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Search Results: 1 - 10 of 297938 matches for " Donna J. Charlevoix "
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Design and Implementation of Inquiry-Based, Technology-Rich Learning Activities in a Large-Enrollment Blended Learning Course
Donna J. Charlevoix,Sara T. Strey,Catrin M. Mills
Journal of the Research Center for Educational Technology , 2009,
Abstract: We propose that the key to creating an effective learning experience in a blended environment with over 100 students is to strategically embed learning activities into the curriculum. Inquiry-based, technology-rich learning activities give students many of the same benefits of community as experienced in a small, traditional class. Technology-based learning activities during in-class meetings assisted in the development of community within student teams. Out-of-class technology-based learning activities leveraged multimedia online resources and provided the means for inquiry-based student learning. Students reported positive experiences with the learning activities. Content knowledge was equivalent to courses without comparable learning activities; however, students developed better application skills, relating theoretical concepts to real-life events.
Clinical supervision for novice millennial nurses in the perinatal setting: The need for generational sensitivity  [PDF]
Jo Watson, G. J. Macdonald, Donna Brown
Open Journal of Nursing (OJN) , 2013, DOI: 10.4236/ojn.2013.35050
Abstract:

This paper reports on a qualitative research study that examined the experience of expert and novice nurses participating in a new, reflective program of “clinical supervision”, intending to facilitate the transition of new graduate nurses into the workforce. Three patterns emerged during the constructivist inquiry: readiness to reflect, valuing of clinical supervision, and sustainability of the clinical supervision model. The researchers suggest generational sensitivity as a key perspective to consider when developing engaging workplace strategies for millennial nurses. The article offers recommendations for the implementation of clinical supervision and would be of interest to nurse leaders in a clinical setting.

"El Rey Algodón". Los Estados Unidos, la Argentina y el desarrollo de la industria algodonera argentina
Donna J. Guy
Mundo agrario , 2000,
Abstract:
Considerations for Combining High-Protease Extracts in Immunotherapy Vaccines  [PDF]
Carol M. Lilley, Donna J. Rekkerth, Brian F. Teske
Open Journal of Nursing (OJN) , 2014, DOI: 10.4236/ojn.2014.44029
Abstract:

Current practice parameters state that extracts rich in proteases, such as fungal and insect extracts, can be combined during preparation of allergy immunotherapy vaccines. However, until recently, this guideline has not been the subject of investigation. Scientists now have data that shed light on high-protease allergenic extract mixtures used in allergy immunotherapy. A study published in Annals of Allergy, Asthma & Immunology in 2012 reports on the compatibility of combining fungal and insect extracts and emphasizes the importance of understanding how protease activities and total glycerin levels in allergy extracts can affect the stability of allergy immunotherapy vaccine mixtures. This research provides a critical assessment of the mixing compatibilities of several well-characterized high-protease extracts and may influence future immunotherapy practice parameters and immunotherapy extract preparation guidelines.

Interpreting interest in interferon-α
Donna L Thibault, Paul J Utz
Arthritis Research & Therapy , 2003, DOI: 10.1186/ar796
Abstract: The group of cytokines known as interferons was first characterized in 1957. Interferons were named for their ability to 'interfere' with viral replication, conferring resistance to infection transferred from virally infected chick cells into uninfected cells [2]. The therapeutic potential of interferon in viral infection was first demonstrated through its ability to inhibit respiratory virus infection [3]. Interferons have since been proven clinically effective antiviral and antineoplastic therapeutic agents for a variety of disorders (for review [4]).There are two groups of interferons: type I interferons (IFN-α, IFN-β, IFN-ω) and type II interferon (IFN-γ). Human IFN-α was cloned in 1980, and was found to represent a mixture of several closely related proteins expressed from distinct genes [5]. A second type of interferon, IFN-β, is produced mainly by fibroblasts, is a single protein species, and was cloned around the same time [6]. A third species of human type I interferon is known as IFN-ω [7]. IFN-γ is produced by activated T cells and has been found to be a single protein in all animal species [8]. Induction of interferon synthesis at high levels is triggered by viruses, and is also induced by a variety of nonviral agents such as bacteria and synthetic polymers [9,10]. The production of IFN-α and IFN-β by virally infected cells induces resistance to viral replication, enhances MHC class I expression, increases antigen presentation, and activates natural killer cells to kill virus-infected cells [11]. Thus, type I interferons are active in both innate and adaptive immunity. The actions of IFN-γ include macrophage activation, increased expression of MHC and antigen processing components, immunoglobulin class switching, and suppression of T-helper-2 responses [11].Many historical studies have indicated a role for the type I interferon system in both human and murine SLE. Although controversial, some studies have shown that serum derived from lupus patients cont
Human mercury exposure and adverse health effects in the Amazon: a review
Passos, Carlos J. S.;Mergler, Donna;
Cadernos de Saúde Pública , 2008, DOI: 10.1590/S0102-311X2008001600004
Abstract: this paper examines issues of human mercury (hg) exposure and adverse health effects throughout the amazon region. an extensive review was conducted using bibliographic indexes as well as secondary sources. there are several sources of hg (mining, deforestation, reservoirs), and exposure takes place through inhalation or from fish consumption. there is a wide range of exposure, with mean hair-hg levels above 15μg/g in several amazonian communities, placing them among the highest reported levels in the world today. dietary hg intake has been estimated in the vicinity of 1-2μg/kg/day, considerably higher than the usepa rfd of 0.1μg/kg/day or the world health organization recommendation of 0.23μg/kg/day. neurobehavioral deficits and, in some cases, clinical signs have been reported both for adults and children in relation to hg exposure in several amazonian countries. there is also some evidence of cytogenetic damage, immune alterations, and cardiovascular toxicity. since fish provide a highly nutritious food source, there is an urgent need to find realistic and feasible solutions that will reduce exposure and toxic risk, while maintaining healthy traditional dietary habits and preserving this unique biodiversity.
Alkene selenenylation: A comprehensive analysis of relative reactivities, stereochemistry and asymmetric induction, and their comparisons with sulfenylation
Vadim A. Soloshonok,Donna J. Nelson
Beilstein Journal of Organic Chemistry , 2011, DOI: 10.3762/bjoc.7.85
Abstract: A broad perspective of various factors influencing alkene selenenylation has been developed by concurrent detailed analysis of key experimental and theoretical data, such as asymmetric induction, stereochemistry, relative reactivities, and comparison with that of alkene sulfenylation. Alkyl group branching α to the double bond was shown to have the greatest effect on alkene reactivity and the stereochemical outcome of corresponding addition reactions. This is in sharp contrast with other additions to alkenes, which depend more on the degree of substitution on C=C or upon substituent electronic effects. Electronic and steric effects influencing asymmetric induction, stereochemistry, regiochemistry, and relative reactivities in the addition of PhSeOTf to alkenes are compared and contrasted with those of PhSCl.
Gap Junctional Intercellular Communication Increases Cytotoxicity and Reduces Resistance to Hydroxyurea  [PDF]
Randall J. Ruch, Paul D. Boucher, Brian G. Gentry, Donna S. Shewach
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.513121
Abstract:

Background: Gap junctions enable small molecules to diffuse between adjacent cells and have been associated with greater cytotoxicity of radiation and anti-cancer drugs. We investigatedwhether this gap junctional intercellular communication (GJIC) affected the cytotoxicity of the classicribonucleotide reductase (RR) inhibitor and anti-cancer agent, hydroxyurea (HU). Materials and Methods: We used GJIC-proficient and deficient, connexin 43-expressing WB rat liver epithelial cell lines. We compared HU toxicity by crystal violet assay, effects of the drug on deoxynucleotide pools by HPLC, and ability of GJIC to increase toxicity of HU-resistant cells through a bystander effect in co-culture experiments. Results: GJIC-proficient cells were three- to five-fold more sensitive (IC500.1 mM) to HU than GJIC-deficient derivatives (IC500.3 - 0.5 mM). This sensitivity depended upon GJIC because treatment of GJIC-proficient cells with the GJIC blocker oleamide decreased HU toxicity by approximately 60% - 80% and restoration of GJIC in GJIC-deficient cells by stable transduction of connexin 32-encodingGjb1increased HU toxicity (IC50

Prevalence of Isolated “Pre-Malignant” Lesions on Prostate Biopsy in a Racially Diverse Community Screened Cohort  [PDF]
Michael A. Liss, Donna Ankerst, David Zapata, Javier Hernandez, Robin J. Leach, Ian M. Thompson
Open Journal of Urology (OJU) , 2015, DOI: 10.4236/oju.2015.512034
Abstract: Objective: We investigated rates of prostate cancer (PCa), high-grade prostatic intraepithelial neoplaisa (HGPIN) and atypical small acinar proliferation (ASAP) in a multiethnic cohort. Methods: We evaluated prostate biopsy outcomes in men enrolled in the San Antonio Center of Biomarkers of Risk for prostate cancer (SABOR) prospective, observational study. PCa-free men underwent annual PSA testing over nearly 14 years with biopsies based on community standards. We investigated biopsy outcomes with a special interest in rates of cancer, HGPIN, and ASAP. Results: We identified 975 prostate biopsies in 801 subjects from 3/1/2001 to 1/9/2014. PCa, HGPIN, or ASAP was encountered in 28.8% (281/975), 10.1% (98/975), and 5.2% (51/975) of prostate biopsy specimens, respectively. The most significant risk factor for a PCa diagnosis was African American race (OR 5.0, 95% CI: 2.2 - 11.4, p < 0.001). HGPIN and ASAP occurred more commonly in association with PCa (both p < 0.001). We identified 57% (24/42) of men diagnosed with a “pre-malignant” lesion on prostate biopsy and had a subsequent biopsy. Of those only 8% (2/24) were diagnosed with prostate cancer (both Gleason 3 + 3) within 1 year of the initial biopsy. Conclusion: We note a 5-fold increased risk of PCa for African American men. The incidence of HGPIN and ASAP are consistent with previously reported incidence. If diagnosed in isolation, repeat biopsy within one year could be delayed or eliminated as it may not change prostate cancer outcomes.
Completely reducible SL(2)-homomorphisms
George J. McNinch,Donna M. Testerman
Mathematics , 2005, DOI: 10.1090/S0002-9947-07-04289-4
Abstract: Let K be any field, and let G be a semisimple group over K. Suppose the characteristic of K is positive and is very good for G. We describe all group scheme homomorphisms phi:SL(2) --> G whose image is geometrically G-completely reducible -- or G-cr -- in the sense of Serre; the description resembles that of irreducible modules given by Steinberg's tensor product theorem. In case K is algebraically closed and G is simple, the result proved here was previously obtained by Liebeck and Seitz using different methods. A recent result shows the Lie algebra of the image of phi to be geometrically G-cr; this plays an important role in our proof.
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