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OALib Journal期刊

ISSN: 2333-9721

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PHYTOCHEMICAL STUDY OF CELL CULTURE JATROPHA CURCAS
ELFAHMI,ARTRI,KOMAR RUSLAN
BIOTROPIA : the Southeast Asian Journal of Tropical Biology , 2011,
Abstract: Jatropha curcas belongs to the Euphorbiaceae family which has potential economically. This plant has been reported to contain toxic compounds such as curcin and phorbol ester and its derivatives. These compounds may become a problem if J. curcas will be explored as a source of biofuel. In order to provide safety plants, the research on the study of phytochemical and initiation of cell and organ culture have been carried out. J curcas which has been collected from different regions in Indonesia showed to contain relatively the same profile of chemical contents. Dominant compounds that were detected by GCMS are hidrocarbon such as 2-heptenal, decadienal, hexsadecane, pentadecane, cyclooctane etc, fatty acid such as oktadecanoate acid, etthyl linoleate, ethyl stearate, heksadecanoate acid and steroid such as stigmasterol, fucosterol, sitosterol. No phorbol ester and its derivatives have been detected yet by the GCMS method. Callus and suspension cultures of J. curcas have been established to be used for further investigation.
Antihypercholesterolemic Effect of Combination of Guazuma ulmifolia Lamk. Leaves and Curcuma xanthorrhiza Roxb. Rhizomes Extract in Wistar Rats
E.Y. Sukandar,Nurdewi,Elfahmi
International Journal of Pharmacology , 2012,
Abstract: Guazuma ulmifolia Lamk. (mutamba) and Curcuma xanthorrhiza Roxb. (java turmeric) has been used traditionally as slimming agent and for treating various diseases including hypercholesterolemia. In this study, the effect of aqueous extract of mutamba leaves in combination with ethanol extract of java turmeric has been determined on lipid blood level of Wistar rats compared to each extract alone in hyperlipidemic induced rats. Thirty male rats weighing 180-200 g were divided into six groups receiving mutamba extract, java turmeric extract, simvastatin as a reference of antihyperlipidemic drug, combination of mutamba and java turmeric at two different doses and one control group. The extract was given daily for 14 days at the same time as the administration of propylthiouracil and food high in cholesterol content to induce hyperlipidemia. The serum levels of total cholesterol, triglyceride, HDL and LDL were measured after 3, 7 and 14 days of treatment. The result were analyzed statistically using ANOVA. The results indicated that combination of aqueous extract of mutamba leaves at a dose of 25 mg kg-1 b.wt. and ethanol extract of Java turmeric rhizome at a dose of 12.5 mg kg-1 b.wt. decreased total cholesterol and LDL level significantly compared to control group (p = 0.004) after 7 days of treatments. Aqueous extract of mutamba leaves at a dose of 50 mg kg-1 b.wt. did not show any significant effect while ethanol extract of java turmeric rhizome at a dose of 25 mg kg-1 b.wt. decreased only LDL level significantly.
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