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Search Results: 1 - 10 of 170941 matches for " E. Alvarez "
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On the origins of arrestin and rhodopsin
Carlos E Alvarez
BMC Evolutionary Biology , 2008, DOI: 10.1186/1471-2148-8-222
Abstract: We found that the arrestin clan is comprised of the Spo0M protein family in archaea and bacteria, and the arrestin and Vps26 families in eukaryotes. The previously known animal arrestins are members of the visual/beta subfamily, which branched from the founding "alpha" arrestins relatively recently. Curiously, we identified both the oldest visual/beta arrestin and opsin genes in Cnidaria (but not in sponges). The arrestin clan has 14 human members: 6 alphas, 4 visual/betas, and 4 Vps26 genes. Others recently showed that the 3D structure of mammalian Vps26 and the biochemical function of the yeast alpha arrestin PalF are similar to those of beta arrestins. We note that only alpha arrestins have PY motifs (known to bind WW domains) in their C-terminal tails, and only visual/betas have helix I in the Arrestin N domain.We identified ciliary opsins in Cnidaria and propose this subfamily is ancestral to all previously known animal opsins. That finding is consistent with Darwin's theory that eyes evolved once, and lends some support to Parker's hypothesis that vision triggered the Cambrian explosion of life forms. Our arrestin findings have implications on the evolution of GPCR signaling, and on the biological roles of human alpha arrestins.G protein coupled receptors (GPCRs) are arguably the most important proteins in human evolution and medicine [1]. The rhodopsin class of GPCRs alone is the most highly represented protein family in mammals [2]. Humans have on the order of 799 [3] to 1,282 [4] GPCRs, and they are the protein family most commonly targeted by clinical drugs. GPCRs are transmembrane receptors that mediate the majority of extracellular signaling in mammals. They can sense diverse types of signals, including hormones, lipids, olfactants, tastants, ions, light, and soluble and surface-anchored peptides. Despite the name, not all GPCRs signal through G proteins. And many or most GPCRs also signal through non-G protein-mediated pathways. The hallmark of GPCRs is
?Se debe criminalizar el consumo de drogas ilegales?
Alvarez Licona, Nelson E.;
Cuicuilco , 2010,
Abstract: the prohibitive policy of the consumption of the named illegal drugs, between which we found the marijuana, is a consequence of the fight by the control of the market of the opium that occurs between the great european metropolises in the middle of century xix in asia. the participation of the united states at the beginning of century xx, impelled by the pure ideas, implements the policy of fight against drugs. it is in this context that the consumption of drugs named illegal is criminalized and his practices are judged from a biologic vision in which the prohibition is justified, that is criterion to understand and to take care of the consumption of this type of substances.
Construindo uma política feminista translocal da tradu??o
Alvarez, Sonia E;
Revista Estudos Feministas , 2009, DOI: 10.1590/S0104-026X2009000300007
Abstract: our collective project on translocalities/translocalidades: feminist politics of translation in the latin/a américas explores how feminist discourses and practices travel across a variety of sites and directionalities to become interpretive paradigms to read/write issues of class, gender, race, sexuality, migration, health, social movements, citizenship, politics, and the circulation of identities and texts. translation is politically and theoretically indispensable to forging feminist, anti-racist, postcolonial/postoccidentalist political alliances and epistemologies because the latin/a américas - as a transborder cultural formation rather than a territorially delimited one - must be understood as translocal in a dual sense. the first sense we will deploy - that of translocation builds on but moves beyond us third world feminist conceptions of the "politics of location." rather than "immigrating" and "assimilating," moreover, many people in the latin/a américas increasingly move back and forth between localities, between historically situated and culturally specific, though increasingly porous, places, across multiple borders, and not just between nations (as implied in the term "transnational migration," for instance). we therefore deploy the notion of translocal in a second sense, which we call translocalities/translocalidades, precisely to capture these multidirectional crossings and movements
Dr Jorge Albertal Un Maestro ... mi Maestro
Carlos E Alvarez
Revista Argentina de Cardiología , 2007,
String Primer
E. Alvarez,P. Meessen
Physics , 1998, DOI: 10.1088/1126-6708/1999/02/015
Abstract: This is the written version of a set of introductory lectures on string theory.
The Holographic Principle and the Renormalization Group
E. Alvarez,C. Gomez
Physics , 1998,
Abstract: We prove a c-theorem for holographic theories.
Fermi Arcs in the Superconducting Clustered State for Underdoped Cuprates
G. Alvarez,E. Dagotto
Physics , 2008, DOI: 10.1103/PhysRevLett.101.177001
Abstract: The one-particle spectral function of a state formed by superconducting (SC) clusters is studied via Monte Carlo techniques. The clusters have similar SC amplitudes but randomly distributed phases. This state is stabilized by the competition with anti-ferromagnetism, after quenched disorder is introduced. Fermi arcs between the critical temperature Tc and the cluster formation temperature scale T* are observed, similarly as in the pseudo-gap state of the cuprates. The arcs originate at metallic regions in between the neighboring clusters that present large SC phase differences.
Single-Band Model for Diluted Magnetic Semiconductors: Dynamical and Transport Properties and Relevance of Clustered States
G. Alvarez,E. Dagotto
Physics , 2003, DOI: 10.1103/PhysRevB.68.045202
Abstract: Dynamical and transport properties of a simple single-band spin-fermion lattice model for (III,Mn)V diluted magnetic semiconductors (DMS) is here discussed using Monte Carlo simulations. This effort is a continuation of previous work (G. Alvarez, Phys. Rev. Lett. 89, 277202 (2002)) where the static properties of the model were studied. The present results support the view that the relevant regime of J/t (standard notation) is that of intermediate coupling, where carriers are only partially trapped near Mn spins, and locally ordered regions (clusters) are present above the Curie temperature T_C. This conclusion is based on the calculation of the resistivity vs. temperature, that shows a soft metal to insulator transition near T_C, as well on the analysis of the density-of-states and optical conductivity. In addition, in the clustered regime a large magnetoresistance is observed in simulations. Formal analogies between DMS and manganites are also discussed.
Newtonian M(atrix) Cosmology
E. Alvarez,P. Meessen
Physics , 1997, DOI: 10.1016/S0370-2693(98)00292-5
Abstract: A Newtonian matrix cosmology, correspoding to the BFSS model of eleven-dimensional M-theory in the IMF as a (0+1) M(atrix) model is constructed. Interesting new results are obtained, such as the existence of (much sought for in the past) static solutions. The possible interpretation of the off-diagonal entries as a background geometry is also briefly discussed.
Non-Critical Confining Strings and the Renormalization Group
E. Alvarez,C. Gomez
Physics , 1999, DOI: 10.1016/S0550-3213(99)00142-X
Abstract: String vacua for non critical strings satisfying the requirements of Zig-Zag invariance are constructed. The Liouville mode is shown to play the r\^ole of scale in the Renormalization Group operation. Differences and similarities with the D-brane near horizon approach to non supersymmetric gauge theories are discussed as well.
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