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Search Results: 1 - 10 of 56 matches for " Dudekula Subhan "
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Dramatic Co-Activation of WWOX/WOX1 with CREB and NF-κB in Delayed Loss of Small Dorsal Root Ganglion Neurons upon Sciatic Nerve Transection in Rats
Meng-Yen Li,Feng-Jie Lai,Li-Jin Hsu,Chen-Peng Lo,Ching-Li Cheng,Sing-Ru Lin,Ming-Hui Lee,Jean-Yun Chang,Dudekula Subhan,Ming-Shu Tsai,Chun-I Sze,Subbiah Pugazhenthi,Nan-Shan Chang,Shur-Tzu Chen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007820
Abstract: Tumor suppressor WOX1 (also named WWOX or FOR) is known to participate in neuronal apoptosis in vivo. Here, we investigated the functional role of WOX1 and transcription factors in the delayed loss of axotomized neurons in dorsal root ganglia (DRG) in rats.
The effect of volitional breathing on the breathlessness-ventilation relationship during progressive exercise in healthy subjects
Reed JW,Subhan MMF
Respiratory Research , 2001, DOI: 10.1186/rr143
Abstract:
Isolation, Characterization and Pharmacological Studies of A Flavonol Glucoside From Trichilia connaroides (W.&A.) Bentilizen
Dudekula Meharoon,Somasekhar Vanitad,Purnima Ashok
International Journal of Research in Pharmacy and Science , 2011,
Abstract: A flavonol glucoside, namely populnin (Kaempferol-7-O-glucoside ) was isolated from the leaves of Trichilia connaroides (W.&A.) Bentilizen. Investigation of the methanolic leaf extract of Trichilia connaroides for analgesic activity led to the isolation of populnin. Structural elucidation of the isolated compound was achieved by IR, 1H-NMR and LC-MS. The methanolic extract and the isolated compound were tested for analgesic activity using the Eddy’s hot plate method and the Acetic acid induced writhing test. In both tests populnin showed significant analgesic activity (P<0.001) at a dose of 50 mg/Kg b.w. The methanolic extract and populnin did not show any acute toxicity. Isolation of the flavonol glucoside and the activity observed in this study may explain in part the use of the tree in traditional medicine as a crude analgesic drug.
Genotype X Environment Interaction in Soybeans Grown in Oklahoma (USA) and in NWFP (Pakistan)
F. Subhan,L. H. Edwards
Journal of Biological Sciences , 2001,
Abstract: Fifteen genotypes of group IV and group V soybeans from the Oklahoma Soybean Variety Test were grown from 1991 to 1994 at four Oklahoma (USA) locations and in 1994 four NWFP (Pakistan) locations to investigate Genotype x Environment (GE) interactions and genotypic stability. Significant Genotype x Locations and Genotype x Location x Year (GLY) interactions was observed for seed yield. The top-yielding genotypes at Bixby were Hartwig, OK 885409, HSC 591 and Hutcheson. At Haskell the top-yielding genotypes included Hutcheson, OK 885409 and Manokin. At Chickasha and Goodwell 7 and 9 genotypes were in the top yielding group; respectively. OK 885409 was in the top-yielding group in 1991, 1992 and 1994 at Bixby, in 1991, 1993 and 1994 at Chickasha, and in all four years at Haskell. A significant Genotype x Location (GL) interaction was observed for seed yield when all eight locations (in Pakistan and the USA) were studied in 1994. Only Haskell-Mansehra and Chickasha-Mansehra showed nonsignificant Genotype x Location interactions. Combined regression analysis was also used. Genotypes OK 885409, Hutcheson, HSC 401 and Bay had nonsignificant residual mean squares but only OK 885409 and Hutcheson had b value close to one and a mean yield higher than the grand mean. These genotypes are less responsive to favorable environments, but should perform in a more predictable or stable manner.
Effect of Increasing Levels of Phosphorus and Seed Rate on the Economic Yield of Maize
M. Qasim,Himayatullah,M. Subhan
Journal of Biological Sciences , 2001,
Abstract: Number of cobs per plot, 1000-grain weight and grain yield were significantly effected by various levels of phosphorus and seed rate. Maximum number of cobs per plot (72.58), 1000-grain weight (334.08 g) and grain yield (3154.43 g) were obtained from plots receiving P2O5 @ 200 kg ha -1. Similarly, seed rate @ 60 kg ha -1 gave comparatively higher economic yield. Hence P2O5 @ 200 kg ha -1 and seed rate @ 60 kg ha -1 proved to be the best fertilizer and seed rate among all the treatments.
Prediction of evolutionarily conserved interologs in Mus musculus
Sailu Yellaboina, Dawood B Dudekula, Minoru SH Ko
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-465
Abstract: To address this issue, we used phylogenetic profile method to filter false positives in interologs based on the notion that evolutionary conserved interactions show similar patterns of occurrence along the genomes. The approach was applied to Mus musculus, in which the experimentally identified interactions are limited. We first inferred the protein-protein interactions in Mus musculus by using two approaches: i) identifying mouse orthologs of interacting proteins (interologs) based on the experimental protein-protein interaction data from other organisms; and ii) analyzing frequency of mouse ortholog co-occurrence in predicted operons of bacteria. We then filtered possible false-positives in the predicted interactions using the phylogenetic profiles. We found that this filtering method significantly increased the frequency of interacting protein-pairs coexpressed in the same cells/tissues in gene expression omnibus (GEO) database as well as the frequency of interacting protein-pairs shared the similar Gene Ontology (GO) terms for biological processes and cellular localizations. The data supports the notion that phylogenetic profile helps to reduce the number of false positives in interologs.We have developed protein-protein interaction database in mouse, which contains 41109 interologs. We have also developed a web interface to facilitate the use of database http://lgsun.grc.nia.nih.gov/mppi/ webcite.Many functions in living organisms are determined by interactions among proteins in cells. Identifying these interactions is an important first step in systems level understanding of various developmental, physiological, and disease processes. High-throughput experimental approaches such as yeast two-hybrid system and tandem affinity purification coupled with mass spectrometry have been carried out to map protein-protein interactions in model organisms [1-6]. These experimental data have been curated to produce protein-protein interaction databases such as BIOGRID [7],
Dynamics of Urbanization and Its Impact on Land-Use/Land-Cover: A Case Study of Megacity Delhi  [PDF]
Manju Mohan, Subhan K. Pathan, Kolli Narendrareddy, Anurag Kandya, Sucheta Pandey
Journal of Environmental Protection (JEP) , 2011, DOI: 10.4236/jep.2011.29147
Abstract: The rapid expansion of urban areas due to rise in population and economic growth is increasing additional demand on natural resources thereby causing land-use changes especially in megacities. Therefore, serious problems associated with rapid development such as additional infrastructure, informal settlements, environmental pollution, destruction of ecological structure and scarcity of natural resources has been studied carefully using remote sensing and GIS technologies for a rapidly grown megacity namely, Delhi. The present work evaluates the land use/land cover (LULC) changes and urban expansion in Mega city Delhi and highlights the major impact of rapid urbanization and population growth on the land cover changes which needs immediate attention. The results indicate that the city is expanding towards its peripheral region with the conversion of rural regions in to urban expansions. Built-up area of Delhi witnessed an overall increment from 540.7 km² to 791.96 km² or 16.86% of the total city area (1,490 km² ) during the study period 1997 to 2008 which mainly came from agriculture land, waste land, scrub-land, sandy areas and water bodies. The increment in forest cover of 0.5 % is very small when considering the increment in built up category to 17%. Total area of waterbodies has reduced by 52.9% in a ten year period (58.26 km² in 1997 to 27.43 km² in 2008) with shallow waterbodies now having a dismal presence. LULC changes are studied with the urban growth parameters such as population, vehicles, gross state domestic product etc. The results lay emphasis on the concepts of urban planning to be applied such that more consideration is towards the preservation and management of natural land use classes which will increase the quality of life in an urban environment.
Successful outcome of a pregnancy in a woman with advanced cirrhosis due to hepatitis B surface antigenemia, delta super-infection and hepatitis C co-infection: a case report
Amna Subhan, Shahab Abid, Wasim Jafri
Journal of Medical Case Reports , 2007, DOI: 10.1186/1752-1947-1-96
Abstract: Pregnancy is uncommon in women with advanced cirrhosis and is associated with an increased risk of complications such as bleeding from esophageal varices, liver failure, and hepatorenal syndrome [1-4]. Maternal deaths have been reported in advanced cirrhosis mainly due to variceal bleeding [4]. Spontaneous abortion and increased risk of premature childbirth or stillbirth have been reported in 15–20% of pregnancies in women with cirrhosis [5]. We are reporting the case of a successful pregnancy outcome of a woman with decompensated cirrhosis, affected by hepatitis B, C and D viruses. To the best of our knowledge this is the first report of pregnancy in a mother who had combined hepatitis B antigenemia, hepatitis delta and hepatitis C infection.A 32 year old mother of two children presented at 16 weeks gestation with abdominal distention and edematous legs. There was no history of hematemesis, melena or altered mental status. Physical examination revealed pallor, spider telangectesia on the arms, palmer erythema and pedal edema. Her abdominal examination showed splenomegaly (to the level of the umbilicus) and moderate ascities. There was no clinical evidence of portosystemic encephalopathy. Her pulmonary, cardiovascular and neurological examinations were unremarkable. Investigations revealed hemoglobin of 8.5 gm/dl with peripheral smear suggestive of microcytic hypochromic anemia, total leukocyte count of 4200/mm3 (63% polymorphs and 32% lymphocytes), platelets 40,000/mm3, total billirubin 2.0 mg/dl, serum glutamic oxaloacetic transaminase 74 (8–32) IU/L, serum glutamic pyruvic transaminase 41 (Normal 3–33) IU/L, GGT of 61 IU/L and alkaline phosphatase 81 (29–132) IU/L, serum albumin 2.3 gm/dl and prothrombin time 15.6 seconds (control 12 seconds). She had normal renal function and electrolytes. Abdominal and pelvic ultrasound revealed a shrunken liver, massive spleenomegaly, dilated portal vein, moderate ascities (fig 1 &2) and a 16 week viable fetus. Ascitic fluid a
Development and application of spectrophotometric method for the determination of cefaclor in pharmaceutical formulations
Raza, Asad;Ijaz, Abdul Subhan;Ahmad, Shabbir;
Química Nova , 2009, DOI: 10.1590/S0100-40422009000500018
Abstract: a simple, fast and sensitive spectrophotometric method for the determination of cefaclor in pharmaceutical raw and dosage forms based on reaction with ninhydrin is developed, optimized and validated. the purple color (ruhemenn's purple) that resulted from the reaction was stabilized and measured at 560 nm. beer's law is obeyed in the concentration range of 4-80 μg ml-1 with molar absorptivity of 1.42 × 105 l mole-1 cm-1. all variables including the reagent concentration, heating time, reaction temperature, color stability period, and cefaclor/ninhydrin ratio were studied in order to optimize the reaction conditions. no interference was observed from common pharmaceutical adjuvant. the developed method is easy to use, accurate and highly cost-effective for routine studies relative to hplc and other techniques.
Research: DESIGN AND DEVELOPMENT OF FAST DISINTEGRATING TABLET BY VACUUM DRYING TECHNIQUE
N G Raghavendra Rao*,Md Subhan
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: Nimodipine is an antihypertensive, calcium channel blocker, vasodilator agent and used in the treatment of various cardiovascular disorders such as angina pectoris, cardiac arrhythmia and hypertension. Oral bioavailability of nimodipine is around 13% and having half life 9 hrs. In present research work an attempt has been made to prepare fast dissolving tablets of nimodipine by vacuum drying technique. The blend was examined for the pre-compressional parameters and post-compressional parameters. Drug compatibility with excipients was checked by FTIR and DSC studies. No chemical interaction between drug and excipients was confirmed by DSC and FTIR studies. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. All the post-compressional parameter are evaluated were prescribed limits and results were within IP acceptable limits. The results obtained showed that quantity of camphor significantly affect the response variables (P> 0.05). The formulations SBP2, SBC2, SBP3 and SBC3 shows less in vitro disintegration time 12.87, 13.48, 11.34 and 12.07 sec respectively. The in-vitro drug release showed 90 % drug released within 5 min. This data reveals that overall, the formulation SBP3 and SBC3 shows nearly faster drug release. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. The results revealed that tablets prepared by the vacuum drying technique using 15 % camphor (SBP3) significantly enhanced the dissolution rate of drug. The results concluded that fast dissolving tablets of Nimodipine showing enhanced dissolution rate may lead to improved bioavailability and effective therapy by using vacuum drying technique.
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