped intervienen en la progresión de la enfermedad. Se describió el comportamiento de variables epidemiológicas asociadas a la hepatitis crónica C y se identificó la posible asociación de estas con la intensidad de la fibrosis. Se estudiaron 80 pacientes con hepatitis C. Se determinó la intensidad de la fibrosis por el sistema de puntuación METAVIR. Se agruparon en: ausencia o poca fibrosis (F0-F1) y fibrosis marcada (F2 a F4) buscando la posible asociación estadística con los factores epidemiológicos. Se halló asociación significativa entre el estimado de antigüedad de la infección, la vía de adquisición y la edad al contraerla con la intensidad de la fibrosis. La progresión de la hepatitis C puede estar determinada por algunos factores epidemiológicos que influyen de forma decisiva en la historia natural de la enfermedad. Approximately 80 % of hepatitis C evolves to chronicity. The epidemiological and viral factors as well as those of the guest take part in the progression of the disease. The behavior of the epidemiological variables associated with chronic hepatitis C was described and the possible association of these ones with the intensity of fibrosis was identified. 80 patients with hepatitis C were studied and the intensity of fibrosis was determined by the METAVIR scoring system. They were grouped into absence or little fibrosis (f0-F1) and marked fibrosis (F2-F4) seeking for the possible statistical association with the epidemiological factors. A significant association was found among the infection's oldness estimate, the way it was acquired, the patient's age on catching it and the intensity of fibrosis. The progression of hepatits C may be determined by some epidemiological factors influencing decisively the natural history of the disease.
Bases fisiopatológicas de la insuficiencia hepática aguda Physiopathological bases of acute liver failure
Eduardo Vilar Gómez,Bienvenido Grá Oramas,Raimundo Llanio Navarro,Enrique Arús Soler
Revista Cubana de Medicina , 2004,
Abstract: Se hace una revisión para explicar cómo influyen y la estrecha relación que tienen los diversos procesos celulares que ocurren en el tejido hepático, severamente da ado, y en la circulación mesentérica con las distintas alteraciones sistémicas que aparecen en la insuficiencia hepática aguda, síndrome clínico resultado de una necrosis hepática masiva que genera disfunción progresiva del órgano con la presencia de profundas alteraciones en sus funciones detoxificadora, metabólica, sintetizadora y excretora. La hipótesis de la masa crítica, así como la de las endotoxinas-citoquinas y sustancias vasoactivas explican de cierta forma los diferentes cambios moleculares que sustentan las bases fisiopatológicas de esta compleja entidad. A review was made to explain how the diverse cellular processes occurring in the severely damaged liver tissue and in the mesenteric circulation influence on the different systemic alterations appearing in acute liver failure, and the close relation existing among them. The acute liver failure is a clinical syndrome resulting from a mass liver necrosis generating progressive dysfunction of the organ with the presence of deep alterations in its detoxicating, metabolic, sinthesizing and excreting functions.The hypothesis of critical mass, as well as that on endotoxins-cytokines and vasoactive substances explain somehow the different molecular changes supporting the physiopathological bases of this complex entity.
Tratamiento prolongado con interferón alfa-2b más lamivudina en pacientes con hepatitis crónica B y antígeno e positivo
Vilar Gómez,Eduardo; Grá Orama,Bienvenido; Arús Soler,Enrique; Ruenes Domech,Caridad; Dávila González,Yudith;
Revista Cubana de Medicina , 2007,
Abstract: the seroconversion rates of e antigen attained with the current antivirals do not exceed 35 %. the combination of immunomodulator and antiviral has been theoretically the most accepted strategy in the last five years; however, the results in clinical practice have been contradictory. this paper is aimed at evaluating the efficacy and security of a treatment scheme prolonged for 52 weeks with alpha-2b interferon plus lamivudine in patients with e antigen positive chronic hepatitis b. 46 patients selected at random were studied: 23 received 150 mg of lamivudine daily during 4 weeks, lamivudine plus alpha-2b (10 mu every other day) for 24 weeks, followed by lamivudine in the same dose and frequency until completing the 52 weeks. other 23 were administered 150 mg of lamivudine daily for 4 weeks plus alpha 2b interferon (5 mu every other day) during 52 weeks. it was found that the antigen seroconversion rates were similar in both groups. a marked proportion of patients with combined prolonged treatment proved to be negative to the viral dna (52 % vs. 26p = 0.06) and the surface antigen (48 % vs. 26 %, p = 0.11) compared with the controls. the improvement in the histological activity rate was observed in 48 % of the patients treated with combined prolonged treatment against 22 % of the controls (p = 0.06) it was concluded that the prolonged treatment of interferon and lamivudine during 52 weeks may have clinical benefits on the rates of sustained viral dna loss, surface antigen and the histological activity index.
Métodos de análisis de las verbalizaciones: ontologías y procesode abducción
Escalante Gómez,Eduardo;
Subjetividad y procesos cognitivos , 2010,
Abstract: this study looks into the need to develop what is known as ontologies as a way to process natural language and as a tool for the exploration and analysis of the verbalizations obtained through interviews in depth and focus groups. each ontology operates in the context of an abductive process, which allows the expansion of the initial ontology. the main idea isn't the construction of ontology for its computerized formalization but rather the compliance with the concept of ontology according to which its use is linked to its pertinence in the representation of a body of knowledge selected from a specific domain of reality which is of interest. the hypothesis of the text is: the analysis of the verbalizations in a research process should follow the abductive method that begins with the construction of an e-ontology and immediately develops into a recursive process of refinement and reconfigurations of what samaja (2003) calls modeling preconceptions.
Bogotá En La Globalización
Corredor Gómez,Eduardo;
Análisis Político , 2007,
Abstract: this article tackles bogotá's situation in terms of economic globalization. it analyses the place of the colombian capital within the new urban scenario provided by globalization. it tests the hypothesis that contemporaneous economic activity is concentrated in the capital and that it is the key place for financial transactions. such thesis is put forward by saskia sassen in the book called the "global city".
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