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Search Results: 1 - 10 of 5920 matches for " Dowlathabad Muralidhara Rao "
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Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
Mahesh, Ayyavu;Jeyachandran, Robert;Rao, Dowlathabad Muralidhara;Thangadurai, Devarajan;
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/S0102-695X2012005000081
Abstract: in the present study, the ethanolic root extract of desmodium gangeticum (l.) dc., fabaceae, (edg), have been studied in various acute and chronic ulcer mouse models. oral administration of root extract, significantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. in gastric ulcerated animal that received high dose of 150 mg/kg edg, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. pylorus ligated mice, pretreated with edg showed significant decrease in ulcerous activity under chronic condition. the highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. our results indicate that the edg possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.
Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models
Ayyavu Mahesh,Robert Jeyachandran,Dowlathabad Muralidhara Rao,Devarajan Thangadurai
Revista Brasileira de Farmacognosia , 2012,
Abstract: In the present study, the ethanolic root extract of Desmodium gangeticum (L.) DC., Fabaceae, (EDG), have been studied in various acute and chronic ulcer mouse models. Oral administration of root extract, significantly decrease the ulcer index and lesion number in a dose dependent manner against ethanol induced acute gastric ulcer in mice. In gastric ulcerated animal that received high dose of 150 mg/kg EDG, the mucosa showed no ulceration with slight focal congestion and the glands appeared normal. Pylorus ligated mice, pretreated with EDG showed significant decrease in ulcerous activity under chronic condition. The highest dose (150 mg/kg) of the extract provoked a marked increase in protein and glutathione levels, when compare to control. Furthermore, gastric juice, free acidity and total acid output were inhibited in a dose-dependent manner at p<0.05 level. Our results indicate that the EDG possess gastroprotective activity and increasing regeneration of damaged gastric mucosa and thus safe for human use.
Comparative modeling of class 1 lysyl tRNA synthetase from Treponema pallidum
Venkata Rao Dodaghatta Krishna Rao,Rallapalli Ramanjeneyulu,Dowlathabad Muralidhara Rao,Chitta Suresh Kumar
Bioinformation , 2006,
Abstract: Lysyl tRNA synthetases facilitate amino acylation and play a crucial role in the essential cellular process of translation. They are grouped into two distinct classes (class I and class II). Class I lysyl tRNA synthetase is considered as a drug target for syphilis caused by Treponema palladium. Comparative genome analysis shows the absence of its sequence homolog in eukaryotes. The structure of class I lysyl tRNA synthetase from Treponema palladium is unknown and the difficulties in the in vitro culturing of Treponema makes it non-trivial. We used the structural template of class I lysyl tRNA synthetase from the archaea Pyrococcus horikoshii for modeling the Treponema palladium lysyl tRNA synthetase structure. Thus, we propose the usefulness of the modeled class I lysyl tRNA synthetase for the design of suitable inhibitors towards the treatment of syphilis.
Comparative modeling of methylentetrahydrofolate reductase (MTHFR) enzyme and its mutational assessment: in silico approach
Dowlathabad Muralidhara Rao,Anuraj Nayarisseri,Mukesh Yadav,Showmy K.S.
International Journal of Bioinformatics Research , 2010,
Abstract: DNA-synthesis, DNA-repair, and DNA imprinting processes require efficient conversion ofhomocysteine to methionine. This methylation is catalyzed by methylentetrahydrofolate reductase throughreduction of 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate. Normal DNA synthesis isconsidered critical for physiological functions of body. The enzyme is coded by the gene with the symbolMTHFR on chromosome 1 location p36.3 in humans. At least 24 mutations in the MTHFR gene have beenidentified in people with homocystinuria. There is DNA sequence variants (genetic polymorphisms)associated with this gene. Two of the most investigated are C677T (rs1801133) and A1298C (rs1801131)single nucleotide polymorphisms (SNP). Mutations at C677T and A1298C which confer amino acidsubstitution Ala222Val and Glu429Ala respectively with a considerable reduced activity. This polymorphismand mild hyperhomocysteinemia are associated with neural tube defects in offspring, arterial and venousthrombosis, and cardiovascular disease. 677TT individuals are at a decreased risk for certain leukemia andcolon cancer. The MTHFR gene could be one of the factors of overall schizophrenia risk. In silico analysisnow has added important and wide range applications to proteomics from structure modeling to its functionallevels. Several algorithms have been suggested from many authors to bring an accurate modeling at its bestbut ultimately every protein has its own variant features to be treated by the same algorithm. Studies inproteomics through computational techniques need complements between critical requirement for a proteinand features available in an algorithm. Comparative modeling is now bridging the gap between availablesequences and structures modeled with accuracy. Effective refinement techniques made it capable ofdriving models toward native structure. Structure of MTHFR can assist the study of involvement of thisenzyme in the disorders and can provide better level of understanding about structural aspects of it. Wehave modeled wild type and mutated type MTHFR using comparative modeling and structure validation hasgiven appreciable values. This work can further account for the structure based drug design community inthe search of MTHFR inhibitors.
Kinetics of substitution of cis-bis(malonato)diaquochromate(III) with glycine, DL-alanine and DL-phenylalanine in alkaline medium
Venkata Subba Rao Mushini, V. Ananta Ramam, V. Muralidhara Rao
Bulletin of the Chemical Society of Ethiopia , 2011,
Abstract: The kinetics of interaction among amino acids such as glycine, DL-alanine and DL-phenylalanine and cis-bis(malonato)diaquochromate(III) has been studied spectrophotometrically as a function of [glycine], [DL-alanine] and [DL-phenylalanine] in alkaline medium. The effect of pH, temperature and substrate was also studied. The substitution reaction has been found to proceed via two steps: amino acid dependent and amino acid independent path. In this process, it indicated that the substitution reaction occurs through an Ia mechanism in the amino acid dependent path and a dissociative mechanism in the independent path, showing the higher reactivity of single ended malonate complex. KEY WORDS: Substitution, cis-bis(Malonato)diaquochromate(III), Amino acids, Alkaline medium Bull. Chem. Soc. Ethiop. 2011, 25(1), 103-110.
Optimising the compression ratio of Mahua fuelled CI engine
GVNSR Ratnakara Rao,V. Ramachandra Raju,M. Muralidhara Rao
Journal of Engineering and Applied Sciences , 2009,
Abstract: Experimental investigations were carried out on a single cylinder variable compression ratio C.I engine using neat Mahua oil as the fuel. Both the performance and exhaust analysis were carried out to find the best suited compression ratio. Tests have been carried out at 7 different compression ratios viz.13.2, 13.9, 14.8, 15.7, 16.9, 18.1 and 20.2. All the experiments were carried out at standard test conditions like 700c cooling water temperature and at constant speed of 1500 rpm. The results shows hat 15.7 is the best compression ratio with Mahua oil. All the results were obtained without any modifications on either engine side or fuel side.
Optimising the compression ratio of diesel fuelled C.I engine
GVNSR Ratnakara Rao,V. Ramachandra Raju,M. Muralidhara Rao
Journal of Engineering and Applied Sciences , 2008,
Abstract: In order to find out optimum compression ratio experiments were carried out on a single cylinder four stroke variable compression ratio diesel engine. Tests were carried out at compression ratios of 13.2, 13.9, 14.8, 15.7, 16.9, 18.1 and 20.2. Results showed a significant improved performance and emission characteristics at a compression ratio 14.8. The compression ratios lesser than 14.8 and greater than 14.8 showed a drop in break thermal efficiency, rise in fuel consumption along with increased smoke densities.
Kinetics of substitution of cis-bis(malonato)diaquochromate(III) with glycine, DL-alanine and DL-phenylalanine in alkaline medium
Venkata Subba Rao Mushini,V. Ananta Ramam,V. Muralidhara Rao
Bulletin of the Chemical Society of Ethiopia , 2011,
Abstract: The kinetics of interaction among amino acids such as glycine, DL-alanine and DL-phenylalanine and cis-bis(malonato)diaquochromate(III) has been studied spectrophotometrically as a function of [glycine], [DL-alanine] and [DL-phenylalanine] in alkaline medium. The effect of pH, temperature and substrate was also studied. The substitution reaction has been found to proceed via two steps: amino acid dependent and amino acid independent path. In this process, it indicated that the substitution reaction occurs through an Ia mechanism in the amino acid dependent path and a dissociative mechanism in the independent path, showing the higher reactivity of single ended malonate complex.
Kinetics of substitution of cis-bis(malonato)diaquochromate(III) with glycine, DL-alanine and DL-phenylalanine
Venkata Subba Rao Mushini,V. Ananta Ramam,V. Muralidhara Rao
Bulletin of the Chemical Society of Ethiopia , 2009,
Abstract: The kinetics of interaction between amino acids such as glycine, DL-alanine and DL-phenylalanine and cis-bis(malonato)diaquochromate(III) has been studied spectrophotometrically as a function of [glycine], [DL-alanine] and [DL-phenylalanine]. The effect of pH, temperature and substrate is also studied. The substrate exists predominantly as the diaquospecies and amino acids (glycine, DL-alanine and DL-phenylalanine) as the zwitterion at the experimental conditions. The substitution reaction has been found to proceed via two steps: amino acid dependent and amino acid independent paths indicating that the substitution reaction occurs through associative interchange (Ia) mechanism in the amino acid dependent path and the dissociative mechanism in the independent path, showing the higher reactivity of single ended malonate complex.
GC-MS analysis of Nigella sativa seeds and antimicrobial activity of its volatile oil
Gerige, Saptha Jyothi;Gerige, Mahesh Kumar Yadav;Rao, Muralidhara;Ramanjaneyulu,;
Brazilian Archives of Biology and Technology , 2009, DOI: 10.1590/S1516-89132009000500016
Abstract: the present study dealt with the hydro distillation of nigella sativa seeds and gc-ms analysis. the total composition of the oil was 86.7%. the seed volatile oil was tested against 19 microbes (gram positive, gram negative and fungi), which showed that gram negative bacteria haemophilus influenza, klebsiella pnemoniae, and proteus vulgaris were highly sensitive against the antimicrobial agent, whereas the fungi such as trichoderma vibriae,. pencillium rubrum; and dermatophyte: trichophyton mentagrophytes; had no response at the 20μl concentration.
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