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Search Results: 1 - 10 of 164 matches for " Dragani?-Gaji? Saveta "
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The effect of pharmacologically active compounds from Ginkgo bilobae extract on contractility of rabbit duodenum and ileum
Pilija Vladimir,Dragani?-GajiSaveta,Savovi? Slobodan,Mihalj Marija
Acta Veterinaria , 2005, DOI: 10.2298/avb0503245p
Abstract: Findings that there are pharmacologically active compounds in the Ginkgo bilobae extract recently provoked numerous investigations of their action on the receptors of the autonomous nervous system. The purpose of the present study was to determine the influence of gingko extract on the contractility of the longitudinal smooth muscle layer in the wall of the rabbit duodenum and ileum using the method of Magnus. Results clearly show that gingko extract causes a dose dependent tonus decrease of duodenal and Heal smooth muscles in the rabbit. It also reduces the stimulation of spontaneous activity of smooth muscles caused by acetylcholine, the reduction being greater in ileum compared to duodenum.
Digeorge syndrome: A case report
Popovi?-Deu?i? Smiljka,Le?i?-To?evski Du?ica,Pejovi?-Milovan?evi? Milica,Dragani?-GajiSaveta
Srpski Arhiv za Celokupno Lekarstvo , 2011, DOI: 10.2298/sarh1110681p
Abstract: Introduction. DiGeorge syndrome is a genetic disorder caused by deletion of chromosome 22. The main features are congenital heart disease, absence or hypoplasia of thymus (with consecutive immunodeficiency and infections), hypoparathyroidism with consecutive hypocalcaemia, gastrointestinal problems, Delayed psychomotor development, abnormalities of head and face, tendency to develop seizures and psychiatric disorders. Syndrome can be detected prenatally, or during early development, which is of great importance for preventive and therapeutic measures. Death rate is high during the first year of life, mostly because of congenital heart disease. With prompt diagnosis and treatment most of the children can survive to adulthood, but they are children with special needs requiring continual care and supervision (because of metal retardation, seizures, neurological and psychiatric disorders). Case Outline. A seven-year-old boy underwent surgical correction of congenital heart disease soon after the birth. Since the age of four years he developed seizures, partially controlled by antiepileptic therapy. Entering the seventh year of age he displayed severe auto and heteroaggressive behaviour. His condition has improved by the introduction of intensive psychiatric and defectological treatment, and daily counselling with his mother the child improved in the sense of calming down, better social communication and acquiring some self-help specific skills. Conclusion. Symptoms of DiGeorge syndrome can be detected soon after the birth, especially that concerning congenital hearth disease. A prompt diagnosis and surgical intervention can save the child’s life. Because of many other symptoms, many diagnostic procedures focused on this syndrome are to be performed, followed by long lasting stimulative treatment and treatment of seizures and psychiatric disorders.
Panic disorder: Psychobiological aspects of personality dimensions
Dragani?-GajiSaveta,Le?i?-To?evski Du?ica,Paunovi? Vladimir R.,Cveji? Vesna
Srpski Arhiv za Celokupno Lekarstvo , 2005, DOI: 10.2298/sarh0504129d
Abstract: Attempts to understand the underlying mechanisms of association between psychological factors and panic disorder have been mostly based on psychodynamic description. Evidence of the importance of serotonergic (5-HT) system in panic disorder (PD), however, has substanti ally increased in recent years. OBJECTIVE The objective of our study was to determine whether there was a specific personality profile of panic disorder patients and how it was related to possible neurobiological mechanisms underlying personality dimensions. PATIENTS AND METHODS Sample consisted of 14 inpatients with ICD-X diagnosis of panic disorder and 34 healthy control subjects. Personality dimensions were assessed by Minnesota Multiphasic Personality Inventory (MMPI-201) and Tridimensional Personality Questionnaire (TPQ). To assess central 5-HT function, platelet monoamine-oxidase (MAO) activity was measured. RESULTS In panic disorder group, higher scores of histrionic, depressive and hypochondriac subscales and significant increase of harm avoidance (HA) scale as well as low MAO activity were found. Negative correlation was established between MAO activity and psychopathic deviance MMPI scale. CONCLUSION The obtained results might indicate a specific personality profile of patients with panic disorder, which is characterized by high neuroticism, fearfulness, inhibition, shyness and apprehensive worry. Low MAO activity and high HA scores possibly indicate underlying hyperserotonergic state. The observed correlation between personality traits and MAO activity provide additional support for the hypothesized functional relationship between underlying central monoaminergic activity and temperament traits associated with anxiety, depression and impulsivity.
Internet addiction: A case report
Pejovi?-Milovan?evi? Milica,Popovi?-Deu?i? Smiljka,Dragani?-GajiSaveta,Le?i?-To?evski Du?ica
Srpski Arhiv za Celokupno Lekarstvo , 2009, DOI: 10.2298/sarh0902086p
Abstract: Some addictions cannot be connected with substance abuse (pathological) gambling, video games playing, binge eating, compulsive physical activity, emotional relationship addiction, TV addiction). Since 1995, Internet addiction has been accepted as a clinical entity with profound negative effect on social, familial, educational and economical personal functioning. The diagnosis of Internet addiction could be established if the person spends more than 38 hours per week on the Internet exempting online professional needs. Basic symptoms are the increased number of hours spent in front of the computer along with the Internet use, development of abstinent syndrome if the Internet access is prohibited, sleep inversion, neglect of basic social requirements and personal hygiene, many somatic symptoms developed due to prolonged sitting or monitor watching, dissocial behavior. In this paper, data about the Internet addiction are presented and a case report of an adolescent with developed Internet addiction.
Sexual dimorphism and specificities of psychopharmacological treatment in women
Dragani?-GajiSaveta,Le?i?-To?evski Du?ica,Pejovi?-Milovan?evi? Milica,Popovi?-Deu?i? Smiljka
Srpski Arhiv za Celokupno Lekarstvo , 2013, DOI: 10.2298/sarh1302116d
Abstract: The scope of gender related differences observed in mentally ill persons provides a major source of inference about the role of gonadal steroids in brain function and behavior. Reported gender dimorphism in psychiatry includes the following: prevalence of certain mental disorders specific to female gender, phenomenology and treatment characteristics, i.e. response to the applied psychopharmacotherapy. Structural and functional relationship between the hormonal system and central nervous system is closely correlated with vulnerability to various psychopathological disturbances in biologically different stages in women. It has been observed, for instance, that the association of gonadal steroid activity with serotonin is relevant to mood change in premenstrual and postpartum mood disturbances. Gender related hormonal fluctuations may cause or be correlated with the development of several gender-related psychopathological disturbances. The aim of this article is to review the literature concerning gender-related specificities of psychopharmacological treatment of some of the most important mental disorders in women, such as affective disorder in menopause, premenstrual syndrome and postpartum mood disorders.
Psychotic spectrum disorders in childhood
Popovi?-Deu?i? Smiljka,Pejovi?-Milovan?evi? Milica,Dragani?-GajiSaveta,Aleksi?-Hil Olivera
Srpski Arhiv za Celokupno Lekarstvo , 2008, DOI: 10.2298/sarh0810555p
Abstract: For a long time, there was a strong belief of existing continuity between childhood-onset psychoses and adult psychoses. Important moment in understanding psychotic presentations during infancy and childhood is Kanner's description of early infantile autism. Later studies of Rutter and Kolvin, as well as new classification systems, have delineated pervasive developmental disorders from all other psychotic disorders in childhood. But clinical experience is showing that in spite of existence of the group of pervasive developmental disorders with subgroups within it and necessary diagnostic criteria there are children with pervasive symptoms, who are not fulfilling all necessary diagnostic criteria for pervasive developmental disorder. Therefore, in this paper we are discussing and pointing at psychotic spectrum presentations in children, which have not the right place in any existing classification system (ICD-10, DSM-IV).
Morphology, size and distribution of corticotropin releasing factor (CRF) immunoreactive neurons in the central nucleus of the rat amygdaloid complex
Pu?ka? Nela,Pu?ka? L.,Dragani?-GajiSaveta,?uleji? V.
Acta Veterinaria , 2006, DOI: 10.2298/avb0606449p
Abstract: The amygdaloid complex (AC) is a heterogenous group of cortical and nuclear structures. As an important component of the limbic system contains numerous neurotransmitters including neuropeptides. In this study we have investigated the types, distribution, and morphometric characteristics of corticotropin releasing factor (CRF) immunoreactive neurons in the central nucleus (Ce) of the AC. We have also identified CRF- immunoreactive fibers in this nucleus. This research was performed on 5 adult rats kept in standard conditions. Animals were perfused 48 hours after application of colhicin. The removed brains were postfixed and cut into free floating sections. The sections were treated with antibodies against the rabbit CRF and ABC immunohistochemstry was applied. The neurons were measured and drawn with a camera lucida. We found uniform distribution of CRF immunoreactive neurons in the Ce of AC of rat. According to morphological type dominant were triangular (50%), while bipolar (25%) and multipolar (25%) types were also present. The most of the CRF immunoreactive neurons had 2-5 primary dendrites. These findings will contribute to understanding the role of CRF neurons in rat Ce during stress and in other behavioral functions.
Attitudes of psychiatry residents toward mental illness
Pejovi?-Milovan?evi? Milica,Le?i?-To?evski Du?ica,Tenjovi? Lazar,Dragani?-GajiSaveta
Medicinski Pregled , 2007, DOI: 10.2298/mpns0708382p
Abstract: Introduction. Attitudes of lay people and physicians towards mentally ill patients are frequently highly biased. The aim of this study was to investigate differences in attitudes of psychiatry and internal medicine residents toward mental illness and to establish the relationship between their attitudes and their personal characteristics. Material and methods. The sample consisted of 45 psychiatry and 36 internal medicine residents. The attitudes toward mental illness were assessed using Opinions about Mental Illness Questionnaire (OMI) and personality traits were examined using the Eysenck Personality Questionnaire (EPQ). Results. Our findings showed that in regard to internal medicine residents, psychiatry residents do not consider mentally ill patients to be inferior and dangerous. Psychiatry residents have a benevolent attitude toward the mentally ill. Personality traits of psychiatry residents were not related to their opinions about mental illness. Discussion. The results suggest that there is a need to develop strategies that would bring about changes in the curriculum of training programs for medical residents, including proper training in mental health issues. Such strategies should help in destigmatization of persons with mental disorders and increase the competence of physicians to deal with mentally ill. .
Marital dysfunction and personality characteristics of partners
Dragani?-GajiSaveta,Le?i?-To?evski Du?ica,?alovska-Hercog Nevena,Naguli? Desanka
Medicinski Pregled , 2005, DOI: 10.2298/mpns0504175d
Abstract: Introduction A number of studies indicate that an early trauma is of extreme importance (most often experienced in the family of origin) in developing personality disorders. Researches on correlations between family dysfunction and individual psychopathology have been rare and controversial. The reason for this stems from an attempt to establish links between traditional medical models and systemic family therapy. The aim of this research was to explore specific personality structures of married couples and the way they relate to the type of dysfunction within the partner relationship. Material and methods The sample consisted of 25 families in the middle of divorce. The examinees were aged 25-45. Specific interactional behavioral patterns were examined by Dyadic Adjustment Scale (DAS), while personality profile data were obtained using Millon Clinical Multiaxial Inventory (MCMI). Results and conclusions In both groups dependency and obsessivness were marked, while males also presented with marked narcissism. Related to structural personality disorders, we have found only a group of men with significantly increased paranoid dimension. Concerning clinical syndromes, the obtained results revealed anxiety and depressive disorder in both genders and a tendency towards alcohol abuse among men. Results indicated to correlation of communication-interactive family patterns on one hand, and certain personality traits on the other. .
Effects of ginkgo biloba extract on an experimental model of epilepsy
Pilija Vladimir I.,Iveti?-Petrovi? Vesna R.,Mihalj Marija,Dragani?-GajiSaveta
Medicinski Pregled , 2004, DOI: 10.2298/mpns0412541p
Abstract: INTRODUCTION The active ingredients of ginkgo biloba extracts were determined by biochemical analyses in the last ten years and they are widely used in classical medicine. The active substances of ginkgo biloba extract, mostly affect muscarinic receptors and adrenergic receptors to a lesser degree. Recently, potential effects of ginkgo biloba on NMDA receptors and on epileptogenic seizures have been considered. The main goal of this research was to investigate effects of ginkgo biloba extracts on the experimantal model of epilepsy. Material and methODS The research was carried out on chinchilla rabbits. GINGIUM solution was used with 40 mg in 1 ml of dry extract of ginkgo biloba leaves. The epileptogenic area was formed by stimulating hippocampus. Bioelectrical activity was registered 60 minutes before the epileptogenic area was formed as well as 90 minutes later. Ginkgo biloba extract was given via IM, in a single daily dose of 1ml/kg/BW. RESULTS A statistically significantly higher frequency of paroxysmal seizures was established after usage of ginkgo biloba. CONCLUSION According to the results obtained in this research, we can conclude that ginkgo biloba extracts have a proconvulsive activity.
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