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The Association Between High Blood Pressure and Cognitive Impairment in Elderly: A Brief Report
Mahmudi MJ,Hedayat M,Sharifi F,Edalat B
Tehran University Medical Journal , 2012,
Abstract: Background: Epidemiological studies have reported positive, negative, U-shaped or J-shaped association between high blood pressure and cognitive function as well as dementia whereas other studies have not reported any significant association. The aim of this study was to examine the association between hypertension and cognitive impairment in the elderly residents of Kahrizak Charity Foundation (KCF). Methods: This cross sectional study was done in Kahrizak Charity Foundation in suburban areas of Tehran, Iran during 2008. The data were collected over one week. Among the 850 elderly residents of the Foundation who were ≥ 65 years old, 185 individuals were chosen randomly. The Mini-Mental State Examination (MMSE) was completed for all. Mean of all blood pressure readings were recorded while anthropometric and biochemical measurements were performed. Results: The findings indicated that in participants with cognitive impairment, systolic blood pressure, diastolic and mean blood pressures were higher than people with normal cognitive function but the differences were not significant statistically. The odds ratio of cognitive impairment in patients with and without hypertension was 1.52 and 1.58, respectively (P>0.05). Conclusion: This study did not show any significant association between hypertension and cognitive impairment in the elderly residents of Kahrizak Charity Foundation.
Cultural management and government role
Edalat Nemati
Management Science Letters , 2012,
Abstract: Culture plays an important role on human lives and it has been in four ancient civilizations of China, Iran, Egypt and Greece. The civilization achievements are normally categorized in two different groups of material and immaterial. Practical experience of the material, social objective is called as a civilization and the mental aspect of spiritual experiences, spiritual and personal is called culture. The purpose of this research is to find a framework for cross-cultural management. First, we define the cultural planning and we review the existing cultural examples in Iranian society and try to provide an overall analysis. The paper also investigates the role of government on creating adaptive culture within the society and explains that government must act as leadership in creating value added culture.
An Extension of Gleason's Theorem for Quantum Computation
A. Edalat
Physics , 2003, DOI: 10.1023/B:IJTP.0000048823.93080.7e
Abstract: We develop a synthesis of Turing's paradigm of computation and von Neumann's quantum logic to serve as a model for quantum computation with recursion, such that potentially non-terminating computation can take place, as in a quantum Turing machine. This model is based on the extension of von Neumann's quantum logic to partial states, defined here as sub-probability measures on the Hilbert space, equipped with the natural pointwise partial ordering. The sub-probability measures allow a certain probability for the non-termination of the computation. We then derive an extension of Gleason's theorem and show that, for Hilbert spaces of dimension greater than two, the partial order of sub-probability measures is order isomorphic with the collection of partial density operators, i.e., trace class positive operators with trace between zero and one, equipped with the usual partial ordering induced from positive operators. We show that the expected value of a bounded observable with respect to a partial state can be defined as a closed bounded interval, which extends the classical definition of expected value.
A numerical investigation into the effects of parabolic curvature on the buckling strength and behaviour of stiffened plates under in-plane compression
Khedmati, Mohammad Reza;Edalat, Pedram;
Latin American Journal of Solids and Structures , 2010, DOI: 10.1590/S1679-78252010000300002
Abstract: the main targets of this research are mainly divided in to two parts: (1) identifying the effects of parabolic curvature on the buckling strength and behaviour of stiffened plates under in-plane compression, (2) generating practical graphs for extracting eigenvalue buckling stress of parabolic curved stiffened plate to dimensionless parameters. a parametric model for study of the problem is created. the model includes different parameters related to plate, stiffeners and also parabolic curvature. three distinct sensitivity cases are assumed. in each sensitivity case, many different models are analysed and their buckling strengths are obtained using a finite element commercial program (ansys). buckling strength and behaviour of all models with different ratios of parabolic curvature are compared to each other.
Protocol of Determining the Effect of Selenium Supplementation on CD4 + T Lymphocyte Count in HIV/AIDS Patients: A Randomized Double Blind Placebo Controlled Trial  [PDF]
Azar Hadadi, Afshin Ostovar, Behnaz Edalat Noor, Mehrnaz Rasoolinejad, Sahar Yousefi, Mahboobeh Haji Abdolbaghi, Hossien Khalili
Advances in Infectious Diseases (AID) , 2011, DOI: 10.4236/aid.2011.12003
Abstract: Background: Acquired immune deficiency syndrome (AIDS) is believed to be both among major epidemics and a critical global health issue. The administration of antiretroviral therapy is recently proposed for all patients with CD4 + T cell count of ≤ 350/μlit in different studies The accessibility of combination therapy has been restricted due to high costs of drugs, particularly in low and middle income countries. In Iran, according to WHO, drugs were distributed among only 6% of adults and 4% - 14% of children in 2009. Moreover, new strains are created and therefore, resistance to the current medication along with a considerable risk of ART-related toxic adverse effects points out the need for more affordable, effective and safer treatments. The use of antioxidants such as Selenium (Se) has been indicated to be beneficial in these patients. Method: In a double-blind randomized placebo control trial, 100 HIV positive, HAART-receiving patients will be selected from more than 2000 individuals covered under IRCHA (Iranian Referral HIV/AIDS Research Centre). They are then randomized to receive daily Se supplement of 200 μgr elemental Se and placebo for 6 months. The baseline assessment of the patients who meet the inclusion and exclusion criteria includes doing some lab tests to determine the absolute count of CD4 + T lymphocyte and the plasma levels of Se. The incidence of opportunistic infection will be assessed during the monthly visits in the first six months of the follow-up and the one performed at the end of the 9th month. For evaluating the trend of CD4 + T cells changes, the absolute count of CD4 + T lymphocyte will be measured every 3 months in the 5th, 8th, and 9th, visits. The plasma levels of Se will be measured in the final follow-up session and compared with the baseline value.
PROPOXUR SELECTION OF THE ADULTS OF ANOPHELES STEPHENSI FROM MINAB, SOUTH OF IRAN
H. Edalat,M.R. Yaghoobi Ershadi
Iranian Journal of Public Health , 1997,
Abstract: Anopheles stephensi is the main malaria vector in south of Iran. It has been known to be resistant to DDT, malathion and dieldrin. After appearance of resistance the area was treated with propoxur, at the rate of 2 g/m2 twice a year for 14 successive years. This species is still susceptible to propoxur. In order to forecast the possibility of development of propoxur resistance in An.stephensi, the females of this species were put under the pressure of propoxur for 14 generations in 1988. Fourteen generations of propoxur selection on the adult females of An.stephensi resulted in an increase in LT60 from 8.5 min to 24.30 minutes, i.e. 2.86 fold increase in tolerance.
Preparation and biological evaluation of 177Lu-labeled rituximab for B-lymphoma treatment
Edalat Radfar,Azim Arbabi,Dariush Sardari
Iranian Journal of Nuclear Medicine , 2010,
Abstract: Introduction: 177Lu is a beta emitter with suitable decay mode [T1/2=6.7 d, Eβmax=497 keV, EΥ=112keV (6.4%) & 208 keV (11%)] for using in radio therapy. Various radiolabeled monoclonal antibodies have been developed in treatment. Rituximab is a chimeric mouse-human monoclonal antibody. Rituximab binds with human B-lymphocate-restricted differentiation antigen: CD20. Rituxsimab was used successfully as an anti-CD20 radiolabeled antibody before. Methods: 177Lu was produced by thermal neutron irradiation of 1 mg of natural Lu2O3 with 4*10^13 n cm-2 s-1 neutron flux at Tehran Research Reactor. The irradiation target was dissolved in 200 μL of 1.0 M HCl, to prepare 177LuCl3. The radionuclide purity of product was measured by using ITLC and gamma spectroscopy by HPGe detector. The macrocyclic bifunctional chelating agent, N-succinimidyl-1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA-NHS) was prepared at 25 C using DOTA, N-hydroxy succinimide (NHS) in CH2Cl2. DOTA-Rituximab was obtained by the adding 0.5 mL of a rituximab pharmaceutical solution (10 mg/mL, in phosphate buffer, pH 7.8) to a glass tube pre-coated with DOTA-NHS (0.01-0.1 mg) at 25C with continuous mild stirring for 15 h. The stability of radiolabeled was studied in human serum. The biodistributions of 177Lu-DOTA-Rituximab and 177LuCl3 were determined for normal rats. The tissue uptakes of each injection were measured. Results: Radiolabeling was performed at 37C in 24 h. Radio-thin layer chromatography showed an overall radiochemical purity of >98% at optimized conditions. The percents of Injected Dose per gram of tissue were compared in different selected times (2-168 h). The peak of uptakes for 177LuCl3 was observed in bone, liver and kidney. High uptakes of 177Lu-DOTA-Rituximab were in spleen, liver and lungs. Conclusion: The radiolabeled complex was stable in human serum at 37C for 24 h. The biodistribution of the radiolabeled antibody is in agreement with other radiolabeled antiCD20 species already reported. 177Lu-DOTA-Rituximab is potential radioimmunotherapeutic agent for B-lymphoma treatment.
Multi-games and a double game extension of the Prisoner's Dilemma
Abbas Edalat,Ali Ghoroghi,Georgios Sakellariou
Computer Science , 2012,
Abstract: We propose a new class of games, called Multi-Games (MG), in which a given number of players play a fixed number of basic games simultaneously. In each round of the MG, each player will have a specific set of weights, one for each basic game, which add up to one and represent the fraction of the player's investment in each basic game. The total payoff for each player is then the convex combination, with the corresponding weights, of the payoffs it obtains in the basic games. The basic games in a MG can be regarded as different environments for the players. When the players' weights for the different games in MG are private information or types with given conditional probability distributions, we obtain a particular class of Bayesian games. We show that for the class of so-called completely pure regular Double Game (DG) with finite sets of types, the Nash equilibria (NE) of the basic games can be used to compute a Bayesian Nash equilibrium of the DG in linear time with respect to the number of types of the players. We study a DG for the Prisoner's Dilemma (PD) by extending the PD with a second so-called Social Game (SG), generalising the notion of altruistic extension of a game in which players have different altruistic levels (or social coefficients). We study two different examples of Bayesian games in this context in which the social coefficients have a finite set of values and each player only knows the probability distribution of the opponent's social coefficient. In the first case we have a completely pure regular DG for which we deduce a Bayesian NE. Finally, we use the second example to compare various strategies in a round-robin tournament of the DG for PD, in which the players can change their social coefficients incrementally from one round to the next.
Optimization of 90Y-antiCD20 preparation for radioimmunotherapy
Ariandokht Vakili,Amirreza Jalilian,Edalat Radfar,Ali Bahrami-Samani
Iranian Journal of Nuclear Medicine , 2010,
Abstract: Introduction: The importance of existence and application of radiolabeled anti-CD20 monoclonal antibodies at nonmyeloablative doses in treating B-cell NHL is well recognized throughout the world. In this work, Rituximab was successively labeled with yttrium-90. Methods: The antibody was labeled with 90Y-yttrium chloride (185 MBq) after conjugation with freshly prepared ccDTPA. Y-90 chloride was obtained by thermal neutron flux (4 × 1013 n.cm-2.s-1) of a natural Y2O3 sample, dissolved in acidic media. Radiolabeling was completed in 24 hours by the addition of DTPA-rituximab conjugate at room temperature. Results: Radiochemical purity of 96% (using ITLC) was obtained for final radioimmunoconjugate (Specific activity = 440-480 MBq/mg). The final isotonic 90Y-rituximab complex was checked by gel electrophoresis for protein integrity retention. Biodistribution studies in normal rats were carried out performed to determine the radioimmunoconjugate distribution up to 72 h. Conclusion: Due to the importance of developing anti lymphoma B agents in nuclear medicine for country use, the optimization of 90Y-antiCD20 radioimmunoconjugate production and quality control methods for future clinical studies in the country was targeted in this work.
Effects of Nitrogen and Plant Density on Rapeseed (Brassica napus L.) Yield and Yield Components in Southern Iran
S.A. Kazemeini,M. Edalat,A. Shekoofa,R. Hamidi
Journal of Applied Sciences , 2010,
Abstract: This study was carried out to evaluate the influence of nitrogen levels (0, 50, 100 and 150 kg N ha-1) and plant densities (70, 80 and 90 plants m-2) on some growth parameters and yield components of the rapeseed. The experimental design was split plot with three replications during 2006-2007 and 2007-2008. Results revealed that with increasing plant density from 70 to 80 and 90 plants m-2, 1000 seed weight (partial R2 = 0.91), number of branches (partial R2 = 0.83) and seed weight (partial R2 = 0.94) were the most important variables contributing seed yield, respectively. As, with increasing nitrogen, variables contributing seed yield, were changed. Stepwise regression analysis showed that with increasing nitrogen from 0 to 50 and from 100 to 150 kg ha-1, seed weight per main pod, pod number per branch and seed number per sub pod explained 91, 89 and 87% variations of seed yield, respectively. It means that, with increasing of nitrogen from 0 to 50 kg N ha-1, the role of seed weight per main pod decreased (partial R2 = 0.91 vs. 0.75). Pearson correlation results revealed that seed yield has positive correlation with seed weight per main pod (r = 0.89*), number of pod per branch (r = 0.93**), number of seed per main pod (r = 0.86*). According to the results, application of 150 kg N ha-1 and 90 plants m-2 for the maximum return unit area were recommended. Finally, it can be concluded that under high density and nitrogen, seed weight per sub pod was the most important variable contributing seed yield.
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