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Search Results: 1 - 10 of 7745 matches for " Dr. Vishal Bhatnagar "
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Secure Association Rule Mining for Distributed Level Hierarchy in Web
Gulshan Shrivastava,,Dr. Vishal Bhatnagar
International Journal on Computer Science and Engineering , 2011,
Abstract: Data mining technology can analyze massive data and it play very important role in many domains, if it used improperly it can also cause some new problem of information security. Thus severalprivacy preserving techniques for association rule mining have also been proposed in the past few years. Various algorithms have been developed for centralized data, while others refer to distributed data scenario. Distributed data Scenarios can also be classified as heterogeneous distributed data and homogenous distributed data and we identify that distributed data could be partitioned as horizontal partition (a.k.a. homogeneous distribution) and vertical partition (a.k.a. heterogeneous distribution). In this paper, we propose an algorithm for secure association rule mining for vertical partition.
Private and Secure Hyperlink Navigability Assessment in Web Mining Information System
Kavita Sharma,,Dr. Vishal Bhatnagar
International Journal on Computer Science and Engineering , 2011,
Abstract: Information explosion in World Wide Web has increased the interest in Web usage mining techniques in both commercial and academic areas. Study of interested web users; provide valuable information for web designers to quickly respond to their individual needs and for the efficient organization of the website. Among the several approaches like Association rule mining, classification, clustering, to extract knowledge from user’s navigation data, this paper uses classification of log data to discover knowledge from web log files and extract knowledge mining from content and index page. In this paper, we present detection of Remote file inclusion Attack & create secure session; based on content page. At the end we proposed a model for Web Mining based secure Navigability Evaluation of Website.
Paradigm Shift in the endocrine therapy for postmenopausal women with advanced breast cancer
Dr Vishal,R. Tandon
Pharmaceutical Reviews , 2005,
Abstract: For many years, tamoxifen has been the 'gold standard' amongst anti-oestrogen therapies for breast cancer, through its ability to antagonize estrogen-dependent growth by binding estrogen receptors (ERs) and inhibiting proliferation of breast epithelial cells. However, tamoxifen has estrogenic agonist effects in other tissues such as bone and endometrium due to liganded ER activating target genes in these different types of cell. Several novel anti-estrogen compounds have been developed which have a reduced agonist profile on breast and gynecological tissues.These compounds offer the potential for enhanced efficacy and reduced toxicity compared with tamoxifen. In advanced breast cancer clinical data exist for the selective estrogen receptor modulators (SERMs), But, the selective oestrogen receptor modulators (SERMs), such as toremifene, droloxifene, idoxifene, raloxifene, and arzoxifene, show minimal activity in tamoxifen-resistant disease and show no superiority over tamoxifen as first-line treatments. In addition to these agents, other treatment options for advanced disease include high-dose oestrogens and progestins. Response rates for high-dose oestrogens and tamoxifen are similar, but the use of oestrogens is limited by their toxicity profile. (1) Hence there is need of drugs with better clinical; profile for the treatment of breast cancer. Aromatase inhibitors and SERDS are new introductions in this field which are discussed in the present review.
Antioxidants : Past And Present
Dr Vishal Tandon
Pharmaceutical Reviews , 2005,
Abstract: The role of oxidative stress is well recognized now in numerous pathological states, where antioxidants can play very important role. Recent studies provide evidences that low levels of antioxidants are associated with increased risk for many pathological states and that increased intake appears to be protective. However, there are conflicting studies also, that question the rationale for antioxidant supplementation in these conditions by suggesting detrimental effects to the health. Suicidal oxidative stress produced by some of the antioxidants under certain circumstances remains the major cause of concern ,as many antioxidants can act as pro-oxidants in certain conditions. Moreover, at present there are number of unanswered questions associated with practical application of antioxidant therapy like appropriate timing of administration, dose & duration of therapy, which still need to be determined. Inspite of these concerns, antioxidant therapy has gained an important status presently in the prevention and treatment of various pathological conditions. However, under the shadow of these concerns, the supplementation of natural dietary antioxidant resources seems to be a safe and effective approach currently.KEY WORDS : Oxidative stress, antioxidants, present, past, status.
Nobel Hiv-1 Protease Inhibitors
Dr. Vishal R.Tandon
Pharmaceutical Reviews , 2005,
Abstract: The HIV protease is essential for viral infectivity and cleaves the viral polyprotein(gag-pol) into active viral enzymes (reverse transcriptase, protease and integrase)and structural proteins. Thus, protease enzyme involved in the production ofstructural proteins and enzymes of virus as well as for maturation of new viralparticle. All available protease inhibitors act by binding reversibly to theactive site of HIV protease. This prevents the protease from cleaving the viralprecursor polypeptide and blocks subsequent viral maturation1. Resistanceto these agents is generally by stepwise accumulation of mutations of the proteasegene and is growing rapidly1. Therefore, there is always a need fornewer protease inhibitors for the effective treatment of HIV infections. Atazanvirand fosamprenavir are two recently approved HIV-1 protease inhibitors.Atazanavir,( BMS-232632)2-5: is a type of antiretroviral agent called a protease inhibitor (PI). It blocks protease, a protein that HIV needs to make more copies of it. It is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. Atazanavir does not care HIV or prevent passing HIV to others.
An Efficient Technique of Image Clustering using Limited Devices
Monika Bhatnagar,Dr. Prashant Kumar Singh
International Journal of Electronics Communication and Computer Technology , 2012,
Abstract: Data mining technique provides several facilities to facilitate several tasks related with large amount of data. Among these tasks the very common ones are association rule mining, classification and clustering. Clustering is gaining its popularity as efficient classifier. Clustering can be easily used as a classifier on limited devices because it uses less amount of space which is an important factor for limited devices. In this paper we present how clustering can be used as an image classifier in limited devices.
Monika Bhatnagar,Dr. Prashant Kumar Singh
International Journal of Electronics and Computer Science Engineering , 2012,
Abstract: Image classification can now be seen as emerging field as its usage is becoming essential in areas such as medical, geographical, satellite etc. Image classification on limited devices such as cellular phone is also coming in demand as the technology is advancing because now people want solutions to their problems available all the time in their hands. Here we are considering the special case of Indian farmers. Now with the several datamining techniques that are available to be used to construct the classifier for images, the choice of classification becomes a trivial task. This paper shows what classification technique can be used to build classifier amongst the available ones.
Segmentation Using Outlier Based Adaptive Thresholding
Vishal B. Langote,Dr. Devendra S. Chaudhari
International Journal of Recent Technology and Engineering , 2012,
Abstract: Image segmentation plays an important role in imageanalysis as a frequent pre-processing step, which divides the imageinto set of different segments. Thresholding is an easy yet efficientmethod for image segmentation, while dividing different objectswith distinct gray levels. Finding an effective threshold is especiallycomplicated task in the segmentation. In this paper, for efficientthreshold selection fuzzy methodology used which produces bettersegmentation results than other methodologies. It was observed thatat different background intensity levels favourable results wereobtained.
Rosuvastatin, a new HMG-CoA Reeductase Inhibitor with advantages over other available statins
Dr Vishal R.Tandon,Dr. B. M. Gupta
Pharmaceutical Reviews , 2005,
Abstract: The Food and Drug administration (FDA) approved a new HMG-CoA reductase inhibitor (rosuvastatin) on august, 2003. Rosuvastatin, is a synthetic, single enantiomer formulated and administered as the calcium salt. Although, dihydroxy heptenoic acid side chain is characteristic of the statin class, but one particular feature of the rosuvastatin molecule is a polar methane sulphonamide group that confers a relatively low lipophilicity, which make rosuvastatin relatively hydrophilic1,2 and hepatoselective1,2,3. Mechanism of action: rosuvastatin is a reversible competitive inhibitor of HMG-CoA reductase, which is the most important rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol1,4. In overall, few studies strongly suggest that rosuvastatin has the relatively greater binding to HMG-CoA reductase in comparison to other statins5,6. Rosuvastatin is relatively selective for liver and as a result of this action it increases the number of hepatic LDL receptors, which has been shown to increase ten time more by this drug in comparison to pravastatin2. This increase in LDL receptors enhances the uptake and catabolism of Low Density Lipoprotein (LDL) and Very Low-Density Lipoprotein (VLDL). This ultimately results in reduced concentrations of VLDL and LDL in the circulation2,4,7. Additionally, significant increase in High Density Lipoprotein (HDL) is also observed with the use of rosuvastatin8. It is more potent than other statins such as atorvastatin, simvastatin and is 8-fold more potent than the hydrophilic comparator, pravastatin5,6.
Visual Challenges among Drivers: A Case Study in Delhi, India
International Journal of Innovative Research in Science, Engineering and Technology , 2013,
Abstract: During the last two decades, developing countries such as India have been exhibiting rapid increase in human population and vehicles, and increase in road accidents. Inappropriate driving behaviour is considered one of the major causes of road accidents in India as compared to defective geometric design of pavement or mechanical defects in vehicles. Apart from the other factors causing accidents such as poor road design ,vehicle conditions, driver characteristics of frequent traffic violations, increase in crashes due to self-centred driving, etc. it can also be resulted in conditions such as lack of psychophysical abilities e.g. poor eye sight, poor vision at night time, glare blindness etc. Hence, improved driver screening facilities accompanied by availability of good driving aids such as anti glare glasses can be an effective and preventive measure to inhibit crash risks. This article is based on a case study jointly done by CSIR-Central Road Research Institute and Institute of Driver Training & Research, Maruti, Loni Border, Delhi, India to highlight visual limitations among the learner drivers which can influence (as per the literature review) driving behaviour with crash chances, which can be reduced through improving safety accompanied with better driver screening, providing free visual aids and modifying present licensing procedures.
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