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Search Results: 1 - 10 of 1691 matches for " Dragovi? Tamara "
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Reversal deterioration of renal function accompanied with primary hypothyrodism
Vojnosanitetski Pregled , 2012, DOI: 10.2298/vsp1202205d
Abstract: Introduction. Hypothyroidism is often accompanied with decline of kidney function, or inability to maintain electrolyte balance. These changes are usually overlooked in everyday practice. Early recognition of this association eliminates unnecessary diagnostic procedures that postpone the adequate treatment. Case report. Two patients with elevated serum creatinine levels due to primary autoimmune hypothyroidism, with complete recovery of creatinine clearance after thyroid hormone substitution therapy are presented. The first patient was a young male whose laboratory tests suggested acute renal failure, and the delicate clinical presentation of reduced thyroid function. The second patient was an elderly woman with a history of a long-term signs and symptoms attributed to ageing, including the deterioration of renal function, with consequently delayed diagnosis of hypothyroidism. Conclusion. Serum thyrotropin and thyroxin levels measurement should be done in all cases of renal failure with undefined renal desease, even if the typical clinical presentation of hypothyroidism is absent. Thyroid hormone assays sholud also be performed in all patients with chronic kidney disease whose kidney function is rapidly worsening.
Uticaj metaboli ke kontrole na nastanak i razvoj bubre ne lezije u e ernoj bolesti
Vojnosanitetski Pregled , 2002, DOI: 10.2298/vsp0203293d
Microalbuminuria in diabetes: Definition, identification techniques, and the significance of early recognition
Vojnosanitetski Pregled , 2006, DOI: 10.2298/vsp0612027d
Individual renal hemodymamic response to chronic angiotensin II receptor bloc-kade and the influence on the renin-angiotensin system gene polymorphisms
DragoviTamara,Ajdinovi? Boris,Ili? Vesna,Magi? Zvonko
Medicinski Pregled , 2010, DOI: 10.2298/mpns1010630d
Abstract: Introduction. Our study was aimed at determining whether the polymorphism of genes for different components of the renin-angiotensin-aldosterone system could influence the renal hemodynamic response to losartan treatment. Material and method. The study included 35 patients with type 1 diabetes mellitus and persistent albuminuria, genotyped for the 1166 A/C polymorphism gene for the angiotensin II type 1 receptor and I/D polymorphism of the angiotensin-converting enzyme gene. The participants were divided into groups according to the combinations of A or C allele: AA, AC, CC; and according to the combinations of I or D allele: II, ID and DD genotype. The patients received losartan therapy for 12 weeks. The renal hemodynamic measurements were determined at baseline and after the examination period. Results. Losartan therapy significantly reduced the filtration fraction from the baseline by 0.018±0.024 (p=0.012) only in the AC genotype. The glomerular filtration rate remained unchanged in all genotype groups. A significant increase in the effective renal plasma flow was obtained only in AC genotype (544±88 vs 575±90ml/min; p=0.02), while significant reductions in the renal vascular resistance were found in AA group (115±25 vs 95±21 mmHgx1-1xmin-1; p=0.001) and in AC group (118±30 vs 101±28 mmHgx1-1xmin-1; p=0.001). A significant reduction of the glomerular filtration rate by 8±10 ml/min was obtained only in the DD genotype (p=0.016), and only the DD genotype achieved a significant reduction of the filtration fraction by 0.019±0,022 (p=0.008). The most pronounced increase of the effective renal plasma flow was found only in the ID genotype (536 ±75 vs 591±63 ml/min; p=0.01). The reduction of the renal vascular resistance was independent of ACE gene polymorphism. Conclusion. Our study shows that individual renal vascular response to losartan treatment in diabetic patients with persistent albuminuria, could be influenced by genetic polymorphisms.
Anterior pituitary lobe atrophy as late complication of hemorrhagic fever with renal syndrome
Jovanovi? Dragan,Kova?evi? Zoran,DragoviTamara,Petrovi? Marijana
Vojnosanitetski Pregled , 2009, DOI: 10.2298/vsp0902166j
Abstract: Introduction. Hemorrhagic fever with renal syndrome (HFRS) is acute infective multisystemic disease followed by febrility, hemorrhages and acute renal insufficiency. Bleeding in the anterior pituitary lobe leading to tissue necrosis occurs in acute stage of severe clinical forms of HFRS, while atrophy of the anterior pituitary lobe with diminution of the gland function occurs after recovery stage. Case report. We presented a patient with the development of chronic renal insufficiency and hypopituitarism as complication that had been diagnosed six years after Hantavirus infection. Magnetic resonance of the pituitary gland revealed atrophy and empty sella turcica. Conclusion. Regarding frequency of this viral infection and its endemic character in some parts of our country partial and/or complete loss of pituitary function should be considered during the late stage of HFRS.
Angiotensin II type 1 receptor gene polymorphism could influence renoprotective response to losartan treatment in type 1 diabetic patients with high urinary albumin excretion rate
DragoviTamara,Ajdinovi? Boris,Hrva?evi? Rajko,Ili? Vesna
Vojnosanitetski Pregled , 2010, DOI: 10.2298/vsp1004273d
Abstract: Background/Aim. Diabetic nephropathy (DN) is a clinical syndrome characterized by persistent albuminuria, increasing arterial blood pressure and progressive decline in glomerular filtration rate (GFR). When persistent albuminuria is established, antihypertensive treatment becomes most important factor in slowing the progression of diabetic glomerulopathy. The aim of this study was to examine if renoprotective response to a short-term losartan therapy depends on 1166 A/C gene polymorphism for its target receptor. Method. The study included 35 patients with diabetes mellitus type 1 and persistently high urinary albumin excretion rate (UAE: > 30 mg/24 h), genotyped for the 1166 A/C gene polymorphism for the angiotensin II type 1 receptor (AT1R). The participants were segregated into 3 genotype groups according to combinations of A or C allele: AA(16%), AC(15%) and CC(11%). The patients received losartan 50 mg daily for 4 weeks, following 100 mg daily for another 8 weeks. At baseline and after 12 weeks of the treatment period UAE, blood pressure, GFR and filtration fraction (FF) were determined. Results. After 12 weeks of the treatment with losartan, albuminuria was reduced from baseline by 9% [95% confidence interval (CI): 1-17, p = 0.039] in the AA genotype, and by 11% (95% CI: 6-17, p = 0.0001) in the AC genotype. Losartan treatment reduced albuminuria in the CC group by 5% (95%CI: -13-22, p = 0.47). Glomerular filtration rate remained unchanged in all genotype groups. Filtration fraction was significantly reduced from baseline by 0.018 ± 0.024 (p = 0.012) only in the AC genotype. In the AA genotype, FF was reduced from baseline by 0.017 ± 0.03 (p = 0.052), and in the CC genotype by 0.01 ± 0.008 (p = 0.092). In the AA group, systolic blood pressure declined from 136 ± 24 mmHg at baseline, to an average of 121 ± 18 mmHg at the end of the study (p = 0.001). The AC group achived reduction from 131 ± 10 mmHg at baseline to 115 ± 7 mmHg (p = 0.001) during the investigation period. In the AA genotype group losartan reduced diastolic blood pressure from 86 ± 13 mmHg at baseline to 78 ± 8 mmHg (p = 0.004), and in the AC genotype from 88 ± 5 mmHg at baseline to 11.7 ± 5.6 mmHg during the investigation period (p = 0.001). In the CC genotype diastolic blood pressure reduction remained nonsignificant (p = 0.066). Conclusion. The results of our small sample size study provide the evidence that 1166 A/C AT1R polymorphism could be associated with the renoprotective response to losartan therapy.
Efficacy of valsartan in the therapy of persistent microalbuminuria in normotensive patients with type 1 diabetes mellitus
DragoviTamara,Hrva?evi? Rajko M.,Ajdinovi? Boris ?.,Vujani? Svetlana
Vojnosanitetski Pregled , 2003, DOI: 10.2298/vsp0305555d
Abstract: Aim. To determine the efficacy of AT1 receptor antagonist (valsartan) in decreasing of urinary excretion of albumin in normotensive patients with type 1 diabetes and incipient diabetic nephropathy (DN). Methods. This was a prospective, randomised, placebo-controlled study, which included 20 patients with insulin-dependent diabetes mellitus, mean age 25.15, and the duration of diabetes of 13.95 years. All the patients were normotensive, with persistent microalbuminuria (incipient phase of DN). Patients were randomly divided into two groups (10 patients each): valsartan group treated with 80 mg valsartan daily during 6 months, and the group treated with placebo during the same period. Both groups were similar and comparable concerning the observed parameters at the beginning of the study. Results. After 6 months therapy, valsartan caused significant decrease of urinary albumin excretion rate (UEAR) by 69.1% from 64.8 to 21.1 mg/24 h, while in placebo group there was an insignificant increase of UEAR by 29.8%. During the follow-up of UEA in the observed groups, at the beginning and the end of the mentioned period highly significant decrease of albumine secretion (p<0.001) was observed. Valsartan significantly lowered mean systolic blood pressure (from 122.0 ± 10.1 to 110.0 ± 11.8 mmHg). After 6 months therapy, the reduced values of total cholesterol and LDL-cholesterol fraction were registered in the valsartan group, while the difference in serum trigliceride values reached statistical significance (1.42 ± 0.79 vs. 1.21 ± 0.89 mmol/L; p<0.05). Neither significant difference in glycoregulation quality between the two groups, nor the occurence of hyperkalemia was detected throughout the study period. Conclusion. Valsartan's efficacy in the decrease of microalbuminuria after 6 months of therapy could justify the use of this group of renin/angiotensin blockers in delaying the clinically manifested DN. Valsartan was well tolerated and did not influence the quality of glycoregulation. It did not increase the level of serum lipids and could be recomended in the treatment of diabetic patients.
O stvarala kom traganju Dje je i lutkarske scene HNK u Vara dinu
Spomenka Dragovi
Radovi Zavoda za Znanstveni Rad Vara?din , 2007,
Abstract: Nakana je rada - pregledom repertoara, te osvrtom na praizvedbe predstava Dje je i lutkarske scene vara dinskoga HNK – ukazati na specifi nosti estetike Scene, kao i zna aj njena djelovanja u vara dinskome kazali nom ivotu, a i ire.U kreiranju autenti nog kazali nog izraza – nerijetko spoja umjetni koga htjenja i nu nog oslu kivanja imperativa prakse – Dje ja i lutkarska scena je u proteklih dvanaest godina postala sukreatorom vara dinskoga kazali nog repertoara i dijelom vara dinskoga kazali nog svakodnevlja, ali i relevantnom injenicom u ivotu hrvatskoga teatra danas
Pseudo-integrable billiards and arithmetic dynamics
Vladimir Dragovi,Milena Radnovi?
Physics , 2012,
Abstract: We introduce a new class of billiard systems in the plane, with boundaries formed by finitely many arcs of confocal conics such that they contain some reflex angles. Fundamental dynamical, topological, geometric, and arithmetic properties of such billiards are studied. The novelty, caused by reflex angles on boundary, induces invariant leaves of higher genera and dynamical behaviour different from Liouville-Arnold's theorem. Its analogue is derived from the Maier theorem on measured foliations. A local version of Poncelet theorem is formulated and necessary algebro-geometric conditions for periodicity are presented. The connection with interval exchange transformation is established together with Keane's type conditions for minimality. It is proved that the dynamics depends on arithmetic of rotation numbers, but not on geometry of a given confocal pencil of conics.
Systems of Kowalevski type, discriminantly separable polynomials and quad-graphs
Vladimir Dragovi,Katarina Kuki?
Mathematics , 2011,
Abstract: We establish a new class of integrable {\it systems of Kowalevski type}, associated with discriminantly separable polynomials of degree two in each of three variables. Defining property of such polynomials, that all discriminants as polynomials of two variables are factorized as products of two polynomials of one variable each (denote one of the polynomial components as $P$), lead to an effective integration procedure. In the motivating example, the celebrated Kowalevski top, the discriminant separability is a property of the polynomial defining the Kowalevski fundamental equation. We construct several new examples of systems of Kowalevski type, and we perform their explicit integration in genus two theta-functions. One of the main tasks of the paper is to classify such discriminantly separable polynomials. Our classification is based on the study of structures of zeros of a polynomial component $P$ of a discriminant. From a geometric point of view, such a classification is related to the types of pencils of conics. We construct also discrete integrable systems on quad-graphs associated with discriminantly separable polynomials. We establish a relationship between our classification and the classification of integrable quad-graphs which has been suggested recently by Adler, Bobenko and Suris. As a fit back, we get a geometric interpretation of their results in terms of pencils of conics, and in the case of general position, when all four zeros of the polynomial $P$ are distinct, we get a connection with the Buchstaber-Novikov two-valued groups on $\mathbb {CP}^1$.
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