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Search Results: 1 - 10 of 175770 matches for " E. Anne Pryde "
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Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome
Darren G. Craig,Patricia Lee,E. Anne Pryde,Ernest Hidalgo,Peter C. Hayes,Stephen J. Wigmore,Stuart J. Forbes,Kenneth J. Simpson
Case Reports in Transplantation , 2014, DOI: 10.1155/2014/272498
Abstract: Background. Small-for-size syndrome (SFSS) occurs in the presence of insufficient liver mass to maintain normal function after liver transplantation. Murine mortality following 85% hepatectomy can be reduced by the use of soluble receptor for advanced glycation end products (sRAGE) to scavenge damage-associated molecular patterns and prevent their engagement with membrane-bound RAGE. Aims. To explore serum levels of sRAGE, high-mobility group box-1 (HMGB1) protein, and other soluble inflammatory mediators in a fatal case of SFSS. Methods. Serum levels of HMGB1, sRAGE, IL-18, and other inflammatory mediators were measured by ELISA in a case of SFSS, and the results were compared with 8 patients with paracetamol-induced acute liver failure (ALF) and 6 healthy controls (HC). Results. HMGB1 levels were markedly higher in the SFSS patient (92.1?ng/mL) compared with the ALF patients (median (IQR) 11.4 (3.7–14.8)?ng/mL) and HC (1.42 (1.38–1.56)?ng/mL). In contrast, sRAGE levels were lower in the SFSS patient (1.88?ng/mL) compared with the ALF patients (3.53 (2.66–12.37)?ng/mL) and were similar to HC levels (1.40 (1.23–1.89)?ng/mL). Conclusion. These results suggest an imbalance between pro- and anti-inflammatory innate immune pathways in SFSS. Modulation of the HMGB1-RAGE axis may represent a future therapeutic avenue in this condition. 1. Introduction The capacity for liver regeneration is finite, placing a restriction upon the minimum mass of liver tissue required to maintain hepatic function following split liver transplantation (LT) or liver resection. Small-for-size syndrome (SFSS) occurs in the presence of insufficient liver mass to maintain normal function and is characterised by severe graft dysfunction and increased ascites output [1]. The pathophysiology of SFSS is multifactorial, involving insufficient graft volume, poor graft quality, and excessive portal inflow [2]. Amplification of proinflammatory mediators in the remnant tissue is also recognised to play an important role in limiting liver regeneration [3]. Recent murine studies have suggested that a key pathway in this process involves the receptor for advanced glycation end products (RAGE), a cell-surface multiligand pattern recognition receptor linked with amplification of the innate inflammatory response to cell death. Engagement of membrane-bound RAGE with ligands such as high-mobility group box 1 (HMGB1) protein sustains inflammatory responses and promotes apoptosis in the hepatic remnant following massive hepatectomy [4]. Soluble RAGE (sRAGE), the truncated extracellular domain of RAGE,
Lésbicas portuguesas no século vinte: Apontamentos para a História Lesbians in 20th Century Portugal: Notes Towards History Lesbiennes portugaises au vingtième siècle : notes pour l’Histoire
Dee Pryde
Revista Crítica de Ciências Sociais , 2012, DOI: 10.4000/rccs.3746
Abstract: A inten o deste artigo é contribuir para a reposi o, no seu devido lugar histórico, das vivências e lutas das lésbicas portuguesas, num meio mediático e académico que ou as avilta, ou lhes vira as costas sobranceiramente. Com particular enfoque nas décadas de 1980/90, ressalta se o Orgulho Lésbico que contrariou a lesbofobia flagrante de numerosas institui es e personalidades. Igualmente se aborda n o só a falta de progresso, mas o real retrocesso na luta pelos direitos das lésbicas, retrocesso esse emblematicamente representado, já no século vinte e um, pelo uso, t o acrítico e anacronístico quanto patologizador, do falso genérico masculino “homossexual”, para subsumir (fazer sumir) as mulheres que amam mulheres. This article is a contribution towards claiming Portuguese lesbians’ rightful place in history, amid media defamation (and/or condescension), and the thundering silence of Academe. Focusing more closely on the 1980s/1990s, my article gives a necessarily brief account of Lesbian Pride speaking out against the open lesbophobia of countless institutions, and political and other players. It further argues that, rather than a progression, there has been a regression in ‘the lesbian possibility’ in Portugal. L’intention de cet article est celle de contribuer à la restitution, en leurs lieux et contextes historiques, des vécus et combats des lesbiennes portugaises, dans un milieu médiatique ou académique qui soit les avilit, soit leur tourne le dos dédaigneusement. On focalise tout particulièrement les décennies 1980/90, où émerge l’Orgulho Lésbico [l’Orgueil Lesbien] qui fit face à la lesbophobie flagrante de nombreuses institutions et personnalités. Nous abordons également non seulement le manque de progrès, mais le réel recul dans la lutte pour les droits des lesbiennes, recul emblématiquement représenté, déjà au cours du vingt-et-unième siècle, par l’usage si acritique et anachronique que pathologisant du faux générique masculin homosexuel , pour englober et ignorer les femmes-qui-aiment-le-femmes.
Moving and Handling of Patients with Dementia
Dev Jootun,Aileen Pryde
Journal of Nursing Education and Practice , 2012, DOI: 10.5430/jnep.v3n2p126
Abstract: Moving and handling is an important aspect of caring for patients with dementia. This can be a serious risk to health care staff, and requires careful risk assessment and planning before execution to minimise any injury. This article explores some of the challenges nurses may face when moving and handling people with dementia. It offers guidance on how to deal with these challenges to promote safe practice and improve patient outcomes.
Evaluation of Physical Symptoms in Patients on Peritoneal Dialysis
Ana Elizabeth Figueiredo,Cate Goodlad,Michelle Clemenger,San San Haddoub,Jacqueline McGrory,Kim Pryde,Emma Tonkins,Nora Hisole,Edwina Anne Brown
International Journal of Nephrology , 2012, DOI: 10.1155/2012/305424
Abstract: Introduction. Little is known about physical symptoms in peritoneal dialysis (PD) Patients. This study aims to determine the prevalence of symptoms (general and abdominal) in PD patients. Methods. A cross-sectional study, with subsequent followup, using an author-designed 21 symptoms questionnaire (15 nonabdominal and 6 abdominal). Each symptom was assessed on a scale 0–3 for severity (none–severe) and frequency (never–every day). Results. We studied 41 patients, mean age years, 56% male, 19.5% diabetics, and 51.5% on APD. Mean number of symptoms was and total symptoms score was with abdominal scores of . Most frequent symptoms were lack of energy, itching, cramps, poor sleep, and loss of appetite. A second evaluation in 20 patients disclosed no statistical difference between the first and second assessments, or between subgroups. Cramps were the only symptoms which decreased over time ( ). Lack of energy did not correlate with haemoglobin, neither did itching with phosphate level. Conclusions. Physical symptoms are frequent and troublesome; they relate to advanced kidney disease and not specifically to PD. Symptoms remain stable over time and do not appear to relate to dialysis parameter markers. 1. Introduction Peritoneal dialysis is a life-sustaining treatment for patients with end-stage renal disease–a chronic illness in which physical and emotional symptoms play a central role in patient’s experience. Symptom burden among dialysis patients can be underdiagnosed and undertreated by providers of care, and the frequency and severity of many symptoms underestimated [1, 2]. Specific symptoms questionnaires, such as the Dialysis Symptom Index [3], the Edmond Symptom Assessment System [4], and the Dialysis Frequency, Severity and Symptom Burden Index (DFSSBI) [5] have been developed, but have been designed predominantly for patients on hemodialysis. Reported quality of life for dialysis patients is lower than in the general population, and it has been suggested that this is a result of comorbidities, lifestyle adaptations, and treatment-related side effects [6–8]. The BOLDE study [9] has previously reported that older patients on PD have less illness intrusion compared to those on HD, and that symptom count is a significant negative contributor to quality of life. The current literature provides an incomplete picture of the prevalence; severity and clinical significance of the symptoms burden in peritoneal dialysis patients, and the main focus has been on single symptoms rather than a range of symptoms. Symptoms represent patients experience so it is not
Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae
Esther R Loney, Peter W Inglis, Sarah Sharp, Fiona E Pryde, Nicholas A Kent, Jane Mellor, Edward J Louis
Epigenetics & Chromatin , 2009, DOI: 10.1186/1756-8935-2-18
Abstract: Chromatin analysis, using microccocal nuclease and indirect end labelling, reveals distinct patterns for ends with different silencing states. Differences were observed in the promoter accessibility of a subtelomeric reporter gene and a characteristic array of phased nucleosomes was observed on the centromere proximal side of core X at a repressive end. The silent information regulator proteins 2 - 4, the yKu heterodimer and the subtelomeric core X element are all required for the maintenance of the chromatin structure of repressive ends. However, gene deletions of particular histone modification proteins can eliminate the silencing without the disruption of this chromatin structure.Our data identifies chromatin features that correlate with the silencing state and indicate that an array of phased nucleosomes is not sufficient for full repression.Heterochromatin is defined as regions of DNA that remain highly condensed throughout the cell cycle. Although, yeast chromosomes are too small to visualize condensed chromatin, several regions of the S. cerevisiae genome show similarities to the heterochromatin of higher organisms [1,2]. The silent mating-type loci, HML and HMR, the tandem rDNA array and regions close to telomeres, in particular, exhibit heterochromatic properties, such as position effects on gene expression and chromatin that is less accessible to restriction enzymes and DNA methylases [3-5].Transcriptional silencing at telomeres and the silent mating-type loci is dependent on the silent information regulator proteins 2 - 4 (Sir2 - 4), which are integral components of the silenced chromatin. The Sir proteins interact with each other and with hypoacetylated histones H3 and H4 to form a repressive structure. At HML and HMR the Sir complex is recruited by Rap1, Abf1 and the origin recognition complex (ORC) which bind to the HM silencers. At telomeres the Sir complex is recruited by Rap1 bound to the telomeric repeats. Once recruited, Sir2 is thought to deacety
Q&A: What is biodiversity?
Anne E Magurran
BMC Biology , 2010, DOI: 10.1186/1741-7007-8-145
Abstract: Biodiversity is simply the variety of life. This can mean anything from the microbes in a few grams of soil to all the organisms that inhabit the earth. In practice, to assess how much diversity we have and what it does, we need to be more specific about the aspect of biodiversity we are concerned with, and the area and time frame over which we want to measure it. For example, we might consider the types and relative abundances of species of trees in a forest, or the genetic diversity associated with the individuals of those species, or even how the number and composition of forests across a biogeographic region have changed over the past century. This hierarchy of organizational levels is implicit in the definition developed by the UN in their Convention on Biological Diversity, which states that biological diversity is 'the variability among living organisms from all sources, including, inter alia, terrestrial, marine, and other aquatic ecosystems, and the ecological complexes of which they are part: this includes diversity within species, between species and of ecosystems'.How much biodiversity we see, such as the number of bird species recorded in a wetland, increases both as a larger area is surveyed, and as the same area is surveyed for a longer time. Thus, if we were to watch the same lake over several years, we would find that some new species would colonize, others would vanish from the area, and there would be occasional unexpected species appearing, perhaps diverted away from their normal migration route by unusual weather conditions. These species-area and species-time relationships are well-known 'laws' of ecology, yet are sometimes overlooked when investigators or conservationists are making comparisons between sites or deciding which places should be designated as nature reserves.As Charles Elton explained in his book The Ecology of Invasions by Animals and Plants, over half a century ago now, there are three main arguments for conserving biodiversity
Revitalisation of the folk epics of the Lower Yangzi Delta: an example of China’s intangible cultural Heritage
Anne E. McLaren
International Journal of Intangible Heritage , 2010,
Abstract: The folk epics of the Han people of the lower Yangzi delta in China have been entered into the national register of Intangible Cultural Heritage (ICH). These lengthy verse narratives were sung by labouring people toiling in paddy fields or working the waterways of the delta before the establishment of socialist China in 1949. Repressed during the Maoist period, the process of their re-discovery, identification and revitalisation as valued examples of China’s heritage has been a difficult one, and their transmission to future generations as a living and valued folk art is by no means assured. As argued here, the case of the folk epics illustrates the cultural and political complexities of the preservation of intangible cultural heritage in economically advanced areas of China.
A piscine history of the Neotropics
Anne E. Magurran
Frontiers of Biogeography , 2011,
Fighting decoherence in a continuous two-qubit odd or even parity measurement with a closed-loop setup
Anne E. B. Nielsen
Physics , 2009, DOI: 10.1103/PhysRevA.81.012307
Abstract: A parity measurement on two qubits, each consisting of a single atom in a cavity, can be realized by measuring the phase shift of a probe beam, which interacts sequentially with the two qubits, but imperfections lead to decoherence within the subspaces of a given parity. We demonstrate that a different setup, where the probe light interacts repeatedly with the qubits, can reduce the rate of decoherence within the odd or the even parity subspace significantly. We consider both the case of a resonant and the case of a nonresonant light-atom interaction and find that the performance is comparable if the parameters are chosen appropriately.
Anyon braiding in semi-analytical fractional quantum Hall lattice models
Anne E. B. Nielsen
Physics , 2014, DOI: 10.1103/PhysRevB.91.041106
Abstract: It has been demonstrated numerically, mainly by considering ground state properties, that fractional quantum Hall physics can appear in lattice systems, but it is very difficult to study the anyons directly. Here, I propose to solve this problem by using conformal field theory to build semi-analytical fractional quantum Hall lattice models having anyons in their ground states, and I carry out the construction explicitly for the family of bosonic and fermionic Laughlin states. This enables me to show directly that the braiding properties of the anyons are those expected from analytical continuation of the wave functions and to compute properties such as internal structure, size, and charge of the anyons with simple Monte Carlo simulations. The models can also be used to study how the anyons behave when they approach or even pass through the edge of the sample. Finally, I compute the effective magnetic field seen by the anyons, which varies periodically due to the presence of the lattice.
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