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Search Results: 1 - 10 of 140591 matches for " Dorian K. Rose "
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Does Inhibitory Repetitive Transcranial Magnetic Stimulation Augment Functional Task Practice to Improve Arm Recovery in Chronic Stroke?
Dorian K. Rose,Carolynn Patten,Theresa E. McGuirk,Xiaomin Lu,William J. Triggs
Stroke Research and Treatment , 2014, DOI: 10.1155/2014/305236
Abstract: Introduction. Restoration of upper extremity (UE) functional use remains a challenge for individuals following stroke. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive modality that modulates cortical excitability and is being explored as a means to potentially ameliorate these deficits. The purpose of this study was to evaluate, in the presence of chronic stroke, the effects of low-frequency rTMS to the contralesional hemisphere as an adjuvant to functional task practice (FTP), to improve UE functional ability. Methods. Twenty-two individuals with chronic stroke and subsequent moderate UE deficits were randomized to receive 16 sessions (4 times/week for 4 weeks) of either real-rTMS or sham-rTMS followed by 1-hour of paretic UE FTP. Results. No differences in UE outcomes were revealed between the real-rTMS and sham-rTMS intervention groups. After adjusting for baseline differences, no differences were revealed in contralesional cortical excitability postintervention. In a secondary analysis, data pooled across both groups revealed small, but statistically significant, improvements in UE behavioral measures. Conclusions. rTMS did not augment changes in UE motor ability in this population of individuals with chronic stroke. The chronicity of our participant cohort and their degree of UE motor impairment may have contributed to inability to produce marked effects using rTMS. 1. Introduction Between 55% and 75% of stroke survivors experience limitations in functional use of the upper extremity at six-months post-stroke [1]. Upper-limb motor recovery post-stroke is of special concern because the impact of UE impairments on disability and health is so marked [2, 3]. The persistence of UE impairments and the resultant inability to use the arm and hand prevents many individuals from returning to work, representing significant socioeconomic impact on the individual, the healthcare systems and society at large. While these problems are well recognized, little progress has been made in demonstrating substantive UE recovery in this population. Repetitive transcranial magnetic stimulation (rTMS) is a form of noninvasive brain stimulation with the capacity to modulate cortical excitability. In health, transcallosal connections create an environment of mutual interhemispheric inhibition [4], critical to normal motor control, and especially relevant to performance of skilled movements. Following stroke, decreased corticospinal excitability in the lesioned hemisphere leads to an asymmetry in this mutual transcallosal inhibition [5, 6]. Decreased
Study protocol: home-based telehealth stroke care: a randomized trial for veterans
Neale R Chumbler, Dorian K Rose, Patricia Griffiths, Patricia Quigley, Nancy McGee-Hernandez, Katherine A Carlson, Phyllis Vandenberg, Miriam C Morey, Jon Sanford, Helen Hoenig
Trials , 2010, DOI: 10.1186/1745-6215-11-74
Abstract: We describe an ongoing Phase II, 2-arm, 3-site randomized controlled trial (RCT) that determines primarily the effect of TR on physical function and secondarily the effect on disability, falls-related self-efficacy, and patient satisfaction. Fifty participants with a diagnosis of ischemic or hemorrhagic stroke will be randomly assigned to one of two groups: (a) TR; or (b) Usual Care. The TR intervention uses a combination of three videotaped visits and five telephone calls, an in-home messaging device, and additional telephonic contact as needed over a 3-month study period, to provide a progressive rehabilitative intervention with a treatment goal of safe functional mobility of the individual within an accessible home environment. Dependent variables will be measured at baseline, 3-, and 6-months and analyzed with a linear mixed-effects model across all time points.For patients recovering from stroke, the use of TR to provide home assessments and follow-up training in prescribed equipment has the potential to effectively supplement existing home health services, assist transition to home and increase efficiency. This may be particularly relevant when patients live in remote locations, as is the case for many veterans.Clinical Trials.gov Identifier: NCT00384748Stroke patients clearly benefit from intensive and coordinated inpatient care. Access to post-acute stroke in-patient rehabilitation is limited for many individuals, especially those residing in rural locations. One study found that over 75% of US veterans treated within the Department of Veterans Health Administration (VHA) with an acute stroke are cared for in hospitals without an inpatient rehabilitation bed-unit (RBU), and fewer than 10% of stroke patients are transferred to a RBU from facilities without a RBU [1].While inpatient rehabilitation care is the preferred form for many patients post-stroke, due to access and financial barriers, many patients do not have this option. Another viable option is home-
Protocol for the Locomotor Experience Applied Post-stroke (LEAPS) trial: a randomized controlled trial
Pamela W Duncan, Katherine J Sullivan, Andrea L Behrman, Stanley P Azen, Samuel S Wu, Stephen E Nadeau, Bruce H Dobkin, Dorian K Rose, Julie K Tilson, The LEAPS Investigative Team
BMC Neurology , 2007, DOI: 10.1186/1471-2377-7-39
Abstract: The objective of the Locomotor Experience Applied Post-Stroke (LEAPS) trial is to determine if there is a difference in the proportion of participants who recover walking ability at one year post-stroke when randomized to a specialized locomotor training program (LTP), conducted at 2- or 6-months post-stroke, or those randomized to a home based non-specific, low intensity exercise intervention (HEP) provided 2 months post-stroke. We will determine if the timing of LTP delivery affects gait speed at 1 year and whether initial impairment severity interacts with the timing of LTP. The effect of number of treatment sessions will be determined by changes in gait speed taken pre-treatment and post-12, -24, and -36 sessions.We will recruit 400 adults with moderate or severe walking limitations within 30 days of stroke onset. At two months post stroke, participants are stratified by locomotor impairment severity as determined by overground walking speed and randomly assigned to one of three groups: (a) LTP-Early; (b) LTP-Late or (c) Home Exercise Program -Early. The LTP program includes body weight support on a treadmill and overground training. The LTP and HEP interventions are delivered for 36 sessions over 12 weeks.Primary outcome measure include successful walking recovery defined as the achievement of a 0.4 m/s gait speed or greater by persons with initial severe gait impairment or the achievement of a 0.8 m/s gait speed or greater by persons with initial moderate gait impairment.LEAPS is powered to detect a 20% difference in the proportion of participants achieving successful locomotor recovery between the LTP groups and the HEP group, and a 0.1 m/s mean difference in gait speed change between the two LTP groups.The goal of this single-blinded, phase III randomized clinical trial is to provide evidence to guide post-stroke walking recovery programs.NCT00243919.Of the 730,000 individuals who will survive a stroke each year, 73% will have residual disability [1]. Locomo
Alluvial Gold Mining Sites as Exposure Pathways for Methyl Mercury Toxicity in Children: A Systematic Review  [PDF]
Rose K. Begani, Alphonse Z. Begani
Health (Health) , 2017, DOI: 10.4236/health.2017.96066
Abstract:
Extensive studies have showed that alluvial gold mining is a predisposing factor for mercury toxicity through occupational exposure. In our systematic review of related literature, we aim to determine if children of alluvial gold miners were at risk of exposure to methyl mercury toxicity through dietary exposure. This was achieved through applying Cochrane PICO methodology for the research question. We selected only the most relevant articles from the thousands of articles that were generated by the Divine Word University (DWU) electronic data base system for our review. Further screening questions were applied based on the CASP method which filtered remaining 105 to only 9 papers for the review. The results from the nine (N = 9) studies analysed showed convincing results of the association between consumption of fish contaminated with methyl mercury and poor growth and development in children whose parents lived near mining sites. We conclude that since mercury is the predominant element used in the extraction of gold in alluvial mining, it is an exposure pathway for methyl mercury toxicity for children through dietary exposure.
Is Exposure to Titanium Dioxide Nanoparticle Associated with Occupational Lung Cancer among Titanium Dioxide Production Workers? An Emerging Issue  [PDF]
Alphonse Z. Begani, Rose K. Begani
Occupational Diseases and Environmental Medicine (ODEM) , 2018, DOI: 10.4236/odem.2018.62004
Abstract: This systemic literature review was conducted to find out if there was an association between exposure to TiO2 NP (Titanium dioxide nanoparticle) and occupational lung cancer among TiO2 production workers. An electronic database search was employed which generated several studies relating to TiO2 nanoparticle toxicity. From these studies only ten (10) articles were chosen for this study because they met the review criteria. Two articles were centered around cohort study design while other 8 studies were on experimental design. The two cohort studies did answer the review question that showed no association of TiO2 toxicity and respiratory diseases while the experimental design studies produced conflicting results. The conflicting results were attributed to their objective, sample size, and the study designs. Despite the different conclusions there is adequate evidence in the experimental studies that demonstrated evidence of TiO2 nanoparticle toxicity. Notable cases include cytotoxicity, genotoxicity, apoptotic and cell necrosis in rat and human cells exposed to TiO2 which is generally dose response related. The strengths and limitations of the 10 studies are also discussed. General understanding gained from these studies is for appropriate agencies to be proactive in developing mitigation and controls measures against nanoparticle exposure. This is necessary to avert repetition of previous experiences with exposure to asbestos fibers as a point of reference.
Negative refraction of photonic and polaritonic waves in periodic structures
K. Kempa , A. Rose
Bulletin of the Polish Academy of Sciences: Technical Sciences , 2009, DOI: 10.2478/v10175-010-0102-7
Abstract: Negative refraction can be achieved in photonic crystals. We briefly summarize recent studies in this field, and show that such effects are also possible in polaritonic and plasmonic structures, such as the dipole crystal. We propose a practical realization of this crystal, a periodic lattice of dielectric spheres. We study its mode structure, and preliminary results demonstrate the negative refraction on a polaritonic band.
Assessment of Knowledge, Attitudes and Practices of Food Handlers in Attieke Production Units in Relation to Food Hygiene and Safety in Côte d’Ivoire in 2012  [PDF]
Theodore N. Djéni, Alfred K. Kouamé, Youssouf Traoré, Rose K. Nevry, Marcellin K. Dje
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.510099
Abstract:

The aims of this study were to investigate the food safety knowledge and practices of food handlers and to assess the sanitary conditions of attieke production units in the South of C?te d’Ivoire. A cross-sectional study was conducted during 4 months in 2012 in 7 localities and data were collected using questionnaire and observation checklist and microbiological analysis of hands. A total of 775 attieke production units were involved in this survey. Seventy-one percent (71%) were located on public domains and only 70 production units (9%) used septic tank as a mean of final deposal for liquid waste. Hygiene conditions and practices of food handlers in attieke production units were inadequate. The presence of specific microorganisms such as Staphylococcus aureus, Klebsiella pneumoniae, Enterobacter agglomerans, Citrobacter youngae, Klebsiella oxytoca and Citrobacter freundi was indicative of a degree of ignorance on the part of food handlers towards proper hygienic practices.

AFACERILE SOCIALE N EUROPA. DE LA B NCI LA ANTREPRENORIAT SOCIAL. INTERVIU CU DL. FRANZ KARL PRüLLER, FUNDA IA ERSTE DIN AUSTRIA
Dorian Ilie
Revista de Economie Sociala , 2013,
Abstract: Acest interviu a fost realizat cu domnul Franz Karl Pruller, membru n consiliul de conducere al Funda iei ERSTE din Austria, una dintre cele mai active organiza ii din Europa Central i de Est n ceea ce prive te implicarea social . Am discutat cu dumnealui despre afaceri sociale n Europa, antreprenoriat social, cazuri de bun practic , situa ia din Romania i despre proiectele funda iei ERSTE n ara noastr .
SOCIAL ENTREPRENEURSHIP IS A LONG TERM SOLUTION. INTERVIEW WITH MRS. MONA NICOLICI, COMMUNITY RELATIONS MANAGER AT PETROM
Dorian Ilie
Revista de Economie Sociala , 2013,
Abstract: The United Nations Development Programme in Romania discussed with Mrs. Mona Nicolici about the social business competition Made in the country of Andrei, a contest that was launched at the beginning of this year, about the project The Country of Andrei of which this competition is part of, about the corporate social responsibility program of Petrom and about the future plans of the company fromthis point of view.
ANTREPRENORIATUL SOCIAL ESTE O SOLU IE PE TERMEN LUNG. INTERVIU CU DOAMNA MONA NICOLICI, MANAGER RELA II COMUNITARE N CADRUL PETROM
Dorian Ilie
Revista de Economie Sociala , 2013,
Abstract: Acest interviu a fost realizat cu doamna Mona Nicolici, Manager Rela ii Comunitare n cadrul Petrom. Am discutat cu doamna Nicolici despre competi ia de afaceri sociale Fabricat n ara lui Andrei, concurs lansat la nceputul acestui an, despre proiectul ara lui Andrei din care face parte aceast competi ie, despre programul de responsabilitate social corporatist al Petrom i despre planurile de viitor ale companiei din acest punct de vedere.
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