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Search Results: 1 - 10 of 1459 matches for " EDMUND; FARAH BARACAT "
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Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies
LINHARES,JOSé JUVENAL; GUERREIRO DA SILVA,ISMAEL DALE COTRIM; NOGUEIRA DE SOUZA,NAIARA C; COELHO NORONHA,EMMANUELLE; FERRARO,ODAIR; DE CARVALHO,CRISTINA VALLETA; CHADA BARACAT,EDMUND; FARAH BARACAT,FAUSTO;
Biological Research , 2005, DOI: 10.4067/S0716-97602005000200017
Abstract: due to the conflicting results regarding the association between breast cancer and the gstm1 null mutation, our aim was to research this association in a brazilian population and correlations with smoking, reproductive history and several clinical pathologies. a case-control study was performed on 105 women with breast cancer and 278 controls. extraction of dna was accomplished according to the protocol of the gfx? kit and polymorphism analysis by the pcr technique. the control and experimental groups were compared and statistical analysis assessed by x2 or fisher's exact test. the deletion in the gstm1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. in the control group, the null mutation was present in 104 (37.4%) women. upon comparison of the two groups, no statistically significant difference of the gstm1 gene was observed, with an odds ratio (or) of 0.74, 95%, confidence interval (ci) 0.45 - 1.20, p = 0.277. the results conclusively show that single gene gstm1 polymorphisms do not confer a substantial risk of breast cancer to its carriers. furthermore, in this study no correlation was found between gsts and smoking, reproductive history and several clinical pathologies with respect to cancer risk.
Associa??o entre a presen?a da proteína p53 e o grau de diferencia??o em carcinomas ductais invasivos de mama
Siroma, Márcia Sanae;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2006, DOI: 10.1590/S0100-72032006000500006
Abstract: purpose: to assess p53 protein expression in infiltrating ductal breast carcinoma and to analyze its association with histological and nuclear grade. methods: sixty-five consecutive females who were diagnosed with primary infiltrating ductal breast tumor from july 1999 to july 2001 were included in the present study. mean patient age at diagnosis was 69.2 years (range 41 - 90). all patients were first treated with surgical therapy, conservative surgery or mastectomy. none of the patients received any preoperative adjuvant therapy. resected breast tumor specimens were fixed in 10% formalin, paraffin embedded, and conserved for immunohistochemical analysis. p53 protein expression was evaluated. primary monoclonal anti-human p53 antibody do-7 (dako) was used. frequency distributions were tested by the c2 test. a level of p<0,05 was considered significant. results: p53 expression was detected in 24 (36,9%) of 65 carcinomas. of the cases with protein expression, 13 (54,2%) were high or histological grade iii, 8 (33,3%), were grade ii, 3 (12,5%) were grade i. on nuclear grade analysis, of the cases with protein expression, 13 (4,2%) were nuclear grade iii, 9 (37,5%) were grade ii and 2 (8,3%) were grade i. p53 expression was frequent in carcinomas with high histological and nuclear grades. conclusions: p53 expression was significantly associated with the histological grade. on the other hand, nuclear grade was not significantly related to p53 expression.
O cuidado psicológico ao médico em reprodu??o assistida: um enquadre diferenciado
Miranda, Keith Laura;Serafini, Paulo Cesar;Baracat, Edmund Chada;
Estudos de Psicologia (Campinas) , 2012, DOI: 10.1590/S0103-166X2012000100008
Abstract: health professionals have to deal with human suffering, even if they don't deal directly with interventions in the psychology area. this study was based on psychoanalysis, with the aim of understanding the aspects of human suffering which emerge with doctors in the exercise of their work with assisted human reproduction, considering the collective model concerning the difficult situations that they have to deal with in their clinics. twenty-two doctors working in hospitals and clinics in the state of s?o paulo, in both private and public facilities, volunteered to participate, ignoring sex, age and time since graduation. the drawing and storytelling thematic was used as the dialogical procedure. the interview was characterized as a special situation with the expression and communication of emotions generated in sessions related to the proposed theme. it was found that there was a need for the proposition of facilitating spaces for emotional expression, promoting the containment of human suffering and the occurrence of the transforming life reflection experiences of reality.
Novos conhecimentos sobre a flora bacteriana vaginal
Linhares, Iara Moreno;Giraldo, Paulo Cesar;Baracat, Edmund Chada;
Revista da Associa??o Médica Brasileira , 2010, DOI: 10.1590/S0104-42302010000300026
Abstract: the aim of this review is to update knowledge about the vaginal ecosystem, non-cultivation methods for bacterial identification (gene amplification), the lactobacillus species that comprise normal vaginal flora and influence of host genetics on bacterial interactions with local innate and acquired immune defenses. a medline (pubmed) search from 1997-2009 for relevant articles was performed and the most informative articles were selected. non-culture techniques (gene amplification) allow a comprehensive analysis of the vaginal ecosystem's composition. in the majority of women in the reproductive age there is a predominance of one or more species of lactobacillus: l. crispatus, l. inners and l gasseri. however, in other apparently healthy women there is a deficiency or complete absence of lactobacilli. instead, there is a substitution by other lactic acid-producing bacteria: atobium, megasphaera and/or leptotrichia species. the infectivity and/or proliferation of pathogenic bacteria in the vagina is suppressed by lactic acid production, by products of endogenous bacteria and by activation of local innate and acquired immunity. vaginal epithelial cells produce several compounds with anti-microbial activity. these cells have toll-like receptors on their membrane that recognize molecular patterns associated with pathogens. recognition leads to production of pro-inflammatory cytokines and stimulation of antigen-specific immunity. the production of igg and iga antibodies is also triggered in the endocervix and vagina in response to infection. vaginal flora composition and the immune mechanisms constitute important defenses. criteria of normal and abnormal flora have to be reviewed and genetic polymorphism can explain variations in flora composition. this new knowledge should be included in the clinical practice of gynecologists and obstetricians to improve patients care.
Resultados perinatais em grávidas com mais de 35 anos: estudo controlado
Andrade, Priscilla Chamelete;Linhares, José Juvenal;Martinelli, Silvio;Antonini, Marcelo;Lippi, Umberto Gazi;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000900004
Abstract: purpose: to evaluate perinatal results in pregnant women over 35 years old and to check differences between two groups: 35 to 39-year-old women and women older than 40. methods: a retrospective survey was made during the period between january/2000 and july/2003, through the analysis of obstetric charts of 3,093 pregnant women who delivered in the "hospital do servidor público estadual - francisco morato de oliveira", excluding 933 patients. the patients were divided into 3 groups: 18 to 29 years old (control group), 35 to 39 years old, and over 40 years old. data collection was done with standardized forms, and the data were transferred to an electronic spreadsheet (excel - microsoft office 2000). statistical analysis was performed using the c2 test and the fisher test. the alpha risk was less or equal to 5% and the confidence interval 95%. results: cesarean section was the most used method not only in the 35 to 39-year-old group (438/792; 55.3%) but also in the group of women over 40 (153/236; 64.8%). the rates of prematurity (39/236; 16.5%), low weight (37/236; 15.7%), and restriction of fetal growth (38/236; 16.1%) were significantly higher in the group of women over 40, when compared to the other groups. concerning fetal death, a five times higher incidence was observed in the group over 40 years old, as compared to the other groups, a statistically significant difference. conclusion: the only difference between the 35 to 39-year-old group and the control group was the cesarean section rate. this allows us to suggest a differentiated prenatal attendance for pregnant women over 40.
índice de risco de malignidade para tumores do ovário incorporando idade, ultra-sonografia e o CA-125
Fernandes, Luís Roberto Araujo;Lippi, Umberto Gazi;Baracat, Fausto Farah;
Revista Brasileira de Ginecologia e Obstetrícia , 2003, DOI: 10.1590/S0100-72032003000500007
Abstract: purpose: to estimate the sensitivity, specificity and accuracy of patient age, ultrasound result and ca-125 marker variables for the differential diagnosis between malignant and benign ovarian tumors. in addition, to establish a risk of malignancy index (rmi) incorporating these three variables and to estimate its sensitivity, specificity and accuracy for the differential diagnosis. methods: one hundred patients with ovarian tumors with surgical indication were included. the age, ultrasonographic findings and ca-125 level variables were evaluated separately and later on together as the rmi. the study was performed based on the evaluation of the sensitivity, specificity and diagnostic accuracy and the use of the measurements: likelihood ratio, odds ratio, and the student's t test, c2, and logistic regression with univariate and multivariate analysis. results: for the age variable, sensitivity, specificity and diagnostic accuracy were 58.8, 68.2 and 65.0%, respectively. for ultrasound, 88.2, 77.3 and 81.0%. for ca-125 dosage, the values were 64.7, 74.2 and 71.0%. when the three variables were put together, as the rmi, a sensitivity of 76.5%, a specificity of 87.9% and a diagnostic accuracy of 84.0% were observed. conclusions: rmi, made up of the association of patient age, ultrasound results and ca-125 dosage variables is a valuable indicator to distinguish between malignant and benign ovarian tumor, especially in regard to its specificity.
Endometrial biopsy with uretral plastic No. 12 sonde
Guerreiro, Ismael Dale Cotrim;Castanho, Paulo Roberto de Oliveira Lima;Baracat, Fausto Farah;
Sao Paulo Medical Journal , 1995, DOI: 10.1590/S1516-31801995000100006
Abstract: the authors demonstrate technique for obtaining endometrial fragments in 25 patients sent to gynecological cancer preventive service of the arnaldo vieira de carvalho cancer institute, during the period of september 1991 through january 1992, presenting abnormal uterine hemorrhage. technique consists in vacuum aspiration with the support of a no. 12 uretral sonde , provided with one lateral opening only. correlation with curettage was positive in 88% of the patients; biopsy with sonde did not result in confirmation in three patients only. no complications at all were observed (infection, hemorrhage or uterus perforation). authors understand that this method is in conformity with a correct diagnostic performance, being a low cost procedure, almost painless, easy to be done and furnishing sufficient material for the histopathologic diagnosis, in 88% of the cases studied.
índice de risco de malignidade para tumores do ovário incorporando idade, ultra-sonografia e o CA-125
Fernandes Luís Roberto Araujo,Lippi Umberto Gazi,Baracat Fausto Farah
Revista Brasileira de Ginecologia e Obstetrícia , 2003,
Abstract: OBJETIVOS: calcular a sensibilidade, a especificidade e a acurácia das variáveis: idade da paciente, aspecto ultra-sonográfico e dosagem do marcador CA-125 para o diagnóstico diferencial entre tumores malignos e benignos do ovário. Estabelecer, ainda, índice de risco de malignidade (IRM) com a incorpora o dessas três variáveis e calcular a sua sensibilidade, especificidade e acurácia para aquele diagnóstico diferencial. MéTODOS: foram incluídas prospectivamente 100 pacientes portadoras de tumor do ovário com indica o cirúrgica. As variáveis idade, resultado da ultra-sonografia e níveis do CA-125 foram avaliadas isoladamente e depois em conjunto, sob a forma de índice (IRM). O estudo compreendeu a avalia o da sensibilidade, da especificidade e da acurácia diagnóstica e a aplica o das medidas: raz o de probabilidade, raz o de chances e dos testes: t de Student, chi2 e regress o logística com análise uni e multivariada. RESULTADOS: para a variável idade, a sensibilidade, a especificidade e a acurácia diagnóstica foram respectivamente 58,8, 68,2 e 65,0%. Para a ultra-sonografia, 88,2, 77,3 e 81,0%. Para a dosagem do CA-125 esses valores foram 64,7, 74,2 e 71,0%. Quando as três variáveis foram agrupadas sob a forma do IRM observou-se sensibilidade de 76,5%, especificidade de 87,9% e acurácia diagnóstica de 84,0%. CONCLUS ES: o IRM constituído pela associa o das variáveis idade da paciente, resultado da ultra-sonografia e dosagem do CA-125 é indicador valioso para se distinguir entre tumores malignos e benignos de ovário, principalmente no que diz respeito à sua especificidade.
Fallopian tube origin of supposed ovarian high-grade serous carcinomas
Diniz, Patricia Martini;Carvalho, Jesus Paula;Baracat, Edmund Chada;Carvalho, Filomena M;
Clinics , 2011, DOI: 10.1590/S1807-59322011000100013
Abstract: introduction: serous carcinomas are the most frequent histologic type of ovarian and peritoneal cancers, and can also be detected in the endometrium and fallopian tubes. serous carcinomas are usually high-grade neoplasms when diagnosed, yet the identification of an associated precursor lesion remains challenging. pathological examination of specimens obtained from prophylactic bilateral salpingo-oophorectomies that were performed for patients harboring brca1/2 mutations suggests that high-grade serous carcinomas may arise in the fallopian tubes rather than in the ovaries. objective: to investigate the presence and extent of fallopian tube involvement in cases of serous pelvic carcinomas. methods: thirty-four cases of serous pelvic carcinoma with clinical presentations suggesting an ovarian origin were analyzed retrospectively. histologic samples of fallopian tube tissues were available for these cases and were analyzed. probable primary site, type of tubal involvement, tissues involved in the neoplasia and vascular involvement were evaluated. results: fallopian tube involvement was observed in 24/34 (70.6%) cases. in 4 (11.8%) of these cases, an intraepithelial neoplasia was present, and therefore these cases were hypothesized to be primary from fallopian tubes. for an additional 7/34 (20.6%) cases, a fallopian tube origin was considered a possible primary. conclusions: fallopian tubes can be the primary site for a subset of pelvic high-grade serous carcinomas.
Fatores biocomportamentais e as altera??es no número das células de Langerhans
Uchimura, Nelson Shozo;Ribalta, Julisa Chamorro Lascasas;Focchi, José;Baracat, Edmund Chada;Uchimura, Taqueco Teruya;
Revista Brasileira de Ginecologia e Obstetrícia , 2004, DOI: 10.1590/S0100-72032004000400004
Abstract: objective: to study the relationship of biobehavioral factors, such as age, menarche, number of gestations, and age of first sexual intercourse, with changes in langerhans'cells in women with negative hybrid capture for hpv. methods: thirty women referred due to abnormal cervical cytology or premalignant cervical lesions were studied and underwent colposcopy, guided biopsy and histopathological exams. the langerhans' cells were identified by immunohistochemical (s100+) exams. langerhans' cells visualized in brown color were counted using the software cytoviewer. the nonparametric wilcoxon rank-sum test was employed for statistical analysis. results: the number of langerhans' cells in women who had menarche after 13 years old presented statistically significant difference (173.34 cell/mm2) compared to the group whose menarche occurred before 13 (271.41 cell/mm2). the age at the first sexual intercourse was associated with the low number of langerhans' cells, 127.15 cell/mm2 and 250.14 cell/mm2, respectively, for the beginning of the sexual activity up to 17 years old and after 17 (p=0.03). previous cauterizations of the uterine cervix have been related to a lower number of langerhans' cells in the epithelium, with the average 120.30 cell/mm2 as compared to 236.06 cell/mm2 for those women who never underwent that procedure (p=0.05). other factors such as the patient's age and the number of gestations showed no statistically significant differences in the density of langerhans' cells. conclusions: the present study reports the association of biobehavioral factors with decrease in the number of langerhans' cell.
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