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Search Results: 1 - 10 of 167626 matches for " E. Winchester "
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Reshaping Cinderella's slipper: the shared epitope hypothesis
Robert Winchester
Arthritis Research & Therapy , 2006, DOI: 10.1186/ar1970
Abstract: This issue of Arthritis Research and Therapy contains a succinct and elegant paper by Michou and colleagues [1] that advances our understanding of the genetic basis of RA by reclassifying the contribution of RA susceptibility alleles according to their structure. This line of research is potentially important in our conceptualization of the mechanism of disease in RA, in predicting disease course and severity, and as a model for further studies on this topic.More than 10 different HLA-DRB alleles predispose to the development of rheumatoid arthritis (RA) and this number alone distinguishes RA from many other autoimmune diseases. Over two decades ago the existence of common structural features of the HLA-DR4 and DR1 molecules encoded by these multiple susceptibility alleles emerged from pioneering sequencing efforts and this structure was termed the shared epitope (SE) [2]. The SE hypothesis was a simple conceptual framework that sought to redirect thinking about disease susceptibility towards a unifying molecular susceptibility structure that would aide in the search for peptides driving the T cell immune response underlying RA, a sort of Cinderella's slipper. The original notion of SE was modified by the concepts of protective alleles [3] and 'homozygosity' or allelic interaction [4]. Additional support for the SE hypothesis came from other unrelated alleles in different populations that encode a SE motif that were identified as RA susceptibility alleles, for example, DRB1*1402 [5] and DRB1*1001 [6].Although a Google search reveals over 40,000 hits for 'shared epitope', reflecting the efforts by many to advance RA genetics, both knowledge of the inciting peptide, and how the nature and conformation of the peptide-binding groove predispose to RA eludes our grasp. Difficulties in identifying which alleles are implicated in RA susceptibility or protection and which regions of molecules encoded by these alleles are functionally important has resulted in several differe
La dimensión económica de la pobreza y precariedad urbana en las ciudades latinoamericanas: Implicaciones para las políticas del habitat
WINCHESTER,LUCY;
EURE (Santiago) , 2008, DOI: 10.4067/S0250-71612008000300002
Abstract: in latin american and caribbean cities, the urban poor are subject to diverse and heterogeneous living conditions that directly and indirectly reflect their economic vulnerability. this article seeks to deepen our understanding of the economic dimension of urban poverty and precarious living conditions in the lives of the urban poor, and to investigate their implications for public policy design. the work relies on the sustainable development framework and the policy discussions regarding capacity building and the creation of opportunities for the poor. our working hypothesis is that an awareness of the economic vulnerability of the urban poor has not been fully integrated into urban policies, limiting their contribution to improving the poor's access to stable incomes and employment.
Desafíos para el desarrollo sostenible de las ciudades en América Latina y El Caribe
Winchester,Lucy;
EURE (Santiago) , 2006, DOI: 10.4067/S0250-71612006000200002
Abstract: the sustainable development of the cities of latin america and the caribbean poses important challenges for the urban territorial policies at their local, subnational, national and regional levels. it requires the convergence in the urban space of the necessity of internalizing the environmental costs (via improvement of the management and governability of the associated systems), assuming and solving social inequities (via improvement of urban habitability and the investement of capitals), and the recognition and approach to economic restrictions related to efficiency (by improving the offer of financing). this work discusses these themes in their social, economic and environmental dimensions, applied to the sustainable development of the human settlements in the region, focused both on present limitations and opportunities in this field, as well as on the regional process in terms of political reforms, implementation of programs and the development of projects. it is suggested that there are certain conditions or factors that systematically fail in the development and implementation of policies aiming at this objective. one of these factors refers to the governability of the system, meaning by this, the characteristics of the relationships between actors (urban management and political will included), and the formal and informal rules of the system. the latter incorporates the institutional and normative frame that governs politics. the other factor refers to the scarcity of development of mechanisms of financing for the sustainable urban development.
The Great Resistance
Winchester, Stuart
Nordicum-Mediterraneum , 2008,
Abstract: Sublimation, in Castoriadis' scheme, is where our relation to what is known exists. This "frontier concept" in which 'reality' and ‘unreality’ flux is a two-way affair. On one hand the psyche replaces private objects of cathexis with "objects which exist and which have worth in and through their social institution". On the other it facilitates "the positing, in and through the institution [of society], of forms and significations."
Ingerid S Straume and J F Humphrey (eds.), Depoliticization: The Political Imaginary of Global Capitalism (Malm : NSU Press, 2011)
Stuart Winchester
Nordicum-Mediterraneum , 2012,
Abstract: Capitalism’s constancy, despite the global economic crisis, prompts this topical nine essay volume to examine the present status of politics and its relation to the economy. It follows the analytical line of theorists like Hannah Arendt, Jürgen Habermas and especially Cornelius Castoriadis, arguing that since the seventies, a separation of politics and economy has been nurtured by a neoliberal agenda.
Jonathan Schlefer, The Assumptions Economists Make (Cambridge, Mass., and London: Belknap Press of Harvard University Press, 2012)
Stuart Winchester
Nordicum-Mediterraneum , 2013,
Abstract: A review of the book by Jonathan Schlefer: The Assumptions Economists Make (Cambridge, Mass., and London: Belknap Press of Harvard University Press, 2012), €26,10 / £21.95 / US$28.95, 356pp HBK (English), ISBN: 9780674052260.
Desafíos para el desarrollo sostenible de las ciudades en América Latina y El Caribe
Lucy Winchester
EURE (Santiago) , 2006,
Abstract: El desarrollo sostenible de las ciudades de América Latina y el Caribe presenta grandes desafíos para la política territorial-urbana en sus niveles regionales, nacionales, subnacionales y locales. Requiere la convergencia en el espacio urbano de la necesidad de internalizar los costos ambientales (vía mejoras en la gestión y gobernabilidad de los sistemas asociados), asumir y resolver las inequidades sociales (vía mejoras en la habitabilidad urbana y la inversión en capitales) y de reconocer y abordar restricciones económicas relacionadas a la eficiencia (mejorar la oferta de financiamiento). Este trabajo discute estos temas en sus dimensiones sociales, económicas y ambientales, aplicado al desarrollo sostenible de los asentamientos humanos en la región, enfocando en las actuales limitaciones y oportunidades en este campo, como también en el progreso regional en términos de reformas de políticas, implementación de programas y el desarrollo de proyectos. Se sugiere que existen ciertas condiciones -o factores- que sistemáticamente fallan en el desarrollo e implementación de políticas que apuntan a esta meta. Uno de los factores se refiere a la gobernabilidad del sistema, entendiendo ésta como las características de las relaciones entre actores (incluyendo cómo es la gestión urbana y la voluntad política) y las reglas formales e informales del sistema. Este último incorpora el marco institucional y normativo que gobierna la política. El otro factor se refiere a la escasez del desarrollo de mecanismos de financiamiento para el desarrollo sostenible urbano The sustainable development of the cities of Latin America and the Caribbean poses important challenges for the urban territorial policies at their local, subnational, national and regional levels. It requires the convergence in the urban space of the necessity of internalizing the environmental costs (via improvement of the management and governability of the associated systems), assuming and solving social inequities (via improvement of urban habitability and the investement of capitals), and the recognition and approach to economic restrictions related to efficiency (by improving the offer of financing). This work discusses these themes in their social, economic and environmental dimensions, applied to the sustainable development of the human settlements in the region, focused both on present limitations and opportunities in this field, as well as on the regional process in terms of political reforms, implementation of programs and the development of projects. It is suggested that there are certain cond
La dimensión económica de la pobreza y precariedad urbana en las ciudades latinoamericanas: Implicaciones para las políticas del habitat
LUCY WINCHESTER
EURE (Santiago) , 2008,
Abstract: En las ciudades de América Latina y el Caribe, los pobres urbanos viven una heterogeneidad de condiciones y carencias que expresan directamente e indirectamente su vulnerabilidad económica. Este artículo busca profundizar nuestra comprensión de la dimensión económica de la pobreza y precariedad urbana en las vidas de los pobres urbanos, y averiguar sobre sus implicancias en el dise o de estrategias de política. El trabajo se basa en los enfoques conceptuales del desarrollo sostenible, y de la generación de capacidades y oportunidades en las personas. Se parte de una hipótesis de trabajo de que la vulnerabilidad económica en los sectores de pobreza urbana no ha sido plenamente integrada en las políticas del habitat, limitando la contribución de éstas a la mejora en el acceso de los pobres urbanos al empleo e ingresos estables. In Latin American and Caribbean cities, the urban poor are subject to diverse and heterogeneous living conditions that directly and indirectly reflect their economic vulnerability. This article seeks to deepen our understanding of the economic dimension of urban poverty and precarious living conditions in the lives of the urban poor, and to investigate their implications for public policy design. The work relies on the sustainable development framework and the policy discussions regarding capacity building and the creation of opportunities for the poor. Our working hypothesis is that an awareness of the economic vulnerability of the urban poor has not been fully integrated into urban policies, limiting their contribution to improving the poor's access to stable incomes and employment.
Enhanced Production of Neutron-Rich Rare Isotopes in the Reaction of 25 MeV/nucleon Kr-86 on Ni-64
G. A. Souliotis,M. Veselsky,G. Chubarian,L. Trache,A. Keksis,E. Martin,A. Ruangma,E. Winchester,S. J. Yennello
Physics , 2002, DOI: 10.1016/S0370-2693(02)02459-0
Abstract: The cross sections and velocity distributions of projectile-like fragments from the reaction of 25 MeV/nucleon 86Kr + 64Ni have been measured using the MARS recoil separator at Texas A&M, with special emphasis on the neutron rich isotopes. Proton-removal and neutron pick-up isotopes have been observed with large cross sections. A model of deep-inelastic transfer (DIT) for the primary interaction stage and the statistical evaporation code GEMINI for the deexcitation stage have been used to describe the properties of the product distributions. The results have also been compared with the EPAX parametrization of high-energy fragmentation yields. The experimental data show an enhancement in the production of neutron-rich isotopes close to the projectile, relative to the predictions of DIT/GEMINI and the expectations of EPAX. We attribute this enhancement mainly to the effect of the extended neutron distribution (neutron ``skin'') of the 64Ni target in peripheral interactions of 86Kr with 64Ni. The large cross sections of such reactions near the Fermi energy, involving peripheral nucleon exchange, suggest that, not only the N/Z of the projectile and the target, but also the N/Z distribution at the nuclear surface may properly be exploited in the production of neutron-rich rare isotopes. This synthesis approach may offer a fruitful pathway to extremely neutron-rich nuclei, towards the neutron-drip line.
Heavy Residues with A<90 in the Asymmetric Reaction of 20 AMeV 124Sn+27Al as a Sensitive Probe of the Onset of Multifragmentation
M. Veselsky,G. A. Souliotis,G. Chubarian,L. Trache,A. Keksis,E. Martin,A. Ruangma,E. Winchester,S. J. Yennello
Physics , 2002, DOI: 10.1016/S0375-9474(03)01571-9
Abstract: The cross sections and velocity distributions of heavy residues from the reaction of 20 AMeV 124Sn + 27Al have been measured at forward angles using the MARS recoil separator at Texas A&M in a wide mass range. A consistent overall description of the measured cross sections and velocity distributions was achieved using a model calculation employing the concept of deep-inelastic transfer for the primary stage of peripheral collisions, pre-equilibrium emission and incomplete fusion for the primary stage of more violent central collisions and the statistical model of multifragmentation (SMM code) for the deexcitation stage. An alternative calculation employing the sequential binary decay (GEMINI code) could not reproduce the observed yields of the residues from violent collisions (A<90) due to different kinematic properties. The success of SMM demonstrates that the heavy residues originate from events where a competition of thermally equilibrated fragment partitions takes place rather than a sequence of binary decays.
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