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Search Results: 1 - 10 of 22192 matches for " Eduardo Gotuzzo "
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Formación de investigadores en el contexto de proyectos colaborativos: experiencias en el Instituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia
Gotuzzo,Eduardo; González,Elsa; Verdonck,Kristien;
Revista Peruana de Medicina Experimental y Salud Pública , 2010, DOI: 10.1590/S1726-46342010000300015
Abstract: research is a main element for human and social development. under this point of view, it involves particular challenges and opportunities for the so-called "developing countries". an approach for those challenges and opportunities comes from the analysis of two interrelated activities; the training of new researchers and the research development with institutions or researchers which are external to the institution ("collaborative research"). both activities are essential for the consolidation, widening and updating of the institutional capabilities for scientific production. we present here the experiences of the instituto de medicina tropical "alexander von humboldt" of the universidad peruana cayetano heredia, in relation to the training of new researchers, we discuss the four elements we consider key for this process; the promotion of stimulating environments for research, the proactive identification of fellows, the complementary advice and networks consolidation; and we analyze three successful models of international collaboration for the training of new researchers under different institutional approaches.
Formación de investigadores en el contexto de proyectos colaborativos: experiencias en el Instituto de Medicina Tropical "Alexander von Humboldt", Universidad Peruana Cayetano Heredia Researchers training in the context of the collaborative projects: experiences of Instituto de Medicina Tropical "Alexander von Humbolt", Universidad Peruana Cayetano Heredia
Eduardo Gotuzzo,Elsa González,Kristien Verdonck
Revista Peruana de Medicina Experimental y Salud Pública , 2010,
Abstract: La investigación constituye un elemento fundamental de desarrollo humano y social. Bajo esta perspectiva, supone desafíos y oportunidades particulares para los llamados países "en vías de desarrollo". Una aproximación a tales desafíos y oportunidades se desprende del análisis de dos actividades interrelacionadas: la formación de nuevos investigadores y el desarrollo de investigación con instituciones o investigadores externos a la propia institución ("investigación colaborativa"). Ambas actividades son esenciales en la consolidación, ampliación y actualización de las capacidades institucionales de producción científica. Presentamos aquí las experiencias del Instituto de Medicina Tropical "Alexander von Humboldt" de la Universidad Peruana Cayetano Heredia con relación a la formación de investigadores; discutimos los cuatro elementos que consideramos clave en dicho proceso: promoción de entornos estimulantes para investigación, identificación proactiva de becarios, asesorías complementarias y consolidación de redes; y analizamos tres modelos de colaboración internacional exitosos en la formación de nuevos investigadores bajo distintas aproximaciones institucionales. Research is a main element for human and social development. Under this point of view, it involves particular challenges and opportunities for the so-called "developing countries". An approach for those challenges and opportunities comes from the analysis of two interrelated activities; the training of new researchers and the research development with institutions or researchers which are external to the institution ("collaborative research"). Both activities are essential for the consolidation, widening and updating of the institutional capabilities for scientific production. We present here the experiences of the Instituto de Medicina Tropical "Alexander von Humboldt" of the Universidad Peruana Cayetano Heredia, in relation to the training of new researchers, we discuss the four elements we consider key for this process; the promotion of stimulating environments for research, the proactive identification of fellows, the complementary advice and networks consolidation; and we analyze three successful models of international collaboration for the training of new researchers under different institutional approaches.
Changes in proviral load (PVL) among patients with rapidly progressive HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) receiving empirical therapy
Gotuzzo Eduardo,Alvarez Carolina,González Elsa,Tipismana Martin A
Retrovirology , 2011, DOI: 10.1186/1742-4690-8-s1-a58
Abstract:
Treatment of methicillin-resistant Staphylococcus aureus in Latin America
Luna, Carlos M;Rodríguez-Noriega, Eduardo;Bavestrello, Luis;Gotuzzo, Eduardo;
Brazilian Journal of Infectious Diseases , 2010, DOI: 10.1590/S1413-86702010000800007
Abstract: the global spread of methicillin-resistant staphylococcus aureus (mrsa) means it is now a pathogen of worldwide public health concern. within latin america, mrsa is highly prevalent, with the proportion of s. aureus isolates that are methicillin-resistant on the rise, yet resources for managing the infection are limited. while several guidelines exist for the treatment of mrsa infections, many are written for the north american or european setting and need adaptation for use in latin america. in this article, we aim to emphasize the importance of appropriate treatment of mrsa in the healthcare and community settings of latin america. we present a summary of the available guidelines and antibiotics, and discuss particular considerations for clinicians treating mrsa in latin america
Asymptomatic Renal Colonization of Humans in the Peruvian Amazon by Leptospira
Christian A. Ganoza,Michael A. Matthias,Mayuko Saito,Manuel Cespedes,Eduardo Gotuzzo,Joseph M. Vinetz
PLOS Neglected Tropical Diseases , 2010, DOI: 10.1371/journal.pntd.0000612
Abstract: Background Renal carriage and shedding of leptospires is characteristic of carrier or maintenance animal hosts. Sporadic reports indicate that after infection, humans may excrete leptospires for extended periods. We hypothesized that, like mammalian reservoir hosts, humans develop asymptomatic leptospiruria in settings of high disease transmission such as the Peruvian Amazon. Methodology/Principal Findings Using a cross-sectional study design, we used a combination of epidemiological data, serology and molecular detection of the leptospiral 16S rRNA gene to identify asymptomatic urinary shedders of Leptospira. Approximately one-third of the 314 asymptomatic participants had circulating anti-leptospiral antibodies. Among enrolled participants, 189/314 (59%) had evidence of recent infection (microscopic agglutination test (MAT0 ≥1:800 or ELISA IgM-positive or both). The proportion of MAT-positive and high MAT-titer (≥1:800) persons was higher in men than women (p = 0.006). Among these people, 13/314 (4.1%) had Leptospira DNA-positive urine samples. Of these, the 16S rRNA gene from 10 samples was able to be sequenced. The urine-derived species clustered within both pathogenic (n = 6) and intermediate clades of Leptospira (n = 4). All of the thirteen participants with leptospiral DNA in urine were women. The median age of the DNA-positive group was older compared to the negative group (p≤0.05). A group of asymptomatic participants (“long-term asymptomatic individuals,” 102/341 (32.5%) of enrolled individuals) without serological evidence of recent infection was identified; within this group, 6/102 (5.9%) excreted pathogenic and intermediate-pathogenic Leptospira (75–229 bacteria/mL of urine). Conclusions/Significance Asymptomatic renal colonization of leptospires in a region of high disease transmission is common, including among people without serological or clinical evidence of recent infection. Both pathogenic and intermediate Leptospira can persist as renal colonization in humans. The pathogenic significance of this finding remains to be explored but is of fundamental biological significance.
Research training needs in Peruvian national TB/HIV programs
Patricia J Garcia, Armando Cotrina, Eduardo Gotuzzo, Elsa Gonzalez, Anne L Buffardi
BMC Medical Education , 2010, DOI: 10.1186/1472-6920-10-63
Abstract: Six institutional workshops were conducted with the participation of 161 mid-level health professionals from agencies involved in national HIV and TB control. At each workshop informants completed a structured questionnaire and participated in small and large group discussions. Additional data and institutional commitment was obtained through in-depth interviews from 32 senior managers and researchers from the Ministry of Health, academia and NGOs.Participants exhibited an overwhelming receptivity for additional research training, observing a gap between current levels of research training and their perceived importance. Specialized skills in obtaining funding, developing research protocols, particularly in operational, behavioral and prevention research were considered in greatest need. Beyond research training, participants identified broader social, economic and political factors as influential in infectious disease control.The needs assessment suggests that future training should focus on operational research techniques, rather than on clinical skill building or program implementation only. Strengthening health systems not only requires additional research training, but also adequate financial resources to implement research findings.Within the last decade, there has been growing international recognition of the central importance of strong health systems in enhancing health and reducing poverty, coupled with increases in funding to achieve these goals. The Global Forum for Health Research has highlighted the crucial role of research in such efforts to strengthen health systems, both the application of existing research, as well as the need for new research better targeted towards preventable health problems that disproportionately affect billions of people living in low and middle income countries. This dual strategy aims to reduce what the WHO terms the 'know-do gap' so that research findings can be translated into health policy and practice. It also requires
Access to health care in relation to socioeconomic status in the Amazonian area of Peru
Charlotte Kristiansson, Eduardo Gotuzzo, Hugo Rodriguez, Alessandro Bartoloni, Marianne Strohmeyer, G?ran Tomson, Per Hartvig
International Journal for Equity in Health , 2009, DOI: 10.1186/1475-9276-8-11
Abstract: Cross-sectional study design included household interviews. Caregivers of 780 children aged 6–72 months in Yurimaguas and 793 children of the same age in Moyobamba were included in the study. Caregivers were interviewed on health care seeking strategies (public/private sectors; formal/informal providers), and medication for their children in relation to reported symptoms and socio-economic status. Self-reported symptoms were classified into illnesses based on the IMCI algorithm (Integrated Management of Childhood Ilness). Wealth was used as a proxy indicator for the economic status. Wealth values were generated by Principal Component Analysis using household assets and characteristics.Significantly more caregivers from the least poor stratum consulted health professionals for cough/cold (p < 0.05: OR = 4.30) than the poorest stratum. The poorest stratum used fewer antibiotics for cough/cold and for cough/cold + diarrhoea (16%, 38%, respectively) than the least poor stratum (31%, 52%, respectively). For pneumonia and/or dysentery, the poorest used significantly fewer antibiotics (16%) than the least poor (80%).The poorest seek less care from health professionals for non-severe illnesses as well as for severe illnesses; and treatment with antibiotics is lacking for illnesses where it would be indicated. Caregivers frequently paid for health services as well as antibiotics, even though all children in the study qualified for free health care and medicines. The implementation of the Seguro Integral de Salud health insurance must be improved.Following health reforms in the 1980s and 1990s, many Latin-American countries moved from universal coverage (free health care financed by public funds) towards cost recovery initiatives utilizing, for example, user fees and social insurances [1-3]. However, user fees have been shown to represent an important barrier to accessing health services, especially for poor people[4]. Strategies including fee exemption – aimed at mitigating
Classic Kaposi?s sarcoma presenting in the oral cavity of two HIV-negative Quechua patients
Mohanna,Salim; Bravo,Francisco; Ferrufino,Juan Carlos; Sanchez,Juvenal; Gotuzzo,Eduardo;
Medicina Oral, Patología Oral y Cirugía Bucal (Internet) , 2007,
Abstract: traditionally, classic ks lesions have a general distribution, often involving the skin of the feet and legs, and to a lesser extent, that of the hands, arms, and trunk. oral involvement is a rare manifestation. initial oral involvement is an even rarer occurrence. we report two unusual cases of classic ks presenting in the oral cavity of two patients from indigenous origin; the first patient with primary oral ks lesion on the hard palate, with no other signs of the condition in any other region of the body; the second patient with generalized dermal ks lesions with lymph node and lower lip involvement. in conclusion, clinicians and pathologists should be aware of the typical clinical, gross, and histologic features of ks. moreover, we would like to emphasize that oral ks may affect patients without aids or exposure to immunosuppression. the awareness of oral classic ks as a diagnostic possibility is important in the work-up of vascular lesions in the oral cavity of non-immunosuppressed individuals.
Un caso de obstrucción de dren de Kehr porFasciola hepatica en una paciente postcolecistectomizada por colangitis aguda: Reporte de caso y revisión de la literatura
MACO,VICENTE; MARCOS,LUIS; MONTENEGRO,JUAN; BELLIDO,JOSé; TERASHIMA,ANGéLICA; GOTUZZO,EDUARDO;
Parasitología latinoamericana , 2003, DOI: 10.4067/S0717-77122003000300012
Abstract: this is a report of a case of acute cholangitis and cholecystitis secondary to fasciolosis in a 22 year old woman from huaral (lima, peru) who had previously consumed emolientes (emolientes are beverages made by steeping leaves of certain plants -watercress, alfalfa- or herbs in hot water). she had been ill for five days prior to admission with abdominal pain, vomiting, icterus, and anorexia. during the operation, foreign bodies were found and during the subsequent days of her hospitalization, adult forms of the trematode fasciola hepatica were found to be obstructing the kehr drain that had been placed intraoperatively. ercp showed the parasites in the biliary tract. this is the second reported case of extraction of this parasite through this means. the epidemiology, radiologic findings, and diagnostic tests for infection by this parasite are discussed, with particular respect to peru, one of the countries with the highest prevalence of infection by this parasite in the world
Parasitosis intestinal en poblaciones urbana y rural en Sandia, Departamento de Puno, Perú
MARCOS,LUIS; MACO,VICENTE; TERASHIMA,ANGELICA; SAMALVIDES,FRINE; MIRANDA,ELBA; GOTUZZO,EDUARDO;
Parasitología latinoamericana , 2003, DOI: 10.4067/S0717-77122003000100006
Abstract: the objective of the present,study, is to determine the rate of intestinal parasitoses in rural and urban populations of sandia district, located at 2178 msnm., department of puno, perú. fecal samples, 35 from rural (group a) and 37 from urban (group b) populations were collected (total 72). four parasitological tests were used: direct microscopy, kato technique, spontaneous tube sedimentation technique and modified cup baermann technique. global prevalences of intestinal parasitoses in both groups were high (a: 88.58%; b: 67.57%). prevalence of intestinal parasitoses was: ascaris lumbricoides (a: 51.42%; b: 29.72%, p = 0.06), entamoeba coli (a: 48.57%; b: 18.91%, p = 0.007), trichuris trichiura (a: 42.85%; b: 13.51%, p = 0.005), blastocystis hominis (a: 40%; b: 32.42%, p = 0.5), endolimax nana (a: 37.14%; b: 16.66%, p = 0.04), giardia lamblia (a: 25.71%; b: 13.51%, p = 0.19), hymenolepis nana (a: 0%; b: 5.4%), iodamoeba butschli (a: 2.85%; b: 0%), entamoeba histolytica / e dispar (a: 2.85%; b: 0%), strngyloides stercoralis (a: 2.85%; b: 0%) and ancylostoma duodenale / necator americanus (a: 0%; b: 2.7%). we conclude that intestinal parasitism is more frequent in rural than urban populations, is associated to poverty, poorer environmental sanitation and lack of hygienic services. due to the high rates of parasitic infection we found, it is important to perform adequate parasitological tests to allow optimal diagnosis and opportune and effective treatment
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