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A Clinical Trial of Melatonin in Elderly Patients with Insomnia
NR Doshi,CR Das,D Sah
Journal of Universal College of Medical Sciences , 2013, DOI: 10.3126/jucms.v1i3.8764
Abstract: BACKGROUND: The quality of life in the fast ageing population in the twentieth century is of great importance. Insomnia and melatonin levels in the geriatric population greatly affect sleep quality thereby also affecting blood pressure, mood changes and immune functions in this large segment of population.
PG E2 gel supplemented with oral PG E2 for induction of labour in high risk pregnancy
NR Doshi,D Sah,CR Das
Journal of Universal College of Medical Sciences , 2013, DOI: 10.3126/jucms.v1i4.9568
Abstract: INTRODUCTION: The risks to the fetus-infant increase substantively in high risk pregnancies. The efforts are always to ensure a vaginal rather than a caesarian delivery. The present study aims to assess the safety and efficacy of Prostaglandin E2( PGE2) intracervical gel and oral PGE2 in inducing and augmenting labour in such patients. METHODS: PGE2 intracervical gel was used for induction oflabour in 100 high risk pregnancies. PGE2 gel was supplemented by oral PGE2 afterARM. RESULTS: PGE2 successfully induced labour in 60% of women while it improved the Bishop's score in the rest of the cases. L.S.C.S. was needed in only 7% of women. CONCLUSION: Intracervical PGE2 gel application is a safe and efficacious method of inducing labour, which can be augmented with oral PGE2 when needed. DOI: http://dx.doi.org/10.3126/jucms.v1i4.9568 Journal of Universal College of Medical Sciences (2013) Vol.1 No.04: 22-25
Estimation of biomarkers berberine and gallic acid in polyherbal formulation punarnavashtak kwath and its clinical study for hepatoprotective potential
Shah V,Doshi D,Shah M,Bhatt P
International Journal of Green Pharmacy , 2010,
Abstract: Punarnavashtak (PN) kwath is a classical Ayurvedic formulation mentioned in Ayurvedic literature "Bhaishyajyaratnavali" for hepatic disorders and asthma. Standardization and clinical trial to support its efficacy are lacking. So, in the present study, standardization of PN kwath was done by using biomarkers, gallic acid and berberine, and its hepatoprotective activity was evaluated by clinical study to rationalise the traditional use of this formulation. PN kwath was standardized by HPTLC (High performance thin layer chromatography) using gallic acid and berberine as biomarkers and was subjected to clinical study. For clinical study patients attending outpatient clinics, with an evidence of liver disease were included in the study. During the study period, patients who fulfilled inclusion criteria were randomly assigned. The recommended dose was 20 ml kwath daily for 8 weeks. All the patients underwent clinical examination and laboratory investigations for liver functions tests before the commencement of therapy. Thereafter, clinical assessments were done after 8 weeks of treatment. The results showed significant changes in liver functions tests [serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin]. There was no report of adverse effects attributable to this formulation. Our results suggest that PN kwath showed significant hepatoprotective activity. Berberine and gallic acid were found to be 0.08 and 4.9%, respectively. Our results suggest that PN kwath showed significant hepatoprotective activity due to presence of various phytoconstituents and support its traditional uses in liver disorder.
Implantation of a Bi-Ventricular Pacing System in the Setting of Dextrocardia with Situs Inversus Totalis
Amit A Doshi,Stephen C Cook,John D Hummel
Indian Pacing and Electrophysiology Journal , 2010,
Abstract: Dextrocardia with situs inversus totalis is a rare disorder but is frequently associated with anomalous venous return. Pacemaker/Internal Cardioverter Defibrillator implantation in this population can be difficult given the difficult venous anatomy. This case illustrates how beforehand knowledge of the venous anatomy by cardiac MRI can facilitate device implantation.
Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies.
Vaidya A,Antarkar D,Doshi J,Bhatt A
Journal of Postgraduate Medicine , 1996,
Abstract: Picrorhiza kurroa (Pk), a known hepatoprotective plant, was studied in experimental and clinical situtations. The standardization of active principles--Picroside 1 and 2 was done with High Performance Liquid Chromatography. Picroside 1 ranged from 2.72 to 2.88 mg/capsule and picroside 2 from 5.50 to 6.00 mg/capsule. In the galactosamine-induced liver injury in rats, Pk at a dose of 200 mg/kg p.o. showed a significant reduction (p < 0.05) in liver lipid content, GOT and GPT. In a randomised, double-blind placebo controlled trial in patients diagnosed to have acute viral hepatitis (HBsAg negative), Pk root powder 375 mg three times a day was given for 2 weeks (n = 15) or a matching placebo (n = 18) was given. Difference in values of bilirubin, SGOT and SGPT was significant between placebo and Pk groups. The time in days required for total serum bilirubin to drop to average value of 2.5 mg% was 75.9 days in placebo as against 27.44 days in Pk group. The present study has shown a biological plausability of efficacy of Pk as supported by clinical trial in viral hepatitis, hepatoprotection in animal model and an approach for standardizing extracts based on picroside content.
Cavernous haemangioma in the interpeduncular cistern: case report and review of literature.
Muzumdar D,Bhatjiwale M,Goel A,Doshi P
Journal of Postgraduate Medicine , 2001,
Abstract: A rare case of a cavernous haemangioma in the interpeduncular cistern is reported. The patient, forty-five year old male presented with excruciating left sided trigeminal neuralgia and diplopia for the past one year. Examination revealed left third and fifth nerve paresis. Magnetic resonance imaging showed a well-defined, lobulated tumour in the interpeduncular cistern. The tumour was totally excised through a subtemporal route. Histology of the tumour revealed a cavernous haemangioma. Extracerebral location for a cavernous haemangioma is rare. An interpeduncular cavernous haemangioma has never been reported earlier in literature. The clinical and radiological features are discussed and relevant literature is briefly reviewed.
Paratesticular myxoliposarcoma--(a case report).
Ranadive N,Varty P,Doshi G,Gupte D
Journal of Postgraduate Medicine , 1989,
Abstract: A rare case of paratesticular myxoliposarcoma spreading to the inguinal region forming satellite nodules, hence clinically mimicking a metastatising testicular malignancy is reported. Its prognostic factors are discussed.
Sexual decision-making of immigrant East Indians: Risky or not?
Neeti V Doshi,Nicole A Yoskowitz,Kelley D Urry
Columbia Undergraduate Science Journal , 2006,
Abstract: Reports of growing HIV/AIDS infection rates in India have brought increasing attention to the concept of sexuality in South Asian culture. There is a lack of awareness of the risks of sexual behavior due to the stigma associated with sexuality. As immigrants in the United States, young South Asians face cultural shock when it comes to sexuality and sexual behavior. Consequently, a tension exists between the belief systems of the country of origin and the individual’s belief system, influenced by American culture. The objective of this study is to understand the socio-cultural influences on individual decision-making regarding the sexual activity of a South Asian (specifically, Indian) immigrant population, using theories and methods from cognitive science. Twenty first- and second-generation, heterosexual, male and female Indians living in New York City were interviewed regarding their sexual activity. Results show that 55% of participants engaged in sexual activity, of which 22% were first-generation and 82% were second-generation. This pattern suggests a trend in sexual behavior that follows a wellknown “U-shaped” curve. The bottom of the curve represents the low risk behavior of first generation immigrants in their transition to an unfamiliar culture, where there is a high level of uncertainty and desire to maintain their original value system. Subsequent generations become assimilated to the new culture, and thus are more likely to adopt the sexual practices of this new culture. The transmission of beliefs from first to second generation is crucial with regard to decision-making governing (safe) sexual behavior for subsequent generations.
The elusive definition of pandemic influenza
Doshi,Peter;
Bulletin of the World Health Organization , 2011, DOI: 10.2471/BLT.11.086173
Abstract: there has been considerable controversy over the past year, particularly in europe, over whether the world health organization (who) changed its definition of pandemic influenza in 2009, after novel h1n1 influenza was identified. some have argued that not only was the definition changed, but that it was done to pave the way for declaring a pandemic. others claim that the definition was never changed and that this allegation is completely unfounded. such polarized views have hampered our ability to draw important conclusions. this impasse, combined with concerns over potential conflicts of interest and doubts about the proportionality of the response to the h1n1 influenza outbreak, has undermined the public trust in health officials and our collective capacity to effectively respond to future disease threats. who did not change its definition of pandemic influenza for the simple reason that it has never formally defined pandemic influenza. while who has put forth many descriptions of pandemic influenza, it has never established a formal definition and the criteria for declaring a pandemic caused by the h1n1 virus derived from "pandemic phase" definitions, not from a definition of "pandemic influenza". the fact that despite ten years of pandemic preparedness activities no formal definition of pandemic influenza has been formulated reveals important underlying assumptions about the nature of this infectious disease. in particular, the limitations of "virus-centric" approaches merit further attention and should inform ongoing efforts to "learn lessons" that will guide the response to future outbreaks of novel infectious diseases.
Ocular injuries in rural industries
Doshi R
Indian Journal of Ophthalmology , 1968,
Abstract:
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