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Search Results: 1 - 10 of 131352 matches for " Edaise Maria da Silva "
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Molecular Analyses of Early-Onset Gastric Cancer in Brazilian Patients: TP53 Mutations, Cadherin-Catenin and Mucins Proteins Expression  [PDF]
Edaise Maria da Silva, José Humberto Tavares Guerreiro Fregnani, Ghyslaine Martel, Wilson Luiz Costa Jr., Felipe José Fernández Coimbra, Maria Isabel Waddington Achatz, Pierre Hainaut, Fernando Augusto Soares
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41A005

Early gastric carcinomas may develop with a molecular profile differing from sporadic carcinomas occurring at a later age. In this study, we analyzed a retrospective series of 88 patients with gastric adenocarcinoma diagnosed before the age of 45 years for the presence of TP53 mutations, clinicopathological features and immunohistochemistry to evaluate the expression of markers considered to be important in gastric carcinogenesis (E-cadherin, β-catenin, MUC1, MUC2, MUC5AC, MUC6 and p53). The majority of proportion of tumors were diffuse-type (70%) and advanced stage (56%). Familial history of cancer was positive in 21% of the cases. There was a significant association between altered expression of E-cadherin and β-catenin, and between p53 expression and perineural invasion. TP53 mutations were detected in 14.5% of evaluated cases, including a germline mutation (p.R337H) in a 12-year old patient. Overall survival analysis showed significant differences in relation with tumor stage and histopathology. The evaluated biomarkers did not present prognostic value in non-exploratory multivariate analyses. The low frequency of TP53 mutations in this series suggests these alterations are not a major molecular event in gastric cancer occurring at early age, although the identification of a case with germline p.R337H mutation is consistent with the hypothesis that a small proportion of early, apparently sporadic gastric cancer, may be associated with widespread Brazilian founder mutations. Further studies are needed to evaluate the prognostic significance of markers for specific groups of patients according to tumor histology and familial history.

O arranjo em matriz de amostras teciduais (tissue microarray): larga escala e baixo custo ao alcance do patologista
Andrade, Victor Piana de;Cunha, Isabela Werneck da;Silva, Edaise Maria da;Ayala, Fernanda;Sato, Yukie;Ferreira, Severino da Silva;Nascimento, Carlos Ferreira;Soares, Fernando Augusto;
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2007, DOI: 10.1590/S1676-24442007000100011
Abstract: tissue microarrays (tma) is a worldwide well accepted technique described in 1998 by kononen et al. it uses an extremely simple concept of ordering hundreds of samples in just one paraffin block to evaluate protein expression in large cohorts with great advantages on costs, time and sample saving. we discuss the technique, its advantages and limitations, strategies to construct the receptor block, its usefulness and difficulties experienced in the last five years at hospital do cancer a.c. camargo.
TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report
Edaise M da Silva, Maria W Achatz, Ghyslaine Martel-Planche, André L Montagnini, Magali Olivier, Patricia A Prolla, Pierre Hainaut, Fernando A Soares
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-449
Abstract: The patient, diagnosed with metastatic disease, died seven months after surgery. DNA from intra-surgical specimens revealed a TP53 mutation at codon 337 (p.R337H) in samples with neoplastic cells (dysplasia, tumor and metastasis) but not in non-transformed cells (incomplete intestinal metaplasia and non-involved celiac lymph node). In all mutation-positive tissues, p.R337H occurred on the same background, a founder allele identified by a specific haplotype previously described in Brazilian Li-Fraumeni syndrome patients. The same mutant haplotype, corresponding to a founder mutation present in 0.3% of the general population in Southern Brazil, was found in the genome of the father. Presence of this inherited haplotype in the tumor as well as in the father's germline, suggests a rare case of microchimerism in this patient, who may have harbored a small number of mutant cells originating in another individual, perhaps a dizygotic twin that died early in gestation.This case represents one of the earliest ages at diagnosis of gastric cancer ever reported. It shows that cancer inheritance can occur in the absence of an obvious germline mutation, calling for caution in assessing early cancers in populations with common founder mutations such as p.R337H in Southern Brazil.Gastric cancer is the 4th most common cancer in both genders in Brazil, as observed in population-based cancer registries across the country, with incidence rates varying from 22.4 to 53.6 per 100.000 individuals in the States of Goiania and S?o Paulo, respectively [1]. Despite recent reduction in incidence and mortality observed in the country, occurrence of gastric cancer remains amongst the highest worldwide, in contrast with the sharp decline observed in many countries over recent years [2,3]. The reasons for high incidence are still unclear and are likely to involve multiple etiological factors.In recent studies on cancer occurrence in Li-Fraumeni syndrome subjects who are carriers of germline TP53 mu
As mulheres, os outros e as mulheres dos outros: feminismo, academia e Isl?o
Silva, Maria Cardeira da;
Cadernos Pagu , 2008, DOI: 10.1590/S0104-83332008000100011
Abstract: nowadays, the veil of the muslim women - either real or metaphoric - make part of clearly and sounding political rhetorics at different levels. it is my intention to remind that gendered relationships between anthropology, islam and international and national politics have largely supplied the production of this speech-making, concurring, thus, for its political thickness. this is why these relations must always stay under scrutiny regardless of the scale of our ethnographies, reminding us that the first step to 'unveil' muslim women is to allow political immunity to anthropological inquiry.
Dimens?o psicossocial da atividade física na velhice
Santana, Maria da Silva;
Fractal : Revista de Psicologia , 2011, DOI: 10.1590/S1984-02922011000200008
Abstract: aim to identify the social representations of physical activity in the context of programs for the elderly in natal (rn), brazil. a study cross-sectional quantitative and qualitative. a non-probability sample and for convenience was formed by seventy individuals. in data collection we used a questionnaire with demographic data, free association of words and open question. the core of the representation was composed of happiness / health / dance and gymnastics, revealing different understandings and also showing that accumulated knowledge of physical activity plays a central role in the lives of older people, gradually acquiring the representation of "life with better health and quality in old age". the composition of the core when considering mental elaborations, emotions, practices and explanations arising from daily life that are introduced into the constitution of social representation in focus, can influence the choices and strategies to promote improvement in health standards and quality of life of elderly.
A deficiência como express?o da diferen?a
Silva, Luciene Maria da;
Educa??o em Revista , 2006, DOI: 10.1590/S0102-46982006000200006
Abstract: this work emphasizes the debate about differences which gives support to the inclusive proposal in the contemporaneity. we have taken as fundamental references the studies who do not consider the disability a stetic, natural, or definitive condition, since it is inserted in the relationships and interactions which determine its comprehension in the society. it is, therefore, a difference which emerges in the production process of people's existence at defined historical moments and places, as the ethnic differences, the linguistic codes , or the religious beliefs are in the same sense. in short, the diferenciation and the individuation which give substance to the human emancipation are still promises, for the individual who is different is someone socially denied, frequently pursued to be molded, included, and adapted.
Hospedaria Vasque: Cultura, ra?a, género e expediente num oásis da Mauritania
Silva,Maria Cardeira da;
Etnográfica , 2006,
Abstract: ouadane, a small oasis in the mauritanian adrar, has recently entered the touristic patrimonialization routes, partly due to a residual portugueseproject of cultural cooperation. through an ethnography centered in the new landscape, but essentially in zeida (a young and successful hostel manager), will lead us into seeing how the impulse of wonder, the desire of knowledge, and the thrust for salvation/protection - attracting tourists, development agents and anthropologists - are transformed into resources and locally incorporated through class, race and gender stratifications. this incorporation arouses new social configurations that, through their apparent unexpectedness, recycle ouadane?s attractive force. in parallel, zeida?s case shows us how islam can offer alternative legitimations for individual behaviors, within rigid and paralyzing social codifications, unready for quick social change.
Social movements in islamic contexts: anthropological approaches
Silva,Maria Cardeira da;
Etnográfica , 2006,
Abstract: i will present, very briefly, some of the main approaches within social sciences, and particularly anthropology, which have contributed to elucidate social movements in islamic contexts. this is specifically intended to provide a general overview, in order to more easily situate the following presentations. this also aims to better integrate those readers less familiarized with the anthropological jargon and current debates on these subjects. i will give particular importance to ethnographic research and its relevant role in preventing or refraining essentialist conclusions and considerations on matters of such political relevance. i will also highlight the authors who have used their ethnographies in order to try to solve the current dilemma between political and analytical approaches, a dilemma that is a frequent source for misunderstandings on these topics.
O sentido dos árabes no nosso sentido: Dos estudos sobre árabes e sobre mu?ulmanos em Portugal
Silva,Maria Cardeira da;
Análise Social , 2005,
Abstract: without seeking to conduct an exhaustive analysis of the field of studies on arabs and muslims in portugal - which only now are being undertaken -, this article seeks to monitor the political uses which have moulded that field over time. traditionally associated with ethno-genetic concerns and archaeology, studies on arabs and islam today continue to inspire the persistent and widely disseminated myth of multicultural/luso-tropicalist tolerance (in an islamophile version of orientalism) - for example by way of that which is here described as the ?mértola effect? - atavistically celebrated in the ethno-genealogy of the portuguese.
O tétano como doen?a de base para disfagia
Silva, Danielle Maria da;
Revista CEFAC , 2010, DOI: 10.1590/S1516-18462010000300018
Abstract: background: swallowing disorders and tetanus. purpose: to review the pathophysiology of tetanus and how swallowing may be affected by this disease. conclusion: despite the low availability of literature that relates tetanus to dysphagia, the search demonstrated data showing that swallowing may be affected at all stages including the esophagus, due to muscle contraction resulting from the action of the tetanospasmin neurotoxin.
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